Article(id=1304414893235523770, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1304414858296971266, articleNumber=null, orderNo=null, doi=10.7501/j.issn.0253-2670.2026.06.030, pmid=null, cstr=null, oa=null, hot=0, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1756742400000, receivedDateStr=2025-09-02, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1788926345404, onlineDateStr=2026-09-09, pubDate=null, pubDateStr=null, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1788926345404, onlineIssueDateStr=2026-09-09, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1788926345404, creator=13701087609, updateTime=1788926345404, updator=13701087609, issue=Issue{id=1304414858296971266, tenantId=1146029695717560320, journalId=1302319053441957962, year='2026', volume='57', issue='6', pageStart='2009', pageEnd='2444', issueExtLink='null', onlineDate='null', pubDate='1774627200000', pubDateStr='2026-03-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1788926337074, creator='13701087609', updateTime=1788926665348, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1304416235240841997, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1304414858296971266, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1304416235240841998, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1304414858296971266, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=2381, endPage=2393, ext={EN=ArticleExt(id=1304414893650759868, articleId=1304414893235523770, tenantId=1146029695717560320, journalId=1302319053441957962, language=EN, title=Research progress on chemical substance basis, modern pharmacology and clinical application of Asteris Radix et Rhizoma , columnId=null, journalTitle=Chinese Traditional and Herbal Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=Ziwan (Asteris Radix et Rhizoma ) is a classic traditional Chinese medicine for relieving cough and resolving phlegm. Its application history can be traced back to Shennong’s Classic of Materia Medica . Under the background of the Silk Road civilization exchange, the compatibility prescription of Asteris Radix et Rhizoma contained in Dunhuang medical classics P.2882 reflects the integration and dissemination of Eastern and Western medical knowledge. Through the integration of herbal textual research and modern research methods, the chemical composition, pharmacological effects and clinical application of Asteris Radix et Rhizoma were systematically analyzed. Studies have shown that triterpenes such as shionone, cyclic peptide astins and flavonoids in Asteris Radix et Rhizoma are the material basis of its antitussive and expectorant, anti-inflammatory and anti-tumor effects. The classical drug pairs formed by its compatibility with Kuandonghua (Farfarae Flos ) and Tinglizi (Descurainiae Semen or Lepidii Semen ) have shown clear efficacy in the treatment of chronic obstructive pulmonary disease, asthma and lung cancer. It provides a scientific basis for the in-depth development of Asteris Radix et Rhizoma , and shows the important value of Silk Road civilization exchange in traditional medicine research., authors=ZHENG Yan, LUO Jianmei, FAN Tingting, LU Wanpeng, CHEN Dandan, XIU Minghui, authorsList=ZHENG Yan, LUO Jianmei, FAN Tingting, LU Wanpeng, CHEN Dandan, XIU Minghui, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1304414893562679483, articleId=1304414893235523770, tenantId=1146029695717560320, journalId=1302319053441957962, language=CN, title=紫菀化学物质基础及现代药理与临床应用研究进展, columnId=1304140194685415572, journalTitle=中草药, columnName=综述, runingTitle=null, highlight=null, articleAbstract=紫菀Asteris Radix et Rhizoma 作为经典止咳化痰中药,其应用历史可溯至《神农本草经》。在丝绸之路文明交流背景下,敦煌医学典籍P.2882所载紫菀配伍方剂,体现了东西方医学知识的融合与传播。通过整合本草学考证与现代研究方法,系统解析紫菀的化学成分、药理作用及临床应用。研究表明,紫菀中紫菀酮等三萜类、环肽astins及黄酮类成分是其止咳化痰、抗炎、抗肿瘤作用的药效物质基础;其与款冬花Farfarae Flos 、葶苈子(Descurainiae Semen 或Lepidii Semen )等配伍形成的经典药对在慢性阻塞性肺疾病、哮喘及肺癌治疗中显示出明确疗效。为紫菀的深入开发提供科学依据,更展现了丝路文明交流在传统药物研究中的重要价值。, authors=郑琰1 , 罗建美1 , 樊婷婷1 , 陆万鹏1 , 陈丹丹1 , 修明慧1,2 , authorsList=郑琰, 罗建美, 樊婷婷, 陆万鹏, 陈丹丹, 修明慧, authorCompany=1 甘肃中医药大学公共卫生学院, 甘肃 兰州 730101; 2 甘肃中医药大学 敦煌医学与转化教育部重点实验室, 甘肃 兰州 730000, correspAuthors=null, authorNote=郑琰: 郑琰,本科生。E-mail:3366293307@qq.com, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=rX2Rq+K10AYLiFZn+vd8dw==, pdfFileSize=1256591, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=教育部产学合作协同育人项目 (2412133147); 甘肃省中医药科研课题 (GZKZ-2022-9); 甘肃中医药大学2022年教学研究与改革一般项目 (3106010201); 敦煌医学与转化教育部重点实验室开放课题 (DHYX24-15))}, authors=null, keywords=[Keyword(id=1304414893801754813, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304414893235523770, language=CN, orderNo=1, keyword=紫菀), Keyword(id=1304414893885640894, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304414893235523770, language=CN, orderNo=2, keyword=槲皮素), Keyword(id=1304414893969526975, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304414893235523770, language=CN, orderNo=3, keyword=紫菀酮), Keyword(id=1304414894045024448, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304414893235523770, language=CN, orderNo=4, keyword=止咳平喘), Keyword(id=1304414894112133313, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304414893235523770, language=CN, orderNo=5, keyword=抗肿瘤), Keyword(id=1304414894208602306, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304414893235523770, language=CN, orderNo=6, keyword=药物配对), Keyword(id=1304414894355402947, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304414893235523770, language=EN, orderNo=1, keyword=Asteris