Article(id=1304140203434726004, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1304140186485543391, articleNumber=null, orderNo=null, doi=10.7501/j.issn.0253-2670.2026.03.033, pmid=null, cstr=null, oa=null, hot=0, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1753718400000, receivedDateStr=2025-07-29, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1788860854251, onlineDateStr=2026-09-08, pubDate=null, pubDateStr=null, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1788860854251, onlineIssueDateStr=2026-09-08, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1788860854251, creator=13701087609, updateTime=1788860854251, updator=13701087609, issue=Issue{id=1304140186485543391, tenantId=1146029695717560320, journalId=1302319053441957962, year='2026', volume='57', issue='3', pageStart='789', pageEnd='1208', issueExtLink='null', onlineDate='null', pubDate='1770825600000', pubDateStr='2026-02-12', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1788860850211, creator='13701087609', updateTime=1788860942564, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1304140573955351430, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1304140186485543391, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1304140573955351431, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1304140186485543391, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1179, endPage=1194, ext={EN=ArticleExt(id=1304140203719938678, articleId=1304140203434726004, tenantId=1146029695717560320, journalId=1302319053441957962, language=EN, title=Research progress on traditional Chinese medicine injection in treatment of chronic heart failure, columnId=null, journalTitle=Chinese Traditional and Herbal Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=Chronic heart failure (CHF) is a cardiovascular end syndrome with high prevalence, high mortality and high re-hospitalization rate, and traditional Chinese medicine (TCM) injections have significant potential in the treatment of CHF because of their combination of TCM evidence-based features and rapid onset of action. Based on ten years of research, this paper systematically investigates the pharmacodynamic material basis and action characteristics of 30 TCM injections to fill the gap of systematic summarization in this field. The study classified TCM injections into three categories according to TCM diagnosis: Activating blood and resolving stasis, replenishing qi and nourishing yin, and warming yang and excreting water. Activating blood and resolving stasis TCM injections can improve microcirculation and inhibit myocardial fibrosis and inflammation; replenishing qi and nourishing yin TCM injections focuses on regulating myocardial energy metabolism and mitochondrial function; warming yang and excreting water TCM injections can regulate intestinal bacterial flora, improve the “intestinal-cardiac axis” and inhibit iron death, etc. The study is the first to integrate single and compound TCM injections, revealing the advantages of TCM injections in multi-component and multi-target interventions in the complex pathology of CHF. It provides systematic evidence on the pharmacodynamic substances, mechanism of action, and clinical application for the clinical treatment of CHF using integrated Chinese and Western medicine, and provides new ideas for the precise identification of drugs and innovative treatment strategies., authors=MENG Lichong, WANG Ziyi, LI Xinchun, LI Lin, HU Zhixi, authorsList=MENG Lichong, WANG Ziyi, LI Xinchun, LI Lin, HU Zhixi, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1304140203652829813, articleId=1304140203434726004, tenantId=1146029695717560320, journalId=1302319053441957962, language=CN, title=中药注射剂治疗慢性心力衰竭的研究进展, columnId=1304140194685415572, journalTitle=中草药, columnName=综述, runingTitle=null, highlight=null, articleAbstract=慢性心力衰竭（chronic heart failure，CHF）是高患病率、高死亡率、高再住院率的心血管终末综合征，中药注射剂兼具中医辨证特色与快速起效优势，在CHF治疗中潜力显著。