中草药

斑马鱼肝损伤-肝纤维化-肝细胞癌模型的建立及中药干预作用研究进展

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中草药 | 综述 2026,57(2): 749-766

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中草药 |综述 2026 , 57 (2) : 749 -766

斑马鱼肝损伤-肝纤维化-肝细胞癌模型的建立及中药干预作用研究进展

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杨佳瑶^1,2, 王雪梅^1,2, 孙海龙^3,4, 姚娟^1,5, 靳晓杰^1,2, 罗慧英¹, 刘雪枫^1,2

作者信息

通讯作者:

罗慧英

作者简介:

杨佳瑶: 杨佳瑶，硕士研究生，研究方向为中药药效物质基础。E-mail: yangjiayao959@163.com

Research progress on establishment of zebrafish liver injury-fibrosis-hepatocellular carcinoma model and intervention effects of traditional Chinese medicine

YANG Jiayao, WANG Xuemei, SUN Hailong, YAO Juan, JIN Xiaojie, LUO Huiying, LIU Xuefeng

Affiliations

doi: 10.7501/j.issn.0253-2670.2026.02.032

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摘要

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斑马鱼凭借其胚胎透明性、遗传可操作性及与哺乳动物高度保守的肝脏结构与功能，已成为肝脏疾病机制研究与药物开发的重要模式生物。通过系统综述斑马鱼在肝损伤、肝纤维化及肝细胞癌中的模型构建方法，重点探讨中药组分在改善肝损伤、抗纤维化及抗肿瘤方面的治疗作用，旨在为拓展斑马鱼模型在肝脏疾病研究中的应用及推动中药防治肝脏疾病的研究提供新思路与方法。

关键词

斑马鱼 / 肝损伤 / 肝纤维化 / 肝细胞癌 / 中药

Abstract

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Zebrafish are a critical model organism for investigating liver disease mechanisms and drug discovery because of their embryonic transparency and genetic manipulability, as well as their possession of a structurally and functionally conserved liver highly homologous to mammals. This review systematically summarizes methodologies for establishing zebrafish models of liver injury, hepatic fibrosis, and hepatocellular carcinoma, and focuses on exploring the therapeutic effects of traditional Chinese medicine (TCM) components in ameliorating liver injury, counteracting fibrogenesis, and inhibiting tumorigenesis,with the aims of providing novel perspectives and methodologies for advancing the application of zebrafish models in hepatopathology research and promoting TCM-based interventions for liver diseases.

Key words

zebrafish / liver injury / hepatic fibrosis / hepatocellular carcinoma / traditional Chinese medicine

引用本文

杨佳瑶, 王雪梅, 孙海龙, 姚娟, 靳晓杰, 罗慧英, 刘雪枫. 斑马鱼肝损伤-肝纤维化-肝细胞癌模型的建立及中药干预作用研究进展. 中草药, 2026 , 57 (2) : 749 -766 . DOI: 10.7501/j.issn.0253-2670.2026.02.032

YANG Jiayao, WANG Xuemei, SUN Hailong, YAO Juan, JIN Xiaojie, LUO Huiying, LIU Xuefeng. Research progress on establishment of zebrafish liver injury-fibrosis-hepatocellular carcinoma model and intervention effects of traditional Chinese medicine[J]. Chinese Traditional and Herbal Drugs, 2026 , 57 (2) : 749 -766 . DOI: 10.7501/j.issn.0253-2670.2026.02.032

基金

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国家自然科学基金项目 (82460841); 甘肃省重点人才（青年团队）项目 (2024QNTD36); 甘肃省自然科学基金项目 (22JR11RA114); 甘肃省高校产业支撑计划项目 (2024CYZC-39); 甘肃省中医药研究中心开放课题 (zyzx-2023-01); 甘肃中医药大学校级创新创业项目 (2026CXCY-319)

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2026年第57卷第2期

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doi: 10.7501/j.issn.0253-2670.2026.02.032

接收时间：2025-07-19
首发时间：2026-09-09

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2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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