Radix et Rhizoma ), Keyword(id=1304414894443483332, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304414893235523770, language=EN, orderNo=2, keyword=quercetin), Keyword(id=1304414894518980805, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304414893235523770, language=EN, orderNo=3, keyword=shionone), Keyword(id=1304414894598672582, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304414893235523770, language=EN, orderNo=4, keyword=relieves cough and asthma), Keyword(id=1304414894682558663, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304414893235523770, language=EN, orderNo=5, keyword=antitumor), Keyword(id=1304414894762250440, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304414893235523770, language=EN, orderNo=6, keyword=herb pair)], refs=null, funds=null, companyList=null, figs=null, attaches=null, journal=Journal(id=1302309778002903112, delFlag=0, nameCn=中草药, nameEn=Chinese Traditional and Herbal Drugs, nameHistory1=null, nameHistory2=null, issn=0253-2670, eissn=null, cn=12-1108/R, coden=null, periodic=3, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=cGpSKCP11AF8PAOcTXYWfg==, journalPrice=null, startedYear=null, abbrevIsoEn=Chinese Traditional and Herbal Drugs, journalRemark=null, publicationField=null, createdTime=1788424446827, updatedTime=1788949289390, createdBy=18614031015, updatedBy=13041195026, firstLetterCn=Z, firstLetterEn=Z, subjectCode=Medical and Pharmaceutical Sciences, subjectName=null, subjectCodeEn=Medical and Pharmaceutical Sciences, subjectNameEn=null, picCn=cGpSKCP11AF8PAOcTXYWfg==, picEn=Xw//kxUC3ON4eHxev0QLhQ==, jcr=null, cjcr=null, exts=[JournalExt(id=1304511127375863983, language=CN, name=中草药, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788949289411, updatedTime=1788949289411, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://www.tiprpress.com/zcy/author/login, submissionEditorUrl=https://www.tiprpress.com/zcy/editor/login, submissionReviewUrl=https://www.tiprpress.com/zcy/reviewer/login, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""}), JournalExt(id=1304511127442972848, language=EN, name=Chinese Traditional and Herbal Drugs, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788949289427, updatedTime=1788949289427, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://www.tiprpress.com/zcy/author/login, submissionEditorUrl=https://www.tiprpress.com/zcy/editor/login, submissionReviewUrl=https://www.tiprpress.com/zcy/reviewer/login, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""})], databaseList=null, tenantJournalId=1302319053441957962, websiteList=[Website(id=1302319176408912052, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1302319053441957962, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zcy/CN, language=CN, createTime=1788426687576, createBy=18614031015, updateTime=1788427346252, updateBy=18614031015, name=中草药-中文, tplId=1146099689490845704, title=中草药, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1302322043651904087, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=articleTextType, value=kx, createTime=1788427371180, updateTime=1788427371180, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043593183828, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=banner, value=null, createTime=1788427371166, updateTime=1788427371166, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043672875610, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=grayFlag, value=0, createTime=1788427371185, updateTime=1788427371185, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043584795219, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=logo, value=https://castjournals.cast.org.cn/joweb/zcy/CN/file/pic?fileId=uiD1gpiRqR++OLOz4iKzDg==, createTime=1788427371164, updateTime=1788427371164, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043689652828, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=minRunFlag, value=0, createTime=1788427371189, updateTime=1788427371189, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043643515478, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zcy/CN/file/pic, createTime=1788427371178, updateTime=1788427371178, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043681264219, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=silenceFlag, value=0, createTime=1788427371187, updateTime=1788427371187, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043601572437, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1788427371168, updateTime=1788427371168, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043660292696, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=themeColor, value=null, createTime=1788427371182, updateTime=1788427371182, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322043668681305, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176408912052, code=themeStyle, value=null, createTime=1788427371184, updateTime=1788427371184, creator=18614031015, updator=18614031015)]), Website(id=1302319176715096246, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1302319053441957962, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zcy/EN, language=EN, createTime=1788426687649, createBy=18614031015, updateTime=1788427341161, updateBy=18614031015, name=中草药-英文, tplId=1146101810881728533, title=Chinese Traditional and Herbal