Article(id=1304406862879813666, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1304406818550206926, articleNumber=null, orderNo=null, doi=10.7501/j.issn.0253-2670.2026.01.005, pmid=null, cstr=null, oa=null, hot=0, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1762444800000, receivedDateStr=2025-11-07, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1788924430818, onlineDateStr=2026-09-09, pubDate=null, pubDateStr=null, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1788924430818, onlineIssueDateStr=2026-09-09, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1788924430818, creator=13701087609, updateTime=1788924430818, updator=13701087609, issue=Issue{id=1304406818550206926, tenantId=1146029695717560320, journalId=1302319053441957962, year='2026', volume='57', issue='1', pageStart='1', pageEnd='389', issueExtLink='null', onlineDate='null', pubDate='1768147200000', pubDateStr='2026-01-12', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1788924420249, creator='13701087609', updateTime=1788924674802, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1304407886289986387, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1304406818550206926, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1304407886289986388, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1304406818550206926, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=39, endPage=44, ext={EN=ArticleExt(id=1304406863286661156, articleId=1304406862879813666, tenantId=1146029695717560320, journalId=1302319053441957962, language=EN, title=A new isocoumarin isolated from flower buds of Panax notoginseng , columnId=null, journalTitle=Chinese Traditional and Herbal Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=Objective To study the non-saponin chemical constituents of the flower buds of Panax notoginseng and evaluate their antioxidant and anti-inflammatory activities. Methods The extraction was performed by refluxing with 65% aqueous ethanol, followed by successive liquid-liquid extraction with petroleum ether, ethyl acetate (EtOAc) and n -butanol. The compounds were isolated and purified using RP-18, silica gel, MCI gel CHP20P, Sephadex LH-20 column chromatography and semi-preparative liquid chromatography. Structural identification was carried out by comprehensive analysis of nuclear magnetic resonance (NMR) spectroscopy, high-resolution mass spectrometry (HR-MS), ultraviolet (UV) spectroscopy, and computational electronic circular dichroism (ECD) spectroscopy. Some purified compounds were evaluated for preliminary antioxidant activity and anti-inflammatory activity. Results A total of seven non-saponin components were isolated from the EtOAc fraction of P . notoginseng flower buds, including one isocoumarin (1 ), four simple phenols (2 —5 ), and two loliolides (6 , 7 ), were obtained from the EtOAc fraction. These were identified as isocoumarin F1 (1 ), ferulic acid (2 ), evofolin A (3 ), p -hydroxybenzoic acid (4 ), 4-hydroxybenzaldehyde (5 ), (+)-epiloliolide (6 ), and (-)-loliolide (7 ), respectively. Conclusion All compounds (1 —7 ) were isolated from P. notoginseng for the first time. Of which, compound 1 is a new isocoumarin and named isocoumarin F1, while compound 2 exhibited obvious DPPH radical scavenging ability., authors=YANG Ping, WANG Xinxin, SHANG Jiahuan, ZHU Hongtao, ZHAO Ping, ZHU Guolei, ZHANG Yingjun, authorsList=YANG Ping, WANG Xinxin, SHANG Jiahuan, ZHU Hongtao, ZHAO Ping, ZHU Guolei, ZHANG Yingjun, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1304406863123083299, articleId=1304406862879813666, tenantId=1146029695717560320, journalId=1302319053441957962, language=CN, title=三七花中1个新异香豆素, columnId=1304140187169214944, journalTitle=中草药, columnName=化学成分, runingTitle=null, highlight=null, articleAbstract=目的 研究三七Panax notoginseng 花中的非皂苷类化学成分及其抗氧化和抗炎活性。