Article(id=1304388061580784216, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1304388047747969563, articleNumber=null, orderNo=null, doi=10.7501/j.issn.0253-2670.2026.10.012, pmid=null, cstr=null, oa=null, hot=0, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1769356800000, receivedDateStr=2026-01-26, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1788919948239, onlineDateStr=2026-09-09, pubDate=null, pubDateStr=null, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1788919948239, onlineIssueDateStr=2026-09-09, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1788919948239, creator=13701087609, updateTime=1788919948239, updator=13701087609, issue=Issue{id=1304388047747969563, tenantId=1146029695717560320, journalId=1302319053441957962, year='2026', volume='57', issue='10', pageStart='3685', pageEnd='4088', issueExtLink='null', onlineDate='null', pubDate='1779897600000', pubDateStr='2026-05-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1788919944940, creator='13701087609', updateTime=1788923403989, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1304402556332037104, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1304388047747969563, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1304402556332037105, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1304388047747969563, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=3807, endPage=3817, ext={EN=ArticleExt(id=1304388061916328538, articleId=1304388061580784216, tenantId=1146029695717560320, journalId=1302319053441957962, language=EN, title=Muscone ameliorates cisplatin-induced acute kidney injury by inhibiting apoptosis of renal tubular epithelial cells via promotion of p53 ubiquitination, columnId=null, journalTitle=Chinese Traditional and Herbal Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=Objective To explore the mechanism by which muscone improves cisplatin-induced acute kidney injury (AKI). Methods C57BL/6J mice were randomly divided into control group, model group, dexamethasone (2 mg/kg) group, muscone low-, medium-, and high-dose (24, 36, 48 mg/kg) groups, a cisplatin-induced AKI mouse model was established. After drug intervention, renal tissue pathological changes were observed using hematoxylin-eosin (HE) staining. Immunohistochemistry was used to detect the expressions and distribution of neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (Kim-1) in kidney. Blood urea nitrogen (BUN) and serum creatinine (SCr) levels were detected. Immunofluorescence staining was used to detect the expression and distribution of cleaved cysteine aspartate protease-3 (cleaved Caspase-3) in renal tissue. An NRK-52E cell injury model induced by cisplatin was established, the effects of cisplatin, muscone and p53 inhibitor pifithrin-μ on cell viability were detected using MTT assay. The morphological change of cells was observed under an inverted microscope. Calcein AM/PI staining was used to observe cell death. Hoechest 33342 staining was used to observe the fragmentation of cell nuclei. Cell death types was observed using transmission electron microscopy. Immunofluorescence staining was used to detect the expression and distribution of p53. Western blotting was used to