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The formula of ZhiziChi Decoction is simple. Modern pharmacological studies have found that the active components of Zhizichi Decoction have the effects such as sedation and sleep induction, hypoglycemic action, regulation of lung tissue damage, protection of liver and myocardial cells. This classic formula is used to treat agrypnia and annoyance with heat, clinically, it has been used for treatment of neurological disorders and gastrointestinal diseases. This paper systematically summarizes and sorts out the pharmacological effects, modern clinical applications and modern research of Zhizichi Decoction, which can provide a theoretical basis for the future research and development of ZhiziChi Decoction., authors=MAO Wenyi, TIAN Zhengyanfei, WANG Shiqi, HONG Yi, HE Jianhua, LU Shan, ZHANG Guizhi, GUO Yujie, authorsList=MAO Wenyi, TIAN Zhengyanfei, WANG Shiqi, HONG Yi, HE Jianhua, LU Shan, ZHANG Guizhi, GUO Yujie, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1304406879468286096, articleId=1304406878931415182, tenantId=1146029695717560320, journalId=1302319053441957962, language=CN, title=栀子豉汤药理作用及临床应用的现代研究进展, columnId=1304140194685415572, journalTitle=中草药, columnName=综述, runingTitle=null, highlight=null, articleAbstract=栀子豉汤首载于汉代张仲景所著伤寒论》，收录于国家中医药管理局公布的古代经典名方目录（第二批）》，是治疗“虚烦”“心中懊侬”的经典方剂。栀子豉汤组方简洁，现代药理学表明其活性成分具有镇静催眠、降糖、调节肺组织损伤、保护肝脏和心肌细胞等作用。该方主治热郁胸膈不寐证，临床多用于神经系统疾病、胃肠道疾病等。通过对栀子豉汤的药理作用、现代临床应用及现代研究等进行系统总结和分析，为栀子豉汤未来的研究和开发提供理论依据。, authors=茅雯怡1 , 田郑妍斐1 , 王诗琪1 , 洪怡1,2 , 贺建华1,2 , 卢山1,2 , 张桂芝1,2 , 郭瑜婕1,2 , authorsList=茅雯怡, 田郑妍斐, 王诗琪, 洪怡, 贺建华, 卢山, 张桂芝, 郭瑜婕, authorCompany=1 湖北中医药大学药学院 药物制剂中心, 湖北 武汉 430065; et al . Geniposide-mediated protection against amyloid deposition and behavioral impairment correlates with downregulation of mTOR signaling and enhanced autophagy in a mouse model of Alzheimer's disease[J]. Aging , 2019, 11(2):536-548.et al . Geniposide protects against neurotoxicity in mouse models of rotenone-induced Parkinson's disease involving the mTOR and Nrf2 pathways[J]. J Ethnopharmacol , 2024, 318(PtA):116914.et al . Neuroprotective effects of Huang-Lian-Jie-Du-Decoction on ischemic stroke rats revealed by 1 H NMR metabolomics approach[J]. J Pharm Biomed Anal , 2014, 88:106-116.et al . Free and bound phenolics of buckwheat varieties:HPLC characterization, antioxidant activity, and inhibitory potency towards α-glucosidase with molecular docking analysis[J]. Antioxidants , 2019, 8(12):606.et al . Gut feelings:The relations between depression, anxiety, psychotropic drugs and the gut microbiome[J]. Gut Microbes, 2023, 15(2):2281360.et al . A systematic review of gut microbiota composition in observational studies of major depressive disorder, bipolar disorder and schizophrenia[J]. Mol Psychiatry , 2022, 27(4):1920-1935.et al . Butyrate emerges as a crucial effector of Zhi-Zi-Chi Decoctions to ameliorate depression via multiple pathways of brain-gut axis[J]. Biomed Pharmacother , 2022, 149:112861.et al . PACAP/VIP in the prefrontal cortex mediates the rapid antidepressant effects of Zhizichi Decoction[J]. J Ethnopharmacol , 2024, 335:118638.et al . Zhizichi Decoction alleviates depressive-like behaviors through modulating mitochondria-associated membrane via the IP3R3-GRP75-VDAC1 complex[J]. J Ethnopharmacol , 2025, 346:119628.et al . Depression- understanding, identifying, and diagnosing[J]. N Engl J Med , 2024, 390(17):e41.et al . Zhi-zi-chi Decoction:A promising remedy for liver inflammation via gut microbiota modulation[J]. Fitoterapia, 2025, 184: 106603.et al . Effective therapeutic verification of crocin I, geniposide, and Gardenia (Gardenia jasminoides Ellis) on type 2 diabetes mellitus in vivo and in vitro[J]. Foods, 2023, 12(8):1668.et al . Inhibition of autophagy by geniposide protects against myocardial ischemia/ reperfusion injury[J]. Int Immunopharmacol , 2020, 85: 106609.et al . Maintained particulate integrity of soy protein nanoparticles during gastrointestinal digestion via genipin crosslinking enhancing stability and bioavailability of curcumin[J]. Int J Biol Macromol, 2024, 274(Pt2):133213.et al . Soy protein isolate/genipin-based nanoparticles for the stabilization of Pickering emulsion to design self-healing guar gum-based hydrogels[J]. Biomacromolecules , 2023, 24(5):2087-2099.)