方法 采用65%乙醇水溶液热回流提取,石油醚、醋酸乙酯与正丁醇萃取,通过RP-18、硅胶、MCI gel CHP20P、Sephadex LH-20等柱色谱及半制备液相色谱等方法进行化合物的分离及纯化,综合运用核磁共振谱、高分辨质谱、紫外、计算ECD等技术进行结构鉴定,并对部分化合物进行初步的抗氧化活性和抗炎活性评价。结果 从三七花醋酸乙酯部分分离纯化得到7个非皂苷类化合物,包括1个异香豆素类(1 )、4个简单酚类(2 ~5 )和2个黑麦草内酯类化合物(6 、7 )。分别鉴定为异香豆素F1(1 )、阿魏酸(2 )、evofolin A(3 )、对羟基苯甲酸(4 )、4-羟基苯甲醛(5 )、异黑麦草内酯(6 )和黑麦草内酯(7 )。结论 化合物1 ~7 均为首次从三七中分离得到,其中化合物1 为新的异香豆素,命名为异香豆素F1;化合物2 有较强的DPPH自由基清除能力。, authors=杨平1,2 , 王新欣2 , 尚佳欢2 , 朱宏涛2 , 赵平1 , 朱国磊1 , 张颖君2 , authorsList=杨平, 王新欣, 尚佳欢, 朱宏涛, 赵平, 朱国磊, 张颖君, authorCompany=1 西南林业大学 西南地区林业生物质资源高效利用国家林业和草原局重点实验室, 云南 昆明 650224; 2 中国科学院昆明植物研究所 植物化学与天然药物全国重点实验室, 云南 昆明 650201, correspAuthors=朱国磊, authorNote=杨平: 杨平,女,硕士研究生,研究方向为天然产物化学。E-mail:yangping@mail.kib.ac.cn
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provinceName=null, collectFlag=false, interPubPlatform=, interPubPlatformUrl=null), detailUrlCn=https://castjournals.cast.org.cn/joweb/zcy/CN/10.7501/j.issn.0253-2670.2026.01.005, detailUrlEn=https://castjournals.cast.org.cn/joweb/zcy/EN/10.7501/j.issn.0253-2670.2026.01.005, pdfUrlCn=https://castjournals.cast.org.cn/joweb/zcy/CN/PDF/10.7501/j.issn.0253-2670.2026.01.005, pdfUrlEn=https://castjournals.cast.org.cn/joweb/zcy/EN/PDF/10.7501/j.issn.0253-2670.2026.01.005, aliStartDate=null, aliEndDate=null, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=0, orderTime=1788924430818, fullTextJson=null, articleText=null, reference=殷勤红,朱艳琴,虞泓,等.三七花化学成分和药理作用的研究进展[J]. 光谱实验室, 2011, 28(3):1194-1197. 甘昌敏,陈洪熠,龚云麒.三七花化学成分的研究进展[J]. 云南中医中药杂志, 2019, 40(9):73-75. Liu J C, Wu Y H, Ma W R, et al. Anti-inflammatory activity of Panax notoginseng flower saponins quantified using LC/MS/MS[J]. Molecules, 2023, 28(5):2416. Li Y, Hei J Y, Wang B, et al. Unraveling the molecular mechanisms of flavonoid biosynthesis in Panax notoginseng flowers across planting patterns and developmental stages using integrated metabolomics and transcriptomics analyses[J]. Sci Hortic, 2024, 335:113362. 周定婷,陈晓彤,张华峰,等.人参花、三七花的化学组成及多糖提取物抗氧化、抑制血糖相关酶活性的比较研究[J]. 特产研究, 2025, 44(7):1-9. 王宁,刘聪毅,丁颖,等.杜仲雄花-三七花药对改善2型糖尿病糖脂代谢的机制研究[J]. 北京中医药大学学报, 2025, 48(10):1-16. 李欣馨,王新欣,廖彭莹,等.三七花中1个新的多烯炔型大环内酯[J]. 中草药, 2024, 55(14):4643-4649. 韦献雅,殷丽琴,钟成,等. DPPH法评价抗氧化活性研究进展[J]. 食品科学, 2014, 35(9):317-322. 俞雅芮.金桂的化学成分和生物活性研究[D]. 成都:四川大学, 2022. 马小龙,王宪,冯娟.一氧化氮对适应性免疫系统功能的调控及在相关疾病中的作用[J]. 生理科学进展,2020, 51(6):415-421. Reif D W, McCreedy S A. N-Nitro-L-arginine and Nmonomethyl-L-arginine exhibit a different pattern of inactivation toward the three nitric oxide synthases[J]. Arch Biochem Biophys, 1995, 320(1):170-176. Krohn K, Kock I, Elsässer B, et al. Bioactive natural products from the endophytic fungus Ascochyta sp. from Meliotus dentatus-configurational assignment by solidstate CD and TDDFT calculations[J]. Eur J Org Chem,2007, 2007(7):1123-1129. 李娜,赵斌,余娅芳,等.白花败酱抗炎作用化学成分研究[J]. 中药材, 2008, 31(1):51-53. 余小红,李盼盼,耿圆圆,等.小远志化学成分研究[J]. 林产化学与工业, 2017, 37(1):149-154. 孟令杰,刘百联,张英,等.地骨皮化学成分研究[J]. 中草药, 2014, 45(15):2139-2142. 李浩华,周燕燕,陈玉婵,等.紫玉盘内生真菌节菱孢中1个新的异香豆素类化合物[J]. 中草药, 2016,47(3):369-373. Park K E, Kim Y A, Jung H A, et al. Three norisoprenoids from the brown Alga Sargassum thunbergii[J]. J Korean Chem Soc, 2004, 48(4):394-398. 张旋,侴桂新.黄花败酱化学成分研究[J]. 天然产物研究与开发, 2020, 32(5):783-791. 霍志鹏,高文庆,王晴,等.阿魏酸抗氧化作用的量子化学密度泛函理论研究[J]. 现代药物与临床, 2025,40(6):1383-1388.)