Drugs, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1302322015206134340, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=articleTextType, value=kx, createTime=1788427364398, updateTime=1788427364398, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015185162817, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=banner, value=null, createTime=1788427364393, updateTime=1788427364393, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015227105863, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=grayFlag, value=0, createTime=1788427364403, updateTime=1788427364403, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015176774208, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=logo, value=https://castjournals.cast.org.cn/joweb/zcy/EN/file/pic?fileId=uiD1gpiRqR++OLOz4iKzDg==, createTime=1788427364391, updateTime=1788427364391, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015239688777, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=minRunFlag, value=0, createTime=1788427364406, updateTime=1788427364406, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015201940035, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zcy/EN/file/pic, createTime=1788427364397, updateTime=1788427364397, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015235494472, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=silenceFlag, value=0, createTime=1788427364405, updateTime=1788427364405, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015193551426, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1788427364395, updateTime=1788427364395, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015214522949, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=themeColor, value=null, createTime=1788427364400, updateTime=1788427364400, creator=18614031015, updator=18614031015), WebsiteProps(id=1302322015218717254, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176715096246, code=themeStyle, value=null, createTime=1788427364401, updateTime=1788427364401, creator=18614031015, updator=18614031015)])], journalTitle=中草药, weixinUrl=null, journalUrl=https://www.tiprpress.com/zcy, iacademicId=null, status=1, seqNo=null, journalTitleEn=Chinese Traditional and Herbal Drugs, journalPhotoCn=cGpSKCP11AF8PAOcTXYWfg==, journalPhotoEn=Xw//kxUC3ON4eHxev0QLhQ==, journalFirstLetter=Z, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false, interPubPlatform=, interPubPlatformUrl=null), detailUrlCn=https://castjournals.cast.org.cn/joweb/zcy/CN/10.7501/j.issn.0253-2670.2026.06.030, detailUrlEn=https://castjournals.cast.org.cn/joweb/zcy/EN/10.7501/j.issn.0253-2670.2026.06.030, pdfUrlCn=https://castjournals.cast.org.cn/joweb/zcy/CN/PDF/10.7501/j.issn.0253-2670.2026.06.030, pdfUrlEn=https://castjournals.cast.org.cn/joweb/zcy/EN/PDF/10.7501/j.issn.0253-2670.2026.06.030, aliStartDate=null, aliEndDate=null, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=0, orderTime=1788926345404, fullTextJson=null, articleText=null, reference=张文娟, 李倩, 孙艳丽, 等. 基于生物信息学和孟德尔随机化方法探索慢性阻塞性肺疾病潜在靶点及干预中药的预测[J]. 中草药, 2025, 56(21): 7840-7858. 吴普. 吴普本草[M]. 北京: 人民卫生出版社, 1987. 陶弘景. 名医别录[M]. 尚志钧辑校. 北京: 人民卫生出版社, 1986: 148. 陶弘景. 本草经集注: 辑校本[M]. 尚志钧, 尚元胜辑校. 北京: 人民卫生出版社, 1994: 307-308. 福建省中医研究所医史、理论研究室. 苏颂及其本草图经[J]. 福建中医药杂志, 1957, 2(3): 37-39. 李佩, 赵付霞, 杨思琦, 等. 紫菀化学成分及其抗炎活性研究[J]. 中成药, 2025, 47(2): 473-479. Yu P, Cheng S, Xiang J, et al . Expectorant, antitussive, anti-inflammatory activities and compositional analysis of Aster tataricus [J]. J Ethnopharmacol , 2015, 164: 328-333. 王明安, 陈耀祖. 线叶紫菀中一个单萜酸的化学结构[J]. 高等学校化学学报, 1994, 15(4): 543-544. Tsankova E, Bohlmann F. A monoterpene from Aster bakeranus [J]. Phytochemistry , 1983, 22(5): 1285-1286. Nagao T, Okabe H, Yamauchi T. Studies on the constituents of Aster tataricus L. f. I. structures of shionosides A and B, monoterpene glycosides isolated from the root[J]. Chem Pharm Bull , 1988, 36(2): 571-577. Jung C M, Kwon H C, Seo J J, et al . Two new monoterpene peroxide glycosides from Aster scaber [J]. Chem Pharm Bull , 2001, 49(7): 912-914. Guo S J, Zhao X H, Cheng D L. A new diterpenoid glucoside from Aster smithianus [J]. Chin Chem Lett , 2004, 15(12): 1451-1453. Guo S J, Katalinic J P, He L, et al . A new kaurane diterpene and a new echinocystic acid saponin from Aster ageratoides [J]. Pharmazie , 1998, 53(7): 481-485. Shi Y P, Jia Z J, Yang L, et al . A new diterpene ester from Euphorbia aleppica [J]. Chem Res Chin Univ , 1994, 10(4): 335-337. Cheng D L, Cao X P, Wei H X, et al . Kaurane diterpenoids from Aster ageratoides [J]. Phytochemistry , 1993, 33(5): 1181-1183. Li E W, Gao K, Jia J Z. Two new diterpene acetylxylosides from Aster veitchianus [J]. Chin Chem Lett , 2004, 15(4): 425-427. Choi S Z, Kwon H C, Choi S U, et al . Five new labdane diterpenes from Aster oharai [J]. J Nat Prod , 2002, 65(8): 1102-1106. Guo S J, Wang L M, Cheng D L. A new neo-clerodane diterpene and its glycoside from Aster souliei [J]. Indian J Chem Sect B , 1997, 36B(4): 339-342. Wang L M, Guo S J, Jia Z J, et al . A new neo-clerodane diterpene from Aster souliei [J]. Chin Chem Lett , 1996, 7(7): 619-620. Tanaka R, Nagao T, Okabe H, et al . Studies on the constituents of Aster tataricus L. f. IV. structures of Aster saponins isolated from the herb[J]. Chem Pharm Bull , 1990, 38(5): 1153-1157. 金晶, 张朝凤, 张勉. 紫菀的化学成分研究[J]. 