基于近10年研究，系统梳理30种中药注射剂的药效物质基础与作用特点，旨在填补该领域系统归纳的空白。按中医辨证将中药注射剂分为活血化瘀、益气养阴、温阳利水3类。活血化瘀类通过改善微循环、抑制心肌纤维化及炎症反应等发挥作用；益气养阴类聚焦调节心肌能量代谢与线粒体功能等；温阳利水类则通过调控肠道菌群、改善“肠-心轴”及抑制铁死亡等机制发挥作用。通过整合单味药与复方注射剂研究，揭示中药注射剂多成分、多靶点干预CHF复杂病理的优势，为CHF中西医结合临床治疗提供药效物质基础、作用机制及临床应用的系统证据，为精准辨证用药及创新治疗策略提供新思路。, authors=孟骊冲1,2 , 王梓仪3 , 李欣春4 , 李琳1,2 , 胡志希1,2 , authorsList=孟骊冲, 王梓仪, 李欣春, 李琳, 胡志希, authorCompany=1 湖南中医药大学, 湖南 长沙 410208; et al . Interventional therapies for chronic heart failure: An overview of recent developments [J]. ESC Heart Fail , 2025, 12(2): 1081-1094.et al . Worsening of chronic heart failure: Definition, epidemiology, management and prevention. A clinical consensus statement by the Heart Failure Association of the European Society of Cardiology [J]. Eur J Heart Fail , 2023, 25(6): 776-791.et al . Heart failure and left ventricular dysfunction in older patients with chronic kidney disease: The China Hypertension Survey (2012-2015) [J]. J Geriatr Cardiol , 2020, 17(10): 597-603.et al . Global, regional, and national burden of heart failure and its underlying causes, 1990-2021: Results from the global burden of disease study 2021 [J]. Biomark Res , 2025, 13(1): 16.et al . Xinmailong injection on left ventricular remodeling and inflammatory mediators in patients with CHF: A systematic review and meta-analysis [J]. Front Pharmacol , 2024, 15: 1370448.et al . 2023 ACC expert consensus decision pathway on management of heart failure with preserved ejection fraction: A report of the American college of cardiology solution set oversight committee [J]. J Am Coll Cardiol , 2023, 81(18): 1835-1878.et al . Pathogenesis of chronic heart failure: Cardiovascular aging, risk factors, comorbidities, and disease modifiers [J]. Heart Fail Rev , 2022, 27(1): 337-344.et al . NYHA classification for decision-making in heart failure: Time to reassess? [J]. Eur J Heart Fail , 2023, 25(7): 929-932.et al . Sodium tanshinone IIA sulfonate improves adverse ventricular remodeling post-MI by reducing myocardial necrosis, modulating inflammation, and promoting angiogenesis [J]. Curr Pharm Des , 2022, 28(9): 751-759.A 磺酸钠注射液联合美托洛尔对老年高血压合并心力衰竭患者的疗效 [J]. 心血管康复医学杂志, 2021, 30(6): 699-703.et al . Danshen injection prevents heart failure by attenuating post-infarct remodeling [J]. J Ethnopharmacol , 2017, 205: 22-32.et al . Effectiveness and safety of Danshen injections in treatment of cardiac failure: A network meta-analysis [J]. Front Pharmacol , 2024, 15: 1319551.A 磺酸钠治疗慢性充血性心力衰竭患者的疗效及对血浆血浆肾素活性和醛固酮的影响 [J]. 世界中医药, 2019, 14(7): 1809-1812.et al . Sodium tanshinone IIA sulfonate injection as adjunctive therapy for the treatment of heart failure: A systematic review and meta-analysis [J]. Phytomedicine , 2022, 95: 153879.et al . Ethnomedicine, phytochemistry, pharmacology, pharmacokinetics, and clinical application of Salvia miltiorrhiza Bunge (Lamiaceae): A comprehensive review [J]. J Ethnopharmacol , 2025, 350: 120032.et al . Guanxinning injection ameliorates cardiac remodeling in HF mouse and 3D heart spheroid models via p38/FOS/MMP1-mediated inhibition of myocardial hypertrophy and fibrosis [J]. Biomed Pharmacother , 2023, 162: 114642.et al . Urinary metabolomics analysis to reveal metabolic mechanism of guanxinning injection on heart failure with renal dysfunction [J]. J Pharm Biomed Anal , 2022, 209: 114516.et al . Effect of Danhong injection on heart failure in rats evaluated by metabolomics [J]. Front Med , 2023, 10: 1259182.et al . Effects of compound Kushen injection on pathology and angiogenesis of tumor tissues [J]. Oncol Lett , 2019, 17(2): 2278-2282.et al . Shenxiong glucose injection inhibits oxidative stress and apoptosis to ameliorate isoproterenol-induced myocardial ischemia in rats and improve the function of HUVECs exposed to CoCl(2) [J]. Front Pharmacol , 2023, 13: 931811.et al . Proteomic analysis reveals the protective effects of Yiqi Fumai lyophilized