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Rehd. et Wils. fruits that intervene in the gastritis-cancer transformation process. Methods The transformation of human gastric mucosal epithelial cells (GES-1 cells) was induced by N -methyl-N ′-nitro-N -nitrosoguanidine (MNNG) to obtain human gastric mucosal epithelial dermatitis-cancer transformation model cells (MC cells)., The activity screening was conducted on the different polar fractions from the 60% ethanol extract of R. odorata var. gigantea fruits. Active fractions were isolated and purified using multiple chromatographic techniques, including silica gel column chromatography, ODS column chromatography, Sephadex LH-20 column chromatography, and preparative high-performance liquid chromatography (preparative HPLC). The chemical structures of the isolated compounds were elucidated based on physico-chemical properties and spectroscopic data. The CCK-8 assay was utilized to evaluate the anti-proliferative activity of the isolated monomeric compounds against MC cells. Results A total of 18 compounds were isolated and identified from the active fractions of R. odorata var. gigantea fruits, namely: (2R ,3R )-3-[(1' S ,2' R ,6' S )-2' ,6' -dihydroxy-1' -(galloyl)cyclohexyl]-2,3-dihydroxypropanoic acid (1 ), microphyllose A (2 ), caffeic acid (3 ), 3,5-dicaffeoylquinic acid (4 ), 5-galloylquinic acid (5 ), ethyl vanillate (6 ), procyanidin B2 (7 ), 3-O- galloylquinic acid (8 ), gallocatechin gallate (9 ), 6-O- galloyl-β-D- glucose (10 ), methyl gallate (11 ), 3,4,5-tri-O- galloylquinic acid (12 ), ethyl gallate (13 ), 3,5,4' -trihydroxystilbene (14 ), quercitrin (15 ), quercetin (16 ), luteolin (17 ), and betulinic acid (18 ). The results of the activity assay indicated that compounds1 , 9 ,14 —18 with an inhibition rate exceeding 50% exhibited the following IC50 values: 93.47, 81.79, 37.44, 81.58, 86.01, 44.02, and 66.12 μmol/L. Conclusion Compound1 is a novel compound, designated as gugongguoic acid A. Compound2 was isolated from the genus Rosa for the first time. Compounds5 ,9 ,11 ,13 ,15 , and17 were isolated from this plant species for the first time. All 18 compounds exhibited inhibitory activity against MC cell proliferation. Among them, compounds1 , 9 ,14 —18 showed inhibition rates greater than 50%, which represent potential bioactive constituents for intervening in the gastritis–cancer transformation process., authors=CHEN Yuhang, YAO Bin, YIN Xiaorong, YUAN Zhen, ZHANG Jingze, LIU Dailin, authorsList=CHEN Yuhang, YAO Bin, YIN Xiaorong, YUAN Zhen, ZHANG Jingze, LIU Dailin, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1304140187248906721, articleId=1304140186963694047, tenantId=1146029695717560320, journalId=1302319053441957962, language=CN, title=固公果果实干预胃炎-癌转化的活性成分研究, columnId=1304140187169214944, journalTitle=中草药, columnName=化学成分, runingTitle=null, highlight=null, articleAbstract=目的 研究固公果Rosa odorata var. gigantea 果实干预胃炎癌转化的活性成分。方法 利用N -甲基-N ′-硝基-N -亚硝基胍（N -methyl-N ′-nitro-N -nitrosoguanidine，MNNG）诱导人胃黏膜上皮细胞（GES-1细胞）转化获得人胃黏膜上皮炎-癌转化模型细胞（MC细胞），对固公果果实60%乙醇提取物的不同极性组分进行活性筛选，采用硅胶柱、ODS柱色谱、Sephadex LH-20柱色谱及制备型高效液相等多种色谱方法对活性组分进行分离、纯化，通过理化数据结合波谱技术鉴定化合物结构，采用CCK-8法对分离得到的单体成分进行活性测试，评价其对MC细胞的抑制作用。