中草药

中药制药过程中胶束自组装的研究现状及存在挑战

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中草药 | 综述 2026,57(9): 3609-3621

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中草药 |综述 2026 , 57 (9) : 3609 -3621

中药制药过程中胶束自组装的研究现状及存在挑战

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陆琳奕¹, 黄鹿鹿¹, 彭国平^1,2,3, 李存玉^1,2,3, 支兴蕾¹

作者信息

通讯作者:

支兴蕾

作者简介:

陆琳奕: 陆琳奕,硕士研究生,研究方向为中药化学与分析学。E-mail:18367604710@163.com

Current status and challenges of micelle self-assembly in traditional Chinese medicine pharmaceutical process

LU Linyi, HUANG Lulu, PENG Guoping, LI Cunyu, ZHI Xinglei

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doi: 10.7501/j.issn.0253-2670.2026.09.029

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摘要

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胶束由双亲性分子自组装而成，作为一种药物递送系统，在提高中药活性成分的溶解性、稳定性及靶向性方面具有极大前景。在中药制药领域，许多活性成分能够自发形成胶束，或通过特定制备工艺包埋于胶束载体中，从而有效提高药物的性能。通过对中药胶束的形成机制、制备工艺及应用现状进行综述，针对复杂中药体系中胶束的杂化性，结合结构表征技术和胶束形成过程中的主要影响因素，指出现有研究中存在的自组装无序性、不可控性等问题，并提出相应的优化建议与展望，为中药现代化及创新制剂的研发提供理论参考。

关键词

胶束 / 双亲性分子 / 自组装 / 无序性 / 杂化性 / 结构表征

Abstract

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Micelles, formed through the self-assembly of amphiphilic molecules, hold significant promise as drug delivery systems for enhancing the solubility, stability, and targeting properties of active components in traditional Chinese medicine (TCM). Within the field of Chinese medicine formulation, numerous active constituents can spontaneously form micelles or be encapsulated within micellar carriers via specific preparation techniques, thereby effectively improving drug performance. This paper reviews the formation mechanisms, preparation techniques, and current applications of TCM micelles. In view of the hybrid nature of micelles within complex TCM systems, it combines structural characterisation techniques with key influencing factors in micelle formation. The study identifies existing issues such as disordered self-assembly and lack of controllability in current research, proposing corresponding suggestions and future directions. This aims to provide theoretical reference for modernisation of TCM and the development of innovative formulations.

Key words

micelles / amphiphilic molecules / self-assembly / disorder / hybridity / structural characterisation

引用本文

陆琳奕, 黄鹿鹿, 彭国平, 李存玉, 支兴蕾. 中药制药过程中胶束自组装的研究现状及存在挑战. 中草药, 2026 , 57 (9) : 3609 -3621 . DOI: 10.7501/j.issn.0253-2670.2026.09.029

LU Linyi, HUANG Lulu, PENG Guoping, LI Cunyu, ZHI Xinglei. Current status and challenges of micelle self-assembly in traditional Chinese medicine pharmaceutical process[J]. Chinese Traditional and Herbal Drugs, 2026 , 57 (9) : 3609 -3621 . DOI: 10.7501/j.issn.0253-2670.2026.09.029

基金

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国家自然科学基金资助项目(82274106);中药制药过程控制与智能制造技术全国重点实验室创新项目(NZYSKL240207);南京中医药大学中药学一流学科科学研究培育项目(ZYXPY2024-006)

