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detailUrlEn=https://castjournals.cast.org.cn/joweb/zcy/EN/10.7501/j.issn.0253-2670.2026.04.027, pdfUrlCn=https://castjournals.cast.org.cn/joweb/zcy/CN/PDF/10.7501/j.issn.0253-2670.2026.04.027, pdfUrlEn=https://castjournals.cast.org.cn/joweb/zcy/EN/PDF/10.7501/j.issn.0253-2670.2026.04.027, aliStartDate=null, aliEndDate=null, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=0, orderTime=1788926306158, fullTextJson=null, articleText=null, reference=中国药典[S]. 一部. 2025: 323.
孙帅, 钱琪, 王鑫国, 等. 基于文献计量学的黄芩研究现状及热点分析[J]. 药物评价研究, 2023, 46(1): 198-207.
中国药典[S]. 四部. 2015.
国家药品监督管理局. 食品药品监管总局关于加强中药生产中提取和提取物监督管理的通知[EB/OL]. (2014-07-29) [2025-10-10]. https://www.beijing.gov.cn/ zhengce/zhengcefagui/qtwj/202411/t20241112_3939754.html.
化药地标升国标第十册[S]. 2002: D10-239.
聂黎行, 吴炎培, 刘静, 等. 中成药质量标准研究有关问题思考[J]. 药学学报, 2023, 58(8): 2260-2270.
李克亚, 肖金银, 罗雯鹏, 等. 黄芩苷调控TUG1/ PTBP1/NLRP3分子网络抑制巨噬细胞焦亡治疗溃疡性结肠炎的机制[J]. 中草药, 2025, 56(5): 1667-1681.
国家药品监督管理局. 国家药监局关于发布丹七片中异性有机物检查项补充检验方法等4项补充检验方法的公告(2023年第66号) [EB/OL]. (2023-05-23) [2026-01-15]. https://www.nmpa.gov.cn/yaopin/ypggtg/20230523095109106.html.
陈裕意.“肺”腑之言: 门诊呼吸系统疾病患者的健康教育[J]. 科学之友, 2024(9): 38-39.
陆琦, 王婧斯, 都暖, 等. 黄芩苷药理作用及应用研究进展[J]. 临床合理用药, 2025, 18(10): 176-180.
Zou M, Yang L, Niu L, et al. Baicalin ameliorates Mycoplasma gallisepticum-induced lung inflammation in chicken by inhibiting TLR6-mediated NF-κB signalling [J]. Br Poult Sci, 2021, 62(2): 199-210.
Wu Z Y, Chen C L, Miao Y S, et al. Baicalin attenuates Mycoplasma gallisepticum-induced inflammation via inhibition of the TLR2-NF-κB pathway in chicken and DF-1 cells [J]. Infect Drug Resist, 2019, 12: 3911-3923.
Lu Z Y, Xie D Y, Chen Y, et al. TLR2 mediates autophagy through ERK signaling pathway in Mycoplasma gallisepticum-infected RAW264.7 cells [J]. Mol Immunol, 2017, 87: 161-170.
Zhang H, Li X, Wang J, et al. Baicalin relieves Mycoplasma pneumoniae infection-induced lung injury through regulating microRNA-221 to inhibit the TLR4/ NF-κB signaling pathway [J]. Mol Med Rep, 2021, 24(2): 571
吴春芝, 刘红在, 岳文, 等. 清开灵制剂的临床应用研究进展[J]. 中国药房, 2017, 28(18): 2588-2592.
毕研龙, 肖岳. 柴黄颗粒对小儿反复呼吸道感染的疗效及对免疫功能的影响[J]. 中药材, 2017, 40(9): 2212-2214.
冯群, 关永霞, 姚景春, 等. 银黄制剂抗感染作用与临床应用进展[J]. 中国药物评价, 2020, 37(3): 211-214.
赵彩玲, 潘铮, 李娟, 等. 柴芩清宁胶囊联合利巴韦林治疗急性上呼吸道感染的临床研究[J]. 现代药物与临床, 2021, 36(3): 475-478.
