Article(id=1304140198187655907, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1304140186485543391, articleNumber=null, orderNo=null, doi=10.7501/j.issn.0253-2670.2026.03.021, pmid=null, cstr=null, oa=null, hot=0, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1756137600000, receivedDateStr=2025-08-26, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1788860853000, onlineDateStr=2026-09-08, pubDate=null, pubDateStr=null, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1788860853000, onlineIssueDateStr=2026-09-08, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1788860853000, creator=13701087609, updateTime=1788860853000, updator=13701087609, issue=Issue{id=1304140186485543391, tenantId=1146029695717560320, journalId=1302319053441957962, year='2026', volume='57', issue='3', pageStart='789', pageEnd='1208', issueExtLink='null', onlineDate='null', pubDate='1770825600000', pubDateStr='2026-02-12', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1788860850211, creator='13701087609', updateTime=1788860942564, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1304140573955351430, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1304140186485543391, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1304140573955351431, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1304140186485543391, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1041, endPage=1053, ext={EN=ArticleExt(id=1304140198485451493, articleId=1304140198187655907, tenantId=1146029695717560320, journalId=1302319053441957962, language=EN, title=Research status and development prospects of traditional Chinese medicine polysaccharides acting on intestinal flora based on bibliometric analysis, columnId=null, journalTitle=Chinese Traditional and Herbal Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=Objective Drawing on bibliometric and visualization techniques, this study systematically maps the current landscape and emerging hotspots of polysaccharide–gut microbiota research, offering an evidence-based roadmap for future investigations. Methods China National Knowledge Infrastructure (CNKI), VIP, Wanfang and Web of Science (WOS) were searched for Chinese- and English-language publications on “gut microbiota AND polysaccharides”. CiteSpace, VOSviewer and Microsoft Excel were employed to visualize and quantify annual output, leading institutes, prolific authors, highly cited journals, keyword clusters and burst terms. Results A total of 1 684 Chinese and 872 English articles were retained. Over the past decade, the field exhibited an “ascend-descend” pattern, entering a rapid-growth phase after 2017. China (Nanchang University and Nanjing Agricultural University as hubs) and the USA dominate the output; China ranks first globally, benefiting from abundant traditional-Chinese-medicine polysaccharide resources and strong policy support. Chinese and English literatures evolved differently: Chinese papers initially focused on single polysaccharides (e.g., Astragali Radix or Lycium barbarum polysaccharides) modulating microbial abundance, then shifted to structure–activity relationships and veterinary/clinical applications, whereas English papers moved from gut-barrier function to ulcerative colitis mechanisms, with in vitro fermentation models advancing studies linking metabolic syndrome to short-chain fatty acids (SCFAs). Keyword clustering and burst detection identified immunomodulation, structural characterization, metabolic syndrome and SCFAs as core topics, while “high-fat diet” and “precision regulation” emerged after 2022. Conclusion Interactions between polysaccharides and gut microbiota, their structure–activity relationships, and