中草药

中药抗结直肠癌关键词可视化分析及其作用机制研究进展

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中草药 | 综述 2026,57(8): 3173-3188

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中草药 |综述 2026 , 57 (8) : 3173 -3188

中药抗结直肠癌关键词可视化分析及其作用机制研究进展

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陈思吟¹, 马理园¹, 贾庆雅¹, 何燕姿¹, 杨露², 曾勇¹, 罗开沛³

作者信息

通讯作者:

曾勇

作者简介:

陈思吟: 陈思吟,硕士研究生,研究方向为中药药理与毒理。E-mail:2312653616@qq.com

Keyword visualization and mechanistic insights into traditional Chinese medicine against colorectal cancer

CHEN Siyin, MA Liyuan, JIA Qingya, HE Yanzi, YANG Lu, ZENG Yong, LUO Kaipei

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doi: 10.7501/j.issn.0253-2670.2026.08.028

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摘要

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结直肠癌是全球范围内常见的消化道恶性肿瘤之一，其发病率和死亡率长期位居各类癌症前列。结直肠癌的发生发展涉及多基因、多通路的复杂病理机制。中医药凭借其多成分、多靶点、低毒性的特点，在干预结直肠癌方面展现出独特优势。中药通过多途径、多层次的整体调节作用，在抑制肿瘤生长、诱导细胞凋亡、抑制血管生成、逆转多药耐药及调节肿瘤微环境等方面显示出巨大潜力。利用CiteSpace对中药治疗结直肠癌的中英文相关文献进行关键词共现网络、关键词聚类图谱和突现词检测的可视化分析，旨在直观展现该领域的研究热点。在此基础上，围绕中药复方、中药药对及单味中药及其有效活性成分3个层面，系统综述其抗结直肠癌的作用机制与分子靶点研究的最新进展，为中药在结直肠癌领域的临床应用及药物研发提供理论依据。

关键词

结直肠癌 / CiteSpace / 中药药对 / 抑制肿瘤生长 / 诱导细胞凋亡 / 抑制血管生成 / 逆转多药耐药 / 调节肿瘤微环境

Abstract

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Colorectal cancer (CRC) is one of the most common malignant tumors of the digestive tract worldwide, with its morbidity and mortality consistently ranking among the highest of all cancers. The development and progression of CRC involve complex pathological mechanisms mediated by multiple genes and pathways. Traditional Chinese medicine (TCM), with its characteristics of multi-component, multi-target, and low toxicity, has demonstrated unique advantages in intervening in CRC. Through holistic regulation across multiple pathways and levels, TCM shows significant potential in inhibiting tumor growth, inducing apoptosis, suppressing angiogenesis, reversing multi-drug resistance, and modulating the tumor microenvironment. CiteSpace was used to conduct a visual analysis of Chinese and English literature on TCM for CRC treatment, focusing on keyword co-occurrence networks, keyword clustering maps, and burst word detection, aiming to intuitively present research hotspots in this field. Furthermore, the latest advances in the mechanisms of action and molecular targets of Chinese herbal compound formulas, herb pairs, and single herb along with its active constituents against CRC were systematically reviewed. This provides a theoretical foundation for the clinical application and drug development of TCM in the field of CRC.

Key words

colorectal cancer / CiteSpace / herb pairs / inhibiting tumor growth / inducing apoptosis / suppressing angiogenesis / reversing multidrug resistance / modulating tumor microenvironment

引用本文

陈思吟, 马理园, 贾庆雅, 何燕姿, 杨露, 曾勇, 罗开沛. 中药抗结直肠癌关键词可视化分析及其作用机制研究进展. 中草药, 2026 , 57 (8) : 3173 -3188 . DOI: 10.7501/j.issn.0253-2670.2026.08.028

CHEN Siyin, MA Liyuan, JIA Qingya, HE Yanzi, YANG Lu, ZENG Yong, LUO Kaipei. Keyword visualization and mechanistic insights into traditional Chinese medicine against colorectal cancer[J]. Chinese Traditional and Herbal Drugs, 2026 , 57 (8) : 3173 -3188 . DOI: 10.7501/j.issn.0253-2670.2026.08.028

