中草药

基于PI3K/Akt信号通路的中医药多靶点调控：肥胖治疗新视角

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中草药 | 综述 2026,57(8): 3196-3209

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中草药 |综述 2026 , 57 (8) : 3196 -3209

基于PI3K/Akt信号通路的中医药多靶点调控：肥胖治疗新视角

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卢玥然¹, 邱林杰¹, 李纪新¹, 任燕¹, 李美洁¹, 邹姹姹¹, 吴梓敬¹, 李宇烁¹, 张晋¹

作者信息

通讯作者:

张晋

作者简介:

卢玥然: 卢玥然,硕士,从事中医药治未病研究。E-mail:lyrwhy@126.com

Multi-target regulation of traditional Chinese medicine based on PI3K/Akt signaling pathway: A new perspective for obesity treatment

LU Yueran, QIU Linjie, LI Jixin, REN Yan, LI Meijie, ZOU Caicai, WU Zijing, LI Yushuo, ZHANG Jin

Affiliations

doi: 10.7501/j.issn.0253-2670.2026.08.030

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摘要

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肥胖作为全球流行的慢性代谢性疾病，与2型糖尿病、代谢相关脂肪性肝病及心血管疾病等并发症密切相关。磷脂酰肌醇-3-羟激酶（phosphatidylinositol-3-hydroxykinase，PI3K）/蛋白激酶B（protein kinase B，Akt）信号通路是调控细胞生长、代谢及胰岛素信号转导的核心枢纽，其功能紊乱是驱动肥胖及其并发症发生发展的关键分子机制。中医药凭借多成分、多靶点与整体调节的特色，在肥胖防治领域展现出独特潜力。系统阐释了PI3K/Akt信号通路的分子构成及其在脂肪、肝脏、肌肉、心血管、胰腺和大脑等多组织能量代谢中的核心调控作用；深入剖析了该通路在肥胖状态下与慢性炎症、脂代谢失衡及细胞异常增殖之间的病理联系；并重点归纳了皂苷、黄酮、生物碱、萜类、酚酸及多糖等中药活性成分，以及经典复方通过精准调控PI3K/Akt通路改善肥胖的作用机制。现有证据表明，中医药可通过激活或抑制PI3K/Akt信号，有效调节糖脂代谢、缓解胰岛素抵抗、抑制炎症与氧化应激，从而多途径干预肥胖及其合并症，为阐释中医药代谢调控的现代科学内涵及推动靶向治疗策略提供了重要理论依据与研究方向。

关键词

PI3K/Akt信号通路 / 肥胖 / 中医药 / 中药复方 / 胰岛素抵抗 / 糖脂代谢 / 氧化应激

Abstract

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Obesity, a chronic metabolic disease prevalent worldwide, is closely associated with complications such as type 2 diabetes, metabolism-related fatty liver disease, and cardiovascular disease. The phosphatidylinositol-3-hydroxykinase (PI3K)/protein kinase B (Akt) signaling pathway is a core hub for regulating cell growth, metabolism, and insulin signal transduction, and its dysfunction is a key molecular mechanism driving the occurrence and development of obesity and its complications. Traditional Chinese medicine (TCM), with its multi-component, multi-target, and holistic regulatory features, has demonstrated unique potential in the prevention and treatment of obesity. This review systematically explains the molecular composition of the PI3K/Akt signaling pathway and its core regulatory role in the energy metabolism of multiple tissues, including adipose, liver, muscle, cardiovascular, pancreatic, and brain. It also deeply analyzes the pathological connection between this pathway and chronic inflammation, lipid metabolism imbalance, and abnormal cell proliferation in obesity. It also focuses on summarizing the active ingredients of TCM, such as saponins, flavonoids, alkaloids, terpenes, phenolic acids, and polysaccharides, as well as the pharmacological mechanisms of classic compound prescriptions in improving obesity through precise regulation of the PI3K/Akt pathway. Existing evidence shows that TCM can effectively regulate glucose and lipid metabolism, alleviate insulin resistance, and inhibit inflammation and oxidative stress by activating or inhibiting PI3K/Akt signaling, thereby intervening in obesity and its complications through multiple pathways. This provides an important theoretical basis and research direction for explaining the modern scientific connotation of metabolic regulation in TCM and promoting the development of targeted treatment strategies.