applications in metabolic diseases such as obesity constitute the central research agenda. Complementary Chinese-English collaboration will propel the field toward precision and clinical translation., authors=WANG Hongjie, WANG Yong, WANG Ying, CHEN Huijuan, ZENG Yong, KUANG Tingting, authorsList=WANG Hongjie, WANG Yong, WANG Ying, CHEN Huijuan, ZENG Yong, KUANG Tingting, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1304140198409954020, articleId=1304140198187655907, tenantId=1146029695717560320, journalId=1302319053441957962, language=CN, title=基于文献计量学分析中药多糖作用于肠道菌群的研究现状与发展前景, columnId=1304140194819629763, journalTitle=中草药, columnName=数据挖掘与循证医学, runingTitle=null, highlight=null, articleAbstract=目的 基于文献计量学和可视化分析技术对多糖作用于肠道菌群的研究现状和热点进行系统性分析，为今后相关研究提供方向。方法 以中国知网、维普、万方及Web of Science为数据来源，检索“肠道微生物群和多糖”相关中英文文献，运用Cite Space、VOS viewer及Microsoft Excel等工具，对文献发文量、核心研究机构、高产作者、高被引期刊、关键词聚类及突现特征展开可视化与计量分析。结果 共纳入有效中文文献1 684篇、英文文献872篇，近10年该领域发文量整体呈“先升后降”趋势，2017年后进入快速增长阶段；中国（以南昌大学、南京农业大学为核心机构）与美国为主要研究力量，其中中国因中药多糖资源丰富、政策支持力度大，发文量居全球首位；中英文研究呈现差异化路径，中文文献早期聚焦单一多糖（如黄芪多糖、枸杞多糖）对肠道菌群丰度的基础调节，后期转向构效关系与畜牧/临床应用；英文文献则从肠道屏障功能研究逐步拓展至溃疡性结肠炎机制解析，体外发酵模型的应用推动了代谢综合征与短链脂肪酸（short-chain fatty acids，SCFAs）的关联研究。关键词聚类与突现分析表明，免疫调节、结构表征、代谢综合征、短链脂肪酸为核心热点，2022年后“高脂饮食”“精准调控”成为新兴方向。结论 多糖与肠道菌群的互作机制、构效关系及在代谢性疾病（肥胖等）中的应用是未来核心研究方向，中英文研究的协作互补将推动该领域向“精准化、临床化”发展。, authors=王虹洁1 , 王永2 , 王英2 , 陈慧娟3 , 曾勇1 , 邝婷婷2 , authorsList=王虹洁, 王永, 王英, 陈慧娟, 曾勇, 邝婷婷, authorCompany=1 成都中医药大学药学院, 四川成都 611137; et al . Biological activities and pharmaceutical applications of polysaccharide from natural resources: A review [J]. Carbohydr Polym , 2018, 183: 91-101.et al . Correlation between the structures of natural polysaccharides and their properties in regulating gut microbiota: Current understanding and beyond [J]. Carbohydr Polym , 2025, 352: 123209.IMA J Appl Math , 1980, 25(4): 387-396.et al . Correction: A comparative study of bibliometric analysis on old adults’ cognitive impairment based on web of science and CNKI via CiteSpace [J]. Health Econ Rev , 2024, 14(1): 15.Anat Rec , 2023, 306(12): 2974-2983.et al . Digestion under saliva, simulated gastric and small intestinal conditions and fermentation in vitro by human intestinal microbiota of polysaccharides from Fuzhuan brick tea [J]. Food Chem , 2018, 244: 331-339.et al . In vitro digestion under simulated saliva, gastric and small intestinal conditions and fermentation by human gut microbiota of polysaccharides from the fruits of Lycium barbarum [J]. Int J Biol Macromol , 2019, 125: 751-760.et al . Fuzhuan brick tea polysaccharides attenuate metabolic syndrome in high-fat diet induced mice in association with modulation in the gut microbiota [J]. J Agric Food Chem , 2018, 66(11): 2783-2795.et al . Galactofucan from Undaria pinnatifida sporophyll enhances immune function by restoring intestinal barrier and microbiota balance and evaluating serum guanidoacetic acid [J]. Int J Biol Macromol , 2025, 327(Pt 1): 147377.et al . The polysaccharides from the fruits of Lycium barbarum ameliorate high-fat and high-fructose diet-induced cognitive impairment via regulating blood glucose and mediating gut microbiota [J]. Int J Biol Macromol , 2024, 258(Pt 2): 129036.et al . Lacticaseibacillus rhamnosus HF01 postbiotics reprogram gut microbial tryptophan metabolism to coordinate enterohepatic barrier-insulin signaling axis [J]. Curr Res Food Sci , 2025, 11: 101111.et al . Mulberry leaf improves type 2 diabetes in mice via gut microbiota-SCFAs-GPRs axis and AMPK signaling pathway [J]. Phytomedicine , 2025, 145: 156970.et al . Integration of 168,000 samples reveals global patterns of the human gut microbiome [J]. Cell , 2025, 188(4): 1100-1118.)
