Alzheimer’s Disease (AD) is a chronic neurodegenerative disorder characterized by a complex pathogenesis and a lack of effective clinical treatments. Shichangpu (Acori Tatarinowii Rhizoma) is the most commonly used single herb in clinical practice for the prevention and management of AD, recognized for its cognitive-enhancing and phlegm-resolving properties. By integrating advances in research on AD pathological mechanisms, this study synthesizes current knowledge regarding the active components of Acori Tatarinowii Rhizoma—including volatile components, alkaloids, organic acids, and terpenes—and their mechanisms of action in AD prevention and treatment. Evidence indicates that Acori Tatarinowii Rhizoma and its bioactive constituents exert anti-AD effects through multiple pathways, such as suppressing neuroinflammation, inhibiting oxidative stress, enhancing cholinergic function, and restoring blood-brain barrier integrity. These findings underscore its multi-component, multi-target therapeutic potential in AD intervention. This review provides a theoretical basis for the rational clinical application of Acori Tatarinowii Rhizoma and offers new perspectives for elucidating its modern pharmacological mechanisms.
YANG Xin, MA Huifen, XIE Zhishen, GUO Yiqing, SU Yunfang, SHAO Simai, ZHANG Zhenqiang, CAO Bing.
Research progress on Acori Tatarinowii Rhizoma and its active constituents in prevention and treatment of Alzheimer’s disease[J].
Chinese Traditional and Herbal Drugs,
2026
, 57
(4)
: 1506
-1519
.
DOI: 10.7501/j.issn.0253-2670.2026.04.026
Knopman D S, Amieva H, Petersen R C, et al. Alzheimer disease [J]. Nat Rev Dis Primers, 2021, 7: 33. 宋志勇, 穆亚敏, 汪勇, 等. 阿尔茨海默病与血管性痴呆的对比分析[J]. 中国卒中杂志, 2024, 19(8): 984. 王刚, 齐金蕾, 刘馨雅, 等. 中国阿尔茨海默病报告2024[J]. 诊断学理论与实践, 2024, 23(3): 219-256. Chen S M, Cao Z, Nandi A, et al. The global macroeconomic burden of Alzheimer’s disease and other dementias: Estimates and projections for 152 countries or territories [J]. Lancet Glob Health, 2024, 12(9): e1534-e1543. Scheltens P, Blennow K, Breteler M M B, et al. Alzheimer’s disease [J]. Lancet, 2016, 388(10043): 505-517. 梁朋朋, 王雅乐, 黄海, 等. 基于生信分析和动力学模拟鉴定阿尔茨海默病免疫标志物及靶向药食同源中药预测[J]. 中草药, 2024, 55(8): 2667-2683. Wang W Z, Zhao F P, Ma X P, et al. Mitochondria dysfunction in the pathogenesis of Alzheimer’s disease: Recent advances [J]. Mol Neurodegener, 2020, 15(1): 30. Tanzi R E, Bertram L. Twenty years of the Alzheimer’s disease amyloid hypothesis: A genetic perspective [J]. Cell, 2005, 120(4): 545-555. Cascella R, Cecchi C. Calcium dyshomeostasis in Alzheimer’s disease pathogenesis [J]. Int J Mol Sci, 2021, 22(9): 4914. Butterfield D A, Halliwell B. Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease [J]. Nat Rev Neurosci, 2019, 20(3): 148-160. Rasoanaivo P, Wright C W, Willcox M L, et al. Whole plant extracts versus single compounds for the treatment of malaria: Synergy and positive interactions [J]. Malar J, 2011, 10(Suppl1): S4. 乔雪, 张亚群, 果德安, 等. 中药药效物质研究方法及进展[J]. 中国科学: 生命科学, 2022, 52(6): 908-919. 谢斯雅. 基于数据挖掘探讨中医药治疗阿尔茨海默病的用药规律[D]. 广州: 广州中医药大学, 2023. 乐颖娜, 张金莲, 钟凌云, 等. 石菖蒲炮制的历史沿革、化学成分及神经药理作用研究进展[J]. 中草药, 2025, 56(11): 4115-4127. 刘禹. 中药治疗阿尔茨海默病的文献研究[D]. 通辽: 内蒙古民族大学, 2020. 聂志玲, 周小莉. 阿尔茨海默病的中医病因病机探析[J]. 时珍国医国药, 2020, 31(6): 1443-1444. 岳晓青, 路童, 王天娇, 等. 战丽彬教授治疗阿尔茨海默病痴呆的经验[J]. 中华中医药学刊, 2024, 42(12): 133-137. 胡雪纯, 贾妮. 应用中医“藏象学说”理论探析阿尔茨海默病[J]. 辽宁中医药大学学报, 2021, 23(1): 177-180. 廖冬颖, 孔凡铭, 姚杨, 等. 基于中医整体观念探析阿尔茨海默病病因病机[J]. 天津中医药, 2022, 39(8): 1009-1012. 吴东南, 刘玲, 明淑萍, 等. 基于“Aβ异常沉积”浅析中医“从痰论治”阿尔茨海默病[J]. 中华中医药杂志, 2019, 34(10): 4699-4702. 董东梅, 常诚. 健忘中医论治探讨[J]. 辽宁中医杂志, 2017, 44(5): 945-946. 时晶, 倪敬年, 刘金民, 等. 呆病防治的理论源流[J]. 现代中医临床, 2022, 29(1): 29-33. 芦锰, 周雨慧, 李晓宁, 等. 基于数据挖掘中医药治疗阿尔茨海默病用药规律研究[J]. 中国中药杂志, 2021, 46(6): 1558-1563. Orobets K S, Karamyshev A L. Amyloid precursor protein and Alzheimer’s disease [J]. Int J Mol Sci, 2023, 24(19): 14794. Gehlot P, Kumar S, Kumar Vyas V, et al. Guanidine-based β amyloid precursor protein cleavage enzyme 1(BACE-1) inhibitors for the Alzheimer’s disease (AD): A review [J]. Bioorg Med Chem, 2022, 74: 117047. 陆雯, 任锦烨, 何湘伟, 等. Aβ25-35致阿尔茨海默病小鼠的脑海马组织炎症因子及BDNF表达分析[J]. 重庆医学, 2024, 53(5): 657-663. 刘旭, 黄渊旭, 张钰华. 氧化应激生物标志物在阿尔茨海默病早期诊断中的作用[J]. 慢性病学杂志, 2023, 24(6): 844-846. Oguchi T, Ono R, Tsuji M, et al. Cilostazol suppresses Aβ-induced neurotoxicity in SH-SY5Y cells through inhibition of oxidative stress and MAPK signaling pathway [J]. Front Aging Neurosci, 2017, 9: 337. 荆玮, 张海涵, 单悦童, 等. 阿尔茨海默病中Aβ在神经元与体内的代谢研究[J]. 神经病学与神经康复学杂志, 2024, 20(4): 125-133. Obregon D, Hou H Y, Deng J, et al. Soluble amyloid precursor protein-α modulates β-secretase activity and amyloid-β generation [J]. Nat Commun, 2012, 3: 777. 成秀梅, 余子楠, 王凌霄, 等. 调节Tau蛋白磷酸化信号通路的研究进展[J]. 中国老年学杂志, 2025, 45(3): 751-756. Waheed Z, Choudhary J, Jatala F H, et al. The role of Tau proteoforms in health and disease [J]. Mol Neurobiol, 2023, 60(9): 5155-5166. Barbier P, Zejneli O, Martinho M, et al. Role of Tau as a microtubule-associated protein: Structural and functional aspects [J]. Front Aging Neurosci, 2019, 11: 204. 姚思凡, 张鑫, 沈丽霞. Tau蛋白在阿尔茨海默病中对线粒体的影响[J]. 神经药理学报, 2024, 14(4): 54-64. 王金春, 刘慧影, 曹云鹏. Tau蛋白与阿尔茨海默病[J]. 