Key words

PI3K/Akt signaling pathway / obesity / traditional Chinese medicine / traditional Chinese medicine compound / insulin resistance / glucose and lipid metabolism / oxidative stress

引用本文

卢玥然, 邱林杰, 李纪新, 任燕, 李美洁, 邹姹姹, 吴梓敬, 李宇烁, 张晋. 基于PI3K/Akt信号通路的中医药多靶点调控：肥胖治疗新视角. 中草药, 2026 , 57 (8) : 3196 -3209 . DOI: 10.7501/j.issn.0253-2670.2026.08.030

LU Yueran, QIU Linjie, LI Jixin, REN Yan, LI Meijie, ZOU Caicai, WU Zijing, LI Yushuo, ZHANG Jin. Multi-target regulation of traditional Chinese medicine based on PI3K/Akt signaling pathway: A new perspective for obesity treatment[J]. Chinese Traditional and Herbal Drugs, 2026 , 57 (8) : 3196 -3209 . DOI: 10.7501/j.issn.0253-2670.2026.08.030

基金

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国家重点研发计划资助项目 (2018YFC2000600); 中国中医科学院科技创新工程 (CI2021A03005); 北京薪火传承3＋3项目：施奠邦名家研究室 (2023-SZ-A51)

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参考文献引证文献

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国家卫生健康委, 周金, 刘旭东. 成人肥胖食养指南(2024年版)[J]. 卫生研究, 2024, 53(3):347.
Mechanick J I, Apovian C, Brethauer S, et al. Clinical practice guidelines for the perioperative nutrition, metabolic, and nonsurgical support of patients undergoing bariatric procedures-2019 update:Cosponsored by American association of clinical endocrinologists/American college of endocrinology, the obesity society, American society for metabolic & bariatric surgery, obesity medicine association, and American society of anesthesiologists-executive summary[J]. Endocr Pract, 2019, 25(12):1346-1359.
Pan X F, Wang L M, Pan A. Epidemiology and determinants of obesity in China[J]. Lancet Diabetes Endocrinol, 2021, 9(6):373-392.
Wang Y F, Zhao L, Gao L W, et al. Health policy and public health implications of obesity in China[J]. Lancet Diabetes Endocrinol, 2021, 9(7):446-461.
王俊龙, 贾慧雨, 冯志海, 等. 中医药调控AMPK信号通路防治肥胖2型糖尿病的研究进展[J]. 中国实验方剂学杂志, 2023, 29(21):264-273.
李纪新, 邱林杰, 任燕, 等. 中药及活性成分靶向M1/M2巨噬细胞极化平衡干预肥胖合并2型糖尿病的研究进展[J]. 中国中药杂志, 2024, 49(13):3441-3451.
李云, 刘天宇, 袁恒杰, 等. 基于网络药理学和实验验证探讨甘草防治非酒精性脂肪肝病及肥胖的作用机制[J]. 中草药, 2023, 54(15):4882-4894.
杜海健, 陈项前, 舒遵华. 中医药调控炎症相关信号通路治疗肥胖的研究进展[J]. 中国老年学杂志, 2025, 45(12):3068.
Savova M S, Mihaylova L V, Tews D, et al. Targeting PI3K/AKT signaling pathway in obesity[J]. Biomed Pharmacother, 2023, 159:114244.
李新颖, 卢利霞, 吴天思, 等. 磷脂酰肌醇-3-激酶/蛋白激酶B与子宫内膜蜕膜化关系的研究进展[J]. 医学综述, 2024, 30(3):269-273.
Yoon H E, Kim S J, Kim S J, et al. Tempol attenuates renal fibrosis in mice with unilateral ureteral obstruction:The role of PI3K-Akt-FoxO3a signaling[J]. J Korean Med Sci, 2014, 29(2):230-237.