detect the expressions of Caspase-3, cleaved Caspase-3 and p53. MitoSOX staining was used to detect the levels of mitochondrial reactive oxygen species (mtROS). Immunoprecipitation was used to detect the level of p53 ubiquitination modification. Results Muscone significantly reduced the renal pathological damage caused by cisplatin, restored the morphology of renal tubules (P < 0.01), decreased the expressions and distribution of NGAL, Kim-1 and cleaved Caspase-3 in renal tissue (P < 0.01), reduced the levels of BUN and SCr (P < 0.01). Muscone and pifithrin-μ significantly inhibited cisplatin-induced apoptosis and mtROS level in NRK-52E cells (P < 0.01), upregulated Caspase-3 protein expression (P < 0.05, 0.01), downregulated cleaved Caspase-3 and p53 protein expressions (P < 0.05, 0.01), and promoted p53 ubiquitination modification (P < 0.05). Conclusion Muscone inhibits apoptosis of renal tubular epithelial cells by promoting p53 ubiquitination modification, thereby improving cisplatin-induced AKI., authors=ZHANG Haiyan, XUE Chen, MA Jingru, GUO Jiaqi, SHI Jianyu, SUI Yang, LIU Haijing, WANG Changhe, ZHANG Zhen, authorsList=ZHANG Haiyan, XUE Chen, MA Jingru, GUO Jiaqi, SHI Jianyu, SUI Yang, LIU Haijing, WANG Changhe, ZHANG Zhen, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1304388061836636761, articleId=1304388061580784216, tenantId=1146029695717560320, journalId=1302319053441957962, language=CN, title=麝香酮通过促进p53泛素化修饰抑制肾小管上皮细胞凋亡并改善顺铂诱导的急性肾损伤, columnId=1304140191707456168, journalTitle=中草药, columnName=药理与临床, runingTitle=null, highlight=null, articleAbstract=目的 探究麝香酮改善顺铂诱导的急性肾损伤（acute kidney injury，AKI）的作用机制。方法 C57BL/6J小鼠随机分为对照组、模型组、地塞米松（2 mg/kg）组和麝香酮低、中、高剂量（24、36、48 mg/kg）组，建立顺铂诱导的AKI小鼠模型，给予药物干预后，采用苏木素-伊红（hematoxylin-eosin，HE）染色观察肾脏组织病理变化；免疫组化检测肾脏中性粒细胞明胶酶相关脂质运载蛋白（neutrophil gelatinase-associated lipocalin，NGAL）和肾损伤分子-1（kidney injury molecule-1，Kim-1）的表达和分布；检测血尿素氮（blood urea nitrogen，BUN）和血肌酐（serum creatinine，SCr）水平；免疫荧光染色检测肾脏组织中剪切型半胱氨酸天冬氨酸蛋白酶-3（cleaved cystein-asparate protease-3，cleaved Caspase-3）的表达和分布。采用顺铂诱导建立NRK-52E细胞损伤模型，MTT法检测顺铂、麝香酮、p53抑制剂pifithrin-μ对细胞活力的影响；倒置显微镜观察细胞形态变化；Calcein AM/PI染色观察细胞死亡情况；Hoechest 33342染色观察细胞核碎裂情况；透射电子显微镜观察细胞死亡类型；免疫荧光染色检测p53的表达和分布；Western blotting检测Caspase-3、cleaved Caspase-3和p53的表达；MitoSOX染色检测线粒体活性氧（mitochondrial reactive oxygen species，mtROS）水平；免疫共沉淀检测p53泛素化修饰水平。结果 麝香酮显著减轻顺铂引起的肾脏病理损伤，恢复肾小管形态（P ＜0.01），降低肾脏组织NGAL、Kim-1、cleaved Caspase-3的表达和分布（P ＜0.01），降低BUN、SCr水平（P ＜0.01）；麝香酮和pifithrin-μ显著抑制顺铂诱导的NRK-52E细胞凋亡及mtROS水平（P ＜0.01），上调Caspase-3蛋白表达（P ＜0.05、0.01），下调cleaved Caspase-3、p53蛋白表达（P ＜0.05、0.01），促进p53泛素化修饰（P ＜0.05）。结论 麝香酮通过促进p53泛素化修饰抑制肾小管上皮细胞凋亡，从而改善顺铂诱导的AKI。, authors=张海宴1 , 薛晨1 , 马敬茹1 , 郭家琪1 , 施建羽1 , 隋阳2 , 刘海静3 , 王嫦鹤1,4 , 张珍1 , authorsList=张海宴, 薛晨, 马敬茹, 郭家琪, 施建羽, 隋阳, 刘海静, 王嫦鹤, 张珍, authorCompany=1 陕西中医药大学 陕西中药资源产业化省部共建协同创新中心, 陕西 咸阳 712046; et al . Acute kidney injury [J]. Lancet , 2025, 405(10474): 241-256.J Clin Invest , 2025, 135(6): e188358.et al . Cisplatin nephrotoxicity: New insights and therapeutic implications [J]. Nat Rev Nephrol , 2023, 19(1): 53-72.et al . Pharmacological effects and mechanisms of muscone [J]. J Ethnopharmacol , 2020, 262: 113120.et al . Analysis of the pharmacodynamic difference between Xiaojin Pills taken