基金

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国家自然科学基金资助项目 (82204633); 国家自然科学基金资助项目 (82304880); 四川省自然科学基金资助项目 (2024NSFSC2112); 四川省自然科学基金资助项目 (2026NSFSC0627); 中华中医药学会青年人才托举工程 (2024-QNRC2-B28)

参考文献

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Li N, Lu B, Luo C Y, et al. Incidence, mortality, survival, risk factor and screening of colorectal cancer:A comparison among China, Europe, and northern America[J]. Cancer Lett, 2021, 522:255-268.
侯立强, 赵义军, 杨志欣. 中药治疗结肠癌的药理作用机制[J]. 中医药学报, 2021, 49(6):118-121.
殷涛涛, 方奕雄, 惠菁华, 等. 中药活性成分逆转结直肠癌耐药的药理作用机制研究进展[J]. 药物评价研究, 2022, 45(11):2357-2363.
李海林, 万校基, 林春培. 基于关键词重要性和近邻传播聚类的主题分析研究[J]. 情报学报, 2018, 37(5):533-542.
Ma L L, Fang X J, Yin X, et al. Investigation of molecular mechanism of Banxia Xiexin Decoction in colon cancer via network pharmacology and in vivo studies[J]. Evid Based Complement Alternat Med, 2022, 2022:4961407.
黄渝清, 王佳梅, 赖恒周, 等. 基于PARG/PARP1/NF-κB通路探究半夏泻心汤抑制结肠癌细胞恶性表型的机制[J]. 中国中药杂志, 2025, 50(2):496-506.
Chan Y T, Cheung F, Zhang C, et al. Ancient Chinese medicine herbal formula Huanglian Jiedu Decoction as a neoadjuvant treatment of chemotherapy by improving diarrhea and tumor response[J]. Front Pharmacol, 2020, 11:252.
张艺凡, 贾苏杰, 刘静远, 等. 基于网络药理学和动物实验探讨黄连解毒汤通过Bcl-2/Bax/Caspase-3信号通路抗结直肠腺瘤作用机制[J]. 中医药导报, 2024, 30(11):32-40.
沈慧, 崔彦收, 杨旭杰. 黄芪桂枝五物汤联合运用化疗对大肠癌术后患者的肿瘤血管生长影响及疗效[J]. 中成药, 2018, 40(11):2603-2606.
Huang B, An H L, Gui M X, et al. Qingjie Fuzheng Granule prevents colitis-associated colorectal cancer by inhibiting abnormal activation of NOD2/NF-κB signaling pathway mediated by gut microbiota disorder[J]. Chin Herb Med, 2025, 17(3):500-512.
Dong Y J, Yang Q L, Niu R Y, et al. Modulation of tumor-associated macrophages in colitis-associated colorectal cancer[J]. J Cell Physiol, 2022, 237(12):4443-4459.
Liu H Q, Yang R M, Zhong H Y, et al. Mechanism of Qingjie Fuzheng Granules in inhibiting colitis associated colorectal cancer by regulating TLR4 and IL-4R mediated macrophage polarization[J]. J Ethnopharmacol, 2025, 344:119511.
焦蕉. 健脾消癌方调控结肠癌源性外泌体整合素α5、β5影响结肠癌肝转移的研究[D]. 长沙:湖南中医药大学, 2022.
贾茹, 张影茹, 邵诗芸, 等. 补肾解毒散结方调控JAK/STAT3信号通路抑制大肠癌侵袭转移的研究[J]. 中华中医药杂志, 2020, 35(3):1433-1436.
张涛, 张馨月, 卢鑫, 等. 健脾清热活血方介导microRNA-222-3p调控TGF-β1、CDKN1B/p27表达防治结肠癌的离体研究[J]. 时珍国医国药, 2021, 32(8):1863-1867.
Liu Y J, Zhang Q, Lu L, et al. Huang-Qin Decoction alleviates deoxycholic acid-induced colorectal cancer in mice by regulating gut microbiota[J]. J Ethnopharmacol, 2025, 346:119715.
Tian T T, Chen G, Sun K, et al. ChanLingGao alleviates intestinal mucosal barrier damage and suppresses the onset and progression of colorectal cancer in AOM/DSS murine model[J]. Int Immunopharmacol, 2024, 143(Pt1):113193.