汪倩, 杨梅, 赵琦, 等. 中药干预PI3K/AKT信号通路防治非酒精性脂肪性肝病研究现状[J]. 辽宁中医杂志, 2025, 52(9):209-213.
王东, 李佳礼, 范珈鑫, 等. 女贞子外囊泡的提取及对秀丽隐杆线虫抗衰老作用机制的探究[J]. 时珍国医国药, 2025, 36(21):4066-4074.
Degan S E, Gelman I H. Emerging roles for AKT isoform preference in cancer progression pathways[J]. Mol Cancer Res, 2021, 19(8):1251-1257.
熊天宇, 赵有权, 谢萍, 等. 雄激素受体与PI3K/AKT通路相互作用机制在前列腺癌中的研究进展[J]. 首都医科大学学报, 2025, 46(2):269-282.
Chen Y J, Jiao D Y, He H Y, et al. Disruption of the Keap1-mTORC2 axis by cancer-derived Keap1/mLST8 mutations leads to oncogenic mTORC2-AKT activation[J]. Redox Biol, 2023, 67:102872.
Ortega M A, Fraile-Martínez O, Asúnsolo Á, et al. Signal transduction pathways in breast cancer:The important role of PI3K/Akt/mTOR[J]. J Oncol, 2020, 2020:9258396.
欧亿林, 彭睿, 徐少杰, 等. 运动通过骨脂crosstalk改善骨质疏松症[J]. 生理学报, (2025-08-07)[2026-04-10]. https://doi.org/10.13294/j.aps.2025.0073.
Świderska E, Strycharz J, Wróblewski A, et al. Chronic and intermittent hyperglycemia modulates expression of key molecules of PI3K/AKT pathway in differentiating human visceral adipocytes[J]. Int J Mol Sci, 2021, 22(14):7712.
Homan E P, Brandão B B, Softic S, et al. Differential roles of FOXO transcription factors on insulin action in brown and white adipose tissue[J]. J Clin Invest, 2021, 131(19):e143328.
徐国燕, 付建红, 胡泳华, 等. 新疆沙枣叶醇提物的化学成分及其抑制黑色素生成作用机制的研究[J]. 天然产物研究与开发, 2026, 38(1):54-60.
Xu H J, Zhao Q, Song N Z, et al. AdipoR1/AdipoR2 dual agonist recovers nonalcoholic steatohepatitis and related fibrosis via endoplasmic reticulum-mitochondria axis[J]. Nat Commun, 2020, 11(1):5807.
李璐, 谷振慧, 冯涛, 等. 类固醇激素在子宫内膜过度增生中的作用机理[J]. 中国畜牧兽医, 2023, 50(9):3652-3662.
Brunner J S, Vogel A, Lercher A, et al. The PI3K pathway preserves metabolic health through MARCO-dependent lipid uptake by adipose tissue macrophages[J]. Nat Metab, 2020, 2(12):1427-1442.
黄振昌, 尚秀国, 杨雪芬, 等. 真菌多糖的生物学功能及其在养猪生产中的应用研究进展[J]. 动物营养学报, 2025, 37(9):5729-5738.
Sylow L, Tokarz V L, Richter E A, et al. The many actions of insulin in skeletal muscle, the paramount tissue determining glycemia[J]. Cell Metab, 2021, 33(4):758-780.
刘钟元, 石龙, 颜鸿宇, 等. 基于网络药理学和实验验证探究黄精治疗肌少症的作用机制[J]. 中国医院药学杂志, 2025, 45(23):2691-2700.
范超文, 高维蔓, 柯尊丽, 等. 肝脏脂质从头合成的机制及其抑制剂在非酒精性脂肪性肝病中的研究进展[J]. 中国病理生理杂志, 2023, 39(9):1642-1649.
赵腾宇, 潘鹏宇, 周禹含, 等. 中医药调控SIRT1治疗阿尔茨海默病的研究进展[J]. 重庆医科大学学报, 2025, 50(12):1634-1643.
李晋南, 吴迪, 范泽, 等. 精氨酸对松浦镜鲤幼鱼生长性能、血液指标和肝脏糖代谢的影响[J]. 动物营养学报, 2025, 37(9):6110-6121.
李芊, 黄天娇, 高聪, 等. 基于网络药理学和实验验证探讨妇科千金胶囊治疗盆腔炎性疾病的作用机制[J]. 中国中药杂志, 2025, 50(22):6289-6298.
邱佳韵. 川崎病冠状动脉损伤机制免疫遗传研究进展[J]. 临床儿科杂志, 2023, 41(1):66-72.