中国现代中药, 2008, 10(6): 20-22. Akihisa T, Kimura Y, Koike K, et al . Astertarone A: A triterpenoid ketone isolated from the roots of Aster tataricus L[J]. Chem Pharm Bull , 1998, 46(11): 1824-1826. Zhou W B, Zeng G Z, Xu H M, et al . Astataricusones A-D and astataricusol A, five new anti-HBV shionane-type triterpenes from Aster tataricus L. f[J]. Molecules , 2013, 18(12): 14585-14596. Zhou W B, Zeng G Z, Xu H M, et al . Astershionones A-F, six new anti-HBV shionane-type triterpenes from Aster tataricus [J]. Fitoterapia , 2014, 93: 98-104. 刘可越, 张铁军, 高文远, 等. 紫菀中三萜及甾体化合物的研究[J]. 天然产物研究与开发, 2006, 18(1): 4-6. 刘可越, 张铁军, 高文远, 等. 紫菀化学成分的研究[J]. 中草药, 2006, 37(1): 31-33. 卢艳花, 王峥涛, 徐珞珊, 等. 紫菀中的多元酚类化合物[J]. 中草药, 2002, 33(1): 17-18. Nagao T, Hachiyama S, Okabe H, et al . Studies on the constituents of Aster tataricus L. f. II. Structures of Aster saponins isolated from the root[J]. Chem Pharm Bull , 1989, 37(8): 1977-1983. Nagao T, Okabe H. Studies on the constituents of Aster scaber Thunb. III. Structures of scaberosides B7, B8 and B9, minor oleanolic acid glycosides isolated from the root[J]. Chem Pharm Bull , 1992, 40(4): 886-888. Nagao T, Okabe H, Yamauchi T. Studies on the constituents of Aster tataricus L. f. III.: Structures of aster saponins E and F isolated from the root[J]. Chem Pharm Bull , 1990, 38(3): 783-785. 卢艳花, 王峥涛, 叶文才, 等. 紫菀化学成分的研究[J]. 中国药科大学学报, 1998, 29(2): 97-99. Morita H, Nagashima S, Takeya K, et al . Structures and conformation of antitumour cyclic pentapeptides, astins A, B and C, from Aster tataricus [J]. Tetrahedron , 1995, 51(4): 1121-1132. 陈士林, 刘洁, 冯梦晗, 等. 基于UHPLC-Q-TOF-MS/ MS联合分子网络策略快速分析紫菀中肽类成分[J]. 质谱学报, 2023, 44(3): 397-411. Cheng D, Shao Y, Hartman R, et al . Oligopeptides from Aster tataricus [J]. Phytochemistry , 1994, 36(4): 945-948. Kosemura S, Ogawa T, Totsuka K. Isolation and Structure of Asterin , a new halogenated cyclic penta-peptide from Aster tataricus [J]. Tetrahedron Lett , 1993, 34(8): 1291-1294. Morita H, Nagashima S, Takeya K, et al . Astins A and B, antitumor cyclic pentapeptides from Aster tataricus [J]. Chem Pharm Bull , 1993, 41(5): 992-993. Morita H, Nagashima S, Takeya K, et al . Structures and conformation of antitumour cyclic pentapeptides, astins A, B and C, from Aster tataricus [J]. Tetrahedron , 1995, 51(4): 1121-1132. Morita H, Nagashima S, Shirota O, et al . Two novel monochlorinated cyclic pentapeptides, astins D and E from Aster tataricus [J]. Chem Lett , 1993, 22(11): 1877-1880. Itokawa H, Morita H, Nagashima S, et al . Cyclic peptides from higher plants. part 8. three novel cyclic pentapeptides, astins F, G and H from Aster tataricus [J]. Heterocycles , 1994, 38(10): 2247-2252. Morita H, Nagashima S, Takeya K, et al . A novel cyclic pentapeptide with a β-hydroxy-γ-chloroproline from Aster tataricus [J]. Chem Lett , 1994, 23(11): 2009-2010. Xu H M, Zeng G Z, Zhou W B, et al . Astins K-P, six new chlorinated cyclopentapeptides from Aster tataricus [J]. Tetrahedron , 2013, 69(37): 7964-7969. Morita H, Nagashima S, Takeya K, et al . Structure of a new peptide, astin J, from Aster tataricus [J]. Chem Pharm Bull , 1995, 43(2): 271-273. Cheng D L, Shao Y, Hartman R, et al . Oligopeptides from Aster tataricus [J]. Phytochemistry , 1994, 36(4): 945-948. Cheng D L, Shao Y, Hartmann R, et al . New pentapeptides from Aster tataricus [J]. Phytochemistry , 1996, 41(1): 225-227. 苏磊, 姜艳艳, 刘斌.《中国药典》收录的植物类中药中含有的寡肽类成分[J]. 中国中药杂志, 2016, 41(16): 2943-2952. Xu H M, Yi H, Zhou W B, et al . Tataricins A and B, two novel cyclotetrapeptides from Aster tataricus , and their absolute configuration assignment[J]. Tetrahedron Lett , 2013, 54(11): 1380-1383. 牛倩, 孙鹏, 张慢慢, 等. 中药紫菀的化学成分研究进展[J]. 安徽农学通报, 2016, 22(13): 30-31. 彭文静, 辛蕊华, 任丽花, 等. 紫菀化学成分及药理作用研究进展[J]. 动物医学进展, 2015, 36(3): 102-106. Ng T B, Liu F, Lu Y H, et al . Antioxidant activity of compounds from the medicinal herb Aster tataricus [J]. Comp Biochem Physiol C Toxicol Pharmacol , 2003, 136(2): 109-115. 刘可越, 张铁军, 高文远, 等. 紫菀化学成分的研究[A] // 中药化学研究与药物创新——中华中医药学会中药化学分会2006年度学术研讨会论文集[C]. 天津: 中华中医药学会中药化学分会2006年度学术研讨会, 2006: 42-45. 王国艳, 吴弢, 林平川, 等. 紫菀酚类化学成分的研究[J]. 中国中药杂志, 2003, 28(10): 946-948. 陈奕君, 吴浩, 魏紫奕, 等. 基于UHPLC-Q-TOF-MS/ MS的紫菀药材全成分解析[J]. 药学学报, 2019, 54(9): 1645-1654. Sun Y P, Li L, Liao M, et al . A systematic data acquisition and mining strategy for chemical profiling of Aster Tataricus Rhizoma (Ziwan) by UHPLC-Q-TOF-MS and the corresponding anti-depressive activity screening[J]. J Pharm Biomed Anal , 2018, 154: 216-226. 刘可越, 张铁军, 高文远, 等. 紫菀中多酚类化合物的研究[J]. 中草药, 2007, 38(12): 1793-1795. 高金海, 王红武, 宋国强, 等. NMR研究紫菀中两个酚性化合物的结构及立体化学[J]. 波谱学杂志, 1994, 11(4): 391-397. 杨滨, 肖永庆, 梁日欣, 等. 紫菀挥发油中祛痰活性化学成分研究[J]. 中国中药杂志, 2008, 33(3): 281-283. 范玲, 王鑫, 朱晓静, 等. 不同炮制方法对紫菀浸出物及主成分含量的影响[J]. 中国现代中药, 2018, 20(12): 1509-1514. 修彦凤, 程雪梅, 刘蕾, 等. 不同紫菀饮片中紫菀酮的含量比较[J]. 上海中医药大学学报, 2006, 20(2): 59-61. 王隽, 刘耀, 李瑞, 等. 不同炮制方法对紫菀化学成分的影响[J]. 中药与临床, 2023, 14(6): 17-20. 周日贵, 涂建雄. 紫菀炮制后对小鼠止咳作用的影响[J]. 湖南中医药导报, 2000, 6(4): 56. 卢艳花, 戴岳, 王峥涛, 等. 紫菀祛痰镇咳作用及其有效部位和有效成分[J]. 中草药, 1999, 30(5): 360-361. 任丽花, 辛蕊华, 彭文静, 等. 紫菀不同极性段提取物的药效比较[J]. 南方农业学报, 2015, 46(4): 675-679. 刘令勉, 于仲范, 吴翠玉. 紫菀散加甘草对离体豚鼠气管解痉作用的研究[J]. 中国中药杂志, 1993, 18(9): 566-567. 李岩, 王丽华, 盛莉. 紫菀与甘草对豚鼠气管作用研究[J]. 中医药信息, 1999(4): 47. 胥倩, 张东升. 中医药辅助治疗常见恶性肿瘤研究进展[J]. 亚太传统医药, 2025, 21(4): 211-215. 李明珠, 杨柱, 吴群, 等. 基于网络药理学探讨“葶苈子-紫菀”抗肺癌的作用机制[J]. 中医肿瘤学杂志, 2021, 3(1): 13-20. 邢海燕. 简述紫菀化学成分与药效学[J]. 中国中医药现代远程教育, 2011, 9(21): 55. 房慧勇, 单高威, 秦桂芳, 等. 紫菀的化学成分及其药理活性研究进展[J]. 医学研究与教育, 2012, 29(5): 73-77. 鲜恩英, 边巴卓玛, 格央, 等. 紫菀酮抑制HeLa细胞迁移侵袭的作用及机制[J]. 高原科学研究, 2021, 5(2): 57-63. 刘晓丽, 梁羽茜, 胡秀华. 体外实验探讨蜜炙紫菀水煎剂对人乳腺癌MCF-7细胞的影响[J]. 世界中西医结合杂志, 2017, 12(4): 496-499. 