Dai Y, Li F, Tang Y, et al. Lichong Decoction represses colorectal cancer progression via inhibiting the PINK1/Parkin pathway regulated by Rab27B[J]. J Ethnopharmacol, 2025, 351:119997.
Dong B Z, Yang Z J, Ju Q, et al. Anticancer effects of Fufang Yiliu Yin Formula on colorectal cancer through modulation of the PI3K/Akt pathway and Bcl-2 family proteins[J]. Front Cell Dev Biol, 2020, 8:704.
Feng H L, Yang Y P, Chen H, et al. Jiedu Xiaozheng Yin extract targets cancer stem cells by Wnt signaling pathway in colorectal cancer[J]. J Ethnopharmacol, 2025, 337(Pt 1):118710.
He S L, Hao L X, Chen Y L, et al. Chinese herbal Jianpi Jiedu Formula suppressed colorectal cancer growth in vitro and in vivo via modulating hypoxia-inducible factor 1 alpha-mediated fibroblasts activation[J]. J Ethnopharmacol, 2025, 337(Pt 1):118753.
Chang Y L, Ou Q L, Zhou X H, et al. Jianpi Jiedu Decoction suppresses colorectal cancer growth by inhibiting M2 polarization of TAMs through the tryptophan metabolism-AhR pathway[J]. Int Immunopharmacol, 2024, 138:112610.
Shang L R, Wang Y C, Li J X, et al. Mechanism of Sijunzi Decoction in the treatment of colorectal cancer based on network pharmacology and experimental validation[J]. J Ethnopharmacol, 2023, 302(Pt A):115876.
Chen G R, Huang L L, Deng G F, et al. Qingre Huayu Jianpi Decoction suppresses colorectal tumorigenesis by inhibiting cancer stem cells and cancer-associated fibroblasts[J]. J Ethnopharmacol, 2025, 347:119722.
Wu Y G, Fang Y L, Li Y N, et al. A network pharmacology approach and experimental validation to investigate the anticancer mechanism of Qi-Qin-Hu-Chang Formula against colitis-associated colorectal cancer through induction of apoptosis via JNK/p38 MAPK signaling pathway[J]. J Ethnopharmacol, 2024, 319(Pt 3):117323.
Wu J M, Shao C, Dong Y, et al. Qu-yu-Jie-du Decoction maintenance therapy improves postoperative survival in metastatic colorectal cancer:A single-center randomized trial with 36-month follow-up[J]. Phytomedicine, 2025, 146:157143.
孟春芹, 刘先勇, 吴皞, 等. 健脾化瘀方治疗结直肠癌脾虚瘀毒型的疗效及对肠道菌群和免疫功能的影响[J]. 河北中医, 2023, 45(6):944-947.
牛泽基. 八珍汤加味治疗气血两虚型晚期结直肠癌的临床观察及网络药理学探讨[D]. 哈尔滨:黑龙江中医药大学, 2023.
黎智燊, 史清华, 张芸, 等. 健脾益肾方联合化疗对晚期老年结肠癌患者生存质量及安全性的研究[J]. 湖南中医杂志, 2021, 37(8):53-55.
黄浩然, 赵杉, 王如然, 等. 扶正消瘤汤对湿热蕴结型晚期结直肠癌术后患者生存率、生活质量及血清白细胞介素6、肿瘤坏死因子α的影响[J]. 河北中医, 2021, 43(8):1266-1271.
王丹丹, 张科. 补中固本益胃方对中晚期结肠癌根治术后化疗患者疗效及免疫平衡、血清鱼精蛋白1的影响[J]. 河北中医, 2020, 42(4):507-511.
严地雪. 健脾渗湿方联合化疗治疗结肠癌患者术后对免疫功能、远期预后的影响[J]. 江西医药, 2021, 56(11):1955-1958.
杨琦, 孙正, 朱亦邈, 等. 黄芪-莪术配伍调控EMT对结肠癌HT-29细胞增殖、迁移和侵袭能力的影响[J]. 中国中药杂志, 2023, 48(3):736-743.
孙若岚. 黄芪-莪术抗结肠癌配伍效应及调控肠道菌群介导的SDF-1/CXCR4/NF-κB通路的机制研究[D]. 南京:南京中医药大学, 2021.
顾俊菲, 孙若岚, 刘夫艳, 等. 黄芪-莪术配伍对结肠癌原位移植瘤模型小鼠SDF-1/CXCR4/NF-κB信号通路的影响[J]. 中国实验方剂学杂志, 2021, 27(21):63-72.