Wang H, Li J, Wang Z, et al. Perivascular brown adipocytes-derived kynurenic acid relaxes blood vessel via endothelium PI3K-Akt-ENOS pathway[J]. Biomed Pharmacother, 2022, 150:113040.
Skovsø S, Panzhinskiy E, Kolic J, et al. Beta-cell specific Insr deletion promotes insulin hypersecretion and improves glucose tolerance prior to global insulin resistance[J]. Nat Commun, 2022, 13(1):735.
陈木雄, 刘亚欣, 白荣盘, 等. 胰岛里的"神秘使者":核糖核酸酶4如何守护血糖健康[J]. 科学通报, 2025, 70(26):4390-4392.
李建宁, 马立荣, 杨怡. 脂肪酸对胰腺β细胞功能及凋亡影响的研究进展[J]. 山东医药, 2017, 57(22):106-108.
Jiang L, Su H R, Wu X Y, et al. Author Correction:Leptin receptor-expressing neuron Sh2b1 supports sympathetic nervous system and protects against obesity and metabolic disease[J]. Nat Commun, 2020, 11:5310.
Attia R T, Abdel-Mottaleb Y, Abdallah D M, et al. Raspberry ketone and Garcinia Cambogia rebalanced disrupted insulin resistance and leptin signaling in rats fed high fat fructose diet[J]. Biomed Pharmacother, 2019, 110:500-509.
Strembitska A, Labouèbe G, Picard A, et al. Lipid biosynthesis enzyme Agpat5 in AgRP-neurons is required for insulin-induced hypoglycemia sensing and glucagon secretion[J]. Nat Commun, 2022, 13(1):5761.
Milstein J L, Ferris H A. The brain as an insulin-sensitive metabolic organ[J]. Mol Metab, 2021, 52:101234.
Wen X, Zhang B H, Wu B Y, et al. Signaling pathways in obesity:Mechanisms and therapeutic interventions[J]. Signal Transduct Target Ther, 2022, 7(1):298.
Meng D D, He W, Zhang Y, et al. Development of PI3K inhibitors:Advances in clinical trials and new strategies (Review)[J]. Pharmacol Res, 2021, 173:105900.
Madsen R R, Knox R G, Pearce W, et al. Oncogenic PIK3CA promotes cellular stemness in an allele dose-dependent manner[J]. Proc Natl Acad Sci USA, 2019, 116(17):8380-8389.
黄婧荷, 邹明珠, 乔静涛, 等. 2型糖尿病患者骨骼肌脂肪含量与糖尿病周围神经病变相关性的研究[J]. 中国糖尿病杂志, 2025, 33(5):328-331.
叶杨阳, 刘霄潇, 易玮, 等. 电针通过调控PPAR-γ/NF-κB通路改善糖尿病大鼠骨骼肌胰岛素抵抗[J]. 针刺研究, 2025, 50(12):1412-1420.
Dall'Agnese A, Platt J M, Zheng M M, et al. The dynamic clustering of insulin receptor underlies its signaling and is disrupted in insulin resistance[J]. Nat Commun, 2022, 13(1):7522.
王天一, 高陈佳, 董晓范, 等. 中药多糖抗糖尿病作用机制及其发展前景[J]. 中草药, 2025, 56(6):2184-2196.
杨迪, 戴天姝, 桂林森, 等. Kisspeptin与RFRP-3协同调控动物季节性繁殖的研究进展[J]. 中国畜牧杂志, 2025, 61(2):89-98.
张国远, 田彩云, 胡晗, 等. 肝硬化患者中性粒细胞免疫功能障碍的研究进展[J]. 中国全科医学, 2021, 24(21):2734-2743.
张雨驰, 范晶, 黄佐天, 等. IPI549调控小鼠肝脏缺血再灌注损伤的作用研究[J]. 重庆医科大学学报, 2019, 44(12):1628-1634.