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排序方式：

徐应怡,汪子贵,尚瑞鹏,等.纳米粒递送中药活性成分在癌症治疗中的应用研究进展[J].天津中医药大学学报, 2025, 44(7):661-672.
Liu Y M, Yang S S, Wang K L, et al. Cellular senescence and cancer:Focusing on traditional Chinese medicine and natural products[J]. Cell Prolif, 2020, 53(10):e12894.
王成志,刘一帆,张晓青,等.中药活性成分调控免疫细胞抗肺癌研究进展[J].药物评价研究, 2024, 47(9):2157-2167.
Hao P P, Jiang F, Chen Y G, et al. Traditional Chinese medication for cardiovascular disease[J]. Nat Rev Cardiol,2015, 12(2):115-122.
Xiong R G, Huang S Y, Wu S X, et al. Anticancer effects and mechanisms of berberine from medicinal herbs:An update review[J]. Molecules, 2022, 27(14):4523.
Qian J C, Guo Y K, Xu Y F, et al. Combination of micelles and liposomes as a promising drug delivery system:A review[J]. Drug Deliv Transl Res, 2023, 13(11):2767-2789.
Huang L, Huang X H, Yang X, et al. Novel nano-drug delivery system for natural products and their application[J]. Pharmacol Res, 2024, 201:107100.
Zhu C X, Zhang Z X, Wen Y T, et al. Cationic micelles as nanocarriers for enhancing intra-cartilage drug penetration and retention[J]. J Mater Chem B, 2023, 11(8):1670-1683.
Li B Q, Shao H L, Gao L, et al. Nano-drug co-delivery system of natural active ingredients and chemotherapy drugs for cancer treatment:A review[J]. Drug Deliv, 2022,29(1):2130-2161.
Chavda V P, Patel A B, Mistry K J, et al. Nano-drug delivery systems entrapping natural bioactive compounds for cancer:Recent progress and future challenges[J].Front Oncol, 2022, 12:867655.
Xiang J W, Meng Y, Zhao M Y, et al. Super-self-assembly extraction from natural herbs[J]. Nano Res, 2025, 18(2):94907094.
Nsairat H, Lafi Z, Al-Najjar B O, et al. How advanced are self-assembled nanomaterials for targeted drug delivery?A comprehensive review of the literature[J]. Int J Nanomedicine, 2025, 20:2133-2161.
黄矗鑫.两亲性茯苓多糖纳米胶束的制备及其作为药物载体的研究[D].武汉:武汉大学, 2017.
Lu Y Q, Lin J P, Wang L Q, et al. Self-assembly of copolymer micelles:Higher-level assembly for constructing hierarchical structure[J]. Chem Rev, 2020,120(9):4111-4140.
Yadav S, Sharma A K, Kumar P. Nanoscale self-assembly for therapeutic delivery[J]. Front Bioeng Biotechnol,2020, 8:127.
Hou Y, Zou L J, Li Q L, et al. Supramolecular assemblies based on natural small molecules:Union would be effective[J]. Mater Today Bio, 2022, 15:100327.
Li S K, Zou Q L, Xing R R, et al. Peptide-modulated selfassembly as a versatile strategy for tumor supramolecular nanotheranostics[J]. Theranostics, 2019, 9(11):3249-3261.
Guerrero-Hernández L, Meléndez-Ortiz H I, CortezMazatan G Y, et al. Gemini and bicephalous surfactants:A review on their synthesis, micelle formation, and uses[J].Int J Mol Sci, 2022, 23(3):1798.
张晓光.表面张力法和电导法对比测定表面活性剂临界胶束浓度[J].化学教育, 2021, 42(18):134-136.
李雅丽,范建训,王炳杰,等.表面活性剂胶束化物理化学性质研究[J].大学化学, 2022, 37(1):165-171.
