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2 河南中医药大学第一临床医学院, 河南 郑州 450000;
3 河南省病毒性疾病中医药防治重点实验室, 河南 郑州 450000;
4 豫药全产业链研发河南省协同创新中心, 河南 郑州 450046;
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基于肠道菌群探讨莲子心治疗失眠的研究进展
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中草药 | 综述 2026,57(9): 3636-3645
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中草药 |综述 2026 , 57 (9) : 3636 -3645
基于肠道菌群探讨莲子心治疗失眠的研究进展
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化玉娇1,2, 徐立然1,2,3,4, 雷丽亚2,5, 孟庆铨1,2, 岳静宇1,2,3
作者信息
    1 河南中医药大学第一附属医院 艾滋病临床研究中心, 河南 郑州 450000;
    2 河南中医药大学第一临床医学院, 河南 郑州 450000;
    3 河南省病毒性疾病中医药防治重点实验室, 河南 郑州 450000;
    4 豫药全产业链研发河南省协同创新中心, 河南 郑州 450046;
    5 河南中医药大学第一附属医院 脑病中心, 河南 郑州 450000
通讯作者:
岳静宇
作者简介:
化玉娇: 化玉娇,硕士研究生,研究方向为中医药防治感染性疾病。E-mail:Hlucky0209@163.com
Research progress on Nelumbinis Plumula treatment for insomnia based on gut microbiota
  • HUA Yujiao, XU Liran, LEI Liya, MENG Qingquan, YUE Jingyu
  • Affiliations
    doi: 10.7501/j.issn.0253-2670.2026.09.031
    文章导航
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    失眠作为一种常见的睡眠障碍,其发病率逐年上升,发病机制与肠道菌群紊乱密切相关。目前临床治疗失眠的方法多存在局限性及不良反应,通过总结近国内外文献发现,莲子心Nelumbinis Plumula具有多成分、多途径、多靶点的特点,通过调控肠道菌群,影响肠道屏障功能、微生物组成及其代谢产物,并抑制炎症反应及调节免疫,从而发挥镇静催眠作用,但其具体分子机制网络尚未完全阐明。阐述肠道菌群在失眠发生发展中的作用机制及莲子心的调节作用,建立“莲子心-肠道菌群-失眠”轴的系统性解析,为莲子心治疗失眠和菌群靶向药的开发提供参考和理论支持,推动中西医协同防治失眠从基础研究向临床精准治疗的跨越。
    失眠  /  肠道菌群  /  莲子心  /  莲心碱  /  芦丁  /  槲皮素  /  短链脂肪酸
    Insomnia, as a common sleep disorder, exhibits a rising incidence rate annually, with its pathogenesis closely linked to gut microbiota dysbiosis. Currently, most of the clinical methods for the treatment of insomnia have limitations and adverse reactions. A review of recent domestic and international literature indicates that Lianzixin (Nelumbinis Plumula) possesses multi-component, multi-pathway, and multi-target characteristics. It exerts sedative and hypnotic effects by regulating the gut microbiota composition, influencing intestinal barrier function, microbial composition, and their metabolites, while also suppressing inflammatory responses and modulating immune homeostasis. However, its specific molecular mechanism network has not yet been fully elucidated. This review elaborates on mechanism of gut microbiota in occurrence and development of insomnia and the regulatory effects of Nelumbinis Plumula, establishes a systematic analysis of “Nelumbinis Plumula-gut microbiota-insomnia” axis, and provides theoretical support and reference for developing Nelumbinis Plumula-based insomnia treatments and microbiota-targeted drugs, advancing the collaborative prevention and treatment of insomnia through traditional Chinese medicine and Western medicine from basic research to precision clinical therapy.
    insomnia  /  gut microbiota  /  Nelumbinis Plumula  /  liensinine  /  rutin  /  quercetin  /  short-chain fatty acides
    化玉娇, 徐立然, 雷丽亚, 孟庆铨, 岳静宇. 基于肠道菌群探讨莲子心治疗失眠的研究进展. 中草药, 2026 , 57 (9) : 3636 -3645 . DOI: 10.7501/j.issn.0253-2670.2026.09.031
    HUA Yujiao, XU Liran, LEI Liya, MENG Qingquan, YUE Jingyu. Research progress on Nelumbinis Plumula treatment for insomnia based on gut microbiota[J]. Chinese Traditional and Herbal Drugs, 2026 , 57 (9) : 3636 -3645 . DOI: 10.7501/j.issn.0253-2670.2026.09.031

      国家自然科学基金面上项目(82473420);辽宁省卫健委中医药多学科交叉创新团队项目(LNZYYCXTD-JCCX-002);广东省教育厅高校重点科研平台项目(2022ZDZX2062)

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    2种不同金属材料的力学参数

    Family
    属数
    Number of
    genus
    种数
    Number of
    species
    占总种数比例
    Percentage of
    total species (%)

    Genus
    种数
    Number of
    species
    占总种数比例
    Percentage of total
    species (%)
    鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
    小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
    多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
    红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
    小菇属 Mycena 11 5.26
    光柄菇属 Pluteus 5 2.39
    红菇属 Russula 17 8.13
    栓菌属 Trametes 5 2.39
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