中草药
|数据挖掘与循证医学
2026
, 57
(3) :
1041
-1053
基于文献计量学分析中药多糖作用于肠道菌群的研究现状与发展前景
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王虹洁, 王永, 王英, 陈慧娟, 曾勇, 邝婷婷
作者信息
通讯作者:
邝婷婷
作者简介:
王虹洁: 王虹洁，硕士研究生，研究方向为中药药理学。E-mail:wanghongjie@stu.cdutcm.edu.cn
Research status and development prospects of traditional Chinese medicine polysaccharides acting on intestinal flora based on bibliometric analysis
WANG Hongjie, WANG Yong, WANG Ying, CHEN Huijuan, ZENG Yong, KUANG Tingting
Affiliations
doi: 10.7501/j.issn.0253-2670.2026.03.021
文章导航
目的 基于文献计量学和可视化分析技术对多糖作用于肠道菌群的研究现状和热点进行系统性分析，为今后相关研究提供方向。方法 以中国知网、维普、万方及Web of Science为数据来源，检索“肠道微生物群和多糖”相关中英文文献，运用Cite Space、VOS viewer及Microsoft Excel等工具，对文献发文量、核心研究机构、高产作者、高被引期刊、关键词聚类及突现特征展开可视化与计量分析。结果 共纳入有效中文文献1 684篇、英文文献872篇，近10年该领域发文量整体呈“先升后降”趋势，2017年后进入快速增长阶段；中国（以南昌大学、南京农业大学为核心机构）与美国为主要研究力量，其中中国因中药多糖资源丰富、政策支持力度大，发文量居全球首位；中英文研究呈现差异化路径，中文文献早期聚焦单一多糖（如黄芪多糖、枸杞多糖）对肠道菌群丰度的基础调节，后期转向构效关系与畜牧/临床应用；英文文献则从肠道屏障功能研究逐步拓展至溃疡性结肠炎机制解析，体外发酵模型的应用推动了代谢综合征与短链脂肪酸（short-chain fatty acids，SCFAs）的关联研究。关键词聚类与突现分析表明，免疫调节、结构表征、代谢综合征、短链脂肪酸为核心热点，2022年后“高脂饮食”“精准调控”成为新兴方向。结论 多糖与肠道菌群的互作机制、构效关系及在代谢性疾病（肥胖等）中的应用是未来核心研究方向，中英文研究的协作互补将推动该领域向“精准化、临床化”发展。
肠道菌群
/
中药
/
多糖
/
文献计量分析
/
研究热点及趋势
/
可视化
Objective Drawing on bibliometric and visualization techniques, this study systematically maps the current landscape and emerging hotspots of polysaccharide–gut microbiota research, offering an evidence-based roadmap for future investigations. Methods China National Knowledge Infrastructure (CNKI), VIP, Wanfang and Web of Science (WOS) were searched for Chinese- and English-language publications on “gut microbiota AND polysaccharides”. CiteSpace, VOSviewer and Microsoft Excel were employed to visualize and quantify annual output, leading institutes, prolific authors, highly cited journals, keyword clusters and burst terms. Results A total of 1 684 Chinese and 872 English articles were retained. Over the past decade, the field exhibited an “ascend-descend” pattern, entering a rapid-growth phase after 2017. China (Nanchang University and Nanjing Agricultural University as hubs) and the USA dominate the output; China ranks first globally, benefiting from abundant traditional-Chinese-medicine polysaccharide resources and strong policy support. Chinese and English literatures evolved differently: Chinese papers initially focused on single polysaccharides (e.g., Astragali Radix or Lycium barbarum polysaccharides) modulating microbial abundance, then shifted to structure–activity relationships and veterinary/clinical applications, whereas English papers moved from gut-barrier function to ulcerative colitis mechanisms, with in vitro fermentation models advancing studies linking metabolic syndrome to short-chain fatty acids (SCFAs). Keyword clustering and burst detection identified immunomodulation, structural characterization, metabolic syndrome and SCFAs as core topics, while “high-fat diet” and “precision regulation” emerged after 2022. Conclusion Interactions between polysaccharides and gut microbiota, their structure–activity relationships, and applications in metabolic diseases such as obesity constitute the central research agenda. Complementary Chinese-English collaboration will propel the field toward precision and clinical translation.
intestinal flora
/
traditional Chinese medicine
/
polysaccharides
/
bibliometric analysis
/
research hotspots and trends
/
visualization
王虹洁, 王永, 王英, 陈慧娟, 曾勇, 邝婷婷.