Kobayashi N, Ueki K, Okazaki Y, et al. Blockade of class IB phosphoinositide-3 kinase ameliorates obesity-induced inflammation and insulin resistance[J]. Proc Natl Acad Sci USA, 2011, 108(14):5753-5758.
萨拉麦提·艾迪热斯, 阿依加·马里克, 古丽菲热·伊力哈木, 等. 新疆酸李提取物对脂多糖诱导RAW264.7炎症模型细胞氧化应激损伤的缓解作用及机制[J]. 食品科学, 2025, 46(20):223-232.
闫帅, 王平. 受激拉曼散射显微成像用于癌症的分析与诊断[J]. 华中科技大学学报:自然科学版, 2025, 53(9):131-139.
吴梓敬, 李纪新, 邱林杰, 等. 中医药调控NF-κB相关信号通路治疗肥胖研究进展[J]. 中国实验方剂学杂志, 2025, 31(5):310-318.
Knight Z A, Gonzalez B, Feldman M E, et al. A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling[J]. Cell, 2006, 125(4):733-747.
Perino A, Beretta M, Kilić A, et al. Combined inhibition of PI3Kβ and PI3Kγ reduces fat mass by enhancing α-MSH-dependent sympathetic drive[J]. Sci Signal, 2014, 7(352):ra110.
Brunner J S, Vogel A, Lercher A, et al. The PI3K pathway preserves metabolic health through MARCO-dependent lipid uptake by adipose tissue macrophages[J]. Nat Metab, 2020, 2(12):1427-1442.
程霜, 尹恒, 胡卓仪, 等. 瘦素抵抗与骨质疏松:代谢失衡中的骨健康调控机制[J]. 中国骨质疏松杂志, 2025, 31(7):1037-1042.
赵霞. 瘦素能促进胎盘滋养细胞HLA-G表达[J]. 基因组学与应用生物学, 2019, 38(8):3836-3842.
徐丹, 黄晓东, 张姮, 等. 瘦素和瘦素受体及其下游信号通路在非酒精性脂肪性肝病中的表达及临床意义研究[J]. 中国全科医学, 2013, 16(35):4126-4130.
Plum L, Rother E, Münzberg H, et al. Enhanced leptin-stimulated PI3K activation in the CNS promotes white adipose tissue transdifferentiation[J]. Cell Metab, 2007, 6(6):431-445.
Foukas L C, Claret M, Pearce W, et al. Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation[J]. Nature, 2006, 441(7091):366-370.
Torres C, Mancinelli G, Cordoba-Chacon J, et al. p110γ deficiency protects against pancreatic carcinogenesis yet predisposes to diet-induced hepatotoxicity[J]. Proc Natl Acad Sci USA, 2019, 116(29):14724-14733.
Luo J H, Luo J C, Wu Y Z, et al. Anti-obesity effects of adzuki bean saponins in improving lipid metabolism through reducing oxidative stress and alleviating mitochondrial abnormality by activating the PI3K/Akt/GSK3β/β-catenin signaling pathway[J]. Antioxidants, 2024, 13(11):1380.
王莹, 王希望, 金晶晶, 等. 内质网应激在急性胰腺炎中的作用及中医药调控研究进展[J]. 时珍国医国药, 2025, 36(11):2149-2154.
Oh S H, Lee M S, Lee B C. Diosgenin alleviates obesity-induced insulin resistance by modulating PI3K/Akt signaling pathway in mice fed a high-fat diet[J]. Chem Pharm Bull, 2024, 72(10):845-855.
Dai S S, Hong Y L, Xu J, et al. Ginsenoside Rb2 promotes glucose metabolism and attenuates fat accumulation via AKT-dependent mechanisms[J]. Biomed Pharmacother, 2018, 100:93-100.
Yuan Y L, Lin B Q, Zhang C F, et al. Timosaponin B-II ameliorates palmitate-induced insulin resistance and inflammation via IRS-1/PI3K/Akt and IKK/NF-[formula:See text] B pathways[J]. Am J Chin Med, 2016, 44(4):755-769.