中草药
|化学成分
2026
, 57
(1) :
39
-44
三七花中1个新异香豆素
全屏
杨平1,2 , 王新欣2 , 尚佳欢2 , 朱宏涛2 , 赵平1 , 朱国磊1 , 张颖君2
作者信息
1 西南林业大学 西南地区林业生物质资源高效利用国家林业和草原局重点实验室, 云南 昆明 650224; 2 中国科学院昆明植物研究所 植物化学与天然药物全国重点实验室, 云南 昆明 650201
通讯作者:
朱国磊
作者简介:
杨平: 杨平,女,硕士研究生,研究方向为天然产物化学。E-mail:yangping@mail.kib.ac.cn
王新欣: 王新欣,女,硕士研究生,研究方向为天然产物化学。E-mail:861504428@qq.com
A new isocoumarin isolated from flower buds of Panax notoginseng
YANG Ping, WANG Xinxin, SHANG Jiahuan, ZHU Hongtao, ZHAO Ping, ZHU Guolei, ZHANG Yingjun
Affiliations
doi: 10.7501/j.issn.0253-2670.2026.01.005
文章导航
目的 研究三七Panax notoginseng 花中的非皂苷类化学成分及其抗氧化和抗炎活性。方法 采用65%乙醇水溶液热回流提取,石油醚、醋酸乙酯与正丁醇萃取,通过RP-18、硅胶、MCI gel CHP20P、Sephadex LH-20等柱色谱及半制备液相色谱等方法进行化合物的分离及纯化,综合运用核磁共振谱、高分辨质谱、紫外、计算ECD等技术进行结构鉴定,并对部分化合物进行初步的抗氧化活性和抗炎活性评价。结果 从三七花醋酸乙酯部分分离纯化得到7个非皂苷类化合物,包括1个异香豆素类(1 )、4个简单酚类(2 ~5 )和2个黑麦草内酯类化合物(6 、7 )。分别鉴定为异香豆素F1(1 )、阿魏酸(2 )、evofolin A(3 )、对羟基苯甲酸(4 )、4-羟基苯甲醛(5 )、异黑麦草内酯(6 )和黑麦草内酯(7 )。结论 化合物1 ~7 均为首次从三七中分离得到,其中化合物1 为新的异香豆素,命名为异香豆素F1;化合物2 有较强的DPPH自由基清除能力。
三七花
/
异香豆素类
/
简单酚类
/
抗氧化
/
抗炎
/
异香豆素F1
/
阿魏酸
/
4-羟基苯甲醛
/
黑麦草内酯
Objective To study the non-saponin chemical constituents of the flower buds of Panax notoginseng and evaluate their antioxidant and anti-inflammatory activities. Methods The extraction was performed by refluxing with 65% aqueous ethanol, followed by successive liquid-liquid extraction with petroleum ether, ethyl acetate (EtOAc) and n -butanol. The compounds were isolated and purified using RP-18, silica gel, MCI gel CHP20P, Sephadex LH-20 column chromatography and semi-preparative liquid chromatography. Structural identification was carried out by comprehensive analysis of nuclear magnetic resonance (NMR) spectroscopy, high-resolution mass spectrometry (HR-MS), ultraviolet (UV) spectroscopy, and computational electronic circular dichroism (ECD) spectroscopy. Some purified compounds were evaluated for preliminary antioxidant activity and anti-inflammatory activity. Results A total of seven non-saponin components were isolated from the EtOAc fraction of P . notoginseng flower buds, including one isocoumarin (1 ), four simple phenols (2 —5 ), and two loliolides (6 , 7 ), were obtained from the EtOAc fraction. These were identified as isocoumarin F1 (1 ), ferulic acid (2 ), evofolin A (3 ), p -hydroxybenzoic acid (4 ), 4-hydroxybenzaldehyde (5 ), (+)-epiloliolide (6 ), and (-)-loliolide (7 ), respectively. Conclusion All compounds (1 —7 ) were isolated from P. notoginseng for the first time. Of which, compound 1 is a new isocoumarin and named isocoumarin F1, while compound 2 exhibited obvious DPPH radical scavenging ability.
flower buds of Panax notoginseng
/
isocoumarin
/
phenolics
/
antioxidant activity
/
anti-inflammatory
/
isocoumarin F1
/
ferulic acid
/
4-hydroxybenzaldehyde
/
(-)-loliolide
杨平, 王新欣, 尚佳欢, 朱宏涛, 赵平, 朱国磊, 张颖君.