结果 从固公果果实的活性组分中分离鉴定18个化合物，分别为 (2R ,3R )-3-[(1'S ,2'R ,6'S )-2' ,6' -二羟基-1' -(没食子酰基)环己基]-2,3-二羟基丙酸（1 ）、microphyllose A（2 ）、咖啡酸（3 ）、3,5-二咖啡酰基奎宁酸（4 ）、5-没食子酰奎宁酸（5 ）、香草酸乙酯（6 ）、原花青素B2（7 ）、3-O- 没食子酰奎宁酸（8 ）、没食子儿茶素没食子酸酯（9 ）、6-O- 没食子酰基-β-D- 葡萄糖（10 ）、没食子酸甲酯（11 ）、3,4,5-三-O- 没食子酰奎宁酸（12 ）、没食子酸乙酯（13 ）、3,5,4' -三羟基二苯乙烯（14 ）、槲皮苷（15 ）、槲皮素（16 ）、木犀草素（17 ）、白桦脂酸（18 ）。活性测试结果显示，抑制率大于50%的化合物为1 、9 、14 ～18 ，其半数抑制浓度（median inhibition concentration，IC₅₀）值分别为93.47、81.7、37.44、81.58、86.01、44.02、66.12 μmol/L。结论 化合物1 为新化合物，命名为固公果酸A，化合物2 为首次从蔷薇属植物中分离得到，化合物5 、9 、11 、13 、15 、17 为首次从该植物中分离得到。18个化合物对MC细胞均具有增殖抑制活性，其中化合物1 、9 、14 、15 、16 、17 、18 抑制率大于50%，是潜在的干预胃炎-癌转化的活性成分。, authors=陈宇航1,2 , 姚彬1,2 , 尹孝荣2 , 原震2 , 张静泽1,2,3 , 刘岱琳1,2,3 , authorsList=陈宇航, 姚彬, 尹孝荣, 原震, 张静泽, 刘岱琳, authorCompany=1 天津中医药大学, 天津 301617; Rosa odorata Sweet var. gigantea (Coll. et Hemsl.) 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orderTime=1788860850324, fullTextJson=null, articleText=null, reference=杨俊美. 固公果根和美丽獐牙菜的化学成分研究 [D]. 昆明: 云南中医学院, 2014.et al . The fruit of Rosa odorata sweet var. Gigantea (Coll. et Hemsl.) Rehd. et Wils attenuates chronic atrophic gastritis induced by MNNG and its potential mechanism [J]. J Ethnopharmacol , 2025, 337(Pt 2): 118876.J Gastrointest Oncol , 2020, 11 (6): 1242-1252. et al . N -Methyl-N -nitro-N '-nitrosoguanidine induces the expression of CCR2 in human gastric epithelial cells promoting CCl2 -mediated migration [J]. Mol Med Rep , 2015, 13(2): 1083-1090.et al . Tanshinone I attenuates gastric precancerous lesions by inhibiting epithelial mesenchymal transition through the p38/STAT3 pathway [J]. Int Immunopharmacol , 2023, 124(Pt A): 110902.et al . A convergent route to enantiomers of the bicyclic monosaccharide bradyrhizose leads to insight into the bioactivity of an immunologically silent lipopolysaccharide [J]. J Org Chem , 2019, 84(1):14-41.Neocarya macrophylla fruits against Naja nigricolli s venom [J]. Carbohydr Res , 2021, 509: 108436.Quercus Stenophylla [J]. Phytochemistry , 1984, 23(11): 2621-2623.O -β-d-glucopyranoside from Indigofera aspalathoides Vahl ex DC. (Papilionaceae) [J]. Med Chem Res , 2015, 24(7): 2889-2897.et al . In vitro tyrosinase inhibitory and antioxidant activities of extracts and constituents of Paeonia lactiflora Pall. flowers [J]. Nat Prod J , 2017, 7(3): 237-245.Quercus stenophylla [J]. Phytochemistry , 1984, 23(11): 2621-2623.et al . Neuraminidase inhibitors from Reynoutria elliptica [J]. Arch Pharmacal Res , 2003, 26(5): 367-374.et al . Decoding inflammatory mediators in the C orrea ’s cascade: From chronic gastritis to carcinogenesis and targeted therapies [J]. Int Immunopharmacol , 2025, 162: 115191.et al . Gallic acid alleviates gastric precancerous lesions through inhibition of epithelial mesenchymal transition via Wnt/β-catenin signaling pathway [J]. J Ethnopharmacol , 2023, 302(Pt A): 115885.et al . Xiao Tan He Wei Decoction reverses MNNG-induced precancerous lesions of gastric carcinoma in vivo and vitro : Regulation of apoptosis through NF-κB pathway [J]. Biomed Pharmacother , 2018, 108: 95-102.
