Article(id=1304140208795054363, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1304140186485543391, articleNumber=null, orderNo=null, doi=10.7501/j.issn.0253-2670.2026.03.009, pmid=null, cstr=null, oa=null, hot=0, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1758211200000, receivedDateStr=2025-09-19, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1788860855530, onlineDateStr=2026-09-08, pubDate=null, pubDateStr=null, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1788860855530, onlineIssueDateStr=2026-09-08, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1788860855530, creator=13701087609, updateTime=1788860855530, updator=13701087609, issue=Issue{id=1304140186485543391, tenantId=1146029695717560320, journalId=1302319053441957962, year='2026', volume='57', issue='3', pageStart='789', pageEnd='1208', issueExtLink='null', onlineDate='null', pubDate='1770825600000', pubDateStr='2026-02-12', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1788860850211, creator='13701087609', updateTime=1788860942564, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1304140573955351430, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1304140186485543391, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1304140573955351431, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1304140186485543391, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=885, endPage=896, ext={EN=ArticleExt(id=1304140209143181597, articleId=1304140208795054363, tenantId=1146029695717560320, journalId=1302319053441957962, language=EN, title=Extraction process optimization and anti-inflammatory activity validation of classic prescription Baizhu Powder using analytic hierarchy process-entropy weight method, columnId=null, journalTitle=Chinese Traditional and Herbal Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=Objective To optimize the extraction process of the classic prescription Baizhu Powder (白术散), and verify its anti-inflammatory activity through cell anti-inflammatory activity experiments, providing a basis for the development of Baizhu Powder. Methods An HPLC detection method was established for the index components puerarin, daidzin, ginsenoside Rg₁, daidzein, ginsenoside Rb₁, and ammonium glycyrrhizinate. Taking the content of index components, paste yield and oil extraction volume as evaluation indicators, the comprehensive weights of each index were determined by analytic hierarchy process (AHP)-entropy weight method. Based on the single-factor experiment, the Box-Behnken design-response surface method (BBD-RSM) was adopted to optimize the Baizhu Powder extraction process. The anti-inflammatory activity of Baizhu Powder was investigated by inducing an inflammatory model of human normal colonic epithelial cells (NCM460) with lipopolysaccharide (LPS), and the feasibility of the process was verified. Results The optimized extraction process of Baizhu Powder was 10 times the volume of water, soaking for 30 min, extraction time for 90 min, and extraction twice. Under these conditions, the average comprehensive score of the three batches of process validation was 0.974, and the RSD value was 1.94%. The pharmacodynamic verification results of Baizhu Powder indicated that the Baizhu Powder prepared by the optimized process could significantly reduce the levels of inflammatory factors interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in the LPS-induced NCM460 cell inflammatory model. The level of the anti-inflammatory factor IL-10 was increased, and there was no significant difference compared with the Baizhu Powder benchmark sample. Conclusion The Baizhu Powder extraction process optimized by AHP-entropy weight method combined with BBD-RSM is stable and reliable, which can provide a basis