梁立, 齐卓操, 杨心玥, 等. 黄芪莪术联合5-氟尿嘧啶对CT26.WT原位移植瘤小鼠CXCL10/CXCR3轴和CCL3/CCR5轴表达的影响[J]. 北京中医药大学学报, 2022, 45(1):62-72.
郭文晖, 齐卓操, 关汉卿, 等. 黄芪-莪术配伍联合5-氟尿嘧啶对CT26.WT结肠癌原位移植瘤模型小鼠中Th17/Treg平衡及肿瘤相关mRNA和蛋白表达的影响[J]. 中国中药杂志, 2022, 47(1):167-175.
常澍晨. 白花蛇舌草-半边莲药对通过下调SALL4调控Wnt/β-catenin信号通路抑制结肠癌的作用机制研究[D]. 南京:南京中医药大学, 2022.
王方园, 王栋, 孔宪斌, 等. 基于网络药理学和分子对接研究丹参-赤芍药对治疗结直肠癌的作用机制[J]. 中草药, 2022, 53(18):5731-5741.
Zhu D Y, Yuan S M, Chen C. Hedyotis diffusa-Sculellaria barbata (HD-SB) suppresses the progression of colorectal cancer cells via the hsa_circ_0039933/hsa-miR-204-5p/wnt11 axis[J]. Sci Rep, 2023, 13(1):13331.
Sun R Q, Sun C, Yue Z, et al. Astragali Radix-Curcumae Rhizoma herb pair reduces the stemness of colorectal cancer cells through HIF-2α/β-catenin pathway[J]. Phytomedicine, 2024, 132:155824.
Sun R L, Liang Y, Zhu S J, et al. Homotherapy-for-heteropathy of Bupleurum chinense DC.-Scutellaria baicalensis Georgi in treating depression and colorectal cancer:A network pharmacology and animal model approach[J]. J Ethnopharmacol, 2024, 328:118038.
彭丽蓉. 仙鹤草-黄连药对干预结直肠炎癌转化的作用与机制研究[D]. 南京:南京中医药大学, 2022.
Wang C L, Yang B W, Wang X Y, et al. Targeting colorectal cancer with Herba Patriniae and Coix seed:Network pharmacology, molecular docking, and in vitro validation[J]. World J Gastrointest Oncol, 2024, 16(8):3539-3558.
Chen M T, Zhong K Y, Tan J C, et al. Baicalein is a novel TLR4-targeting therapeutics agent that inhibits TLR4/HIF-1α/VEGF signaling pathway in colorectal cancer[J]. Clin Transl Med, 2021, 11(11):e564.
毛海燕, 殷旭东, 乔大伟, 等. 汉黄芩素调控胆绿素还原酶A对结肠癌细胞的抑制作用[J]. 中成药, 2021, 43(8):2181-2188.
Jia Y M, Chen L R, Guo S J, et al. Baicalin induced colon cancer cells apoptosis through miR-217/DKK1-mediated inhibition of Wnt signaling pathway[J]. Mol Biol Rep, 2019, 46(2):1693-1700.
林浩, 代伟宏, 刘昌江, 等. 基于Hedgehog信号通路的黄芩苷抗炎性结直肠癌的机制研究[J]. 天然产物研究与开发, 2023, 35(5):741-749.
Song L J, Zhu S M, Liu C, et al. Baicalin triggers apoptosis, inhibits migration, and enhances anti-tumor immunity in colorectal cancer via TLR4/NF-κB signaling pathway[J]. J Food Biochem, 2022, 46(3):e13703.
Qin Y, Yu Y W, Yang C D, et al. Atractylenolide I inhibits NLRP3 inflammasome activation in colitis-associated colorectal cancer via suppressing Drp1-mediated mitochondrial fission[J]. Front Pharmacol, 2021, 12:674340.
Zhang D, Li X F, Song D Q, et al. Atractylenolide III induces apoptosis by regulating the Bax/Bcl-2 signaling pathway in human colorectal cancer HCT-116 cells in vitro and in vivo[J]. Anticancer Drugs, 2022, 33(1):30-47.
Li Y X, Wang Y P, Liu Z X, et al. Atractylenolide I induces apoptosis and suppresses glycolysis by blocking the JAK2/STAT3 signaling pathway in colorectal cancer cells[J]. Front Pharmacol, 2020, 11:273.
