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However, their clinical application is limited by challenges including high molecular weight, low solubility, and consequently poor bioavailability. Selenization modification has emerged as an effective strategy to improve the physicochemical properties and biological functions of APS, leading to the formation of selenized APS (Se-APS) and APS-selenium nanoparticles (APS-SeNPs). This review systematically summarizes the preparation methods, structural characteristics, biological activities, and structure-activity relationships of selenium-containing APS derivatives, and discusses their application prospects. Primary preparation techniques include biological transformation and chemical synthesis approaches. Following selenization, the resulting products demonstrate significantly improved solubility, stability, and bioavailability, and can form uniformly sized nanoparticles. Research indicates that selenium-containing APS derivatives exhibit superior pharmacological efficacy compared to native APS, including enhanced antioxidant, immunomodulatory, antitumor, and hepatoprotective activities. Furthermore, APS-SeNPs can serve as effective drug delivery carriers and show synergistic effects when combined with other bioactive compounds. Structure-activity relationship studies suggest that their bioactivity is closely associated with selenium content, molecular weight, and nanostructural attributes. Nevertheless, several challenges remain in this field, such as insufficient characterization of selenization sites and a lack of systematic toxicological evaluation. Future research should focus on optimizing preparation processes, strengthening safety assessments, and promoting clinical translation to advance their applications in the pharmaceutical and functional food industries., authors=CHEN Fangyuan, YAO Jinlong, WANG Pan, WANG Jilong, authorsList=CHEN Fangyuan, YAO Jinlong, WANG Pan, WANG Jilong, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1304406862619763329, articleId=1304406862376493696, tenantId=1146029695717560320, journalId=1302319053441957962, language=CN, title=黄芪硒多糖的制备、结构、活性及应用研究进展, columnId=1304140194685415572, journalTitle=中草药, columnName=综述, runingTitle=null, highlight=null, articleAbstract=黄芪多糖（Astragalus polysaccharides，APS）是黄芪的主要活性成分，具有多种药理活性，但因其高相对分子质量、低溶解性导致生物利用度较低，限制了其临床应用。硒化修饰可有效改善其理化特性及生物活性，形成硒化黄芪多糖（Se-APS）和黄芪多糖纳米硒（APS-SeNPs）。通过系统综述黄芪硒多糖的制备方法、结构特性、生物活性及构效关系，并展望其应用前景。目前制备方法主要包括生物转化法和化学合成法，硒化后产物溶解性、稳定性显著提高，并可形成粒径均匀的纳米颗粒，生物利用度明显提升。研究表明，黄芪硒多糖表现出优于APS的抗氧化、免疫调节、抗肿瘤、保肝等药理活性，且APS-SeNPs可作为良好药物载体与其他活性成分协同增效。构效关系表明其活性与硒含量、相对分子质量及纳米结构密切相关。目前该领域仍面临硒化位点解析不足、系统毒理学研究缺乏等挑战，后续应加强制备工艺优化、安全性评价及临床转化研究，推动其在医药和功能食品领域的应用与发展。, authors=陈方圆¹, 姚进龙¹, 王盼¹, 王继龙², authorsList=陈方圆, 姚进龙, 王盼, 王继龙, authorCompany=1 甘肃卫生职业学院, 甘肃 兰州 730207;
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Extraction, structure, and activity of polysaccharide from Radix Astragali[J]. Biomed Pharmacother, 2022, 150:113015.
杨乾方,王帆,叶婷,等.黄芪多糖提取工艺、化学结构及药理作用的研究进展[J]. 中草药, 2023, 54(12):4069-4081.
吴建军,邹剑,马致洁,等.从2005-2023年国家自然科学基金资助项目浅谈中药多糖的研究现状[J]. 中草药, 2024, 55(4):1053-1062.
Du Y, Wan H T, Huang P, et al. A critical review of Astragalus polysaccharides:From therapeutic mechanisms to pharmaceutics[J]. Biomed Pharmacother,2022, 147:112654.