三七花中1个新异香豆素.
中草药,
2026
, 57
(1)
: 39
-44
.
DOI: 10.7501/j.issn.0253-2670.2026.01.005
YANG Ping, WANG Xinxin, SHANG Jiahuan, ZHU Hongtao, ZHAO Ping, ZHU Guolei, ZHANG Yingjun.
A new isocoumarin isolated from flower buds of Panax notoginseng [J].
Chinese Traditional and Herbal Drugs ,
2026
, 57
(1)
: 39
-44
.
DOI: 10.7501/j.issn.0253-2670.2026.01.005
参考文献
引证文献
殷勤红,朱艳琴,虞泓,等.三七花化学成分和药理作用的研究进展[J]. 光谱实验室, 2011, 28(3):1194-1197. 甘昌敏,陈洪熠,龚云麒.三七花化学成分的研究进展[J]. 云南中医中药杂志, 2019, 40(9):73-75. Liu J C, Wu Y H, Ma W R, et al. Anti-inflammatory activity of Panax notoginseng flower saponins quantified using LC/MS/MS[J]. Molecules, 2023, 28(5):2416. Li Y, Hei J Y, Wang B, et al. Unraveling the molecular mechanisms of flavonoid biosynthesis in Panax notoginseng flowers across planting patterns and developmental stages using integrated metabolomics and transcriptomics analyses[J]. Sci Hortic, 2024, 335:113362. 周定婷,陈晓彤,张华峰,等.人参花、三七花的化学组成及多糖提取物抗氧化、抑制血糖相关酶活性的比较研究[J]. 特产研究, 2025, 44(7):1-9. 王宁,刘聪毅,丁颖,等.杜仲雄花-三七花药对改善2型糖尿病糖脂代谢的机制研究[J]. 北京中医药大学学报, 2025, 48(10):1-16. 李欣馨,王新欣,廖彭莹,等.三七花中1个新的多烯炔型大环内酯[J]. 中草药, 2024, 55(14):4643-4649. 韦献雅,殷丽琴,钟成,等. DPPH法评价抗氧化活性研究进展[J]. 食品科学, 2014, 35(9):317-322. 俞雅芮.金桂的化学成分和生物活性研究[D]. 成都:四川大学, 2022. 马小龙,王宪,冯娟.一氧化氮对适应性免疫系统功能的调控及在相关疾病中的作用[J]. 生理科学进展,2020, 51(6):415-421. Reif D W, McCreedy S A. N-Nitro-L-arginine and Nmonomethyl-L-arginine exhibit a different pattern of inactivation toward the three nitric oxide synthases[J]. Arch Biochem Biophys, 1995, 320(1):170-176. Krohn K, Kock I, Elsässer B, et al. Bioactive natural products from the endophytic fungus Ascochyta sp. from Meliotus dentatus-configurational assignment by solidstate CD and TDDFT calculations[J]. Eur J Org Chem,2007, 2007(7):1123-1129. 李娜,赵斌,余娅芳,等.白花败酱抗炎作用化学成分研究[J]. 中药材, 2008, 31(1):51-53. 余小红,李盼盼,耿圆圆,等.小远志化学成分研究[J]. 林产化学与工业, 2017, 37(1):149-154. 孟令杰,刘百联,张英,等.地骨皮化学成分研究[J]. 中草药, 2014, 45(15):2139-2142. 李浩华,周燕燕,陈玉婵,等.紫玉盘内生真菌节菱孢中1个新的异香豆素类化合物[J]. 中草药, 2016,47(3):369-373. Park K E, Kim Y A, Jung H A, et al. Three norisoprenoids from the brown Alga Sargassum thunbergii[J]. J Korean Chem Soc, 2004, 48(4):394-398. 张旋,侴桂新.黄花败酱化学成分研究[J]. 天然产物研究与开发, 2020, 32(5):783-791. 霍志鹏,高文庆,王晴,等.阿魏酸抗氧化作用的量子化学密度泛函理论研究[J]. 现代药物与临床, 2025,40(6):1383-1388.
2026年第57卷第1期
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doi: 10.7501/j.issn.0253-2670.2026.01.005
接收时间:2025-11-07
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2种不同金属材料的力学参数
科 Family 属数 Number of genus 种数 Number of species 占总种数比例 Percentage of total species (%) 属 Genus 种数 Number of species 占总种数比例 Percentage of total species (%) 鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78 小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39 多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39 红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87 小菇属 Mycena 11 5.26 光柄菇属 Pluteus 5 2.39 红菇属 Russula 17 8.13 栓菌属 Trametes 5 2.39
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