中草药
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2026
, 57
(2) :
737
-748
栀子豉汤药理作用及临床应用的现代研究进展
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茅雯怡1 , 田郑妍斐1 , 王诗琪1 , 洪怡1,2 , 贺建华1,2 , 卢山1,2 , 张桂芝1,2 , 郭瑜婕1,2
作者信息
1 湖北中医药大学药学院 药物制剂中心, 湖北 武汉 430065;
通讯作者:
张桂芝
作者简介:
茅雯怡: 茅雯怡，硕士研究生。E-mail: mwy122000@163.com
Modern research progress on pharmacological effects and clinical applications of Zhizichi Decoction
MAO Wenyi, TIAN Zhengyanfei, WANG Shiqi, HONG Yi, HE Jianhua, LU Shan, ZHANG Guizhi, GUO Yujie
Affiliations
doi: 10.7501/j.issn.0253-2670.2026.02.031
文章导航
栀子豉汤首载于汉代张仲景所著伤寒论》，收录于国家中医药管理局公布的古代经典名方目录（第二批）》，是治疗“虚烦”“心中懊侬”的经典方剂。栀子豉汤组方简洁，现代药理学表明其活性成分具有镇静催眠、降糖、调节肺组织损伤、保护肝脏和心肌细胞等作用。该方主治热郁胸膈不寐证，临床多用于神经系统疾病、胃肠道疾病等。通过对栀子豉汤的药理作用、现代临床应用及现代研究等进行系统总结和分析，为栀子豉汤未来的研究和开发提供理论依据。
栀子豉汤
/
催眠镇静
/
抗抑郁
/
失眠症
/
抑郁症
Zhizichi Decoction (栀子豉汤) firstly recorded in the Treatise on Febrile Diseases written by Zhang Zhongjing, was included in the Catalogue of Ancient Classical Prescriptions (second batch) published by the National Administration of Traditional Chinese Medicine, which is a classic prescription for treating “restlessness due to deficiency” and “inner distress”. The formula of ZhiziChi Decoction is simple. Modern pharmacological studies have found that the active components of Zhizichi Decoction have the effects such as sedation and sleep induction, hypoglycemic action, regulation of lung tissue damage, protection of liver and myocardial cells. This classic formula is used to treat agrypnia and annoyance with heat, clinically, it has been used for treatment of neurological disorders and gastrointestinal diseases. This paper systematically summarizes and sorts out the pharmacological effects, modern clinical applications and modern research of Zhizichi Decoction, which can provide a theoretical basis for the future research and development of ZhiziChi Decoction.
Zhizichi Decoction
/
hypnotic sedation
/
anti-depression
/
insomnia
/
depression
茅雯怡, 田郑妍斐, 王诗琪, 洪怡, 贺建华, 卢山, 张桂芝, 郭瑜婕.
栀子豉汤药理作用及临床应用的现代研究进展.
中草药,
2026
, 57
(2)
: 737
-748
.
DOI: 10.7501/j.issn.0253-2670.2026.02.031
MAO Wenyi, TIAN Zhengyanfei, WANG Shiqi, HONG Yi, HE Jianhua, LU Shan, ZHANG Guizhi, GUO Yujie.