钱树树, 彭林, 杨映映, 等. 蜜炙紫菀水煎剂对大肠癌Lovo细胞凋亡及迁移的影响[J]. 中华中医药学刊, 2015, 33(9): 2146-2150. Zhang Y X, Wang Q S, Wang T, et al . Inhibition of human gastric carcinoma cell growth in vitro by a polysaccharide from Aster tataricus [J]. Int J Biol Macromol , 2012, 51(4): 509-513. 李聪, 黄芳, 窦昌贵, 等. 紫菀、款冬花配伍对抗炎作用的影响[J]. 中国临床药理学与治疗学, 2009, 14(2): 155-159. 王芳, 任刚, 潘玲玲, 等. 紫菀酮基于NF-κB信号通路的体外抗炎机制研究[J]. 中华中医药杂志, 2016, 31(4): 1430-1433. 王晓溪, 徐慧星, 王博, 等. 紫菀水提液对肺炎支原体感染小鼠肺组织病理变化、细胞凋亡及TGF-β1表达的影响[J]. 中国中医药科技, 2022, 29(6): 975-977. 景临林, 马慧萍, 蒙萍, 等. 藏紫菀醇提物的抗氧化与抗缺氧作用研究[J]. 中药材, 2016, 39(2): 398-403. NG T B, LIU F, LU Y H, et al . Antioxidant activity of compounds from the medicinal herb Aster tataricus [J]. Comp Biochem Physiol C Toxicol Pharmacol , 2003, 136(2): 109-115. 张应鹏, 张海雷, 杨云裳, 等. 紫菀提取物不同极性部位体外抗氧化活性研究[J]. 时珍国医国药, 2011, 22(11): 2799-2800. 唐小武, 刘湘新, 唐宇龙, 等. 紫菀有效成分分析及生物碱的提取与体外抑菌研究[J]. 中兽医医药杂志, 2006, 25(1): 16-18. 李德富, 叶园园, 章洪萍, 等. 烟草烟雾与机动车尾气暴露建立的大鼠慢性阻塞性肺疾病模型比较[J]. 解放军医学杂志, 2024, 49(9): 1038-1044. 中华医学会呼吸病学分会慢性阻塞性肺疾病学组. 慢性阻塞性肺疾病诊治指南(2013年修订版)[J]. 中国医学前沿杂志: 电子版, 2014, 6(2): 67-80. 邹华兰. 中西医结合疗法治疗AECOPD合并呼吸衰竭疗效观察[J]. 中国社区医师, 2020, 36(1): 97-98. 蔡一杰, 史学礼, 刘红云, 等. 中药紫菀有效成分及药理作用[J]. 中兽医医药杂志, 2023, 42(2): 39-42. 高卫东, 高英, 李卫民, 等. 百部紫菀配对分析和临床应用[J]. 新中医, 2007, 39(4): 72. 李娜, 马世平, 黄芳, 等. 紫菀、款冬配伍中紫菀的祛痰研究[J]. 中国临床药理学与治疗学, 2009, 14(2): 159-162. 郑历史, 孙淑仃, 刘学芳. 紫菀的化学成分及在慢性阻塞性肺疾病中的应用研究进展[J]. 辽宁中医药大学学报, 2026, 28(1): 48-54. 张九思, 郝瑞芳, 李芳. 基于文献分析中药治疗小儿肺炎的用药规律[J]. 湖南中医杂志, 2021, 37(8): 159-162. 陈少旭, 梁小银, 甘长朋, 等. 六君子汤合紫菀散配方颗粒治疗慢性阻塞性肺疾病的疗效观察[J]. 湖北中医杂志, 2022, 44(5): 10-14. Deng L, Zhang X Y, Dong Y, et al . Erchen Decoction combined with Sanziyangqin Decoction for chronic obstructive pulmonary disease: A protocol for systematic review and Meta-analysis[J]. Medicine , 2020, 99(40): e22315. 吴文华, 沈旭艳, 花梁. 射干麻黄汤治疗小儿咳嗽变异性哮喘的研究进展[J]. 临床合理用药, 2024, 17(27): 174-177. 翟俊杰, 段梦云, 李金洋, 等. 紫菀的本草考证[J]. 辽宁中医药大学学报, 2024, 26(2): 185-189. 赵显国, 王峥涛, 林鸽, 等. 山紫菀类药材的原植物及其毒性考证[J]. 中国中药杂志, 1998, 23(3): 3-5. 李恒阳, 李文杰, 丁笑颖, 等. 经典名方中紫菀的本草考证[J]. 中国实验方剂学杂志, 2024, 30(7): 20-30. 田慧, 徐坤元, 毕超然, 等. 紫菀的临床应用及其用量探究[J]. 吉林中医药, 2021, 41(1): 99-102. 娄钰杰, 娄永亮. 款冬花本草考证及应用价值探讨[J]. 河南中医, 2025, 45(7): 1005-1009. 钱丽超, 郑晨, 骆天炯, 等. 基于网络药理学研究紫菀-百部治疗感染后咳嗽的作用机制[J]. 药物生物技术, 2025, 32(3): 278-283. 罗申. 射干麻黄汤加减治疗痰湿蕴肺型儿童急性支气管炎临床研究[J]. 河南中医, 2025, 45(2): 183-188. 江勇, 刘城鑫, 谢依, 等. 中医药治疗寒证支气管哮喘的临床对照试验的用药规律挖掘[J]. 广州中医药大学学报, 2023, 40(5): 1287-1293. 肖祥, 吴宣諭, 韩洁榕, 等.“肺与大肠相表里”视角下探索肠道菌群与肺癌因果关联及潜在干预中药预测[J]. 中草药, 2024, 55(12): 4108-4120. 胡蝶, 张念志. 基于数据挖掘的中医药治疗社区获得性肺炎患者的用药特点研究[J]. 中国医院用药评价与分析, 2024, 24(8): 905-909. 谭梅傲, 曹敏, 佘世锋, 等. 基于网络药理学探讨“紫菀-款冬”药理作用机制[J]. 中药材, 2019, 42(7): 1646-1651. 姚平波, 刘雨露, 朱子贵, 等. 紫菀水提物对人肺癌A549细胞增殖、侵袭及裸鼠成瘤能力的影响及作用机制探讨[J]. 药物分析杂志, 2022, 42(3): 380-386. 马梅芳, 李芳. 葶苈子本草与文献学考证[J]. 中医药通报, 2022, 21(7): 31-36. 吕心怡, 陈思敏, 王雅楠, 等. 基于肠道关键菌探究中医药治疗肺癌的潜在靶点[J]. 浙江中医药大学学报, 2025, 49(5): 617-621. 樊毓运, 孙百荣, 金鑫, 等. 陈无择紫菀汤临床应用心得[J]. 中国中医药现代远程教育, 2017, 15(14): 134-136. 张齐军, 许秀萍. 补肺汤在肺癌虚证中的应用[J]. 湖北中医杂志, 1999, 21(5): 34.)
中草药
|综述
2026
, 57
(6) :
2381
-2393
紫菀化学物质基础及现代药理与临床应用研究进展
全屏
郑琰1 , 罗建美1 , 樊婷婷1 , 陆万鹏1 , 陈丹丹1 , 修明慧1,2
作者信息
1 甘肃中医药大学公共卫生学院, 甘肃 兰州 730101; 2 甘肃中医药大学 敦煌医学与转化教育部重点实验室, 甘肃 兰州 730000
作者简介:
郑琰: 郑琰,本科生。E-mail:3366293307@qq.com
Research progress on chemical substance basis, modern pharmacology and clinical application of Asteris Radix et Rhizoma
ZHENG Yan, LUO Jianmei, FAN Tingting, LU Wanpeng, CHEN Dandan, XIU Minghui
Affiliations
doi: 10.7501/j.issn.0253-2670.2026.06.030
文章导航
紫菀Asteris Radix et Rhizoma 作为经典止咳化痰中药,其应用历史可溯至《神农本草经》。在丝绸之路文明交流背景下,敦煌医学典籍P.2882所载紫菀配伍方剂,体现了东西方医学知识的融合与传播。通过整合本草学考证与现代研究方法,系统解析紫菀的化学成分、药理作用及临床应用。研究表明,紫菀中紫菀酮等三萜类、环肽astins及黄酮类成分是其止咳化痰、抗炎、抗肿瘤作用的药效物质基础;其与款冬花Farfarae Flos 、葶苈子(Descurainiae Semen 或Lepidii Semen )等配伍形成的经典药对在慢性阻塞性肺疾病、哮喘及肺癌治疗中显示出明确疗效。为紫菀的深入开发提供科学依据,更展现了丝路文明交流在传统药物研究中的重要价值。
紫菀
/
槲皮素
/
紫菀酮
/
止咳平喘
/
抗肿瘤
/
药物配对
Ziwan (Asteris Radix et Rhizoma ) is a classic traditional Chinese medicine for relieving cough and resolving phlegm. Its application history can be traced back to Shennong’s Classic of Materia Medica . Under the background of the Silk Road civilization exchange, the compatibility prescription of Asteris Radix et Rhizoma contained in Dunhuang medical classics P.2882 reflects the integration and dissemination of Eastern and Western medical knowledge. Through the integration of herbal textual research and modern research methods, the chemical composition, pharmacological effects and clinical application of Asteris Radix et Rhizoma were systematically analyzed. Studies have shown that triterpenes such as shionone, cyclic peptide astins and flavonoids in Asteris Radix et Rhizoma are the material basis of its antitussive and expectorant, anti-inflammatory and anti-tumor effects. The classical drug pairs formed by its compatibility with Kuandonghua (Farfarae Flos ) and Tinglizi (Descurainiae Semen or Lepidii Semen ) have shown clear efficacy in the treatment of chronic obstructive pulmonary disease, asthma and lung cancer. It provides a scientific basis for the in-depth development of Asteris Radix et Rhizoma , and shows the important value of Silk Road civilization exchange in traditional medicine research.
Asteris Radix et Rhizoma
/
quercetin
/
shionone
/
relieves cough and asthma
/
antitumor
/
herb pair
郑琰, 罗建美, 樊婷婷, 陆万鹏, 陈丹丹, 修明慧.
紫菀化学物质基础及现代药理与临床应用研究进展.
中草药,
2026
, 57
(6)
: 2381
-2393
.
DOI: 10.7501/j.issn.0253-2670.2026.06.030
ZHENG Yan, LUO Jianmei, FAN Tingting, LU Wanpeng, CHEN Dandan, XIU Minghui.