Zheng X, Zhao M G, Jiang C H, et al. Triterpenic acids-enriched fraction from Cyclocarya paliurus attenuates insulin resistance and hepatic steatosis via PI3K/Akt/GSK3β pathway[J]. Phytomedicine, 2020, 66:153130.
Zhang Y, Yang S N, Zhang M, et al. Glycyrrhetinic acid improves insulin-response pathway by regulating the balance between the ras/MAPK and PI3K/Akt pathways[J]. Nutrients, 2019, 11(3):604.
Savova M S, Todorova M N, Apostolov A G, et al. Betulinic acid counteracts the lipid accumulation in Caenorhabditis elegans by modulation of nhr-49 expression[J]. Biomed Pharmacother, 2022, 156:113862.
Li Y, Wang J W, Gu T G, et al. Oleanolic acid supplement attenuates liquid fructose-induced adipose tissue insulin resistance through the insulin receptor substrate-1/phosphatidylinositol 3-kinase/Akt signaling pathway in rats[J]. Toxicol Appl Pharmacol, 2014, 277(2):155-163.
王鹏, 刘春凌, 徐彤, 等. 黄芩对人工致脂肪肝出血综合征肉鸡肝脏脂代谢及PPAR-γ mRNA表达的影响[J]. 黑龙江畜牧兽医:下半月, 2020(10):122-127.
Miao L C, Zhang X T, Zhang H L, et al. Baicalin ameliorates insulin resistance and regulates hepatic glucose metabolism via activating insulin signaling pathway in obese pre-diabetic mice[J]. Phytomedicine, 2024, 124:155296.
崔梦娇, 徐启明, 曹玉, 等. 王不留行黄酮苷调控STAT3改善肾纤维化模型小鼠EMT的机制研究[J]. 中国药理学通报, 2025, 41(4):745-752.
Jia X, Liu W S. Vaccarin improves insulin sensitivity and glucose uptake in diet-induced obese mice via activation of GPR120-PI3K/AKT/GLUT4 pathway[J]. Biochem Biophys Res Commun, 2022, 634:189-195.
Kwon M, Kim Y, Lee J, et al. Neohesperidin dihydrochalcone and neohesperidin dihydrochalcone-O-glycoside attenuate subcutaneous fat and lipid accumulation by regulating PI3K/AKT/mTOR pathway in vivo and in vitro[J]. Nutrients, 2022, 14(5):1087.
杨逸轩, 杜炎远, 俞天辰, 等. 中药黄酮类化合物干预白癜风作用机制研究进展[J]. 中成药, 2025, 47(6):1931-1937.
Liu B, Yao Z Q, Song L, et al. Vitexin alleviates lipid metabolism disorders and hepatic injury in obese mice through the PI3K/AKT/mTOR/SREBP-1c pathway[J]. Eur J Med Chem, 2025, 287:117379.
Yang B, Wang Q, Li Y, et al. Resveratrol inhibits white adipose deposition by the ESR1-mediated PI3K/AKT signaling pathway[J]. Cell Signal, 2024, 124:111448.
董朋涛, 王耀献, 李晓羽, 等. 姜黄素对糖尿病肾病的治疗作用及相关机制研究进展[J]. 中草药, 2025, 56(5):1830-1839.
Kim Y, Rouse M, González-Mariscal I, et al. Dietary curcumin enhances insulin clearance in diet-induced obese mice via regulation of hepatic PI3K-AKT axis and IDE, and preservation of islet integrity[J]. Nutr Metab, 2019, 16:48.
