中草药

基于相态特征的中药质量评价研究进展

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中草药 | 综述 2026,57(1): 314-321

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中草药 |综述 2026 , 57 (1) : 314 -321

基于相态特征的中药质量评价研究进展

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作者信息

通讯作者:

史静超

作者简介:

胡英还: 胡英还,讲师,从事中药药效成分与机制研究。E-mail:huyinghuan@sxtcm.edu.cn

Research progress on quality evaluation of traditional Chinese medicine based on phase

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doi: 10.7501/j.issn.0253-2670.2026.01.028

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摘要

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现有中药质量评价多聚焦于静态的化学成分解析，忽视了成分间的相互作用。中药相态是不同或相同成分通过分子间作用力组成的有序组合物，是中药发挥药效的重要形式，也是中药质量评价的重要补充，体现了中药多成分协同发挥药效的特征。通过系统综述中药相态特征作为质量评价新维度的重要性，总结了中药相态的形成机制、研究方法及其在配伍减毒、增效中的作用，并探讨了活性相态筛选、表征策略及可能存在的问题，为中药质量评价从成分论向“化学-结构-功能”一体化转变提供理论依据。

关键词

中药质量评价 / 相态 / 自组装 / 超分子 / 质量标志物

Abstract

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Current quality evaluation of traditional Chinese medicine (TCM) primarily focuses on chemical composition analysis, neglecting the interactions among components. The phase of TCM is an ordered combination formed by different or identical components through intermolecular forces, serving as a crucial form for TCM efficacy and a vital supplement to its quality assessment. It reflects the characteristic of multiple components synergistically exerting pharmacological effects. This article systematically reviewed the importance of TCM phase in quality evaluation. We summarized the formation mechanisms and research methods of TCM phase, as well as their roles in reducing toxicity and enhancing efficacy. Furthermore, we discussed the research strategies for screening active phases, characterization approaches, and potential challenges, providing a theoretical basis for transitioning TCM quality evaluation from a composition-based perspective to a “chemistry-structure-function integrated” model.

Key words

quality evaluation of traditional Chinese medicine / phase / self-assembly / supramolecule / quality markers

引用本文

胡英还, 于舒婷, 李若彤, 史静超, 秦雪梅. 基于相态特征的中药质量评价研究进展. 中草药, 2026 , 57 (1) : 314 -321 . DOI: 10.7501/j.issn.0253-2670.2026.01.028

HU Yinghuan, YU Shuting, LI Ruotong, SHI Jingchao, QIN Xuemei. Research progress on quality evaluation of traditional Chinese medicine based on phase[J]. Chinese Traditional and Herbal Drugs, 2026 , 57 (1) : 314 -321 . DOI: 10.7501/j.issn.0253-2670.2026.01.028

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国家自然科学基金区域创新发展联合基金项目 (U23A20517); 中药生命组学与创新药物研发研究室 (zyyjs2024019)

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2026年第57卷第1期

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doi: 10.7501/j.issn.0253-2670.2026.01.028

接收时间：2025-09-15
首发时间：2026-09-09

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2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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