Research progress on chemical substance basis, modern pharmacology and clinical application of Asteris Radix et Rhizoma [J].
Chinese Traditional and Herbal Drugs ,
2026
, 57
(6)
: 2381
-2393
.
DOI: 10.7501/j.issn.0253-2670.2026.06.030
教育部产学合作协同育人项目 (2412133147); 甘肃省中医药科研课题 (GZKZ-2022-9); 甘肃中医药大学2022年教学研究与改革一般项目 (3106010201); 敦煌医学与转化教育部重点实验室开放课题 (DHYX24-15)
参考文献
引证文献
张文娟, 李倩, 孙艳丽, 等. 基于生物信息学和孟德尔随机化方法探索慢性阻塞性肺疾病潜在靶点及干预中药的预测[J]. 中草药, 2025, 56(21): 7840-7858. 吴普. 吴普本草[M]. 北京: 人民卫生出版社, 1987. 陶弘景. 名医别录[M]. 尚志钧辑校. 北京: 人民卫生出版社, 1986: 148. 陶弘景. 本草经集注: 辑校本[M]. 尚志钧, 尚元胜辑校. 北京: 人民卫生出版社, 1994: 307-308. 福建省中医研究所医史、理论研究室. 苏颂及其本草图经[J]. 福建中医药杂志, 1957, 2(3): 37-39. 李佩, 赵付霞, 杨思琦, 等. 紫菀化学成分及其抗炎活性研究[J]. 中成药, 2025, 47(2): 473-479. Yu P, Cheng S, Xiang J, et al . Expectorant, antitussive, anti-inflammatory activities and compositional analysis of Aster tataricus [J]. J Ethnopharmacol , 2015, 164: 328-333. 王明安, 陈耀祖. 线叶紫菀中一个单萜酸的化学结构[J]. 高等学校化学学报, 1994, 15(4): 543-544. Tsankova E, Bohlmann F. A monoterpene from Aster bakeranus [J]. Phytochemistry , 1983, 22(5): 1285-1286. Nagao T, Okabe H, Yamauchi T. Studies on the constituents of Aster tataricus L. f. I. structures of shionosides A and B, monoterpene glycosides isolated from the root[J]. Chem Pharm Bull , 1988, 36(2): 571-577. Jung C M, Kwon H C, Seo J J, et al . Two new monoterpene peroxide glycosides from Aster scaber [J]. Chem Pharm Bull , 2001, 49(7): 912-914. Guo S J, Zhao X H, Cheng D L. A new diterpenoid glucoside from Aster smithianus [J]. Chin Chem Lett , 2004, 15(12): 1451-1453. Guo S J, Katalinic J P, He L, et al . A new kaurane diterpene and a new echinocystic acid saponin from Aster ageratoides [J]. Pharmazie , 1998, 53(7): 481-485. Shi Y P, Jia Z J, Yang L, et al . A new diterpene ester from Euphorbia aleppica [J]. Chem Res Chin Univ , 1994, 10(4): 335-337. Cheng D L, Cao X P, Wei H X, et al . Kaurane diterpenoids from Aster ageratoides [J]. Phytochemistry , 1993, 33(5): 1181-1183. Li E W, Gao K, Jia J Z. Two new diterpene acetylxylosides from Aster veitchianus [J]. Chin Chem Lett , 2004, 15(4): 425-427. Choi S Z, Kwon H C, Choi S U, et al . Five new labdane diterpenes from Aster oharai [J]. J Nat Prod , 2002, 65(8): 1102-1106. Guo S J, Wang L M, Cheng D L. A new neo-clerodane diterpene and its glycoside from Aster souliei [J]. Indian J Chem Sect B , 1997, 36B(4): 339-342. Wang L M, Guo S J, Jia Z J, et al . A new neo-clerodane diterpene from Aster souliei [J]. Chin Chem Lett , 1996, 7(7): 619-620. Tanaka R, Nagao T, Okabe H, et al . Studies on the constituents of Aster tataricus L. f. IV. structures of Aster saponins isolated from the herb[J]. Chem Pharm Bull , 1990, 38(5): 1153-1157. 金晶, 张朝凤, 张勉. 紫菀的化学成分研究[J]. 中国现代中药, 2008, 10(6): 20-22. Akihisa T, Kimura Y, Koike K, et al . Astertarone A: A triterpenoid ketone isolated from the roots of Aster tataricus L[J]. Chem Pharm Bull , 1998, 46(11): 1824-1826. Zhou W B, Zeng G Z, Xu H M, et al . Astataricusones A-D and astataricusol A, five new anti-HBV shionane-type triterpenes from Aster tataricus L. f[J]. Molecules , 2013, 18(12): 14585-14596. Zhou W B, Zeng G Z, Xu H M, et al . Astershionones A-F, six new anti-HBV shionane-type triterpenes from Aster tataricus [J]. Fitoterapia , 2014, 93: 98-104. 刘可越, 张铁军, 高文远, 等. 紫菀中三萜及甾体化合物的研究[J]. 天然产物研究与开发, 2006, 18(1): 4-6. 刘可越, 张铁军, 高文远, 等. 紫菀化学成分的研究[J]. 中草药, 2006, 37(1): 31-33. 卢艳花, 王峥涛, 徐珞珊, 等. 紫菀中的多元酚类化合物[J]. 中草药, 2002, 33(1): 17-18. Nagao T, Hachiyama S, Okabe H, et al . Studies on the constituents of Aster tataricus L. f. II. Structures of Aster saponins isolated from the root[J]. Chem Pharm Bull , 1989, 37(8): 1977-1983. Nagao T, Okabe H. Studies on the constituents of Aster scaber Thunb. III. Structures of scaberosides B7, B8 and B9, minor oleanolic acid glycosides isolated from the root[J]. Chem Pharm Bull , 1992, 40(4): 886-888. Nagao T, Okabe H, Yamauchi T. Studies on the constituents of Aster tataricus L. f. III.: Structures of aster saponins E and F isolated from the root[J]. Chem Pharm Bull , 1990, 38(3): 783-785. 