中国组织工程研究, 2020, 24(17): 2775-2781. Ai J, Wang H Y, Chu P,et al. The neuroprotective effects of phosphocreatine on amyloid beta 25-35-induced differentiated neuronal cell death through inhibition of Akt/GSK-3β/Tau/APP/CDK5 pathways in vivo and vitro [J]. Free Radic Biol Med, 2021, 162: 181-190. 胡鑫, 汪蒨, 张晨曦, 等. 小胶质细胞-星形胶质细胞的交互作用及其介导的神经炎症在阿尔茨海默病中的研究进展[J]. 中国比较医学杂志, 2023, 33(11): 142-149. Heneka M T, van der Flier W M, Jessen F, et al. Neuroinflammation in Alzheimer disease [J]. Nat Rev Immunol, 2025, 25(5): 321-352. Singh D. Astrocytic and microglial cells as the modulators of neuroinflammation in Alzheimer’s disease [J]. J Neuroinflammation, 2022, 19(1): 206. 张隽, 张兰. 阿尔茨海默病神经炎症分子信号通路及相关抗炎药物研究进展[J]. 临床药物治疗杂志, 2025, 23(2): 5-9. 李鹏, 刘瑛丽, 骆彤, 等. 阿尔茨海默病的神经炎症及中药抗炎机制研究进展[J/OL]. 中医学报, (2024-09-29) [2026-01-23]. https://link.cnki.net/urlid/41.1411.R. 20240929.1446.048. 雷露, 吕沛然, 赵耀, 等. 神经炎症与阿尔茨海默病的关系及针灸调控机制研究进展[J]. 世界科学技术—中医药现代化, 2024, 26(4): 1028-1035. 程美佳, 袁常斌, 鞠业涛, 等. 开心散通过调控NLRP3/Caspase-1/GSDMD信号通路抑制阿尔茨海默病小鼠神经炎症的作用机制[J]. 中华中医药杂志, 2024, 39(3): 1203-1208. 米彩云, 彭超, 周君, 等. 黑逍遥散调控p38 MAPK/ ATF2/COX-2信号通路对阿尔茨海默病大鼠神经炎症的影响[J]. 中成药, 2024, 46(2): 590-595. Chen R D, Gao H, Zhu T S, et al. Syringaldehyde ameliorates cognitive dysfunction in APP/PS1 mice by stabilizing the NLRP3 pathway [J]. Mol Neurobiol, 2025, 62(12): 15844-15858. Zhou Y, Rong Y. Hypoxic natural killer cells-derived HIF-1α-containing exosomes inhibit cellular senescence and apoptosis in neurocytes to ameliorate Alzheimer’s disease by eliminating oxidative damages [J]. Mol Neurobiol, 2025, 62(10): 13089-13102. Vashisht K, Kumar H, Ankalgi A, et al. Asperuloside as a promising multi-target agent for Alzheimer’s disease: Molecular mechanisms and therapeutic perspectives [J]. Inflammopharmacology, 2025, 33(8): 4311-4321. Plascencia-Villa G, Perry G. Roles of oxidative stress in synaptic dysfunction and neuronal cell death in Alzheimer’s disease [J]. Antioxidants, 2023, 12(8): 1628. 刘军. 氧化应激在阿尔茨海默病病理发生中的作用机制与干预策略[J]. 中山大学学报: 医学科学版, 2020, 41(5): 661-668. Praticò D. Evidence of oxidative stress in Alzheimer’s disease brain and antioxidant therapy: Lights and shadows [J]. Ann N Y Acad Sci, 2008, 1147: 70-78. Xie Z S, Zhao J P, Wu L M, et al. Hederagenin improves Alzheimer’s disease through PPARα/TFEB-mediated autophagy [J]. Phytomedicine, 2023, 112: 154711. Long Z M, Chen J F, Zhao Y Y, et al. Dynamic changes of autophagic flux induced by Abeta in the brain of postmortem Alzheimer’s disease patients, animal models and cell models [J]. Aging, 2020, 12(11): 10912-10930. Lee J H, Yang D S, Goulbourne C N, et al. Faulty autolysosome acidification in Alzheimer’s disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaques [J]. Nat Neurosci, 2022, 25(6): 688-701. 