Article(id=1304140189320897172, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1304140186485543391, articleNumber=null, orderNo=null, doi=10.7501/j.issn.0253-2670.2026.03.004, pmid=null, cstr=null, oa=null, hot=0, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1788860850887, onlineDateStr=2026-09-08, pubDate=null, pubDateStr=null, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1788860850887, onlineIssueDateStr=2026-09-08, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1788860850887, creator=13701087609, updateTime=1788860850887, updator=13701087609, issue=Issue{id=1304140186485543391, tenantId=1146029695717560320, journalId=1302319053441957962, year='2026', volume='57', issue='3', pageStart='789', pageEnd='1208', issueExtLink='null', onlineDate='null', pubDate='1770825600000', pubDateStr='2026-02-12', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1788860850211, creator='13701087609', updateTime=1788860942564, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1304140573955351430, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1304140186485543391, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1304140573955351431, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1304140186485543391, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=817, endPage=824, ext={EN=ArticleExt(id=1304140189702578838, articleId=1304140189320897172, tenantId=1146029695717560320, journalId=1302319053441957962, language=EN, title=Chemical constituents from leaves of Musa × paradisiaca and their anti-proliferative activities, columnId=null, journalTitle=Chinese Traditional and Herbal Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=Objective To investigate the chemical constituents from the leaves of Musa × paradisiaca and their inhibitory activities on cell proliferation in vitro. Methods The compounds were isolated and purified using various chromatographic techniques, including silica gel, MCI gel CHP-20P, reversed-phase ODS, Sephadex LH-20 column chromatographies, and semi-preparative HPLC. Their structures were elucidated by spectroscopic methods such as NMR and MS. The inhibitory activities of all compounds on cell proliferation in vitro were evaluated using the CCK-8 assay. Results A total of 19 compounds were isolated from the leaves of Musa × paradisiaca and identified as di(2-ethylhexyl) phthalate (1), myristic acid (2), pentadecanoic acid (3), linoleic acid (4), dibutyl phthalate (5), ethyl 4-hydroxy-3-methoxybenzoate (6), dihydroactinidolide (7), MF-EA-705β (8), butyl 2-ethylhexyl phthalate (9), n-tetratriacont-20,23-dienoic acid (10), 3-hydroxystigmasta-5,22-dien-7-one (11), 3-hydroxystigmast-5-en-7-one (12), luffarin X (13), 6-hydroxystigmasta-4,22-dien-3-one (14), 6-hydroxystigmast-4-en-3-one(15), (3S,5R,6S,7E)-5,6-epoxy-3-hydroxy-7-megastigmen-9-one (16), ethyl p-hydroxybenzoate (17), p-diethoxybenzene (18), and methyl (9Z,12Z,15Z)-octadeca-9,12,15-trienoate (19). Among them, compounds2 , 5 ,7 ,11 ,13 ,15 , and17 exhibited certain anti-proliferative activities against human hepatocellular carcinoma HepG₂, cervical cancer Hela, breast cancer MCF-7, and