袁春筱. 礞石滚痰片质量标准研究[J]. 中国药业, 2015, 24(20): 83-85.
刘燕, 兑靖冬, 兰瑞容, 等. ICP-MS测定珍黄胶囊中铅、汞、镉、铜、砷的含量[J]. 华西药学杂志, 2020, 35(2): 208-210.
汤超, 刘爱萍, 李丹平, 等. 鼻炎通喷雾剂的制备及应用[J]. 中国医院药学杂志, 2000, 20(4): 29-30.
李杨, 杨倩, 肖志华, 等. 喘舒片联合沙美特罗替卡松治疗支气管哮喘急性发作期的临床研究[J]. 现代药物与临床, 2024, 39(5): 1242-1246.
蔡秋晗, 胡思源, 刘颖, 等. 儿童清咽解热口服液治疗小儿急性咽炎(肺胃实热证)的药物经济学评价[J]. 药物评价研究, 2018, 41(4): 519-526.
吴海泉. 复方蒲芩片在肺炎患者中的临床效果及对肺功能的影响研究[J]. 中国处方药, 2018, 16(11): 75-76.
金金, 吕健, 王志飞, 等. 感咳双清胶囊治疗急性上呼吸道感染有效性与安全性的系统评价与Meta分析[J]. 世界中医药, 2020, 15(1): 24-29.
刘磊, 甘淳. 从“伏毒”探析慢性肝炎病因病机[J]. 中医药信息, 2019, 36(2): 100-102.
Lin Y, Wang Z Y, Wang M J, et al. Baicalin attenuate diet-induced metabolic syndrome by improving abnormal metabolism and gut microbiota [J]. Eur J Pharmacol, 2022, 925: 174996.
侯晓杰, 张建锋, 侯长周, 等. 黄芩苷药理活性和作用机制研究进展[J]. 药物评价研究, 2024, 47(11): 2688-2696.
高鑫, 尹柏坤, 左军. 黄芩提取物及其有效成分的药理作用研究进展[J]. 中医药学报, 2025, 53(3): 112-117.
陶景渊. 浅谈急性肠胃炎症状及治疗方法[J]. 求医问药: 下半月刊, 2012(7): 267.
龙宇, 向燕, 谭裕君, 等. 黄芩苷药理作用及新剂型的研究进展[J]. 中草药, 2019, 50(24): 6142-6148.
Liu S Y, Wang C Q, Luo T T, et al. Baicalin ameliorates ulcerative colitis by regulating macrophage polarization through the JAK1/STAT1/SOCS1 pathway [J]. J Ethnopharmacol, 2026, 359: 121057.
袁绍莉, 徐宁宁, 王娟. 肝得治片质量标准的研究[J]. 山东化工, 2015, 44(20): 65-68.
范建伟, 李蔚群, 李艳芳, 等. 茵栀黄制剂处方渊源、剂型沿革与质量控制的研究进展[J]. 中成药, 2017, 39(11): 2365-2368.
宋颖民, 王大鹏, 王永宽. 双黄肠炎分散片治疗急性肠炎的安全性观察[J]. 中外女性健康研究, 2019(18): 25-26.
龚发萍, 郑鸣. 黄芩的化学成分及药理作用[J]. 临床合理用药杂志, 2021, 14(34): 176-178.
田恒运, 闫春生, 贾安, 等. 黄芩苷对脑缺血再灌注损伤保护作用的研究进展[J]. 现代药物与临床, 2025, 40(3): 811-815.
于泓, 梅俊, 张萍, 等. 牛黄降压中成药治疗原发性高血压疗效与安全性系统评价[J]. 北京中医药, 2019, 38(5): 487-491.
牛慧艳, 曹阳, 王龙. 珍黄安宫片治疗原发性头痛的临床疗效研究[J]. 中国医药指南, 2025, 23(18): 94-96.