Rasoulianboroujeni M, de Villiers M M, Kwon G S.Entropy-driven liquid-liquid phase separation transition to polymeric micelles[J]. J Phys Chem B, 2023, 127(37):7925-7936.
黄旭,韩玉淳,王毅琳.尾链含对硝基苯醚基团的阳离子Gemini表面活性剂的胶束化热力学[J].化学学报,2013, 71(6):897-905.
董芋双,王志国,李徐佳,等.基于热力学界面作用的表面活性剂驱油特性分析[J].工程热物理学报, 2024,45(12):3626-3633.
Shen C Y, Wei X L, Du C Y, et al. Comparative evaluation of nano-assemblies from Shaoyao Gancao Decoction on paeoniflorin bioavailability[J]. Int J Nanomed, 2025, 20:14313-14328.
Gao G Z, He C Q, Wang H Q, et al. Polysaccharide nanoparticles from Isatis indigotica Fort. root Decoction:Diversity, cytotoxicity, and antiviral activity[J].Nanomaterials, 2021, 12(1):30.
管庆霞,周小影,吕邵娃,等.中药复方汤剂多成分自组装纳米相态的形成原理及现状探析[J].海南医学院学报, 2023, 29(11):872-880.
Zhang Y L, Wang Y L, Yan K, et al. Nanostructures in Chinese herbal medicines(CHMs)for potential therapy[J]. Nanoscale Horiz, 2023, 8(8):976-990.
Reichert C L, Salminen H, Weiss J. Quillaja saponin characteristics and functional properties[J]. Annu Rev Food Sci Technol, 2019, 10:43-73.
Böttcher S, Drusch S. Saponins:Self-assembly and behavior at aqueous interfaces[J]. Adv Colloid Interface Sci, 2017, 243:105-113.
李存玉,支兴蕾,牛学玉,等.基于成分状态分析溶液环境对三七总皂苷超滤分离行为的影响[J].中草药,2019, 50(21):5246-5252.
Li M S, Lan J, Li X F, et al. Novel ultra-small micelles based on ginsenoside Rb1:A potential nanoplatform for ocular drug delivery[J]. Drug Deliv, 2019, 26(1):481-489.
韩静,包纯洁,段嘉伦.中药活性成分作为药物递送纳米载体的研究进展[J].中草药, 2024, 55(16):5678-5691.
赵军宁,蒋建东,陈春英,等.方剂纳米体药物发现(FDD):多靶点药物技术创新与新药发现的新策略[J].中国药学杂志, 2025, 60(16):1661-1672.
韦盛伟,苏明哲,肖秀琼,等.中药单体与化疗药物共载纳米制剂治疗肝癌研究进展[J].中草药, 2025,56(13):4914-4925.
Lehtinen O P, Nugroho R W N, Lehtimaa T, et al. Effect of temperature, water content and free fatty acid on reverse micelle formation of phospholipids in vegetable oil[J].Colloids Surf B Biointerfaces, 2017, 160:355-363.
刘艳菊,武月丹,位小杰,等.包载金丝桃苷的磷脂酰胆碱/壳聚糖自组装纳米粒的制备、表征及其口服药动学研究[J].中草药, 2025, 56(3):819-830.
Nemati M, Fathi-Azarbayjani A, Al-Salami H, et al. Bile acid-based advanced drug delivery systems, bilosomes and micelles as novel carriers for therapeutics[J]. Cell Biochem Funct, 2022, 40(6):623-635.
于慧敏,姚梅悦,李文星,等.聚合物胶束在药物缓释递送系统中的应用进展[J].生物化工, 2024, 10(6):230-233.
罗晓健,何煜,陆浩伟,等.一氧化氮供体型姜黄素胶束在脑缺血再灌注模型小鼠体内的药代动力学研究[J].实用药物与临床, 2025, 28(3):161-168.
Sharma S, Lal U R, Bal T. pH-sensitive polymeric micelles of polyvinyl acetate grafted neem gum amphiphilic graft copolymer for curcumin delivery[J]. Int J Biol Macromol,2025, 303:140574.
王勇平,黄福满,汪新娌,等.姜黄素装载的混合聚合物胶束物理表征、体外释放及药代动力学研究[J].江西中医药大学学报, 2025, 37(1):82-87.
夏云,徐志红.灯盏花乙素Soluplus/TPGS混合胶束的制备及评价[J].西北药学杂志, 2024, 39(6):9-15.
Stepanova D A, Pigareva V A, Berkovich A K, et al.Ultrasonic film rehydration synthesis of mixed polylactide micelles for enzyme-resistant drug delivery nanovehicles[J]. Polymers, 2022, 14(19):4013.