Wang K L, Huang W, Sang X N, et al. Atractylenolide I inhibits colorectal cancer cell proliferation by affecting metabolism and stemness via Akt/mTOR signaling[J]. Phytomedicine, 2020, 68:153191.
Zhang R J, Wang Z J, Yu Q Y, et al. Atractylenolide II reverses the influence of lncRNA XIST/miR-30a-5p/ROR1 axis on chemo-resistance of colorectal cancer cells[J]. J Cell Mol Med, 2019, 23(5):3151-3165.
Sun Y, Liu Y, Cai Y, et al. Atractylenolide I inhibited the development of malignant colorectal cancer cells and enhanced oxaliplatin sensitivity through the PDK1-FoxO1 axis[J]. J Gastrointest Oncol, 2022, 13(5):2382-2392.
冯子芳, 杨瑞宾. 白术多糖通过TLR4信号通路对结肠癌CT26荷瘤小鼠肿瘤生长及免疫调节的影响[J]. 中成药, 2022, 44(1):231-235.
Feng Z F, Yang R B, Wu L S, et al. Atractylodes macrocephala polysaccharides regulate the innate immunity of colorectal cancer cells by modulating the TLR4 signaling pathway[J]. Onco Targets Ther, 2019, 12:7111-7121.
肖娟. 黄芪多糖对结直肠癌LoVo细胞生长的影响[D]. 新乡:新乡医学院, 2021.
郅强, 张楠, 冯光玲, 等. 基于PI3K/Akt/mTOR信号通路探讨黄芪多糖对结直肠癌自噬的影响[J]. 天津医药, 2023, 51(3):240-245.
王奇钰, 吴晗, 唐立垚, 等. 黄芪多糖对VEGF-C表达的抑制与结直肠癌细胞内淋巴管生成的相关性研究[J]. 西部中医药, 2023, 36(3):47-51.
侯本超, 何志坚, 刘海云, 等. 黄芪甲苷对结直肠癌HCT116细胞增殖、迁移及侵袭的影响[J]. 中国实验方剂学杂志, 2023, 29(5):144-149.
Liang J J, Yang C Y, Li P C, et al. Astragaloside IV inhibits AOM/DSS-induced colitis-associated tumorigenesis via activation of PPARγ signaling in mice[J]. Phytomedicine, 2023, 121:155116.
Bian Y, Yin G, Wang G, et al. Degradation of HIF-1α induced by curcumol blocks glutaminolysis and inhibits epithelial-mesenchymal transition and invasion in colorectal cancer cells[J]. Cell Biol Toxicol, 2023, 39(5):1957-1978.
Liu H W, Wang J, Tao Y X, et al. Curcumol inhibits colorectal cancer proliferation by targeting miR-21 and modulated PTEN/PI3K/Akt pathways[J]. Life Sci, 2019, 221:354-361.
Gao J F, Hou D R, Hu P, et al. Curcumol increases the sensitivity of colon cancer to 5-FU by regulating Wnt/β-catenin signaling[J]. Transl Cancer Res, 2021, 10(5):2437-2450.
王洪倩. 莪术油下调OPN基因表达抑制结肠癌细胞增殖及肝转移分子机制的研究[D]. 杭州:浙江中医药大学, 2019.
Feng Y W, Deng L, Guo H R, et al. The anti-colon cancer effects of essential oil of Curcuma phaeocaulis through tumour vessel normalisation[J]. Front Oncol, 2021, 11:728464.
朱婷婷, 厉挺, 赵叶芳. 甘草素调控circ_0006916/microRNA-513a-3p对结直肠癌细胞LoVo生物行为的影响[J]. 中国中西医结合消化杂志, 2021, 29(11):809-814.
Huo X W, Liu D Y, Gao L, et al. Flavonoids extracted from licorice prevents colitis-associated carcinogenesis in AOM/DSS mouse model[J]. Int J Mol Sci, 2016, 17(9):1343.
Zhao L X, Zhang Y M, Li Y J, et al. Therapeutic effects of ginseng and ginsenosides on colorectal cancer[J]. Food Funct, 2022, 13(12):6450-6466.