中草药
|化学成分
2026
, 57
(3) :
806
-816
固公果果实干预胃炎-癌转化的活性成分研究
全屏
陈宇航1,2 , 姚彬1,2 , 尹孝荣2 , 原震2 , 张静泽1,2,3 , 刘岱琳1,2,3
作者信息
1 天津中医药大学, 天津 301617;
通讯作者:
刘岱琳
作者简介:
陈宇航: 陈宇航，硕士研究生，中药学专业。E-mail:15154788751@163.com
Active components of Rosa odorata var. gigantea fruits in intervening gastritis-cancer transformation
CHEN Yuhang, YAO Bin, YIN Xiaorong, YUAN Zhen, ZHANG Jingze, LIU Dailin
Affiliations
doi: 10.7501/j.issn.0253-2670.2026.03.003
文章导航
目的 研究固公果Rosa odorata var. gigantea 果实干预胃炎癌转化的活性成分。方法 利用N -甲基-N ′-硝基-N -亚硝基胍（N -methyl-N ′-nitro-N -nitrosoguanidine，MNNG）诱导人胃黏膜上皮细胞（GES-1细胞）转化获得人胃黏膜上皮炎-癌转化模型细胞（MC细胞），对固公果果实60%乙醇提取物的不同极性组分进行活性筛选，采用硅胶柱、ODS柱色谱、Sephadex LH-20柱色谱及制备型高效液相等多种色谱方法对活性组分进行分离、纯化，通过理化数据结合波谱技术鉴定化合物结构，采用CCK-8法对分离得到的单体成分进行活性测试，评价其对MC细胞的抑制作用。结果 从固公果果实的活性组分中分离鉴定18个化合物，分别为 (2R ,3R )-3-[(1'S ,2'R ,6'S )-2' ,6' -二羟基-1' -(没食子酰基)环己基]-2,3-二羟基丙酸（1 ）、microphyllose A（2 ）、咖啡酸（3 ）、3,5-二咖啡酰基奎宁酸（4 ）、5-没食子酰奎宁酸（5 ）、香草酸乙酯（6 ）、原花青素B2（7 ）、3-O- 没食子酰奎宁酸（8 ）、没食子儿茶素没食子酸酯（9 ）、6-O- 没食子酰基-β-D- 葡萄糖（10 ）、没食子酸甲酯（11 ）、3,4,5-三-O- 没食子酰奎宁酸（12 ）、没食子酸乙酯（13 ）、3,5,4' -三羟基二苯乙烯（14 ）、槲皮苷（15 ）、槲皮素（16 ）、木犀草素（17 ）、白桦脂酸（18 ）。活性测试结果显示，抑制率大于50%的化合物为1 、9 、14 ～18 ，其半数抑制浓度（median inhibition concentration，IC₅₀）值分别为93.47、81.7、37.44、81.58、86.01、44.02、66.12 μmol/L。结论 化合物1 为新化合物，命名为固公果酸A，化合物2 为首次从蔷薇属植物中分离得到，化合物5 、9 、11 、13 、15 、17 为首次从该植物中分离得到。18个化合物对MC细胞均具有增殖抑制活性，其中化合物1 、9 、14 、15 、16 、17 、18 抑制率大于50%，是潜在的干预胃炎-癌转化的活性成分。
固公果
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胃炎-癌转化
/
固公果酸A
/
5-没食子酰奎宁酸
/
没食子儿茶素没食子酸酯
/
槲皮苷
/
木犀草素
Objective This study aimed to explore the bioactive constituents of Rosa odorata Sweet var. gigantea (Coll. et Hemsl.) Rehd. et Wils. fruits that intervene in the gastritis-cancer transformation process. Methods The transformation of human gastric mucosal epithelial cells (GES-1 cells) was induced by N -methyl-N ′-nitro-N -nitrosoguanidine (MNNG) to obtain human gastric mucosal epithelial dermatitis-cancer transformation model cells (MC cells)., The activity screening was conducted on the different polar fractions from the 60% ethanol extract of R. odorata var. gigantea fruits. Active fractions were isolated and purified using multiple chromatographic techniques, including silica gel column chromatography, ODS column chromatography, Sephadex LH-20 column chromatography, and preparative high-performance liquid chromatography (preparative HPLC). The chemical structures of the isolated compounds were elucidated based on physico-chemical properties and spectroscopic data. The CCK-8 assay was utilized to evaluate the anti-proliferative activity of the isolated monomeric compounds against MC cells. Results A total of 18 compounds were isolated and identified from the active fractions of R. odorata var. gigantea fruits, namely: (2R ,3R )-3-[(1' S ,2' R ,6' S )-2' ,6' -dihydroxy-1' -(galloyl)cyclohexyl]-2,3-dihydroxypropanoic acid (1 ), microphyllose A (2 ), caffeic acid (3 ), 3,5-dicaffeoylquinic acid (4 ), 5-galloylquinic acid (5 ), ethyl vanillate (6 ), procyanidin B2 (7 ), 3-O- galloylquinic acid (8 ), gallocatechin gallate (9 ), 6-O- galloyl-β-D- glucose (10 ), methyl gallate (11 ), 3,4,5-tri-O- galloylquinic acid (12 ), ethyl gallate (13 ), 3,5,4' -trihydroxystilbene (14 ), quercitrin (15 ), quercetin (16 ), luteolin (17 ), and betulinic acid (18 ). The results of the activity assay indicated that compounds1 , 9 ,14 —18 with an inhibition rate exceeding 50% exhibited the following IC50 values: 93.47, 81.79, 37.44, 81.58, 86.01, 44.02, and 66.12 μmol/L. Conclusion Compound1 is a novel compound, designated as gugongguoic acid A. Compound2 was isolated from the genus Rosa for the first time. Compounds5 ,9 ,11 ,13 ,15 , and17 were isolated from this plant species for the first time. All 18 compounds exhibited inhibitory activity against MC cell proliferation. Among them, compounds1 , 9 ,14 —18 showed inhibition rates greater than 50%, which represent potential bioactive constituents for intervening in the gastritis–cancer transformation process.