Zhang S, Guo S, Gao X B, et al. Matrine attenuates high-fat diet-induced in vivo and ox-LDL-induced in vitro vascular injury by regulating the PKCα/ENOS and PI3K/Akt/ENOS pathways[J]. J Cellular Molecular Medi, 2019, 23(4):2731-2743.
曹单单, 邓长财, 杜彭, 等. 盐酸小檗碱联合缬沙坦治疗老年糖尿病肾病疗效及对患者肾脏功能、氧化应激和炎症反应的影响[J]. 中国老年学杂志, 2025, 45(16):3946-3949.
El-Zeftawy M, Ghareeb D, ElBealy E R, et al. Berberine chloride ameliorated PI3K/Akt-p/SIRT-1/PTEN signaling pathway in insulin resistance syndrome induced in rats[J]. J Food Biochem, 2019, 43(12):e13049.
Sun J C, Wang X T, He Y L, et al. Sophoridine counteracts obesity via src-mediated inhibition of VEGFR expression and PI3K/AKT phosphorylation[J]. Int J Mol Sci, 2024, 25(2):1206.
才让吉, 朵德龙, 李娟, 等. 茯苓多糖对肺气肿大鼠肺损伤及TLR4/NF-κB信号通路的影响[J]. 中国老年学杂志, 2024, 44(10):2497-2501.
Liu W W, Yu L Z, Chen Q, et al. Poria cocos polysaccharides alleviate obesity-related adipose tissue insulin resistance via gut microbiota-derived short-chain fatty acids activation of FGF21/PI3K/AKT signaling[J]. Food Res Int, 2025, 215:116671.
Savova M S, Vasileva L V, Mladenova S G, et al. Ziziphus jujuba Mill. leaf extract restrains adipogenesis by targeting PI3K/AKT signaling pathway[J]. Biomed Pharmacother, 2021, 141:111934.
Wang X, Huang M J, Lu Y X, et al. Integrated metabolomics and network pharmacology reveal the PI3K/Akt-mediated therapeutic mechanism of Abrus cantoniensis in lipid metabolism disorders[J]. Phytomedicine, 2025, 145:156953.
陈苗, 马会明, 冯亚宏, 等. 健脾益肾化浊方对多囊卵巢综合征模型大鼠卵巢颗粒细胞凋亡蛋白及PI3K/Akt/mTOR通路的影响[J]. 中医杂志, 2023, 64(15):1585.
黄兰蔚, 王瑞华, 王宇, 等. 补气消脂方调控PI3K/Akt/mTOR通路改善自噬减轻小鼠非酒精性脂肪肝机制研究[J]. 中国医院药学杂志, 2025, 45(3):241.
陈丹丹, 孙琛, 宋亮, 等. 柴芩承气汤干预急性胰腺炎的配伍规律及作用机制[J]. 世界中医药, 2024, 19(9):1258-1261.
Yang X M, Yao L B, Yuan M, et al. Transcriptomics and network pharmacology reveal the protective effect of Chaiqin Chengqi decoction on obesity-related alcohol-induced acute pancreatitis via oxidative stress and PI3K/Akt signaling pathway[J]. Front Pharmacol, 2022, 13:896523.
Hu R N, Geng Y L, Huang Y J, et al. Jiawei Buzhong Yiqi Decoction attenuates polycystic ovary syndrome through regulating kisspeptin-GPR54-AKT-SHBG system[J]. Phytomedicine, 2024, 133:155931.
周帅亮, 徐中菊, 张佳璐, 等. 基于PI3K/Akt信号通路探讨健脾理气降脂汤联合肥三针治疗单纯性肥胖临床研究[J]. 陕西中医, 2025, 46(9):1278-1283.

2026年第57卷第8期

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doi: 10.7501/j.issn.0253-2670.2026.08.030

接收时间：2025-12-01
首发时间：2026-09-09

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2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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