卢艳花, 王峥涛, 叶文才, 等. 紫菀化学成分的研究[J]. 中国药科大学学报, 1998, 29(2): 97-99. Morita H, Nagashima S, Takeya K, et al . Structures and conformation of antitumour cyclic pentapeptides, astins A, B and C, from Aster tataricus [J]. Tetrahedron , 1995, 51(4): 1121-1132. 陈士林, 刘洁, 冯梦晗, 等. 基于UHPLC-Q-TOF-MS/ MS联合分子网络策略快速分析紫菀中肽类成分[J]. 质谱学报, 2023, 44(3): 397-411. Cheng D, Shao Y, Hartman R, et al . Oligopeptides from Aster tataricus [J]. Phytochemistry , 1994, 36(4): 945-948. Kosemura S, Ogawa T, Totsuka K. Isolation and Structure of Asterin , a new halogenated cyclic penta-peptide from Aster tataricus [J]. Tetrahedron Lett , 1993, 34(8): 1291-1294. Morita H, Nagashima S, Takeya K, et al . Astins A and B, antitumor cyclic pentapeptides from Aster tataricus [J]. Chem Pharm Bull , 1993, 41(5): 992-993. Morita H, Nagashima S, Takeya K, et al . Structures and conformation of antitumour cyclic pentapeptides, astins A, B and C, from Aster tataricus [J]. Tetrahedron , 1995, 51(4): 1121-1132. Morita H, Nagashima S, Shirota O, et al . Two novel monochlorinated cyclic pentapeptides, astins D and E from Aster tataricus [J]. Chem Lett , 1993, 22(11): 1877-1880. Itokawa H, Morita H, Nagashima S, et al . Cyclic peptides from higher plants. part 8. three novel cyclic pentapeptides, astins F, G and H from Aster tataricus [J]. Heterocycles , 1994, 38(10): 2247-2252. Morita H, Nagashima S, Takeya K, et al . A novel cyclic pentapeptide with a β-hydroxy-γ-chloroproline from Aster tataricus [J]. Chem Lett , 1994, 23(11): 2009-2010. Xu H M, Zeng G Z, Zhou W B, et al . Astins K-P, six new chlorinated cyclopentapeptides from Aster tataricus [J]. Tetrahedron , 2013, 69(37): 7964-7969. Morita H, Nagashima S, Takeya K, et al . Structure of a new peptide, astin J, from Aster tataricus [J]. Chem Pharm Bull , 1995, 43(2): 271-273. Cheng D L, Shao Y, Hartman R, et al . Oligopeptides from Aster tataricus [J]. Phytochemistry , 1994, 36(4): 945-948. Cheng D L, Shao Y, Hartmann R, et al . New pentapeptides from Aster tataricus [J]. Phytochemistry , 1996, 41(1): 225-227. 苏磊, 姜艳艳, 刘斌.《中国药典》收录的植物类中药中含有的寡肽类成分[J]. 中国中药杂志, 2016, 41(16): 2943-2952. Xu H M, Yi H, Zhou W B, et al . Tataricins A and B, two novel cyclotetrapeptides from Aster tataricus , and their absolute configuration assignment[J]. Tetrahedron Lett , 2013, 54(11): 1380-1383. 牛倩, 孙鹏, 张慢慢, 等. 中药紫菀的化学成分研究进展[J]. 安徽农学通报, 2016, 22(13): 30-31. 彭文静, 辛蕊华, 任丽花, 等. 紫菀化学成分及药理作用研究进展[J]. 动物医学进展, 2015, 36(3): 102-106. Ng T B, Liu F, Lu Y H, et al . Antioxidant activity of compounds from the medicinal herb Aster tataricus [J]. Comp Biochem Physiol C Toxicol Pharmacol , 2003, 136(2): 109-115. 刘可越, 张铁军, 高文远, 等. 紫菀化学成分的研究[A] // 中药化学研究与药物创新——中华中医药学会中药化学分会2006年度学术研讨会论文集[C]. 天津: 中华中医药学会中药化学分会2006年度学术研讨会, 2006: 42-45. 王国艳, 吴弢, 林平川, 等. 紫菀酚类化学成分的研究[J]. 中国中药杂志, 2003, 28(10): 946-948. 陈奕君, 吴浩, 魏紫奕, 等. 基于UHPLC-Q-TOF-MS/ MS的紫菀药材全成分解析[J]. 药学学报, 2019, 54(9): 1645-1654. Sun Y P, Li L, Liao M, et al . A systematic data acquisition and mining strategy for chemical profiling of Aster Tataricus Rhizoma (Ziwan) by UHPLC-Q-TOF-MS and the corresponding anti-depressive activity screening[J]. J Pharm Biomed Anal , 2018, 154: 216-226. 刘可越, 张铁军, 高文远, 等. 紫菀中多酚类化合物的研究[J]. 中草药, 2007, 38(12): 1793-1795. 高金海, 王红武, 宋国强, 等. NMR研究紫菀中两个酚性化合物的结构及立体化学[J]. 波谱学杂志, 1994, 11(4): 391-397. 杨滨, 肖永庆, 梁日欣, 等. 紫菀挥发油中祛痰活性化学成分研究[J]. 中国中药杂志, 2008, 33(3): 281-283. 范玲, 王鑫, 朱晓静, 等. 不同炮制方法对紫菀浸出物及主成分含量的影响[J]. 中国现代中药, 2018, 20(12): 1509-1514. 修彦凤, 程雪梅, 刘蕾, 等. 不同紫菀饮片中紫菀酮的含量比较[J]. 上海中医药大学学报, 2006, 20(2): 59-61. 王隽, 刘耀, 李瑞, 等. 不同炮制方法对紫菀化学成分的影响[J]. 中药与临床, 2023, 14(6): 17-20. 周日贵, 涂建雄. 紫菀炮制后对小鼠止咳作用的影响[J]. 湖南中医药导报, 2000, 6(4): 56. 卢艳花, 戴岳, 王峥涛, 等. 紫菀祛痰镇咳作用及其有效部位和有效成分[J]. 中草药, 1999, 30(5): 360-361. 任丽花, 辛蕊华, 彭文静, 等. 紫菀不同极性段提取物的药效比较[J]. 南方农业学报, 2015, 46(4): 675-679. 刘令勉, 于仲范, 吴翠玉. 紫菀散加甘草对离体豚鼠气管解痉作用的研究[J]. 中国中药杂志, 1993, 18(9): 566-567. 李岩, 王丽华, 盛莉. 紫菀与甘草对豚鼠气管作用研究[J]. 中医药信息, 1999(4): 47. 胥倩, 张东升. 中医药辅助治疗常见恶性肿瘤研究进展[J]. 亚太传统医药, 2025, 21(4): 211-215. 李明珠, 杨柱, 吴群, 等. 