Sun Y, Wang Z N, Gong P, et al. Review on the healthpromoting effect of adequate selenium status[J]. Front Nutr, 2023, 10:1136458.
Wang P Z, Chen B, Huang Y, et al. Selenium intake and multiple health-related outcomes:An umbrella review of Meta-analyses[J]. Front Nutr, 2023, 10:1263853.
蔡姝雅,唐增煦,赵丽云,等.中国18岁及以上成人膳食硒的摄入状况[J]. 中国食物与营养, 2024, 30(10):78-83.
何倩倩,刘雨,满长森,等.硒多糖研究进展[J]. 食品与发酵工业, 2025, 51(11):416-425.
陈方圆,王继龙.中药多糖纳米硒的制备、活性和应用研究进展[J]. 中草药, 2025, 56(16):5994-6005.
吴应亮,蔡宗源,何康明,等.富硒植物中硒化合物的提取和分析[J]. 暨南大学学报:自然科学与医学版,1994, 15(3):70-73.
Li S, Bian F L, Yue L, et al. Selenium-dependent antitumor immunomodulating activity of polysaccharides from roots of A. membranaceus[J]. Int J Biol Macromol, 2014, 69:64-72.
陈弘.生物转化提高黄芪多糖含量及多糖富硒的研究[D]. 杭州:浙江工业大学, 2018.
Huang F, Sun X Y, Ouyang J M. Preparation and characterization of selenized Astragalus polysaccharide and its inhibitory effect on kidney stones[J]. Mater Sci Eng C Mater Biol Appl, 2020, 110:110732.
Li H Y, Wang Y X, Wang C, et al. Extraction, selenylation modification and antitumor activity of the glucan from Castanea mollissima Blume[J]. Glycoconj J, 2017, 34(2):207-217.
龚晓钟,欧阳政.硒化黄芪多糖制备条件及其结构的研究[J]. 天然产物研究与开发, 1998, 10(2):26-32.
Jiao J S, Yu J, Ji H Y, et al. Synthesis of macromolecular Astragalus polysaccharide-nano selenium complex and the inhibitory effects on HepG2 cells[J]. Int J Biol Macromol, 2022, 211:481-489.
Meng Y B, Zhang Y Y, Jia N, et al. Synthesis and evaluation of a novel water-soluble high Se-enriched Astragalus polysaccharide nanoparticles[J]. Int J Biol Macromol, 2018, 118(PtB):1438-1448.
Yue L Q, Song X X, Cui X, et al. Synthesis,characterization, and evaluation of microwave-assisted fabricated selenylation Astragalus polysaccharides[J]. Int J Biol Macromol, 2022, 221:8-15.
Ji H Y, Lou X W, Jiao J S, et al. Preliminary structural characterization of selenium nanoparticle composites modified by Astragalus polysaccharide and the cytotoxicity mechanism on liver cancer cells[J]. Molecules, 2023, 28(4):1561.
Rao S Y, Lin Y P, Lin R, et al. Traditional Chinese medicine active ingredients-based selenium nanoparticles regulate antioxidant selenoproteins for spinal cord injury treatment[J]. J Nanobiotechnology, 2022, 20(1):278.
Mai L Q, Liu J G, Wu H M, et al. Enhanced inhibition of neuronal ferroptosis and regulation of microglial polarization with multifunctional traditional Chinese medicine active ingredients-based selenium nanoparticles for treating spinal cord injury[J]. Mater Today Bio, 2025,32:101758.
Wu X X, Jia W. Multilayer annotation strategy AnnoSePS:Disentangling the intricate structure of seleniumcontaining polysaccharides based on preferential fragmentation patterns[J]. Anal Chem, 2024, 96(26):10696-10704.
陈浒华.黄芪多糖的硒化修饰及其体外抗氧化作用的研究[D]. 南京:南京农业大学, 2010.
刘婕.黄芪多糖和白术多糖及其硒化衍生物增强免疫和抗氧化活性的研究[D]. 南京:南京农业大学, 2015.