Liao H F, Ye J, Gao L L, et al. The main bioactive compounds of Scutellaria baicalensis Georgi. for alleviation of inflammatory cytokines: A comprehensive review [J]. Biomed Pharmacother, 2021, 133: 110917.
姜希红, 刘树民. 黄芩药理作用及其化学物质基础研究[J]. 中国药师, 2020, 23(10): 2004-2010.
Kumar Maurya D, Lomte R. Baicalin protected mice against radiation-induced lethality: A mechanistic study employing in silico and wet lab techniques [J]. Comput Toxicol, 2022, 23: 100229.
李启智, 刘俊, 田永强, 等. 黄芩苷测定方法及药代动力学研究进展[J]. 亚太传统医药, 2025, 21(4): 216-224.
Zhang J Y, Cai W, Zhou Y, et al. Profiling and identification of the metabolites of baicalin and study on their tissue distribution in rats by ultra-high-performance liquid chromatography with linear ion trap-orbitrap mass spectrometer [J]. J Chromatogr B, 2015, 985: 91-102.
Liu T M, Jiang X H. Investigation of the absorption mechanisms of baicalin and baicalein in rats [J]. J Pharm Sci, 2006, 95(6): 1326-1333.
Wei Y M, Pi C, Yang G, et al. LC-UV determination of baicalin in rabbit plasma and tissues for application in pharmacokinetics and tissue distribution studies of baicalin after intravenous administration of liposomal and injectable formulations [J]. Molecules, 2016, 21(4): 444.
Fong S Y K, Li C R, Ho Y C, et al. Brain uptake of bioactive flavones in Scutellariae Radix and its relationship to anxiolytic effect in mice [J]. Mol Pharm, 2017, 14(9): 2908-2916.
孙欣光, 张洁, 庞旭, 等. 天然黄酮苷的代谢途径研究进展[J]. 中草药, 2020, 51(11): 3078-3089.
Akao T, Sato K, Hanada M. Hepatic contribution to a marked increase in the plasma concentration of baicalin after oral administration of its aglycone, baicalein, in multidrug resistance-associated protein 2-deficient rat [J]. Biol Pharm Bull, 2009, 32(12): 2079-2082.)
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中草药 |综述 2026 , 57 (4) : 1520 -1527
黄芩提取物及黄芩苷在药物领域的应用现状
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韩雨婷1, 曲萍2, 李科1, 陈建丽1, 李震宇1
作者信息
    1 山西大学 中医药现代研究中心, 山西 太原 030006;
    2 山西省检验检测中心(山西省标准计量技术研究院), 山西 太原 030001
通讯作者:
曲萍
作者简介:
韩雨婷: 韩雨婷,女,硕士研究生,研究方向为中药监管科学。E-mail:zdxddssb@163.com
Current application status of Scutellaria extract and baicalin in pharmaceutical field
  • HAN Yuting, QU Ping, LI Ke, CHEN Jianli, LI Zhenyu
  • Affiliations
    doi: 10.7501/j.issn.0253-2670.2026.04.027
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    黄芩Scutellariae Radix作为传统中药材,其提取物及主要活性成分黄芩苷已成为现代中药制剂中不可或缺的重要原料。综述黄芩提取物与黄芩苷的制备工艺、质量标准、监管政策及在中成药中的应用现状。黄芩提取物按中药提取物备案管理,仅能用于口服中成药;黄芩苷则作为化学原料药进行关联审评,其应用范围更广,除口服中成药外,还可用于注射剂、滴眼液等剂型。黄芩提取物和黄芩苷原料药均是以黄芩苷为主要成分的混合物,但质量标准均以单一黄芩苷为质控指标。含黄芩提取物、黄芩苷的中成药很多纳入医保目录和非处方药目录,说明了黄芩苷作为中成药原料的重要性。为了保证用药安全有效,尤其是针对注射用黄芩苷原料,未来应进一步强化外源污染物控制并建立多组分全面质量控制体系。
    黄芩提取物  /  黄芩苷  /  市场分析  /  质量标准  /  临床应用
    Huangqin (Scutellaria Radix) is a traditional Chinese medicine. Scutellaria extract and main active ingredient baicalin have become an indispensable and important raw material in modern Chinese medicine preparations. The preparation technology, quality standards, regulatory policies and application status of Scutellaria extract and baicalin in Chinese patent medicine were reviewed. Scutellaria extract is managed as a traditional Chinese medicine extract and can only be used for oral Chinese patent medicine; Baicalin is used as a chemical raw material for association review. Its application scope is wider. In addition to oral Chinese patent medicine, it can also be used in injection, eye drops and other dosage forms. Scutellaria extract and baicalin are mixtures with baicalin as the main component, but the quality standard is a single baicalin as the quality control index. Many Chinese patent medicines containing Scutellaria extract and baicalin have been included in the medical insurance catalog and the list of over-the-counter drugs, indicating the importance of baicalin as a raw material of Chinese patent medicines. In order to ensure the safety and effectiveness of drug use, especially for baicalin for injection, we should further strengthen the control of exogenous pollutants and establish a multi-component total quality control system in the future.