injection on chronic heart failure by improving myocardial energy metabolism [J]. Front Pharmacol , 2021, 12: 719532.et al . HPLC-QTOF/MS-based metabolomics to explore the molecular mechanisms of Yiqi Fumai Lyophilized Injection in heart failure mice [J]. J Sep Sci , 2021, 44(13): 2545-2563.et al . Shengmai injection suppresses angiotensin II-induced cardiomyocyte hypertrophy and apoptosis via activation of the AMPK signaling pathway through energy-dependent mechanisms [J]. Front Pharmacol , 2019, 10: 1095.et al . Shenmai injection revives cardiac function in rats with hypertensive heart failure: Involvement of microbial-host co-metabolism [J]. BMC Complement Med Ther , 2025, 25(1): 24.et al . Shenmai injection improves hypertensive heart failure by inhibiting myocardial fibrosis via TGF-β1/smad pathway regulation [J]. Chin J Integr Med , 2023, 29(2): 119-126.Front Microbiol , 2025, 16: 1509548.et al . Study on the mechanism of Xinmailong injection against chronic heart failure based on transcriptomics and proteomics [J]. J Pharm Biomed Anal , 2025, 253: 116529.et al . The effect of recombinant human brain natriuretic peptide combined with xinmailong on heart failure and its impact on cardiac function and inflammatory response [J]. Int J Gen Med , 2025, 18: 1999-2008.et al . Oxymatrine attenuated isoproterenol-induced heart failure in rats via regulation of COX-2/PGI(2) pathway [J]. Biomed Pharmacother , 2016, 84: 1359-1366.
中草药
|综述
2026
, 57
(3) :
1179
-1194
中药注射剂治疗慢性心力衰竭的研究进展
全屏
孟骊冲1,2 , 王梓仪3 , 李欣春4 , 李琳1,2 , 胡志希1,2
作者信息
1 湖南中医药大学, 湖南 长沙 410208;
通讯作者:
胡志希
作者简介:
孟骊冲: 孟骊冲，博士研究生，从事病证诊断标准及证候学生物学基础研究。E-mail:1752331103@qq.com
Research progress on traditional Chinese medicine injection in treatment of chronic heart failure
MENG Lichong, WANG Ziyi, LI Xinchun, LI Lin, HU Zhixi
Affiliations
doi: 10.7501/j.issn.0253-2670.2026.03.033
文章导航
慢性心力衰竭（chronic heart failure，CHF）是高患病率、高死亡率、高再住院率的心血管终末综合征，中药注射剂兼具中医辨证特色与快速起效优势，在CHF治疗中潜力显著。基于近10年研究，系统梳理30种中药注射剂的药效物质基础与作用特点，旨在填补该领域系统归纳的空白。按中医辨证将中药注射剂分为活血化瘀、益气养阴、温阳利水3类。活血化瘀类通过改善微循环、抑制心肌纤维化及炎症反应等发挥作用；益气养阴类聚焦调节心肌能量代谢与线粒体功能等；温阳利水类则通过调控肠道菌群、改善“肠-心轴”及抑制铁死亡等机制发挥作用。通过整合单味药与复方注射剂研究，揭示中药注射剂多成分、多靶点干预CHF复杂病理的优势，为CHF中西医结合临床治疗提供药效物质基础、作用机制及临床应用的系统证据，为精准辨证用药及创新治疗策略提供新思路。
中药注射剂
/
慢性心力衰竭
/
辨证论治
/
中西医结合
/
活血化瘀
/
益气养阴
/
温阳利水
Chronic heart failure (CHF) is a cardiovascular end syndrome with high prevalence, high mortality and high re-hospitalization rate, and traditional Chinese medicine (TCM) injections have significant potential in the treatment of CHF because of their combination of TCM evidence-based features and rapid onset of action. Based on ten years of research, this paper systematically investigates the pharmacodynamic material basis and action characteristics of 30 TCM injections to fill the gap of systematic summarization in this field. The study classified TCM injections into three categories according to TCM diagnosis: Activating blood and resolving stasis, replenishing qi and nourishing yin, and warming yang and excreting water. Activating blood and resolving stasis TCM injections can improve microcirculation and inhibit myocardial fibrosis and inflammation; replenishing qi and nourishing yin TCM injections focuses on regulating myocardial energy metabolism and mitochondrial function; warming yang and excreting water TCM injections can regulate intestinal bacterial flora, improve the “intestinal-cardiac axis” and inhibit iron death, etc. The study is the first to integrate single and compound TCM injections, revealing the advantages of TCM injections in multi-component and multi-target interventions in the complex pathology of CHF. It provides systematic evidence on the pharmacodynamic substances, mechanism of action, and clinical application for the clinical treatment of CHF using integrated Chinese and Western medicine, and provides new ideas for the precise identification of drugs and innovative treatment strategies.