翟天瑞,刘华伟,易明瀚,等.硒化黄芪多糖对蛋鸡生长性能、抗氧化能力和免疫功能的影响[J]. 中国家禽,2024, 46(2):44-51.
李树颖,李科,秦雪梅,等.注射用黄芪多糖研究进展与二次开发思路[J]. 中国中药杂志, 2019, 44(13):2736-2741.
Long Y, Yang J J, Ji H F, et al. Gut microbiota mediated immunoregulatory effects of Dendrobium officinale polysaccharides-selenium nanoparticles complexes[J]. Food Biosci, 2025, 69:107033.
Bray F, Laversanne M, Sung H, et al. Global cancer statistics 2022:GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin, 2024, 74(3):229-263.
陈璇.黄芪硒多糖对人肝癌HepG-2细胞凋亡作用的研究[D]. 哈尔滨:哈尔滨商业大学, 2014.
Ji Y B, Dong F, Yu M. Selenylation, characterization and cytotoxic activity of seleno-Astragalus polysaccharide[J]. Appl Mech Mater, 2013, 411-414:3146-3149.
柏冬志.黄芪硒多糖对人体MCF-7乳腺癌细胞的凋亡研究[D]. 哈尔滨:哈尔滨商业大学, 2014.
唐文婷.黄芪硒多糖对于人胃癌SGC-7901细胞凋亡作用研究[D]. 哈尔滨:哈尔滨商业大学, 2014.
张亚非,吴凤兰,张明珠.维生素E与硒化黄芪多糖对小鼠S180肉瘤的抑瘤作用及相互影响[J]. 癌症,1996, 15(3):192-194.
刘丹.黄芪硒多糖对S180荷瘤小鼠抑瘤作用及血清中抗氧化酶系的影响[D]. 哈尔滨:哈尔滨商业大学,2014.
张亚非,吴凤兰,张明珠.硒化黄芪多糖对小鼠的抑瘤和抗氧化作用研究[J]. 中国公共卫生学报, 1997,16(4):229-230.
Duan Z Y, Liang M D, Yang C C, et al. Selenium nanoparticles coupling with Astragalus polysaccharides exert their cytotoxicities in MCF-7 cells by inhibiting autophagy and promoting apoptosis[J]. J Trace Elem Med Biol, 2022, 73:127006.
Hamid M, Liu D D, Abdulrahim Y, et al. Amelioration of CCl4-induced liver injury in rats by selenizing Astragalus polysaccharides:Role of proinflammatory cytokines,oxidative stress and hepatic stellate cells[J]. Res Vet Sci,2017, 114:202-211.
Hamid M, Liu D D, Abdulrahim Y, et al. Inactivation of kupffer cells by selenizing Astragalus polysaccharides prevents CCl4-induced hepatocellular necrosis in the male wistar rat[J]. Biol Trace Elem Res, 2017, 179(2):226-236.
Sheng X X, Ward M D, Wesson J A. Crystal surface adhesion explains the pathological activity of calcium oxalate hydrates in kidney stone formation[J]. J Am Soc Nephrol, 2005, 16(7):1904-1908.
Coe F L, Evan A P, Worcester E M, et al. Three pathways for human kidney stone formation[J]. Urol Res, 2010,38(3):147-160.
Han J, Guo D, Sun X Y, et al. Repair effects of Astragalus polysaccharides with different molecular weights on oxidatively damaged HK-2 cells[J]. Sci Rep, 2019, 9(1):9871.
Huang F, Sun X Y, Chen X W, et al. Effects of selenized Astragalus polysaccharide on the adhesion and endocytosis of nanocalcium oxalate dihydrate after the repair of damaged HK-2 cells[J]. ACS Biomater Sci Eng,2021, 7(2):739-751.
Liu D D, Xu J, Qian G, et al. Selenizing Astragalus polysaccharide attenuates PCV2 replication promotion caused by oxidative stress through autophagy inhibition via PI3K/Akt activation[J]. Int J Biol Macromol, 2018,108:350-359.)