with Chinese Baijiu and water based on serum pharmacochemistry and pharmacokinetics [J]. J Ethnopharmacol , 2023, 300: 115723.et al . Preventive effect of muscone against cisplatin nephrotoxicity in LLC-PK1 cells [J]. Biomolecules , 2020, 10(10): 1444.et al . Pretreatment of Huaiqihuang Extractum protects against cisplatin-induced nephrotoxicity [J]. Sci Rep , 2018, 8: 7333.et al . Lipin3 deficiency aggravates cisplatin induced acute kidney injury via activating Sirt1-p21-Caspase 3-GSDME pyroptosis pathway [J]. Int J Biol Sci , 2025, 21(12): 5185-5205.et al . THU-116 Novel chemotherapy selectively induces double-strand DNA breaks and death in naïve and cisplatin-resistant cholangiocarcinoma tumours [J]. J Hepatol , 2025, 82: S444.et al . An oligonucleotide-distortion-responsive organic transistor for platinum-drug-induced DNA-damage detection [J]. Adv Mater , 2021, 33(25): 2100489.et al . A renal YY1-KIM1-DR5 axis regulates the progression of acute kidney injury [J]. Nat Commun , 2023, 14(1): 4261.et al . Autophagy-deficient macrophages exacerbate cisplatin-induced mitochondrial dysfunction and kidney injury via miR-195a-5p-SIRT3 axis [J]. Nat Commun , 2024, 15: 4383.et al . Tiliroside attenuates acute kidney injury by inhibiting ferroptosis through the disruption of NRF2-KEAP1 interaction [J]. Phytomedicine , 2024, 126: 155407.Kidney Dis , 2016, 1(4): 241-257.et al . Intraoperative high-dose dexamethasone and severe AKI after cardiac surgery [J]. J Am Soc Nephrol , 2015, 26(12): 2947-2951.et al . The prevalence and management of multiple myeloma-induced kidney disease in China [J]. Kidney Dis , 2016, 1(4): 235-240.Nat Rev Nephrol , 2015, 11(9): 509-510.et al . Effect of concurrent medications on cisplatin-induced nephrotoxicity in patients with head and neck cancer [J]. Anticancer Drugs , 2006, 17(2): 207-215.et al . Single-cell sequencing reveals homogeneity and heterogeneity of the cytopathological mechanisms in different etiology-induced AKI [J]. Cell Death Dis , 2023, 14: 318.et al . N -acetylcysteine transforms necrosis into apoptosis and affords tailored protection from cisplatin cytotoxicity [J]. Toxicol Appl Pharmacol , 2018, 349: 83-93.et al . Targeting p53 pathways: Mechanisms, structures, and advances in therapy [J]. Signal Transduct Target Ther , 2023, 8(1): 92.et al . DNA damage induces p53-independent apoptosis through ribosome stalling [J]. Science , 2024, 384(6697): 785-792.Free Radic Biol Med , 2023, 207: 183-193.et al . Cr(VI) induces premature senescence through ROS-mediated p53 pathway in L-02 hepatocytes [J]. Sci Rep , 2016, 6: 34578.Semin Cancer Biol , 2022, 85: 4-32.et al . Understanding the complexity of p53 in a new era of tumor suppression [J]. Cancer Cell , 2024, 42(6): 946-967.et al . Targeting p53-MDM2 interaction by small-molecule inhibitors: Learning from MDM2 inhibitors in clinical trials [J]. J Hematol Oncol , 2022, 15(1): 91.et al . USP38 functions as an oncoprotein by downregulating the p53 pathway through deubiquitination and stabilization of MDM2[J]. Cell Death Differ , 2025, 32(6): 1128-1141.et al . UFMylation maintains tumour suppressor p53 stability by antagonizing its ubiquitination [J]. Nat Cell Biol , 2020, 22(9): 1056-1063.)