traditional Chinese medicine injection
/
chronic heart failure
/
syndrome differentiation and treatment
/
combination of traditional Chinese and Western medicine
/
activating blood and resolving stasis
/
replenishing qi and nourishing yin
/
warming yang and excreting water
孟骊冲, 王梓仪, 李欣春, 李琳, 胡志希.
中药注射剂治疗慢性心力衰竭的研究进展.
中草药,
2026
, 57
(3)
: 1179
-1194
.
DOI: 10.7501/j.issn.0253-2670.2026.03.033
MENG Lichong, WANG Ziyi, LI Xinchun, LI Lin, HU Zhixi.
Research progress on traditional Chinese medicine injection in treatment of chronic heart failure[J].
Chinese Traditional and Herbal Drugs ,
2026
, 57
(3)
: 1179
-1194
.
DOI: 10.7501/j.issn.0253-2670.2026.03.033
国家自然科学基金项目(82274412);国家自然科学基金项目(82305092);湖南省自然科学基金项目(2023JJ30453);国家中医药管理局高水平中医药重点学科建设项目(ZYYZDXK-2023147)
参考文献
引证文献
Guo B C, Shi S, Guo Y T, et al . Interventional therapies for chronic heart failure: An overview of recent developments [J]. ESC Heart Fail , 2025, 12(2): 1081-1094.et al . Worsening of chronic heart failure: Definition, epidemiology, management and prevention. A clinical consensus statement by the Heart Failure Association of the European Society of Cardiology [J]. Eur J Heart Fail , 2023, 25(6): 776-791.et al . Heart failure and left ventricular dysfunction in older patients with chronic kidney disease: The China Hypertension Survey (2012-2015) [J]. J Geriatr Cardiol , 2020, 17(10): 597-603.et al . Global, regional, and national burden of heart failure and its underlying causes, 1990-2021: Results from the global burden of disease study 2021 [J]. Biomark Res , 2025, 13(1): 16.et al . Xinmailong injection on left ventricular remodeling and inflammatory mediators in patients with CHF: A systematic review and meta-analysis [J]. Front Pharmacol , 2024, 15: 1370448.et al . 2023 ACC expert consensus decision pathway on management of heart failure with preserved ejection fraction: A report of the American college of cardiology solution set oversight committee [J]. J Am Coll Cardiol , 2023, 81(18): 1835-1878.et al . Pathogenesis of chronic heart failure: Cardiovascular aging, risk factors, comorbidities, and disease modifiers [J]. Heart Fail Rev , 2022, 27(1): 337-344.et al . NYHA classification for decision-making in heart failure: Time to reassess? [J]. Eur J Heart Fail , 2023, 25(7): 929-932.et al . Sodium tanshinone IIA sulfonate improves adverse ventricular remodeling post-MI by reducing myocardial necrosis, modulating inflammation, and promoting angiogenesis [J]. Curr Pharm Des , 2022, 28(9): 751-759.A 磺酸钠注射液联合美托洛尔对老年高血压合并心力衰竭患者的疗效 [J]. 心血管康复医学杂志, 2021, 30(6): 699-703.et al . Danshen injection prevents heart failure by attenuating post-infarct remodeling [J]. J Ethnopharmacol , 2017, 205: 22-32.et al . Effectiveness and safety of Danshen injections in treatment of cardiac failure: A network meta-analysis [J]. Front Pharmacol , 2024, 15: 1319551.A 磺酸钠治疗慢性充血性心力衰竭患者的疗效及对血浆血浆肾素活性和醛固酮的影响 [J]. 