董圆霞, 李宇松, 马婉熔, 等. 中药调控自噬治疗阿尔茨海默病的研究进展[J]. 中国当代医药, 2025, 32(4): 188-193. Levine B, Kroemer G. Biological functions of autophagy genes: A disease perspective [J]. Cell, 2019, 176(1/2): 11-42. 王红娟, 闫中瑞, 刘厚林. 自噬在阿尔茨海默病发病中作用机制的研究进展[J]. 山东医药, 2016, 56(15): 95-98. Lachance V, Wang Q, Sweet E, et al. Autophagy protein NRBF2 has reduced expression in Alzheimer’s brains and modulates memory and amyloid-beta homeostasis in mice [J]. Mol Neurodegener, 2019, 14(1): 43. Berry A S, Harrison T M. New perspectives on the basal forebrain cholinergic system in Alzheimer’s disease [J]. Neurosci Biobehav Rev, 2023, 150: 105192. Malik R, Kalra S, Bhatia S, et al. Overview of therapeutic targets in management of dementia [J]. Biomed Pharmacother, 2022, 152: 113168. Bekdash R A. The cholinergic system, the adrenergic system and the neuropathology of Alzheimer’s disease [J]. Int J Mol Sci, 2021, 22(3): 1273. 陈思宇, 孙璇, 王欢, 等. 胆碱能神经系统障碍在阿尔茨海默病中的作用及相关研究[J]. 中华老年心脑血管病杂志, 2025, 27(3): 392-394. Xia Y, Dore V, Fripp J, et al. Association of basal forebrain atrophy with cognitive decline in early Alzheimer disease [J]. Neurology, 2024, 103(2): e209626. 路伟钊, 宋天彬, 卢洁. 磁共振影像组学在阿尔茨海默病中的研究进展[J]. 中华老年心脑血管病杂志, 2024, 26(10): 1244-1246. Campos-Peña V, Pichardo-Rojas P, Sánchez-Barbosa T, et al. Amyloid β, lipid metabolism, basal cholinergic system, and therapeutics in Alzheimer’s disease [J]. Int J Mol Sci, 2022, 23(20): 12092. Zhang J F, Zhang Y L, Wang J X, et al. Recent advances in Alzheimer’s disease: Mechanisms, clinical trials and new drug development strategies [J]. Signal Transduct Target Ther, 2024, 9(1): 211. Morató X, Pytel V, Jofresa S, et al. Symptomatic and disease-modifying therapy pipeline for Alzheimer’s disease: Towards a personalized polypharmacology patient-centered approach [J]. Int J Mol Sci, 2022, 23(16): 9305. Teipel S J, Fritz H C, Grothe M J. Neuropathologic features associated with basal forebrain atrophy in Alzheimer disease [J]. Neurology, 2020, 95(10): e1301-e1311. Bootman M D, Bultynck G. Fundamentals of cellular calcium signaling: A primer [J]. Cold Spring Harb Perspect Biol, 2020, 12(1): a038802. Cheng J B, Dong Y, Ma J, et al. Microglial Calhm2 regulates neuroinflammation and contributes to Alzheimer’s disease pathology [J]. Sci Adv, 2021, 7(35): eabe3600. 房国梁, 王淑凡, 杜晴丽. 钙稳态在运动改善阿尔茨海默症中的作用与机制[J]. 