for the subsequent research and development of Baizhu Powder., authors=HAO Lingfeng, LIU Yihao, WANG Tingting, WANG Danfeng, HU Xiaohong, ZANG Zhenzhong, WU Yangming, ZHU Weifeng, GUAN Yongmei, authorsList=HAO Lingfeng, LIU Yihao, WANG Tingting, WANG Danfeng, HU Xiaohong, ZANG Zhenzhong, WU Yangming, ZHU Weifeng, GUAN Yongmei, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1304140209059295516, articleId=1304140208795054363, tenantId=1146029695717560320, journalId=1302319053441957962, language=CN, title=基于层次分析-熵权法的经典名方白术散提取工艺优化及其抗炎活性验证, columnId=1304140189132149234, journalTitle=中草药, columnName=药剂与工艺, runingTitle=null, highlight=null, articleAbstract=目的 优化经典名方白术散（Baizhu Powder）的提取工艺，并通过细胞抗炎活性实验验证其抗炎活性，为白术散的开发提供依据。方法 建立指标成分葛根素、大豆苷、人参皂苷Rg₁、大豆苷元、人参皂苷Rb₁、甘草酸铵的HPLC检测方法；以指标成分含量、出膏率和提油量为评价指标，层次分析法（analytic hierarchy process，AHP）-熵权法确定各指标综合权重系数，在单因素实验基础上，采用Box-Behnken设计-响应面法（Box-Behnken design-response surface method，BBD-RSM）优化白术散提取工艺；通过脂多糖（lipopolysaccharide，LPS）诱导人正常结肠上皮NCM460细胞炎症模型，考察白术散抗炎活性，验证工艺可行性。结果 白术散优化提取工艺为10倍量水、浸泡30 min、提取2次、每次提取90 min，此条件下，3批工艺验证综合评分的均值为0.974，RSD值为1.94%；白术散药效学验证结果表明，优化工艺制备的白术散能显著降低LPS诱导的NCM460细胞炎症模型的炎症因子白细胞介素-6（interleukin-6，IL-6）、肿瘤坏死因子-α（tumor necrosis factor-α，TNF-α）水平，提高抑炎因子IL-10水平，且与白术散基准样品相比，无显著性差异。结论 AHP-熵权法结合BBD-RSM优选的白术散提取工艺稳定可靠，可为白术散的后续研究及开发提供依据。, authors=郝凌烽¹, 刘义豪¹, 王婷婷^1,2, 王丹凤², 胡晓红², 臧振中¹, 吴样明², 朱卫丰¹, 管咏梅^1,2, authorsList=郝凌烽, 刘义豪, 王婷婷, 王丹凤, 胡晓红, 臧振中, 吴样明, 朱卫丰, 管咏梅, authorCompany=1 江西中医药大学 现代中药制剂教育部重点实验室, 江西 南昌 330004;
2 经典名方现代中药创制全国重点实验室, 江西南昌 330004, correspAuthors=管咏梅, authorNote=郝凌烽: 郝凌烽（1999—），男，硕士研究生，主要从事中药新制剂与新技术研究。E-mail:haolingfeng0312@163.com, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=g6liJkxWlulSWha5t4dvMQ==, pdfFileSize=1955604, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=全国重点实验室专项(2023QGZDSYS002);2024江西省重点研发项目(20243BCC31010);经典名方研发与国际拓展研究(20232BBH80009))}, authors=null, keywords=[Keyword(id=1304140209269010718, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304140208795054363, language=CN, orderNo=1, keyword=白术散), Keyword(id=1304140209331925279, tenantId=1146029695717560320, journalId=1302319053441957962, articleId=1304140208795054363, language=CN, orderNo=2, 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aliStartDate=null, aliEndDate=null, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=0, orderTime=1788860855530, fullTextJson=null, articleText=null, reference=陆跃, 陈仁寿. 经典名方白术散的古代文献分析和考证 [J]. 中国实验方剂学杂志, 2023, 29(8): 150-160.
刘昌孝, 陈士林, 肖小河, 等. 中药质量标志物 (Q-Marker): 中药产品质量控制的新概念 [J]. 中草药, 2016, 47(9): 1443-1457.
管咏梅, 郝凌烽, 王智权, 等. 经典名方白术散化学成分、药理作用、临床应用研究进展及质量标志物预测分析 [J]. 中华中医药学刊, 2025, 43(12): 5-14.
黎舒婷, 税典奎. 七味白术散在消化系统疾病中的应用及药理作用研究进展 [J]. 现代中西医结合杂志, 2021, 30(17): 1928-1933.
姜丽, 张文彤, 肖彤, 等. 参苓白术散抗溃疡性结肠炎的物质基础、作用机制及安全性评价 [J]. 武汉大学学报: 理学版, 2024, 70(2): 236-252.
刘昌孝. 中药质量标志物 (Q-Marker) 研究发展的5年回顾 [J]. 中草药, 2021, 52(9): 2511-2518.
唐圆, 黄莉莉, 谭周进, 等. 响应面法优化七味白术散总苷提取工艺 [J]. 湖南农业科学, 2021(5): 80-83.
唐圆, 刘海会, 黄莉莉, 等. 七味白术散总苷含量测定方法的探索与优化 [J]. 湖南农业科学, 2021(4): 96-99.
董珂旭, 张媛, 高如汐, 等. AHP-熵权法结合Box-Behnken设计-响应面法优选枸杞汁制巴戟天炮制工艺 [J]. 中草药, 2025, 56(7): 2301-2311.
王晓丽, 沈哲苑, 李丽萍, 等. 基于正交试验结合基准关联度和AHP-熵权法优化经典名方黄连汤提取工艺 [J]. 中草药, 2023, 54(15): 4804-4811.
Shao X X, Xu Y, Xiao H Y, et al. Higenamine improves DSS-induced ulcerative colitis in mice through the Galectin-3/TLR4/NF-κB pathway [J]. Tissue Cell, 2023, 82: 102111.
Jiang Y W, Xu H C, Wu J L, et al. A hierarchically assembled oral formulation with drug-convertible carriers for targeted ulcerative colitis therapy through a three-pronged strategy [J]. Adv Compos Hybrid Mater, 2025, 8(4): 280.
Tan C, Xiang Z X, Wang S, et al. Diosmin alleviates colitis by inhibiting PAN optosis of intestinal epithelial cells and regulating gut microbiota and metabolites [J]. Phytomedicine, 2025, 141: 156671.