中草药
|药理与临床
2026
, 57
(10) :
3807
-3817
麝香酮通过促进p53泛素化修饰抑制肾小管上皮细胞凋亡并改善顺铂诱导的急性肾损伤
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张海宴1 , 薛晨1 , 马敬茹1 , 郭家琪1 , 施建羽1 , 隋阳2 , 刘海静3 , 王嫦鹤1,4 , 张珍1
作者信息
1 陕西中医药大学 陕西中药资源产业化省部共建协同创新中心, 陕西 咸阳 712046;
通讯作者:
王嫦鹤
作者简介:
张海宴: 张海宴,硕士研究生,研究方向为中药学。E-mail:223120012130@email.sntcm.edu.cn
Muscone ameliorates cisplatin-induced acute kidney injury by inhibiting apoptosis of renal tubular epithelial cells via promotion of p53 ubiquitination
ZHANG Haiyan, XUE Chen, MA Jingru, GUO Jiaqi, SHI Jianyu, SUI Yang, LIU Haijing, WANG Changhe, ZHANG Zhen
Affiliations
doi: 10.7501/j.issn.0253-2670.2026.10.012
文章导航
目的 探究麝香酮改善顺铂诱导的急性肾损伤（acute kidney injury，AKI）的作用机制。方法 C57BL/6J小鼠随机分为对照组、模型组、地塞米松（2 mg/kg）组和麝香酮低、中、高剂量（24、36、48 mg/kg）组，建立顺铂诱导的AKI小鼠模型，给予药物干预后，采用苏木素-伊红（hematoxylin-eosin，HE）染色观察肾脏组织病理变化；免疫组化检测肾脏中性粒细胞明胶酶相关脂质运载蛋白（neutrophil gelatinase-associated lipocalin，NGAL）和肾损伤分子-1（kidney injury molecule-1，Kim-1）的表达和分布；检测血尿素氮（blood urea nitrogen，BUN）和血肌酐（serum creatinine，SCr）水平；免疫荧光染色检测肾脏组织中剪切型半胱氨酸天冬氨酸蛋白酶-3（cleaved cystein-asparate protease-3，cleaved Caspase-3）的表达和分布。采用顺铂诱导建立NRK-52E细胞损伤模型，MTT法检测顺铂、麝香酮、p53抑制剂pifithrin-μ对细胞活力的影响；倒置显微镜观察细胞形态变化；Calcein AM/PI染色观察细胞死亡情况；Hoechest 33342染色观察细胞核碎裂情况；透射电子显微镜观察细胞死亡类型；免疫荧光染色检测p53的表达和分布；Western blotting检测Caspase-3、cleaved Caspase-3和p53的表达；MitoSOX染色检测线粒体活性氧（mitochondrial reactive oxygen species，mtROS）水平；免疫共沉淀检测p53泛素化修饰水平。结果 麝香酮显著减轻顺铂引起的肾脏病理损伤，恢复肾小管形态（P ＜0.01），降低肾脏组织NGAL、Kim-1、cleaved Caspase-3的表达和分布（P ＜0.01），降低BUN、SCr水平（P ＜0.01）；麝香酮和pifithrin-μ显著抑制顺铂诱导的NRK-52E细胞凋亡及mtROS水平（P ＜0.01），上调Caspase-3蛋白表达（P ＜0.05、0.01），下调cleaved Caspase-3、p53蛋白表达（P ＜0.05、0.01），促进p53泛素化修饰（P ＜0.05）。结论 麝香酮通过促进p53泛素化修饰抑制肾小管上皮细胞凋亡，从而改善顺铂诱导的AKI。
麝香酮
/
顺铂
/
p53
/
凋亡
/
泛素化修饰
/
急性肾损伤
Objective To explore the mechanism by which muscone improves cisplatin-induced acute kidney injury (AKI). Methods C57BL/6J mice were randomly divided into control group, model group, dexamethasone (2 mg/kg) group, muscone low-, medium-, and high-dose (24, 36, 48 mg/kg) groups, a cisplatin-induced AKI mouse model was established. After drug intervention, renal tissue pathological changes were observed using hematoxylin-eosin (HE) staining. Immunohistochemistry was used to detect the expressions and distribution of neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (Kim-1) in kidney. Blood urea nitrogen (BUN) and serum