体育科学, 2024, 44(9): 71-80. Guan P P, Cao L L, Wang P. Elevating the levels of calcium ions exacerbate Alzheimer’s disease via inducing the production and aggregation of β-amyloid protein and phosphorylated tau [J]. Int J Mol Sci, 2021, 22(11): 5900. He K W, Nie L L, Yang C, et al. Exhaustive exercise decreases Tau phosphorylation and modifies biological processes associated with the protein translation and electron transport chain in P301L Tau transgenic mice [J]. Exp Gerontol, 2024, 187: 112375. Liu Y, Dai Y, Li Q, et al. Beta-amyloid activates NLRP3 inflammasome via TLR4 in mouse microglia [J]. Neurosci Lett, 2020, 736: 135279. Popugaeva E, Chernyuk D, Bezprozvanny I. Reversal of calcium dysregulation as potential approach for treating Alzheimer’s disease [J]. Curr Alzheimer Res, 2020, 17(4): 344-354. Wei H F. New approaches to develop drug treatment for Alzheimer’s disease: Targeting calcium dysregulation [J]. Curr Alzheimer Res, 2020, 17(4): 311-312. 申杰, 徐桂华. 阿尔茨海默病与血脑屏障的相关性研究进展[J]. 实用医学杂志, 2024, 40(11): 1602-1606. Nation D A, Sweeney M D, Montagne A, et al. Blood-brain barrier breakdown is an early biomarker of human cognitive dysfunction [J]. Nat Med, 2019, 25(2): 270-276. 王兵兵, 罗与, 白岩, 等. 阿尔茨海默病相关血脑屏障的影像学研究进展[J]. 磁共振成像, 2024, 15(4): 192-196. Wang D, Chen F L, Han Z L, et al. Relationship between amyloid-β deposition and blood-brain barrier dysfunction in Alzheimer’s disease [J]. Front Cell Neurosci, 2021, 15: 695479. Sharma C, Woo H, Kim S R. Addressing blood-brain barrier impairment in Alzheimer’s disease [J]. Biomedicines, 2022, 10(4): 742. Halder S K, Sapkota A, Milner R. The importance of laminin at the blood-brain barrier [J]. Neural Regen Res, 2023, 18(12): 2557-2563. Huang X W, Hussain B, Chang J L. Peripheral inflammation and blood-brain barrier disruption: Effects and mechanisms [J]. CNS Neurosci Ther, 2021, 27(1): 36-47. 梁冰, 许海英, 郭莉琛, 等. 石菖蒲-川芎配伍对阿尔茨海默病神经-血管的作用研究[J]. 中国药理学通报, 2024, 40(7): 1397-1398. 陈亮, 方成维, 蒙吉, 等. 石菖蒲治疗阿尔兹海默病的作用机制[J]. 山东大学学报: 理学版, 2024, 59(11): 64-73. 郭美彤, 赵佳奇, 韩诚, 等. 石菖蒲药效物质基础和作用机制研究进展[J]. 中药药理与临床, 2019, 35(2): 179-184. 胡小玲, 唐怡, 袁金斌. 石菖蒲中生物碱成分的分离与鉴定[J]. 中国药房, 2019, 30(5): 642-645. 李天英, 杜丽坤, 鞠爱霞, 等. 石菖蒲化学成分及抗抑郁机制研究进展[J]. 化学工程师, 2024, 38(7): 77-80. 冯鹏, 王明露, 王宇彤, 等. 石菖蒲挥发油化学成分及药理作用研究进展[J]. 中药药理与临床, 2025, 41(6): 100-109. 王彬, 裴科, 汪小莉, 等. 气相色谱-质谱联用测定石菖蒲中26种挥发性成分的研究[J]. 时珍国医国药, 2015, 26(11): 2627-2630. 谢芳, 刘智勇, 陈惠云. 石菖蒲挥发油成分的气相色谱-质谱实验结果分析[J]. 北方药学, 2024, 21(8): 1-3. 石坚宏, 姬丽婷, 骆启晗, 等. 石菖蒲化学成分、药理作用及质量标志物预测分析研究进展[J]. 中成药, 2021, 43(5): 1286-1290. Wen J X, Yang Y, Hao J J. Acori Tatarinowii Rhizoma: A comprehensive review of its chemical composition, pharmacology, pharmacokinetics and toxicity [J]. Front Pharmacol, 2023, 14: 1090526. Zhang W X, Song D, Xu D, et al. Characterization of polysaccharides with antioxidant and immunological activities from Rhizoma Acori Tatarinowii [J]. Carbohydr Polym, 2015, 133: 154-162. 