Li X, Liu W, Geng C, et al. Ginsenoside Rg3 suppresses epithelial-mesenchymal transition via downregulating Notch-Hes1 signaling in colon cancer cells[J]. Am J Chin Med, 2021, 49(1):217-235.
Cong Z Y, Zhao Q, Yang B, et al. Ginsenoside Rh3 inhibits proliferation and induces apoptosis of colorectal cancer cells[J]. Pharmacology, 2020, 105(5/6):329-338.
Zong G F, Deng R, Pan Y H, et al. Ginseng polysaccharides ameliorate colorectal tumorigenesis through Lachnospiraceae-mediated immune modulation[J]. Int J Biol Macromol, 2025, 307(Pt 2):142015.
Wang C Z, Hou L F, Wan J Y, et al. Ginseng berry polysaccharides on inflammation-associated colon cancer:Inhibiting T-cell differentiation, promoting apoptosis, and enhancing the effects of 5-fluorouracil[J]. J Ginseng Res, 2020, 44(2):282-290.
Yang L, Zheng L J, Xie X N, et al. Targeting PLA2G16 a lipid metabolism gene, by ginsenoside compound K to suppress the malignant progression of colorectal cancer[J]. J Adv Res, 2022, 36:265-276.
Han B, Jiang P, Li Z X, et al. Coptisine-induced apoptosis in human colon cancer cells (HCT-116) is mediated by PI3K/Akt and mitochondrial-associated apoptotic pathway[J]. Phytomedicine, 2018, 48:152-160.
Chen H T, Ye C X, Wu C H, et al. Berberine inhibits high fat diet-associated colorectal cancer through modulation of the gut microbiota-mediated lysophosphatidylcholine[J]. Int J Biol Sci, 2023, 19(7):2097-2113.
Yan S H, Chang J Y, Hao X H, et al. Berberine regulates short-chain fatty acid metabolism and alleviates the colitis-associated colorectal tumorigenesis through remodeling intestinal flora[J]. Phytomedicine, 2022, 102:154217.
Varlı M, Ji M, Kim E, et al. Emodin disrupts the KITENIN oncogenic complex by binding ErbB4 and suppresses colorectal cancer progression in dual blockade with KSRP-binding compound[J]. Phytomedicine, 2025, 136:156247.
Song X Q, He H H, Zhang Y, et al. Mechanisms of action of triptolide against colorectal cancer:Insights from proteomic and phosphoproteomic analyses[J]. Aging, 2022, 14(7):3084-3104.
张明发, 沈雅琴. 苦参碱和氧化苦参碱抗大肠癌药理作用研究进展[J]. 药物评价研究, 2020, 43(6):1189-1196.
王蕊, 刘宏伟, 邵莹莹, 等. 槐定碱通过靶向MAPKAPK2抑制人结直肠癌的发展[J]. 中国药理学与毒理学杂志, 2019, 33(9):722.
金少举, 王蓉, 李海龙, 等. 氧化槐定碱通过下调IKK/IκB/NF-κB信号通路抑制结直肠癌SW480细胞增殖[J]. 中药药理与临床, 2019, 35(2):63-67.
朱丽娟, 宋润泽, 罗慧英, 等. 当归挥发油对人结直肠癌HCT-116细胞增殖、迁移及凋亡的作用[J]. 中成药, 2022, 44(10):3321-3325.
Ma J, Mei J, Lu J, et al. Ligustilide promotes apoptosis of cancer-associated fibroblasts via the TLR4 pathways[J]. Food Chem Toxicol, 2020, 135:110991.
刘博, 张传凤, 马克龙, 等. 基于STAT-3/NF-κB/ICAM-1通路探讨丹皮酚缓解小鼠结肠炎相关性结直肠癌的作用机制[J]. 安徽中医药大学学报, 2021, 40(1):88-92.
Yue M, Li S Q, Yan G Q, et al. Paeoniflorin inhibits cell growth and induces cell cycle arrest through inhibition of FoxM1 in colorectal cancer cells[J]. Cell Cycle, 2018, 17(2):240-249.