    Scutellaria extract  /  baicalin  /  market analysis  /  quality standards  /  clinical application
    韩雨婷, 曲萍, 李科, 陈建丽, 李震宇. 黄芩提取物及黄芩苷在药物领域的应用现状. 中草药, 2026 , 57 (4) : 1520 -1527 . DOI: 10.7501/j.issn.0253-2670.2026.04.027
    HAN Yuting, QU Ping, LI Ke, CHEN Jianli, LI Zhenyu. Current application status of Scutellaria extract and baicalin in pharmaceutical field[J]. Chinese Traditional and Herbal Drugs, 2026 , 57 (4) : 1520 -1527 . DOI: 10.7501/j.issn.0253-2670.2026.04.027

      山西省中医药科技创新工程项目 (2025kjzy005); 山西省卫生健康委中医药科研课题 (2025YYAD33)

    参考文献 引证文献
    排序方式:
    中国药典[S]. 一部. 2025: 323.
    孙帅, 钱琪, 王鑫国, 等. 基于文献计量学的黄芩研究现状及热点分析[J]. 药物评价研究, 2023, 46(1): 198-207.
    中国药典[S]. 四部. 2015.
    国家药品监督管理局. 食品药品监管总局关于加强中药生产中提取和提取物监督管理的通知[EB/OL]. (2014-07-29) [2025-10-10]. https://www.beijing.gov.cn/ zhengce/zhengcefagui/qtwj/202411/t20241112_3939754.html.
    化药地标升国标第十册[S]. 2002: D10-239.
    聂黎行, 吴炎培, 刘静, 等. 中成药质量标准研究有关问题思考[J]. 药学学报, 2023, 58(8): 2260-2270.
    李克亚, 肖金银, 罗雯鹏, 等. 黄芩苷调控TUG1/ PTBP1/NLRP3分子网络抑制巨噬细胞焦亡治疗溃疡性结肠炎的机制[J]. 中草药, 2025, 56(5): 1667-1681.
    国家药品监督管理局. 国家药监局关于发布丹七片中异性有机物检查项补充检验方法等4项补充检验方法的公告(2023年第66号) [EB/OL]. (2023-05-23) [2026-01-15]. https://www.nmpa.gov.cn/yaopin/ypggtg/20230523095109106.html.
    陈裕意.“肺”腑之言: 门诊呼吸系统疾病患者的健康教育[J]. 科学之友, 2024(9): 38-39.
    陆琦, 王婧斯, 都暖, 等. 黄芩苷药理作用及应用研究进展[J]. 临床合理用药, 2025, 18(10): 176-180.
    Zou M, Yang L, Niu L, et al. Baicalin ameliorates Mycoplasma gallisepticum-induced lung inflammation in chicken by inhibiting TLR6-mediated NF-κB signalling [J]. Br Poult Sci, 2021, 62(2): 199-210.