creatinine (SCr) levels were detected. Immunofluorescence staining was used to detect the expression and distribution of cleaved cysteine aspartate protease-3 (cleaved Caspase-3) in renal tissue. An NRK-52E cell injury model induced by cisplatin was established, the effects of cisplatin, muscone and p53 inhibitor pifithrin-μ on cell viability were detected using MTT assay. The morphological change of cells was observed under an inverted microscope. Calcein AM/PI staining was used to observe cell death. Hoechest 33342 staining was used to observe the fragmentation of cell nuclei. Cell death types was observed using transmission electron microscopy. Immunofluorescence staining was used to detect the expression and distribution of p53. Western blotting was used to detect the expressions of Caspase-3, cleaved Caspase-3 and p53. MitoSOX staining was used to detect the levels of mitochondrial reactive oxygen species (mtROS). Immunoprecipitation was used to detect the level of p53 ubiquitination modification. Results Muscone significantly reduced the renal pathological damage caused by cisplatin, restored the morphology of renal tubules (P < 0.01), decreased the expressions and distribution of NGAL, Kim-1 and cleaved Caspase-3 in renal tissue (P < 0.01), reduced the levels of BUN and SCr (P < 0.01). Muscone and pifithrin-μ significantly inhibited cisplatin-induced apoptosis and mtROS level in NRK-52E cells (P < 0.01), upregulated Caspase-3 protein expression (P < 0.05, 0.01), downregulated cleaved Caspase-3 and p53 protein expressions (P < 0.05, 0.01), and promoted p53 ubiquitination modification (P < 0.05). Conclusion Muscone inhibits apoptosis of renal tubular epithelial cells by promoting p53 ubiquitination modification, thereby improving cisplatin-induced AKI.
muscone
/
cisplatin
/
p53
/
apoptosis
/
ubiquitination
/
acute kidney injury
张海宴, 薛晨, 马敬茹, 郭家琪, 施建羽, 隋阳, 刘海静, 王嫦鹤, 张珍.
麝香酮通过促进p53泛素化修饰抑制肾小管上皮细胞凋亡并改善顺铂诱导的急性肾损伤.
中草药,
2026
, 57
(10)
: 3807
-3817
.
DOI: 10.7501/j.issn.0253-2670.2026.10.012
ZHANG Haiyan, XUE Chen, MA Jingru, GUO Jiaqi, SHI Jianyu, SUI Yang, LIU Haijing, WANG Changhe, ZHANG Zhen.
Muscone ameliorates cisplatin-induced acute kidney injury by inhibiting apoptosis of renal tubular epithelial cells via promotion of p53 ubiquitination[J].
Chinese Traditional and Herbal Drugs ,
2026
, 57
(10)
: 3807
-3817
.