基于网络药理学探讨“葶苈子-紫菀”抗肺癌的作用机制[J]. 中医肿瘤学杂志, 2021, 3(1): 13-20. 邢海燕. 简述紫菀化学成分与药效学[J]. 中国中医药现代远程教育, 2011, 9(21): 55. 房慧勇, 单高威, 秦桂芳, 等. 紫菀的化学成分及其药理活性研究进展[J]. 医学研究与教育, 2012, 29(5): 73-77. 鲜恩英, 边巴卓玛, 格央, 等. 紫菀酮抑制HeLa细胞迁移侵袭的作用及机制[J]. 高原科学研究, 2021, 5(2): 57-63. 刘晓丽, 梁羽茜, 胡秀华. 体外实验探讨蜜炙紫菀水煎剂对人乳腺癌MCF-7细胞的影响[J]. 世界中西医结合杂志, 2017, 12(4): 496-499. 钱树树, 彭林, 杨映映, 等. 蜜炙紫菀水煎剂对大肠癌Lovo细胞凋亡及迁移的影响[J]. 中华中医药学刊, 2015, 33(9): 2146-2150. Zhang Y X, Wang Q S, Wang T, et al . Inhibition of human gastric carcinoma cell growth in vitro by a polysaccharide from Aster tataricus [J]. Int J Biol Macromol , 2012, 51(4): 509-513. 李聪, 黄芳, 窦昌贵, 等. 紫菀、款冬花配伍对抗炎作用的影响[J]. 中国临床药理学与治疗学, 2009, 14(2): 155-159. 王芳, 任刚, 潘玲玲, 等. 紫菀酮基于NF-κB信号通路的体外抗炎机制研究[J]. 中华中医药杂志, 2016, 31(4): 1430-1433. 王晓溪, 徐慧星, 王博, 等. 紫菀水提液对肺炎支原体感染小鼠肺组织病理变化、细胞凋亡及TGF-β1表达的影响[J]. 中国中医药科技, 2022, 29(6): 975-977. 景临林, 马慧萍, 蒙萍, 等. 藏紫菀醇提物的抗氧化与抗缺氧作用研究[J]. 中药材, 2016, 39(2): 398-403. NG T B, LIU F, LU Y H, et al . Antioxidant activity of compounds from the medicinal herb Aster tataricus [J]. Comp Biochem Physiol C Toxicol Pharmacol , 2003, 136(2): 109-115. 张应鹏, 张海雷, 杨云裳, 等. 紫菀提取物不同极性部位体外抗氧化活性研究[J]. 时珍国医国药, 2011, 22(11): 2799-2800. 唐小武, 刘湘新, 唐宇龙, 等. 紫菀有效成分分析及生物碱的提取与体外抑菌研究[J]. 中兽医医药杂志, 2006, 25(1): 16-18. 李德富, 叶园园, 章洪萍, 等. 烟草烟雾与机动车尾气暴露建立的大鼠慢性阻塞性肺疾病模型比较[J]. 解放军医学杂志, 2024, 49(9): 1038-1044. 中华医学会呼吸病学分会慢性阻塞性肺疾病学组. 慢性阻塞性肺疾病诊治指南(2013年修订版)[J]. 中国医学前沿杂志: 电子版, 2014, 6(2): 67-80. 邹华兰. 中西医结合疗法治疗AECOPD合并呼吸衰竭疗效观察[J]. 中国社区医师, 2020, 36(1): 97-98. 蔡一杰, 史学礼, 刘红云, 等. 中药紫菀有效成分及药理作用[J]. 中兽医医药杂志, 2023, 42(2): 39-42. 高卫东, 高英, 李卫民, 等. 百部紫菀配对分析和临床应用[J]. 新中医, 2007, 39(4): 72. 李娜, 马世平, 黄芳, 等. 紫菀、款冬配伍中紫菀的祛痰研究[J]. 中国临床药理学与治疗学, 2009, 14(2): 159-162. 郑历史, 孙淑仃, 刘学芳. 紫菀的化学成分及在慢性阻塞性肺疾病中的应用研究进展[J]. 辽宁中医药大学学报, 2026, 28(1): 48-54. 张九思, 郝瑞芳, 李芳. 基于文献分析中药治疗小儿肺炎的用药规律[J]. 湖南中医杂志, 2021, 37(8): 159-162. 陈少旭, 梁小银, 甘长朋, 等. 六君子汤合紫菀散配方颗粒治疗慢性阻塞性肺疾病的疗效观察[J]. 湖北中医杂志, 2022, 44(5): 10-14. Deng L, Zhang X Y, Dong Y, et al . Erchen Decoction combined with Sanziyangqin Decoction for chronic obstructive pulmonary disease: A protocol for systematic review and Meta-analysis[J]. Medicine , 2020, 99(40): e22315. 吴文华, 沈旭艳, 花梁. 射干麻黄汤治疗小儿咳嗽变异性哮喘的研究进展[J]. 临床合理用药, 2024, 17(27): 174-177. 翟俊杰, 段梦云, 李金洋, 等. 紫菀的本草考证[J]. 辽宁中医药大学学报, 2024, 26(2): 185-189. 赵显国, 王峥涛, 林鸽, 等. 山紫菀类药材的原植物及其毒性考证[J]. 中国中药杂志, 1998, 23(3): 3-5. 李恒阳, 李文杰, 丁笑颖, 等. 经典名方中紫菀的本草考证[J]. 中国实验方剂学杂志, 2024, 30(7): 20-30. 田慧, 徐坤元, 毕超然, 等. 紫菀的临床应用及其用量探究[J]. 吉林中医药, 2021, 41(1): 99-102. 娄钰杰, 娄永亮. 款冬花本草考证及应用价值探讨[J]. 河南中医, 2025, 45(7): 1005-1009. 钱丽超, 郑晨, 骆天炯, 等. 基于网络药理学研究紫菀-百部治疗感染后咳嗽的作用机制[J]. 药物生物技术, 2025, 32(3): 278-283. 罗申. 射干麻黄汤加减治疗痰湿蕴肺型儿童急性支气管炎临床研究[J]. 河南中医, 2025, 45(2): 183-188. 江勇, 刘城鑫, 谢依, 等. 中医药治疗寒证支气管哮喘的临床对照试验的用药规律挖掘[J]. 广州中医药大学学报, 2023, 40(5): 1287-1293. 肖祥, 吴宣諭, 韩洁榕, 等.“肺与大肠相表里”视角下探索肠道菌群与肺癌因果关联及潜在干预中药预测[J]. 中草药, 2024, 55(12): 4108-4120. 胡蝶, 张念志. 基于数据挖掘的中医药治疗社区获得性肺炎患者的用药特点研究[J]. 中国医院用药评价与分析, 2024, 24(8): 905-909. 谭梅傲, 曹敏, 佘世锋, 等. 基于网络药理学探讨“紫菀-款冬”药理作用机制[J]. 中药材, 2019, 42(7): 1646-1651. 姚平波, 刘雨露, 朱子贵, 等. 紫菀水提物对人肺癌A549细胞增殖、侵袭及裸鼠成瘤能力的影响及作用机制探讨[J]. 药物分析杂志, 2022, 42(3): 380-386. 马梅芳, 李芳. 葶苈子本草与文献学考证[J]. 中医药通报, 2022, 21(7): 31-36. 吕心怡, 陈思敏, 王雅楠, 等. 基于肠道关键菌探究中医药治疗肺癌的潜在靶点[J]. 浙江中医药大学学报, 2025, 49(5): 617-621. 樊毓运, 孙百荣, 金鑫, 等. 陈无择紫菀汤临床应用心得[J]. 中国中医药现代远程教育, 2017, 15(14): 134-136. 张齐军, 许秀萍. 补肺汤在肺癌虚证中的应用[J]. 湖北中医杂志, 1999, 21(5): 34.
2026年第57卷第6期
PDF下载
28
9
引用本文
BibTeX
文章信息
doi: 10.7501/j.issn.0253-2670.2026.06.030
接收时间:2025-09-02
首发时间:2026-09-09
https://castjournals.cast.org.cn/joweb/zcy/CN/10.7501/j.issn.0253-2670.2026.06.030
复制链接
引用本文
BibTeX
2种不同金属材料的力学参数
科 Family 属数 Number of genus 种数 Number of species 占总种数比例 Percentage of total species (%) 属 Genus 种数 Number of species 占总种数比例 Percentage of total species (%) 鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78 小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39 多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39 红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87 小菇属 Mycena 11 5.26 光柄菇属 Pluteus 5 2.39 红菇属 Russula 17 8.13 栓菌属 Trametes 5 2.39
关闭全屏
BibTeX
EndNote
RefWorks
TxT