malignant melanoma A375 cell lines, with median inhibition concentration (IC₅₀) values ranging from 40.26 to 97.75 μmol/L. Specifically, compounds7 and11 showed selective inhibitory activity against A375 cells (IC₅₀ = 43.0 and 50.0 μmol/L, respectively), which was slightly weaker than that of the positive control cisplatin (IC₅₀ = 40.13 μmol/L). In contrast, compounds2 and15 demonstrated stronger inhibitory effects against MCF-7 cells (IC₅₀ = 40.26 and 45.00 μmol/L, respectively) compared to cisplatin (IC₅₀ = 48.36 μmol/L). Conclusion Compounds1 and6 —19 were isolated from this genus for the first time, while compounds2 —5 were first identified from this specific plant. Furthermore, compounds2 ,7 ,11 , and15 exhibited selective inhibitory activities against specific tumor cell lines ., authors=YAN Xuhua, SUN Jiale, LIANG Qiuming, WANG Feng, FANG Zhenfeng, authorsList=YAN Xuhua, SUN Jiale, LIANG Qiuming, WANG Feng, FANG Zhenfeng, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1304140189585138325, articleId=1304140189320897172, tenantId=1146029695717560320, journalId=1302319053441957962, language=CN, title=大蕉叶化学成分及细胞增殖抑制活性研究, columnId=1304140187169214944, journalTitle=中草药, columnName=化学成分, runingTitle=null, highlight=null, articleAbstract=目的 研究大蕉Musa × paradisiaca叶化学成分以及体外细胞增殖抑制活性。方法 采用硅胶、MCI gel CHP-20P、反相ODS和Sephadex LH-20柱色谱以及半制备型高效液相等色谱方法进行分离和纯化，通过核磁共振、质谱等技术手段鉴定了化合物的结构。利用CCK-8法评价了所有化合物体外细胞增殖抑制活性。结果 从大蕉叶提取物中分离得到19个化合物，分别鉴定为邻苯二甲酸二(2-乙基)己酯（1）、肉豆蔻酸（2）、正十五酸（3）、亚油酸（4）、邻苯二甲酸二丁酯（5）、4-羟基-3-甲氧基苯甲酸乙酯（6）、二氢猕猴桃内酯（7）、MF-EA-705β（8）、邻苯二甲酸丁基酯2-乙基己基酯（9）、三十四碳-(20,23)-二烯酸（10）、3-羟基豆甾-5,22-二烯-7-酮（11）、3-羟基豆甾-5-烯-7-酮（12）、luffarin X（13）、6-羟基豆甾-4,22-二烯-3-酮（14）、6-羟基豆甾-4-烯-3-酮（15）、(3S,5R,6S,7E)-5,6-环氧-3-羟基-7-巨豆烯-9-酮（16）、对羟基苯甲酸乙酯（17）、对二乙氧基苯（18）、(9Z,12Z,15Z)-十八烷基-9,12,15-三烯酸甲酯（19）。化合物2、5、7、11、13、15和17分别对人肝癌HepG2细胞、人宫颈癌Hela细胞、人乳腺癌MCF-7细胞和人皮肤恶性黑色素瘤A375细胞增殖表现出一定的抑制活性，半数抑制浓度（median inhibition concentration，IC₅₀）值为40.26～97.75μmol/L，其中化合物7和11对A375细胞增殖有选择性抑制活性（IC₅₀值分别为43.0、50.0 μmol/L），略低于阳性对照顺铂（IC₅₀值40.13 μmol/L），而化合物2和15对MCF-7细胞增殖选择性抑制活性（IC₅₀值分别为40.26、45.00 μmol/L）强于阳性对照（IC₅₀值为48.36 μmol/L）。结论 化合物1、6～19为首次从该属植物中分离得到；化合物2～5为首次在该植物中分离得到。活性测试表明，化合物2、7、11和15对特定肿瘤细胞株表现出选择性增殖抑制活性。, authors=严绪华¹, 孙佳乐², 梁秋明^3,4, 王峰^3,4, 方振峰^2,5,6, authorsList=严绪华, 孙佳乐, 梁秋明, 王峰, 方振峰, authorCompany=1 武汉市中医医院药学综合部, 湖北 武汉 430010;
2 江汉大学医学部药学系, 湖北 武汉 430056;
3 国家中医药管理局中药数字化质量评价技术重点研究室, 广东 广州 510006;
4 广东省中药质量工程技术研究中心, 广东 广州 510006;
5 湖北省认知与情感障碍重点实验室, 湖北武汉 430056;
6 湖北省实验医学教育示范中心, 湖北武汉 430056, correspAuthors=王峰, authorNote=严绪华: 严绪华，副主任药师，主要从事中药功效和质量研究。E-mail:13906630@qq.com Tel:(027)84476993, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=va81MKyM1ZfhTQASmRTA/A==, pdfFileSize=1258544, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=广东省普通高校重点领域专项(2022ZDZX2035))}, authors=[Author(id=1307443573775953944, tenantId=1146029695717560320, journalId=null, articleId=1304140189320897172, orderNo=null, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=null, email=null, emailSecond=null, emailThird=null, correspondingAuthor=null, authorType=null, ext={EN=AuthorExt(id=null, tenantId=null, 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