基于文献计量学分析中药多糖作用于肠道菌群的研究现状与发展前景.
中草药,
2026
, 57
(3)
: 1041
-1053
.
DOI: 10.7501/j.issn.0253-2670.2026.03.021
WANG Hongjie, WANG Yong, WANG Ying, CHEN Huijuan, ZENG Yong, KUANG Tingting.
Research status and development prospects of traditional Chinese medicine polysaccharides acting on intestinal flora based on bibliometric analysis[J].
Chinese Traditional and Herbal Drugs ,
2026
, 57
(3)
: 1041
-1053
.
DOI: 10.7501/j.issn.0253-2670.2026.03.021
四川省自然科学基金项目（面上项目）(2026NSFSC0614);四川省自然科学基金项目（青年基金项目）(2025ZNSFSC1821);2023年全国中药特色技术传承人才培训项目(T20234832005)
参考文献
引证文献
Yu Y, Shen M Y, Song Q Q, et al . Biological activities and pharmaceutical applications of polysaccharide from natural resources: A review [J]. Carbohydr Polym , 2018, 183: 91-101.et al . Correlation between the structures of natural polysaccharides and their properties in regulating gut microbiota: Current understanding and beyond [J]. Carbohydr Polym , 2025, 352: 123209.IMA J Appl Math , 1980, 25(4): 387-396.et al . Correction: A comparative study of bibliometric analysis on old adults’ cognitive impairment based on web of science and CNKI via CiteSpace [J]. Health Econ Rev , 2024, 14(1): 15.Anat Rec , 2023, 306(12): 2974-2983.et al . Digestion under saliva, simulated gastric and small intestinal conditions and fermentation in vitro by human intestinal microbiota of polysaccharides from Fuzhuan brick tea [J]. Food Chem , 2018, 244: 331-339.et al . In vitro digestion under simulated saliva, gastric and small intestinal conditions and fermentation by human gut microbiota of polysaccharides from the fruits of Lycium barbarum [J]. Int J Biol Macromol , 2019, 125: 751-760.et al . Fuzhuan brick tea polysaccharides attenuate metabolic syndrome in high-fat diet induced mice in association with modulation in the gut microbiota [J]. J Agric Food Chem , 2018, 66(11): 2783-2795.et al . Galactofucan from Undaria pinnatifida sporophyll enhances immune function by restoring intestinal barrier and microbiota balance and evaluating serum guanidoacetic acid [J]. Int J Biol Macromol , 2025, 327(Pt 1): 147377.et al . The polysaccharides from the fruits of Lycium barbarum ameliorate high-fat and high-fructose diet-induced cognitive impairment via regulating blood glucose and mediating gut microbiota [J]. Int J Biol Macromol , 2024, 258(Pt 2): 129036.et al . Lacticaseibacillus rhamnosus HF01 postbiotics reprogram gut microbial tryptophan metabolism to coordinate enterohepatic barrier-insulin signaling axis [J]. Curr Res Food Sci , 2025, 11: 101111.et al . Mulberry leaf improves type 2 diabetes in mice via gut microbiota-SCFAs-GPRs axis and AMPK signaling pathway [J]. Phytomedicine , 2025, 145: 156970.et al . Integration of 168,000 samples reveals global patterns of the human gut microbiome [J]. Cell , 2025, 188(4): 1100-1118.
2026年第57卷第3期
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doi: 10.7501/j.issn.0253-2670.2026.03.021
接收时间：2025-08-26
首发时间：2026-09-08
https://castjournals.cast.org.cn/joweb/zcy/CN/10.7501/j.issn.0253-2670.2026.03.021
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2种不同金属材料的力学参数
科 属数 种数 占总种数比例 属 种数 占总种数比例 鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78 小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39 多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39 红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87 小菇属 Mycena 11 5.26 光柄菇属 Pluteus 5 2.39 红菇属 Russula 17 8.13 栓菌属 Trametes 5 2.39
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