世界中医药, 2019, 14(7): 1809-1812.et al . Sodium tanshinone IIA sulfonate injection as adjunctive therapy for the treatment of heart failure: A systematic review and meta-analysis [J]. Phytomedicine , 2022, 95: 153879.et al . Ethnomedicine, phytochemistry, pharmacology, pharmacokinetics, and clinical application of Salvia miltiorrhiza Bunge (Lamiaceae): A comprehensive review [J]. J Ethnopharmacol , 2025, 350: 120032.et al . Guanxinning injection ameliorates cardiac remodeling in HF mouse and 3D heart spheroid models via p38/FOS/MMP1-mediated inhibition of myocardial hypertrophy and fibrosis [J]. Biomed Pharmacother , 2023, 162: 114642.et al . Urinary metabolomics analysis to reveal metabolic mechanism of guanxinning injection on heart failure with renal dysfunction [J]. J Pharm Biomed Anal , 2022, 209: 114516.et al . Effect of Danhong injection on heart failure in rats evaluated by metabolomics [J]. Front Med , 2023, 10: 1259182.et al . Effects of compound Kushen injection on pathology and angiogenesis of tumor tissues [J]. Oncol Lett , 2019, 17(2): 2278-2282.et al . Shenxiong glucose injection inhibits oxidative stress and apoptosis to ameliorate isoproterenol-induced myocardial ischemia in rats and improve the function of HUVECs exposed to CoCl(2) [J]. Front Pharmacol , 2023, 13: 931811.et al . Proteomic analysis reveals the protective effects of Yiqi Fumai lyophilized injection on chronic heart failure by improving myocardial energy metabolism [J]. Front Pharmacol , 2021, 12: 719532.et al . HPLC-QTOF/MS-based metabolomics to explore the molecular mechanisms of Yiqi Fumai Lyophilized Injection in heart failure mice [J]. J Sep Sci , 2021, 44(13): 2545-2563.et al . Shengmai injection suppresses angiotensin II-induced cardiomyocyte hypertrophy and apoptosis via activation of the AMPK signaling pathway through energy-dependent mechanisms [J]. Front Pharmacol , 2019, 10: 1095.et al . Shenmai injection revives cardiac function in rats with hypertensive heart failure: Involvement of microbial-host co-metabolism [J]. BMC Complement Med Ther , 2025, 25(1): 24.et al . Shenmai injection improves hypertensive heart failure by inhibiting myocardial fibrosis via TGF-β1/smad pathway regulation [J]. Chin J Integr Med , 2023, 29(2): 119-126.Front Microbiol , 2025, 16: 1509548.et al . Study on the mechanism of Xinmailong injection against chronic heart failure based on transcriptomics and proteomics [J]. J Pharm Biomed Anal , 2025, 253: 116529.et al . The effect of recombinant human brain natriuretic peptide combined with xinmailong on heart failure and its impact on cardiac function and inflammatory response [J]. Int J Gen Med , 2025, 18: 1999-2008.et al . Oxymatrine attenuated isoproterenol-induced heart failure in rats via regulation of COX-2/PGI(2) pathway [J]. Biomed Pharmacother , 2016, 84: 1359-1366.
2026年第57卷第3期
PDF下载
25
6
引用本文
BibTeX
文章信息
doi: 10.7501/j.issn.0253-2670.2026.03.033
接收时间：2025-07-29
首发时间：2026-09-08
https://castjournals.cast.org.cn/joweb/zcy/CN/10.7501/j.issn.0253-2670.2026.03.033
引用本文
BibTeX
2种不同金属材料的力学参数
科 属数 种数 占总种数比例 属 种数 占总种数比例 鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78 小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39 多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39 红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87 小菇属 Mycena 11 5.26 光柄菇属 Pluteus 5 2.39 红菇属 Russula 17 8.13 栓菌属 Trametes 5 2.39
关闭全屏
BibTeX
EndNote
RefWorks
TxT
PDF下载
全屏
25
6
关闭全屏
北京市海淀区学院南路86号
010-62199257（仅加盟咨询）
qkjq@cast.org.cn
