中草药

马钱苷的药动学及药理作用研究进展

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中草药 | 综述 2026,57(6): 2337-2355

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中草药 |综述 2026 , 57 (6) : 2337 -2355

马钱苷的药动学及药理作用研究进展

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刘博¹, 靳静¹, 郭锦鹏¹, 何逸¹, 马璇¹, 张岩², 王锋¹

作者信息

作者简介:

刘博: 刘博,硕士研究生,研究方向为生物活性物质开发。E-mail:2740986954@qq.com

Research progress on pharmacokinetics and pharmacological effects of loganin

LIU Bo, JIN Jing, GUO Jinpeng, HE Yi, MA Xuan, ZHANG Yan, WANG Feng

Affiliations

doi: 10.7501/j.issn.0253-2670.2026.06.027

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摘要

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马钱苷作为典型的环烯醚萜苷类天然化合物，是传统中药山茱萸Corni Fructus的代表性活性成分，近年来因其显著的神经保护、抗肿瘤、代谢调节及骨关节保护等多靶点生物活性而备受关注。当前研究普遍聚焦于其药效验证与单一信号通路的探讨，但仍存在体内机制复杂、生物利用度低及代谢产物作用未明等关键科学问题。通过系统综述马钱苷在体内的吸收、分布、代谢与排泄特征，揭示其药动学过程受多药耐药蛋白、肠道菌群及病理状态协同调控的规律；并深入总结其在神经系统、肿瘤、代谢性疾病及骨关节疾病等中的药理作用机制，阐明其通过多条关键信号通路实现抗炎、抗凋亡及代谢稳态重建等多层调控效应，从系统药理学角度为中药活性成分机制研究提供新思路。

关键词

马钱苷 / 药动学 / 制剂开发 / 生物利用度 / 神经保护 / 抗肿瘤 / 代谢调节 / 骨关节保护

Abstract

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Loganin, a representative iridoid glycoside derived from Shanzhuyu (Corni Fructus), has attracted increasing attention due to its significant multi-target biological activities, including neuroprotective, antitumor, metabolic regulatory, and osteoarticular protective effects. Despite substantial progress in pharmacodynamic validation and the exploration of individual signaling pathways, critical scientific issues remain unresolved, particularly regarding its complex in vivo mechanisms, limited bioavailability, and unclear effects of its metabolites. By systematically reviewing the absorption, distribution, metabolism, and excretion characteristics of loganin in vivo, this review elucidates the coordinated regulation of its pharmacokinetic behavior by multidrug resistance transporters, gut microbiota, and pathological states. Furthermore, we comprehensively summarize its pharmacological mechanisms in neurological disorders, cancer, metabolic diseases, and osteoarticular conditions, highlighting its multi-layered regulatory effects mediated through key signaling networks involved in anti-inflammation, anti-apoptosis, and reconstruction of metabolic homeostasis via multiple key signaling pathways. From a systems pharmacology perspective, this work provides an integrated framework for understanding the mechanistic basis of bioactive constituents derived from traditional Chinese medicine.

Key words

loganin / pharmacokinetics / preparation development / bioavailability / neuroprotection / antitumor / metabolic regulation / bone and joint protection

引用本文

刘博, 靳静, 郭锦鹏, 何逸, 马璇, 张岩, 王锋. 马钱苷的药动学及药理作用研究进展. 中草药, 2026 , 57 (6) : 2337 -2355 . DOI: 10.7501/j.issn.0253-2670.2026.06.027

LIU Bo, JIN Jing, GUO Jinpeng, HE Yi, MA Xuan, ZHANG Yan, WANG Feng. Research progress on pharmacokinetics and pharmacological effects of loganin[J]. Chinese Traditional and Herbal Drugs, 2026 , 57 (6) : 2337 -2355 . DOI: 10.7501/j.issn.0253-2670.2026.06.027

基金

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河南省重大科技专项 (231100310200)

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2026年第57卷第6期

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doi: 10.7501/j.issn.0253-2670.2026.06.027

接收时间：2025-10-11
首发时间：2026-09-09

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2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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