Shen D, Shen Y, Chen Q, et al. Macrophage escape by cholesterol-polyoxyethylene sorbitol oleate micelles for pulmonary delivery[J]. Nanomedicine, 2020, 15(5):489-509.
Yue Z Q, Zhu Y, Chen T, et al. Bletilla striata polysaccharide-coated andrographolide nanomicelles for targeted drug delivery to enhance anti-colon cancer efficacy[J]. Front Immunol, 2024, 15:1380229.
Liu M, Zhang Z X, Wang J H, et al. Immunomodulatory and anti-ovarian cancer effects of novel Astragalus polysaccharide micelles loaded with podophyllotoxin[J].Int J Biol Macromol, 2025, 290:138960.
Gong F R, Wang R R, Zhu Z Q, et al. Drug-interactive m PEG-b-PLA-Phe(Boc)micelles enhance the tolerance and anti-tumor efficacy of docetaxel[J]. Drug Deliv, 2020,27(1):238-247.
Ye F, Li Q, Huang L P, et al. Reliable high-PAP-1-loaded polymeric micelles for cancer therapy:Preparation,characterization, and evaluation of anti-tumor efficacy[J].Drug Deliv, 2025, 32(1):2490269.
Kim S, Shi Y Z, Kim J Y, et al. Overcoming the barriers in micellar drug delivery:Loading efficiency, in vivo stability, and micelle-cell interaction[J]. Expert Opin Drug Deliv, 2010, 7(1):49-62.
邓鸿丹,张倩,刘芳,等. Box-Behnken响应面优化厚朴酚-分离乳清蛋白自组装纳米粒制备工艺及体外评价[J].中华中医药学刊, 2025, 43(9):77-82.
Youden B, Jiang R Q, Carrier A J, et al. A nanomedicine structure-activity framework for research, development,and regulation of future cancer therapies[J]. ACS Nano,2022, 16(11):17497-17551.
Nowak M, Brown T D, Graham A, et al. Size, shape, and flexibility influence nanoparticle transport across brain endothelium under flow[J]. Bioeng Transl Med, 2019,5(2):e10153.
Lagarrigue P, Moncalvo F, Cellesi F. Non-spherical polymeric nanocarriers for therapeutics:The effect of shape on biological systems and drug delivery properties[J]. Pharmaceutics, 2022, 15(1):32.
Matsuoka K, ARIMA M, Goto Y, et al. Micelle formation of monoammonium glycyrrhizinate[J]. J Oleo Sci, 2021,70(7):911-918.
Khoshnood A, Lukanov B, Firoozabadi A. Temperature effect on micelle formation:Molecular thermodynamic model revisited[J]. Langmuir, 2016, 32(9):2175-2183.
Patiño-AgudeloÁJ, de Almeida Ueti L, Trindade S G, et al. The effect of p-halogenobenzoate counterions on the thermodynamic forces governing wormlike micelle formation of tetradecyltrimethylammonium in the dilute regime[J]. J Colloid Interface Sci, 2025, 694:137654.
Lim C, Ramsey J D, Hwang D, et al. Drug-dependent morphological transitions in spherical and worm-like polymeric micelles define stability and pharmacological performance of micellar drugs[J]. Small, 2022, 18(4):e2103552.
Scariot D B, Staneviciute A, Machado R R B, et al.Efficacy of benznidazole delivery during chagas disease nanotherapy is dependent on the nanocarrier morphology[J]. Biomaterials, 2025, 322:123358.