董玉, 石任兵, 孙玉博. 石菖蒲的氨基酸成分分析[J]. 内蒙古大学学报: 自然科学版, 2007, 38(3): 296-298. 杨娟. 石菖蒲对D-半乳糖诱导AD模型小鼠认知障碍的影响及机制研究[D]. 天津: 天津中医药大学, 2022. Zeng L L, Zhang D, Liu Q, et al. Alpha-asarone improves cognitive function of APP/PS1 mice and reducing Aβ42, p-Tau and neuroinflammation, and promoting neuron survival in the hippocampus [J]. Neuroscience, 2021, 458: 141-152. 张春霞, 郭俊和, 陈云波, 等. 石菖蒲活性成分对双转基因小鼠APP及神经突触超微结构的影响[J]. 中药新药与临床药理, 2014, 25(1): 18-23. 李秋实, 李熙东, 田步先, 等. β-细辛醚对APP/PS1小鼠神经炎症的影响及机制研究[J]. 解剖科学进展, 2023, 29(2): 142-145. Yang C, Li X G, Mo Y S, et al. β-Asarone mitigates amyloidosis and downregulates RAGE in a transgenic mouse model of Alzheimer’s disease [J]. Cell Mol Neurobiol, 2016, 36(1): 121-130. 王珊, 褚红珊, 生晓娜, 等. 丹皮酚通过激活Nrf2/HO-1通路改善阿尔茨海默病大鼠海马组织的氧化应激损伤[J]. 脑与神经疾病杂志, 2019, 27(12): 740-743. Jung M J, Kim N, Jeon S H, et al. Eugenol relieves the pathological manifestations of Alzheimer’s disease in 5× FAD mice [J]. Phytomedicine, 2023, 118: 154930. 薛小燕, 巫莉萍, 王丽芳. 原儿茶酸对阿尔茨海默病模型小鼠体内多靶向的疗效及机制研究[J]. 抗感染药学, 2020, 17(8): 1090-1093. 武涛. 咖啡酸同时防治动脉粥样硬化及阿尔茨海默氏症的功效机制研究[D]. 济南: 齐鲁工业大学, 2022. Mori T, Koyama N, Guillot-Sestier M V, et al. Ferulic acid is a nutraceutical β-secretase modulator that improves behavioral impairment and Alzheimer-like pathology in transgenic mice [J]. PLoS One, 2013, 8(2): e55774. Caruso G, Torrisi S A, Mogavero M P, et al. Polyphenols and neuroprotection: Therapeutic implications for cognitive decline [J]. Pharmacol Ther, 2022, 232: 108013. 李星, 张宏, 陶吉明. 阿尔兹海默病本虚标实病机的现代神经生物学探讨[J]. 时珍国医国药, 2023, 34(2): 398-400. Fu Y B, Yang Y X, Shi J H, et al. Acori Tatarinowii Rhizoma extract ameliorates Alzheimer’s pathological syndromes by repairing myelin injury and lowering Tau phosphorylation in mice [J]. Pharmazie, 2020, 75(8): 395-400. 刘立权, 江萌, 张伊黎, 等. 石菖蒲挥发油成分改善阿尔茨海默病症状的作用及机制研究[J]. 浙江医学, 2024, 46(11): 1151-1156. 许英, 陈玲, 张兰, 等. 阿魏酸通过调节GSK-3β减轻阿尔茨海默样变化[J]. 中南药学, 2022, 20(4): 805-811. 杨海淦, 曹蕊, 王茂杰, 等. 石菖蒲水提取物对人脑神经胶质细胞NO表达的影响[J]. 中国医药导报, 2019, 16(25): 24-26. Xu Z W, Zhou X J, Hong X, et al. Essential oil of Acorus tatarinowii Schott inhibits neuroinflammation by suppressing NLRP3 inflammasome activation in 3× Tg-AD transgenic mice [J]. Phytomedicine, 2023, 112: 154695. Lam K Y C, Wu Q Y, Hu W H, et al. Asarones from Acori Tatarinowii Rhizoma stimulate expression and secretion of neurotrophic factors in cultured astrocytes [J]. Neurosci Lett, 2019, 707: 134308. Lim H W, Kumar H, Kim B W, et al. β-Asarone (cis-2,4,5-trimethoxy-1-allyl phenyl), attenuates pro-inflammatory mediators by inhibiting NF-κB signaling and the JNK pathway in LPS activated BV-2 microglia cells [J]. Food Chem Toxicol, 2014, 72: 265-272. 