Wang L, Wang R, Wei G Y, et al. Cryptotanshinone alleviates chemotherapy-induced colitis in mice with colon cancer via regulating fecal-bacteria-related lipid metabolism[J]. Pharmacol Res, 2021, 163:105232.
Ge T R, Li H Z, Xiang P, et al. Tanshinone IIA induces ferroptosis in colorectal cancer cells through the suppression of SLC7A11 expression via the PI3K/Akt/mTOR pathway[J]. Eur J Med Res, 2025, 30(1):576.
于剑, 李佳锜, 周怡婷, 等. 穿心莲内酯通过Hippo通路调控伊立替康对结肠癌HT-29细胞凋亡及TOPO-1表达影响[J]. 临床军医杂志, 2020, 48(11):1332-1334.
Budiatin A S, Sagitaras I B, Nurhayati I P, et al. Attenuation of hyperplasia in lung parenchymal and colonic epithelial cells in DMBA-induced cancer by administering Andrographis paniculata Nees extract using animal model[J]. J Basic Clin Physiol Pharmacol, 2021, 32(4):497-504.
Liu C F, Rokavec M, Huang Z K, et al. Curcumin activates a ROS/Keap1/Nrf2/miR-34a/b/c cascade to suppress colorectal cancer metastasis[J]. Cell Death Differ, 2023, 30(7):1771-1785.
Zhou M T, Li R, Lian G Y, et al. Tetrahydrocurcumin alleviates colorectal tumorigenesis by modulating the SPP1/CD44 axis and preventing M2 tumor-associated macrophage polarization[J]. Phytomedicine, 2025, 141:156674.
谢涛, 杨正强, 徐文武, 等. 冬凌草化学成分、药理作用及临床应用研究进展[J]. 中草药, 2022, 53(1):317-325.
Zhou F Y, Gao H Y, Shang L R, et al. Oridonin promotes endoplasmic reticulum stress via TP53-repressed TCF4 transactivation in colorectal cancer[J]. J Exp Clin Cancer Res, 2023, 42(1):150.
Wang Z F, Cui Q F, Shi L, et al. Network pharmacology-based prediction and verification of shikonin for treating colorectal cancer[J]. Recent Pat Anticancer Drug Discov, 2022, 17(3):297-311.
Zhang N, Peng F, Wang Y J, et al. Shikonin induces colorectal carcinoma cells apoptosis and autophagy by targeting galectin-1/JNK signaling axis[J]. Int J Biol Sci, 2020, 16(1):147-161.
Chen B C, Tu S L, Zheng B A, et al. Schizandrin A exhibits potent anticancer activity in colorectal cancer cells by inhibiting heat shock factor 1[J]. Biosci Rep, 2020, 40(3):BSR20200203.
Pu Z C, Zhang W W, Wang M H, et al. Schisandrin B attenuates colitis-associated colorectal cancer through SIRT1 linked SMURF2 signaling[J]. Am J Chin Med, 2021, 49(7):1773-1789.
Hu J N, Wang Y M, Zhang H, et al. Schisandra B, a representative lignan from Schisandra chinensis, improves cisplatin-induced toxicity:An in vitro study[J]. Phytother Res, 2023, 37(2):658-671.
Lee P K, Co V A, Yang Y, et al. Bioavailability and interactions of schisandrin B with 5-fluorouracil in a xenograft mouse model of colorectal cancer[J]. Food Chem, 2025, 463(Pt 3):141371.
Sun J G, Wang Z P, Yun Y L, et al. Schisandrin B exerts anti-colorectal cancer effect through CXCL2/ERK/DUSP11 signaling pathway[J]. Cancer Cell Int, 2025, 25(1):97.