Yang Y Q, Li F F, Yan M M, et al. Revealing the toxicityenhancing essence of Glycyrrhiza on Genkwa Flos based on ultra-high-performance liquid chromatography coupled with quadrupole-orbitrap high-resolution mass spectrometry and self-assembled supramolecular technology[J]. Front Chem, 2021, 9:740952.
Cetin E, Boyacioglu O, Orenay-Boyacioglu S. An effective treatment approach of liposomally encapsulated metformin in colon cancer[J]. Med Oncol, 2024, 41(4):82.
黄鹿鹿.基于传质模型研究中药复杂溶液中甘草皂苷的超滤分离规律[D].南京:南京中医药大学, 2025.
Liang P, Bi T, Zhou Y N, et al. Insights into the mechanism of supramolecular self-assembly in the Astragalus membranaceus-Angelica sinensis codecoction[J]. ACS Appl Mater Interfaces, 2023, 15(41):47939-47954.
阮明月,李加玲,董昱男,等.姜黄素-槲皮素无载体复合纳米颗粒用于抗肿瘤的实验研究[J].中华中医药学刊, 2026, 44(3):129-133.
黄小超,胡艺雯,沈鹏宇,等.黄芩苷-小檗碱复合物纳米晶肠溶微球的研制及其抗溃疡性结肠炎的药效学评价[J].中国中药杂志, 2025, 50(15):4263-4274.
Huang X M, Wang P L, Li T, et al. Self-assemblies based on traditional medicine berberine and cinnamic acid for adhesion-induced inhibition multidrug-resistant Staphylococcus aureus[J]. ACS Appl Mater Interfaces,2020, 12(1):227-237.
György C, Armes S P. Recent advances in polymerizationinduced self-assembly(PISA)syntheses in non-polar media[J]. Angew Chem Int Ed, 2023, 62(42):e202308372.
Takagi H, Nakano T, Aoki T, et al. Temperature dependence of the casein micelle structure in the range of10-40℃:An in-situ SAXS study[J]. Food Chem, 2022,393:133389.
Häkkinen S, Tanaka J, Garcia Maset R, et al.Polymerisation-induced self-assembly of graft copolymers[J]. Angew Chem Int Ed, 2022, 61(44):e202210518.
Bekir M, Schenderlein M, Ruickoldt J, et al. A photoswitchable surfactant possessing a spiropyran-moiety in its backbone-unravelling the structure of micelles with small-angle neutron scattering(SANS)and transmission electron microscopy(TEM)[J]. Chem Commun, 2025,61(30):5585-5588.
Duran T, Costa A, Gupta A, et al. Coarse-grained molecular dynamics simulations of paclitaxel-loaded polymeric micelles[J]. Mol Pharm, 2022, 19(4):1117-1134.
Wang Z X, Liu J, Chen Q Y, et al. Bioactive glycyrrhizic acid ionic liquid self-assembled nanomicelles for enhanced transdermal delivery of anti-photoaging signal peptides[J]. Adv Sci, 2025, 12(8):2412581.
Kehrein J, Gürsöz E, Davies M, et al. Unravel the tangle:Atomistic insight into ultrahigh curcumin-loaded polymer micelles[J]. Small, 2023, 19(44):e2303066.
Xu X L, Liu A, Liu S Q, et al. Application of molecular dynamics simulation in self-assembled cancer nanomedicine[J]. Biomater Res, 2023, 27(1):39.
王世荣,李祥高,郭俊杰.表面活性剂化学[M].第3版.北京:化学工业出版社, 2022.
Li F F, Liu B, Li T, et al. Review of constituents and biological activities of triterpene saponins from Glycyrrhizae Radix et Rhizoma and its solubilization characteristics[J]. Molecules, 2020, 25(17):3904.
黄娣,姜霆,王文娟,等.新型表面活性剂柠檬酸单酯的溶液性能研究及其在凝胶油中的应用[J].现代食品科技, 2018, 34(5):113-122.
叶鑫煌,薛嘉豪,赵玉来.可聚型Gemini表面活性剂的制备、表征及其稳定高内相乳液的研究[J].化工学报, 2025, 76(8):4331-4340.