程玉洁. β-石竹烯对阿尔茨海默病模型小鼠学习记忆的影响及其机制研究[D]. 重庆: 重庆医科大学, 2014. Zhang L Q, Zhang Z G, Fu Y, et al. Trans-cinnamaldehyde improves memory impairment by blocking microglial activation through the destabilization of iNOS mRNA in mice challenged with lipopolysaccharide [J]. Neuropharmacol, 2016, 110: 503-518. 吴永康, 高洁, 卢志园, 等. 桂皮醛通过阻止海马神经炎症反应改善阿尔茨海默病老年小鼠记忆障碍的作用研究[J]. 世界科学技术—中医药现代化, 2021, 23(5): 1627-1635. Swanson K V, Deng M, Ting J P. The NLRP3 inflammasome: Molecular activation and regulation to therapeutics [J]. Nat Rev Immunol, 2019, 19(8): 477-489. Singh G, Shankar G, Panda S R, et al. Design, synthesis, and biological evaluation of ferulic acid template-based novel multifunctional ligands targeting NLRP3 inflammasome for the management of Alzheimer’s disease [J]. ACS Chem Neurosci, 2024, 15(7): 1388-1414. 王星烨, 孔祥日, 金梦丽, 等. β-谷甾醇对阿尔茨海默病模型小鼠认知功能的改善作用及其机制[J]. 吉林大学学报: 医学版, 2023, 49(3): 599-607. Mitroshina E V, Vedunova M V. The role of oxygen homeostasis and the HIF-1 factor in the development of neurodegeneration [J]. Int J Mol Sci, 2024, 25(9): 4581. Liu L Q, Jiang M, Zhang Y L, et al. Acori Tatarinowii Rhizoma inhibited neuroinflammation in Alzheimer’s disease rats by modulating the intestinal flora [J]. Brain Res, 2025, 1865: 149878. 魏飞亭, 董嘉皓, 唐怡, 等. 石菖蒲醇提物对SH-SY5Y细胞增殖及抗氧化损伤作用[J]. 江西中医药, 2018, 49(8): 55-57. Liu W B, Zhang B Y, Xin Z Q, et al. GC-MS fingerprinting combined with chemometric methods reveals key bioactive components in Acori Tatarinowii Rhizoma [J]. Int J Mol Sci, 2017, 18(7): 1342. 唐洪梅, 招荣鑑, 邓玉群. 石菖蒲挥发油和水溶性成分对癫痫小鼠脑组织SOD、LPO、NO的影响[J]. 中国药师, 2005, 8(12): 983-985. Hei X X, Xie M, Xu J Q, et al. β-Asarone exerts antioxidative effects on H2O2-stimulated PC12 cells by activating Nrf2/HO-1 pathway [J]. Neurochem Res, 2020, 45(8): 1953-1961. Meng M M, Zhang L J, Ai D, et al. β-Asarone ameliorates β-amyloid-induced neurotoxicity in PC12 cells by activating PI3K/Akt/Nrf2 signaling pathway [J]. Front Pharmacol, 2021, 12: 659955. Saki G, Eidi A, Mortazavi P, et al. Effect of β-asarone in normal and β-amyloid-induced Alzheimeric rats [J]. Arch Med Sci, 2020, 16(3): 699-706. 王博林, 宣玲, 戴世杰, 等. β-细辛醚对Aβ1-42联合2-VO致AD大鼠的保护作用及机制初探[J]. 中国中药杂志, 2017, 42(24): 4847-4854. Ma Z C, Hong Q, Wang Y G, et al. Ferulic acid protects human umbilical vein endothelial cells from radiation induced oxidative stress by phosphatidylinositol 3-kinase and extracellular signal-regulated kinase pathways [J]. Biol Pharm Bull, 2010, 33(1): 29-34. 