    Wu Z Y, Chen C L, Miao Y S, et al. Baicalin attenuates Mycoplasma gallisepticum-induced inflammation via inhibition of the TLR2-NF-κB pathway in chicken and DF-1 cells [J]. Infect Drug Resist, 2019, 12: 3911-3923.
    Lu Z Y, Xie D Y, Chen Y, et al. TLR2 mediates autophagy through ERK signaling pathway in Mycoplasma gallisepticum-infected RAW264.7 cells [J]. Mol Immunol, 2017, 87: 161-170.
    Zhang H, Li X, Wang J, et al. Baicalin relieves Mycoplasma pneumoniae infection-induced lung injury through regulating microRNA-221 to inhibit the TLR4/ NF-κB signaling pathway [J]. Mol Med Rep, 2021, 24(2): 571
    吴春芝, 刘红在, 岳文, 等. 清开灵制剂的临床应用研究进展[J]. 中国药房, 2017, 28(18): 2588-2592.
    毕研龙, 肖岳. 柴黄颗粒对小儿反复呼吸道感染的疗效及对免疫功能的影响[J]. 中药材, 2017, 40(9): 2212-2214.
    冯群, 关永霞, 姚景春, 等. 银黄制剂抗感染作用与临床应用进展[J]. 中国药物评价, 2020, 37(3): 211-214.
    赵彩玲, 潘铮, 李娟, 等. 柴芩清宁胶囊联合利巴韦林治疗急性上呼吸道感染的临床研究[J]. 现代药物与临床, 2021, 36(3): 475-478.
    袁春筱. 礞石滚痰片质量标准研究[J]. 中国药业, 2015, 24(20): 83-85.
    刘燕, 兑靖冬, 兰瑞容, 等. ICP-MS测定珍黄胶囊中铅、汞、镉、铜、砷的含量[J]. 华西药学杂志, 2020, 35(2): 208-210.
    汤超, 刘爱萍, 李丹平, 等. 鼻炎通喷雾剂的制备及应用[J]. 中国医院药学杂志, 2000, 20(4): 29-30.
    李杨, 杨倩, 肖志华, 等. 喘舒片联合沙美特罗替卡松治疗支气管哮喘急性发作期的临床研究[J]. 现代药物与临床, 2024, 39(5): 1242-1246.
    蔡秋晗, 胡思源, 刘颖, 等. 儿童清咽解热口服液治疗小儿急性咽炎(肺胃实热证)的药物经济学评价[J]. 药物评价研究, 2018, 41(4): 519-526.
    吴海泉. 复方蒲芩片在肺炎患者中的临床效果及对肺功能的影响研究[J]. 中国处方药, 2018, 16(11): 75-76.
    金金, 吕健, 王志飞, 等. 感咳双清胶囊治疗急性上呼吸道感染有效性与安全性的系统评价与Meta分析[J]. 世界中医药, 2020, 15(1): 24-29.
    刘磊, 甘淳. 从“伏毒”探析慢性肝炎病因病机[J]. 中医药信息, 2019, 36(2): 100-102.
    Lin Y, Wang Z Y, Wang M J, et al. Baicalin attenuate diet-induced metabolic syndrome by improving abnormal metabolism and gut microbiota [J]. Eur J Pharmacol, 2022, 925: 174996.
    侯晓杰, 张建锋, 侯长周, 等. 黄芩苷药理活性和作用机制研究进展[J]. 药物评价研究, 2024, 47(11): 2688-2696.
    高鑫, 尹柏坤, 左军. 黄芩提取物及其有效成分的药理作用研究进展[J]. 中医药学报, 2025, 53(3): 112-117.
    陶景渊. 浅谈急性肠胃炎症状及治疗方法[J]. 求医问药: 下半月刊, 2012(7): 267.
    龙宇, 向燕, 谭裕君, 等. 黄芩苷药理作用及新剂型的研究进展[J]. 中草药, 2019, 50(24): 6142-6148.