尚丹,张广辉,李晓婷,等.基于“药辅合一”的甜菊素-隐丹参酮自胶束化固体分散体制备、表征及体内评价[J].中草药, 2025, 56(13):4621-4633.
张宇强,贾旭宏,朱新华.温度影响下两性氟碳表面活性剂的性能研究[J].日用化学工业:中英文, 2025,55(2):162-169.
张亚林,郭志刚,王丹凤,等.鞣花酸自胶束化固体分散体制备及口服药动学行为研究[J].中草药, 2024,55(13):4350-4360.
孟雨婷,薛玉叶,刘燕,等.甘草新型自组装纳米粒的形成及抗炎作用评价[J].中草药, 2024, 55(9):2912-2922.
Mella M, Tagliabue A, Mollica L, et al. Inducing pH control over the critical micelle concentration of zwitterionic surfactants via polyacids adsorption:Effect of chain length and structure[J]. J Colloid Interface Sci,2022, 606(Pt2):1636-1651.
Zhou J W, Zhang J, Gao G Z, et al. Boiling licorice produces self-assembled protein nanoparticles:A novel source of bioactive nanomaterials[J]. J Agric Food Chem,2019, 67(33):9354-9361.
林娜.不同pH对板蓝根汤剂生物活性及胶体性质的影响[D].福州:福州大学, 2011.
喻冬秀,梁英琪,钟建军.咪唑类离子液体与茶皂素复配体系CMC的探究[J].化学研究与应用, 2023, 35(9):2139-2147.
高婕,张婉莹,王保玉,等.黄芩黄酮类化合物提取过程中的溶剂诱导自组装现象及其水凝胶制备[J].中草药, 2025, 56(13):4594-4607.
朱煜文.波棱瓜子新型自组装纳米粒的构建及其肠吸收机制研究[D].南昌:江西中医药大学, 2024.
张双.人参-五味子药对汤液相态的拆分、表征及活性研究[D].长春:长春中医药大学, 2024.
谭心如,皮雯敏,赵一航,等.基于中药超分子探究不同混合顺序对黄连解毒汤的物质形态及抗菌活性的影响[J].药学学报, 2025, 60(6):1948-1954.
Sana S S, Chandel A K S, Raorane C J, et al. Recent advances in nano and micro formulations of ginsenoside to enhance their therapeutic efficacy[J]. Phytomedicine,2024, 134:156007.
Zhang S C, Zhao Y W, Tan L J, et al. A novel berberineglycyrrhizic acid complex formulation enhanced the prevention effect to doxorubicin-induced cardiotoxicity by pharmacokinetic modulation of berberine in rats[J]. Front Pharmacol, 2022, 13:891829.
Gao F Y, Ma Z Y, Luo X, et al. Self-assembled micelles based on ginsenoside Rg5 for the targeted treatment of PTX-resistant tumors[J]. Mol Pharm, 2024, 21(7):3502-3512.
Dai X X, Liao Y Y, Yang C T, et al. Diammonium glycyrrhizinate-based micelles for improving the hepatoprotective effect of baicalin:Characterization and biopharmaceutical study[J]. Pharmaceutics, 2022, 15(1):125.
朱卫丰,况文亮,李文栋,等.共载同源成分葛根素与大豆苷元的聚合物混合胶束的制备及表征[J].中草药, 2022, 53(4):1004-1012.
张壮丽,王纪芬,汪婉莹,等.鱼腥草挥发油聚合物胶束的制备[J].中成药, 2019, 41(7):1490-1495.
Xia X J, Tao J, Ji Z W, et al. Increased antitumor efficacy of ginsenoside Rh2 via mixed micelles:In vivo and in vitro evaluation[J]. Drug Deliv, 2020, 27(1):1369-1377.
Kim A V, Shelepova E A, Evseenko V I, et al. Mechanism of the enhancing effect of glycyrrhizin on nifedipine penetration through a lipid membrane[J]. J Mol Liq, 2021,344:117759.
Yang F H, Zhang Q, Liang Q Y, et al. Bioavailability enhancement of paclitaxel via a novel oral drug delivery system:Paclitaxel-loaded glycyrrhizic acid micelles[J].Molecules, 2015, 20(3):4337-4356.
Kong R P, Zhu X Y, Meteleva E S, et al. Enhanced solubility and bioavailability of simvastatin by mechanochemically obtained complexes[J]. Int J Pharm,2017, 534(1/2):108-118.
Kong R P, Zhu X Y, Meteleva E S, et al. Atorvastatin calcium inclusion complexation with polysaccharide Arabinogalactan and saponin disodium glycyrrhizate for increasing of solubility and bioavailability[J]. Drug Deliv Transl Res, 2018, 8(5):1200-1213.