DOI: 10.7501/j.issn.0253-2670.2026.10.012
参考文献
引证文献
Ostermann M, Lumlertgul N, Jeong R, et al . Acute kidney injury [J]. Lancet , 2025, 405(10474): 241-256.J Clin Invest , 2025, 135(6): e188358.et al . Cisplatin nephrotoxicity: New insights and therapeutic implications [J]. Nat Rev Nephrol , 2023, 19(1): 53-72.et al . Pharmacological effects and mechanisms of muscone [J]. J Ethnopharmacol , 2020, 262: 113120.et al . Analysis of the pharmacodynamic difference between Xiaojin Pills taken with Chinese Baijiu and water based on serum pharmacochemistry and pharmacokinetics [J]. J Ethnopharmacol , 2023, 300: 115723.et al . Preventive effect of muscone against cisplatin nephrotoxicity in LLC-PK1 cells [J]. Biomolecules , 2020, 10(10): 1444.et al . Pretreatment of Huaiqihuang Extractum protects against cisplatin-induced nephrotoxicity [J]. Sci Rep , 2018, 8: 7333.et al . Lipin3 deficiency aggravates cisplatin induced acute kidney injury via activating Sirt1-p21-Caspase 3-GSDME pyroptosis pathway [J]. Int J Biol Sci , 2025, 21(12): 5185-5205.et al . THU-116 Novel chemotherapy selectively induces double-strand DNA breaks and death in naïve and cisplatin-resistant cholangiocarcinoma tumours [J]. J Hepatol , 2025, 82: S444.et al . An oligonucleotide-distortion-responsive organic transistor for platinum-drug-induced DNA-damage detection [J]. Adv Mater , 2021, 33(25): 2100489.et al . A renal YY1-KIM1-DR5 axis regulates the progression of acute kidney injury [J]. Nat Commun , 2023, 14(1): 4261.et al . Autophagy-deficient macrophages exacerbate cisplatin-induced mitochondrial dysfunction and kidney injury via miR-195a-5p-SIRT3 axis [J]. Nat Commun , 2024, 15: 4383.et al . Tiliroside attenuates acute kidney injury by inhibiting ferroptosis through the disruption of NRF2-KEAP1 interaction [J]. Phytomedicine , 2024, 126: 155407.Kidney Dis , 2016, 1(4): 241-257.et al . Intraoperative high-dose dexamethasone and severe AKI after cardiac surgery [J]. J Am Soc Nephrol , 2015, 26(12): 2947-2951.et al . The prevalence and management of multiple myeloma-induced kidney disease in China [J]. Kidney Dis , 2016, 1(4): 235-240.Nat Rev Nephrol , 2015, 11(9): 509-510.et al . Effect of concurrent medications on cisplatin-induced nephrotoxicity in patients with head and neck cancer [J]. Anticancer Drugs , 2006, 17(2): 207-215.et al . Single-cell sequencing reveals homogeneity and heterogeneity of the cytopathological mechanisms in different etiology-induced AKI [J]. Cell Death Dis , 2023, 14: 318.et al . N -acetylcysteine transforms necrosis into apoptosis and affords tailored protection from cisplatin cytotoxicity [J]. Toxicol Appl Pharmacol , 2018, 349: 83-93.et al . Targeting p53 pathways: Mechanisms, structures, and advances in therapy [J]. Signal Transduct Target Ther , 2023, 8(1): 92.et al . DNA damage induces p53-independent apoptosis through ribosome stalling [J]. Science , 2024, 384(6697): 785-792.Free Radic Biol Med , 2023, 207: 183-193.et al . Cr(VI) induces premature senescence through ROS-mediated p53 pathway in L-02 hepatocytes [J]. Sci Rep , 2016, 6: 34578.Semin Cancer Biol , 2022, 85: 4-32.et al . Understanding the complexity of p53 in a new era of tumor suppression [J]. Cancer Cell , 2024, 42(6): 946-967.et al . Targeting p53-MDM2 interaction by small-molecule inhibitors: Learning from MDM2 inhibitors in clinical trials [J]. J Hematol Oncol , 2022, 15(1): 91.et al . USP38 functions as an oncoprotein by downregulating the p53 pathway through deubiquitination and stabilization of MDM2[J]. Cell Death Differ , 2025, 32(6): 1128-1141.et al . UFMylation maintains tumour suppressor p53 stability by antagonizing its ubiquitination [J]. Nat Cell Biol , 2020, 22(9): 1056-1063.
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doi: 10.7501/j.issn.0253-2670.2026.10.012
接收时间：2026-01-26
首发时间：2026-09-09
https://castjournals.cast.org.cn/joweb/zcy/CN/10.7501/j.issn.0253-2670.2026.10.012
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2种不同金属材料的力学参数
科 属数 种数 占总种数比例 属 种数 占总种数比例 鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78 小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39 多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39 红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87 小菇属 Mycena 11 5.26 光柄菇属 Pluteus 5 2.39 红菇属 Russula 17 8.13 栓菌属 Trametes 5 2.39
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