程宝仓, 夏昱, 杨会杰, 等. 石菖蒲挥发油对帕金森病模型小鼠黑质多巴胺能神经元自噬的影响及其机制[J]. 卒中与神经疾病, 2022, 29(2): 101-105. 王浩, 高磊, 张金莲, 等. 石菖蒲中α-细辛醚和β-细辛醚药理作用及机制研究进展[J]. 中国中药杂志, 2025, 50(9): 2305-2316. Wang N B, Wang H Y, Li L Y, et al. β-Asarone inhibits amyloid-β by promoting autophagy in a cell model of Alzheimer’s disease [J]. Front Pharmacol, 2020, 10: 1529. Han Y F, Wang N B, Kang J, et al. β-Asarone improves learning and memory in Aβ1-42-induced Alzheimer’s disease rats by regulating PINK1-Parkin-mediated mitophagy [J]. Metab Brain Dis, 2020, 35(7): 1109-1117. Deng M Z, Huang L P, Zhong X Q. β-Asarone modulates Beclin-1, LC3 and p62 expression to attenuate Aβ40 and Aβ42 levels in APP/PS1 transgenic mice with Alzheimer’s disease [J]. Mol Med Rep, 2020, 21(5): 2095-2102. Xie Y M, Liu L, Zheng J Z, et al. Polygoni Multiflori Radix Praeparata and Acori Tatarinowii Rhizoma ameliorate scopolamine-induced cognitive impairment by regulating the cholinergic and synaptic associated proteins [J]. J Ethnopharmacol, 2023, 311: 116400. Mathew M, Subramanian S. In vitro screening for anti-cholinesterase and antioxidant activity of methanolic extracts of ayurvedic medicinal plants used for cognitive disorders [J]. PLoS One, 2014, 9(1): e86804. Feng P, Chen Y H, Sun K X, et al. Volatile oil from Acori Graminei Rhizoma affected the synaptic plasticity of rats with tic disorders by modulating dopaminergic and glutamatergic systems [J]. J Ethnopharmacol, 2024, 335: 118676. 方洪, 韩沅沅, 谷丽华, 等. 石菖蒲中乙酰胆碱酯酶抑制剂的筛选[J]. 中成药, 2022, 44(3): 836-841. 杨丽, 邓扬鸥, 吴世星, 等. 石菖蒲远志有效成分组合抑制β淀粉样蛋白25-35神经毒性的钙相关机制[J]. 中华中医药杂志, 2015, 30(10): 3511-3515. Yang Q Q, Xue W Z, Zou R X, et al. β-Asarone rescues Pb-induced impairments of spatial memory and synaptogenesis in rats [J]. PLoS One, 2016, 11(12): e0167401. Wang N B, Zhang Q X, Ning B L, et al. β-Asarone promotes Temozolomide’s entry into glioma cells and decreases the expression of P-glycoprotein and MDR1[J]. Biomed Pharmacother, 2017, 90: 368-374. Li J Y, Shan X X, Gao Y, et al. Acori Tatarinowii Rhizoma regulates OCT3/OATP2 and P-gp/MRP1 to “guide medicines upwards” in Kai-Xin-San to treat Alzheimer’s disease [J]. J Ethnopharmacol, 2025, 343: 119484. 王语晴, 刘欣欣, 姜玲, 等. 自噬调控阿尔茨海默病作用机制及中医药从“痰”论治研究进展[J]. 辽宁中医药大学学报, 2024, 26(3): 32-37. 邓香华, 曲丽媛, 孙冬梅, 等. 基于GC-MS与急性经口毒性试验的石菖蒲挥发油肝毒性研究[J]. 中南药学, 2025, 23(7): 1935-1942. Liu J, Ping X, Sun S J, et al. Safety assessment of Acori Tatarinowii Rhizoma: Acute and subacute oral toxicity [J]. Front Pharmacol, 2024, 15: 1377876.
PDF下载
全屏
27
8
关闭全屏
北京市海淀区学院南路86号
010-62199257（仅加盟咨询）
qkjq@cast.org.cn