Sun Y, Zou W, Bian S Q, et al. Bioreducible PAA-g-PEG graft micelles with high doxorubicin loading for targeted antitumor effect against mouse breast carcinoma[J].Biomaterials, 2013, 34(28):6818-6828.
Zhang J M, Jiang Y Y, Li Y P, et al. Micelles modified with a chitosan-derived homing peptide for targeted intracellular delivery of ginsenoside compound K to liver cancer cells[J]. Carbohydr Polym, 2020, 230:115576.
李晶,刘访遥,陈剑超.黄芩苷PEG-PCL纳米胶束的体外评价、细胞内分布及抗心肌细胞凋亡的研究[J].中国现代应用药学, 2020, 37(12):1427-1432.
袁海龙,朱煜文.中药制剂研究新方向:改良自组装纳米粒的构建及应用[J].中国中药杂志, 2025, 50(13):3569-3573.
Shi Y, Lammers T, Storm G, et al. Physico-chemical strategies to enhance stability and drug retention of polymeric micelles for tumor-targeted drug delivery[J].Macromol Biosci, 2017, 17(1):1600160.
Al-Kassas R, Bansal M, Shaw J. Nanosizing techniques for improving bioavailability of drugs[J]. J Control Release,2017, 260:202-212.
Lu Y, Yue Z G, Xie J B, et al. Micelles with ultralow critical micelle concentration as carriers for drug delivery[J]. Nat Biomed Eng, 2018, 2(5):318-325.
Wu R, Dai H Y, Guan W J, et al. Clusteroluminescence from random aggregation of micrometers to ordered assembly of sub-10 nanometers by space-confined template synthesis[J]. Small, 2025, 21(30):e2412133.
Akar S, Fardindoost S, Hoorfar M. High throughput microfluidics-based synthesis of PEGylated liposomes for precise size control and efficient drug encapsulation[J].Colloids Surf B Biointerfaces, 2024, 238:113926.
邢欢纯,郭帅,曹文缤,等.不同表面电荷和粒径的脂质纳米颗粒在小鼠体内的生物分布[J].中国药理学与毒理学杂志, 2025, 39(6):425-431.
Zhao S G, Huang P H, Zhang H Y, et al. Fabrication of tunable, high-molecular-weight polymeric nanoparticles via ultrafast acoustofluidic micromixing[J]. Lab Chip,2021, 21(12):2453-2463.
Kazaryan P S, Chertovich A V, Gavrilov A A. Tuning polymer micelle size and dynamics with solvophobic block structure[J]. J Colloid Interface Sci, 2025,680(PtA):496-505.
黄秋萍,欧阳惠枝,黄彩霞,等. TPGS修饰的羧甲基壳聚糖-大黄酸偶联物载药胶束制剂的冻干保护剂筛选及稳定性研究[J].福建中医药, 2024, 55(2):53-56.
徐建昌.非线形双亲分子组装体的结构调控及其药物载体性能的介观模拟研究[D].广州:华南理工大学,2021.
Li J T, Jia X Y. Photo-controlled self-assembly of nanoparticles:A promising strategy for development of novel structures[J]. Nanomaterials, 2023, 13(18):2562.
Zhi W W, Pu Z C, Ma C, et al. α-Cyclodextrin-catalyzed symmetry breaking and precise regulation of supramolecular self-assembly handedness with haratakodaka’s rule[J]. ACS Nano, 2021, 15(12):19621-19628.

2026年第57卷第9期

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doi: 10.7501/j.issn.0253-2670.2026.09.029

接收时间：2025-10-24
首发时间：2026-09-09

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2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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