Zhu L Q, Zhang L, Zhang J, et al. Evodiamine inhibits high-fat diet-induced colitis-associated cancer in mice through regulating the gut microbiota[J]. J Integr Med, 2021, 19(1):56-65.
Byun W S, Bae E S, Kim W K, et al. Antitumor activity of rutaecarpine in human colorectal cancer cells by suppression of Wnt/β-catenin signaling[J]. J Nat Prod, 2022, 85(5):1407-1418.
庞林荣, 陈俊, 陆静尔, 等. 槲皮素对HSP-27敲减结肠癌SW480细胞增殖、迁移和侵袭的影响及作用机制研究[J]. 中药材, 2021, 44(6):1470-1476.
Liang X, Xie R X, Su J F, et al. Inhibition of RNA polymerase III transcription by Triptolide attenuates colorectal tumorigenesis[J]. J Exp Clin Cancer Res, 2019, 38(1):217.
Jiang X, Cao G, Gao G Y, et al. Triptolide decreases tumor-associated macrophages infiltration and M2 polarization to remodel colon cancer immune microenvironment via inhibiting tumor-derived CXCL12[J]. J Cell Physiol, 2021, 236(1):193-204.
Yu Y, Chen D D, Wu T, et al. Dihydroartemisinin enhances the anti-tumor activity of oxaliplatin in colorectal cancer cells by altering PRDX2-reactive oxygen species-mediated multiple signaling pathways[J]. Phytomedicine, 2022, 98:153932.
Dai X S, Chen W, Qiao Y, et al. Dihydroartemisinin inhibits the development of colorectal cancer by GSK-3β/TCF7/MMP9 pathway and synergies with capecitabine[J]. Cancer Lett, 2024, 582:216596.
Huang Z Y, Gan S, Zhuang X R, et al. Artesunate inhibits the cell growth in colorectal cancer by promoting ROS-dependent cell senescence and autophagy[J]. Cells, 2022, 11(16):2472.
Gao Q, Sheng Q S, Yang Z J, et al. Honokiol-magnolol-baicalin possesses synergistic anticancer potential and enhances the efficacy of anti-PD-1 immunotherapy in colorectal cancer by triggering GSDME-dependent pyroptosis[J]. Adv Sci, 2025, 12(13):2417022.
Bai S B, Sun Y, Cheng Y, et al. MCP mediated active targeting calcium phosphate hybrid nanoparticles for the treatment of orthotopic drug-resistant colon cancer[J]. J Nanobiotechnology, 2021, 19(1):367.
Du L, Min H, Meng Y K, et al. LRG1-targeted camptothecin nanomicelles with simultaneous delivery of olaparib for enhanced colorectal cancer chemotherapy[J]. Nano Lett, 2025, 25(8):3130-3140.
Jiang Y W, Xu H C, Wu J L, et al. A hierarchically assembled oral formulation with drug-convertible carriers for targeted ulcerative colitis therapy through a three-pronged strategy[J]. Adv Compos Hybrid Mater, 2025, 8(4):280.

2026年第57卷第8期

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doi: 10.7501/j.issn.0253-2670.2026.08.028

接收时间：2025-09-25
首发时间：2026-09-09

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2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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