Rosa odorata Sweet var. gigantea (Coll. et Hemsl.) Rehd. et Wils.
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gastritis-cancer transformation
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gugongguoic acid A
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5-galloylquinic acid
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gallocatechin gallate
/
quercitrin
/
luteolin
陈宇航, 姚彬, 尹孝荣, 原震, 张静泽, 刘岱琳.
固公果果实干预胃炎-癌转化的活性成分研究.
中草药,
2026
, 57
(3)
: 806
-816
.
DOI: 10.7501/j.issn.0253-2670.2026.03.003
CHEN Yuhang, YAO Bin, YIN Xiaorong, YUAN Zhen, ZHANG Jingze, LIU Dailin.
Active components of Rosa odorata var. gigantea fruits in intervening gastritis-cancer transformation[J].
Chinese Traditional and Herbal Drugs ,
2026
, 57
(3)
: 806
-816
.
DOI: 10.7501/j.issn.0253-2670.2026.03.003
参考文献
引证文献
杨俊美. 固公果根和美丽獐牙菜的化学成分研究 [D]. 昆明: 云南中医学院, 2014.et al . The fruit of Rosa odorata sweet var. Gigantea (Coll. et Hemsl.) Rehd. et Wils attenuates chronic atrophic gastritis induced by MNNG and its potential mechanism [J]. J Ethnopharmacol , 2025, 337(Pt 2): 118876.J Gastrointest Oncol , 2020, 11 (6): 1242-1252. et al . N -Methyl-N -nitro-N '-nitrosoguanidine induces the expression of CCR2 in human gastric epithelial cells promoting CCl2 -mediated migration [J]. Mol Med Rep , 2015, 13(2): 1083-1090.et al . Tanshinone I attenuates gastric precancerous lesions by inhibiting epithelial mesenchymal transition through the p38/STAT3 pathway [J]. Int Immunopharmacol , 2023, 124(Pt A): 110902.et al . A convergent route to enantiomers of the bicyclic monosaccharide bradyrhizose leads to insight into the bioactivity of an immunologically silent lipopolysaccharide [J]. J Org Chem , 2019, 84(1):14-41.Neocarya macrophylla fruits against Naja nigricolli s venom [J]. Carbohydr Res , 2021, 509: 108436.Quercus Stenophylla [J]. Phytochemistry , 1984, 23(11): 2621-2623.O -β-d-glucopyranoside from Indigofera aspalathoides Vahl ex DC. (Papilionaceae) [J]. Med Chem Res , 2015, 24(7): 2889-2897.et al . In vitro tyrosinase inhibitory and antioxidant activities of extracts and constituents of Paeonia lactiflora Pall. flowers [J]. Nat Prod J , 2017, 7(3): 237-245.Quercus stenophylla [J]. Phytochemistry , 1984, 23(11): 2621-2623.et al . Neuraminidase inhibitors from Reynoutria elliptica [J]. Arch Pharmacal Res , 2003, 26(5): 367-374.et al . Decoding inflammatory mediators in the C orrea ’s cascade: From chronic gastritis to carcinogenesis and targeted therapies [J]. Int Immunopharmacol , 2025, 162: 115191.et al . Gallic acid alleviates gastric precancerous lesions through inhibition of epithelial mesenchymal transition via Wnt/β-catenin signaling pathway [J]. J Ethnopharmacol , 2023, 302(Pt A): 115885.et al . Xiao Tan He Wei Decoction reverses MNNG-induced precancerous lesions of gastric carcinoma in vivo and vitro : Regulation of apoptosis through NF-κB pathway [J]. Biomed Pharmacother , 2018, 108: 95-102.
2026年第57卷第3期
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doi: 10.7501/j.issn.0253-2670.2026.03.003
https://castjournals.cast.org.cn/joweb/zcy/CN/10.7501/j.issn.0253-2670.2026.03.003
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2种不同金属材料的力学参数
科 属数 种数 占总种数比例 属 种数 占总种数比例 鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78 小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39 多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39 红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87 小菇属 Mycena 11 5.26 光柄菇属 Pluteus 5 2.39 红菇属 Russula 17 8.13 栓菌属 Trametes 5 2.39
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