谢佳辰, 杨艺, 李昆蔚, 等. 基于UPLC-Q/TOF-MS代谢组学技术探究药根碱治疗溃疡性结肠炎模型小鼠的作用机制 [J]. 中草药, 2025, 56(5): 1617-1627.
李美慧, 黄友, 付豪, 等. 广藿香酮对溃疡性结肠炎的抗炎作用及其作用机制研究 [J]. 成都大学学报: 自然科学版, 2025, 44(1): 1-8.
宋洁, 郭瑞芳, 聂虹, 等. 木香烃内酯对溃疡性结肠炎小鼠肠道免疫炎症的影响及其机制 [J]. 广西医科大学学报, 2021, 38(12): 2300-2305.
方瑞康, 张冬娜, 李菁菁, 等. 白术内酯III在小鼠慢性炎性肠病模型中通过抑制STAT3信号维持Th17/Treg平衡 [J]. 中国病理生理杂志, 2024, 40(12): 2336-2342.
Zhu Y, Zhang K X, Bu Q Y, et al. Ginsenosides from Panax ginseng improves hepatic lipid metabolism disorders in HFD-fed rats by regulating gut microbiota and cholesterol metabolism signaling pathways [J]. Phytother Res, 2024, 39(2): 714-732.
张睿. ADSCs移植治疗DSS诱导的炎症性肠病模型及人参皂苷Rg₁的协同作用 [D]. 南京: 南京中医药大学, 2020.
孟晓伟, 郭风梅, 王倩倩, 等. 葛根素的药理作用研究进展 [J]. 中国中药杂志, 2025, 50(11): 2954-2968.
赵慧颖, 余诗强, 蒋林树, 等. 大豆异黄酮的代谢及其对动物肠道保护机制的研究进展 [J]. 动物营养学报, 2022, 34(7): 4132-4142.
冯永波, 周忠海, 高玉华, 等. 甘草泻心汤治疗溃疡性结肠炎的疗效及患者肠道菌群、炎症免疫细胞因子变化研究 [J]. 吉林中医药, 2023, 43(8): 940-944.
张莉, 胡卫东, 杜林, 等. 人参皂苷Rg₁、Re对脂多糖诱导的肠道屏障损伤的保护作用 [J]. 中国兽医学报, 2024, 44(3): 527-535.
李欢, 张相安. 葛根在治疗炎症性肠病中的作用机制和应用研究进展 [J]. 中草药, 2025, 56(4): 1428-1439.
张钰异, 王浩, 王思琳, 等. 中医药调控NF-κB相关信号通路干预溃疡性结肠炎相关性癌变的研究进展 [J]. 中国中药杂志, 2024, 49(6): 1455-1466.
石海杰, 文萍. 葛根提取物对溃疡性结肠炎大鼠肠黏膜损伤影响及机制 [J]. 中国公共卫生, 2019, 35(8): 1038-1042.
杨万荷, 崔路佳, 张东艳, 等. 九味白术汤对急性溃疡性结肠炎大鼠肠黏膜免疫屏障及miR-155/SOCS-1轴的影响 [J]. 中成药, 2023, 45(7): 2393-2397.
高广淼, 杨玲玲, 杨秀娟, 等. 甘草有效成分及复方治疗溃疡性结肠炎的研究进展 [J]. 中国实验方剂学杂志, 2023, 29(23): 264-274.
姚建国. 复方甘草酸苷联合美沙拉嗪治疗慢性溃疡性结肠炎的临床研究 [J]. 中国药物与临床, 2021, 21(13): 2316-2318.
衡宇. 甘草酸调节紧密连接蛋白修复溃疡性结肠炎肠黏膜屏障损伤的药理作用研究 [D]. 西安: 第四军医大学, 2017.
梅佳华, 查学志, 柯瑾, 等. 基于AHP-熵权法及化学计量学的虎力散提取工艺研究 [J]. 中草药, 2025, 56(13): 4643-4653.
朱月, 陈燕, 钟芙蓉, 等. 基于层次分析-熵权法的经典名方黄连解毒汤提取工艺优化及其抗炎活性研究 [J]. 中草药, 2025, 56(7): 2291-2300.
卢新颖, 毕嘉谣, 李明慧, 等. Box-Behnken响应面法结合基准关联度和AHP-EWM优化经典名方易黄汤的提取工艺 [J]. 中国中药杂志, 2023, 48(21): 5798-5808.
管咏梅, 万鑫浩, 邹斌, 等. 基于“自洽调节”的葛根异黄酮类成分对葛根素溶解性及渗透性影响研究 [J]. 中草药, 2021, 52(23): 7138-7147.
Zou P R, Chen S X, Otero P, et al. Advances on resource, biosynthesis pathway, bioavailability, and bioactivity of dihydrodaidzein [J]. Phytochem Rev, 2025, 24(5): 3915-3940.)