Modern research progress on pharmacological effects and clinical applications of Zhizichi Decoction[J].
Chinese Traditional and Herbal Drugs ,
2026
, 57
(2)
: 737
-748
.
DOI: 10.7501/j.issn.0253-2670.2026.02.031
参考文献
引证文献
国家药品监督管理局.关于印发古代经典名方目录(第二批)》的通知[EB/OL]. (2023-08-23)[2025-06-27]. http://www.natcm.gov.cn/kejisi/gongzuodongtai/2023-09-01/31743.html.et al . Geniposide-mediated protection against amyloid deposition and behavioral impairment correlates with downregulation of mTOR signaling and enhanced autophagy in a mouse model of Alzheimer's disease[J]. Aging , 2019, 11(2):536-548.et al . Geniposide protects against neurotoxicity in mouse models of rotenone-induced Parkinson's disease involving the mTOR and Nrf2 pathways[J]. J Ethnopharmacol , 2024, 318(PtA):116914.et al . Neuroprotective effects of Huang-Lian-Jie-Du-Decoction on ischemic stroke rats revealed by 1 H NMR metabolomics approach[J]. J Pharm Biomed Anal , 2014, 88:106-116.et al . Free and bound phenolics of buckwheat varieties:HPLC characterization, antioxidant activity, and inhibitory potency towards α-glucosidase with molecular docking analysis[J]. Antioxidants , 2019, 8(12):606.et al . Gut feelings:The relations between depression, anxiety, psychotropic drugs and the gut microbiome[J]. Gut Microbes, 2023, 15(2):2281360.et al . A systematic review of gut microbiota composition in observational studies of major depressive disorder, bipolar disorder and schizophrenia[J]. Mol Psychiatry , 2022, 27(4):1920-1935.et al . Butyrate emerges as a crucial effector of Zhi-Zi-Chi Decoctions to ameliorate depression via multiple pathways of brain-gut axis[J]. Biomed Pharmacother , 2022, 149:112861.et al . PACAP/VIP in the prefrontal cortex mediates the rapid antidepressant effects of Zhizichi Decoction[J]. J Ethnopharmacol , 2024, 335:118638.et al . Zhizichi Decoction alleviates depressive-like behaviors through modulating mitochondria-associated membrane via the IP3R3-GRP75-VDAC1 complex[J]. J Ethnopharmacol , 2025, 346:119628.et al . Depression- understanding, identifying, and diagnosing[J]. N Engl J Med , 2024, 390(17):e41.et al . Zhi-zi-chi Decoction:A promising remedy for liver inflammation via gut microbiota modulation[J]. Fitoterapia, 2025, 184: 106603.et al . Effective therapeutic verification of crocin I, geniposide, and Gardenia (Gardenia jasminoides Ellis) on type 2 diabetes mellitus in vivo and in vitro[J]. Foods, 2023, 12(8):1668.et al . Inhibition of autophagy by geniposide protects against myocardial ischemia/ reperfusion injury[J]. Int Immunopharmacol , 2020, 85: 106609.et al . Maintained particulate integrity of soy protein nanoparticles during gastrointestinal digestion via genipin crosslinking enhancing stability and bioavailability of curcumin[J]. Int J Biol Macromol, 2024, 274(Pt2):133213.et al . Soy protein isolate/genipin-based nanoparticles for the stabilization of Pickering emulsion to design self-healing guar gum-based hydrogels[J]. Biomacromolecules , 2023, 24(5):2087-2099.
2026年第57卷第2期
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doi: 10.7501/j.issn.0253-2670.2026.02.031
接收时间：2025-08-03
首发时间：2026-09-09
https://castjournals.cast.org.cn/joweb/zcy/CN/10.7501/j.issn.0253-2670.2026.02.031
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2种不同金属材料的力学参数
科 属数 种数 占总种数比例 属 种数 占总种数比例 鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78 小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39 多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39 红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87 小菇属 Mycena 11 5.26 光柄菇属 Pluteus 5 2.39 红菇属 Russula 17 8.13 栓菌属 Trametes 5 2.39
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