    Liu S Y, Wang C Q, Luo T T, et al. Baicalin ameliorates ulcerative colitis by regulating macrophage polarization through the JAK1/STAT1/SOCS1 pathway [J]. J Ethnopharmacol, 2026, 359: 121057.
    袁绍莉, 徐宁宁, 王娟. 肝得治片质量标准的研究[J]. 山东化工, 2015, 44(20): 65-68.
    范建伟, 李蔚群, 李艳芳, 等. 茵栀黄制剂处方渊源、剂型沿革与质量控制的研究进展[J]. 中成药, 2017, 39(11): 2365-2368.
    宋颖民, 王大鹏, 王永宽. 双黄肠炎分散片治疗急性肠炎的安全性观察[J]. 中外女性健康研究, 2019(18): 25-26.
    龚发萍, 郑鸣. 黄芩的化学成分及药理作用[J]. 临床合理用药杂志, 2021, 14(34): 176-178.
    田恒运, 闫春生, 贾安, 等. 黄芩苷对脑缺血再灌注损伤保护作用的研究进展[J]. 现代药物与临床, 2025, 40(3): 811-815.
    于泓, 梅俊, 张萍, 等. 牛黄降压中成药治疗原发性高血压疗效与安全性系统评价[J]. 北京中医药, 2019, 38(5): 487-491.
    牛慧艳, 曹阳, 王龙. 珍黄安宫片治疗原发性头痛的临床疗效研究[J]. 中国医药指南, 2025, 23(18): 94-96.
    Liao H F, Ye J, Gao L L, et al. The main bioactive compounds of Scutellaria baicalensis Georgi. for alleviation of inflammatory cytokines: A comprehensive review [J]. Biomed Pharmacother, 2021, 133: 110917.
    姜希红, 刘树民. 黄芩药理作用及其化学物质基础研究[J]. 中国药师, 2020, 23(10): 2004-2010.
    Kumar Maurya D, Lomte R. Baicalin protected mice against radiation-induced lethality: A mechanistic study employing in silico and wet lab techniques [J]. Comput Toxicol, 2022, 23: 100229.
    李启智, 刘俊, 田永强, 等. 黄芩苷测定方法及药代动力学研究进展[J]. 亚太传统医药, 2025, 21(4): 216-224.
    Zhang J Y, Cai W, Zhou Y, et al. Profiling and identification of the metabolites of baicalin and study on their tissue distribution in rats by ultra-high-performance liquid chromatography with linear ion trap-orbitrap mass spectrometer [J]. J Chromatogr B, 2015, 985: 91-102.
    Liu T M, Jiang X H. Investigation of the absorption mechanisms of baicalin and baicalein in rats [J]. J Pharm Sci, 2006, 95(6): 1326-1333.
    Wei Y M, Pi C, Yang G, et al. LC-UV determination of baicalin in rabbit plasma and tissues for application in pharmacokinetics and tissue distribution studies of baicalin after intravenous administration of liposomal and injectable formulations [J]. Molecules, 2016, 21(4): 444.
    Fong S Y K, Li C R, Ho Y C, et al. Brain uptake of bioactive flavones in Scutellariae Radix and its relationship to anxiolytic effect in mice [J]. Mol Pharm, 2017, 14(9): 2908-2916.
    孙欣光, 张洁, 庞旭, 等. 天然黄酮苷的代谢途径研究进展[J]. 中草药, 2020, 51(11): 3078-3089.
    Akao T, Sato K, Hanada M. Hepatic contribution to a marked increase in the plasma concentration of baicalin after oral administration of its aglycone, baicalein, in multidrug resistance-associated protein 2-deficient rat [J]. Biol Pharm Bull, 2009, 32(12): 2079-2082.
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    Percentage of total
    species (%)
    鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
    小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
    多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
    红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
    小菇属 Mycena 11 5.26
    光柄菇属 Pluteus 5 2.39
    红菇属 Russula 17 8.13
    栓菌属 Trametes 5 2.39
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