Article(id=1304406819431010766, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1304406818550206926, articleNumber=null, orderNo=null, doi=10.7501/j.issn.0253-2670.2026.01.003, pmid=null, cstr=null, oa=null, hot=0, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1759593600000, receivedDateStr=2025-10-05, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1788924420459, onlineDateStr=2026-09-09, pubDate=null, pubDateStr=null, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1788924420459, onlineIssueDateStr=2026-09-09, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1788924420459, creator=13701087609, updateTime=1788924420459, updator=13701087609, issue=Issue{id=1304406818550206926, tenantId=1146029695717560320, journalId=1302319053441957962, year='2026', volume='57', issue='1', pageStart='1', pageEnd='389', issueExtLink='null', onlineDate='null', pubDate='1768147200000', pubDateStr='2026-01-12', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1788924420249, creator='13701087609', updateTime=1788924674802, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1304407886289986387, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1304406818550206926, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1304407886289986388, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1304406818550206926, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=24, endPage=30, ext={EN=ArticleExt(id=1304406821406527953, articleId=1304406819431010766, tenantId=1146029695717560320, journalId=1302319053441957962, language=EN, title=Flavans from Daemonorops draco and their myocardial cell protective activity, columnId=null, journalTitle=Chinese Traditional and Herbal Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=Objective To investigate the chemical constituents and their myocardial cell protective activity from the fruits of Daemonorops draco. Methods Compounds were isolated and purified using a combination of silica gel, RP-C₁₈, Sephadex LH-20 and semi-preparative HPLC. Their structures were elucidated through comprehensive spectroscopic analysis, UV, IR, HRESIMS and NMR. The protective effects of all isolates on the H9c2 myocardial cells injury induced by oxygen-glucose deprivation (OGD) were evaluated. Results Three pairs of new flavans were purified and elucidated as (2S)-2-ethoxy-7-hydroxy-5-methoxy-6-methylflavan (1a), (2R)-2-ethoxy-7-hydroxy-5-methoxy-6-methylflavan (1b), (2S,3S)-2-ethoxy-3,7-dihydroxy-5-methoxy-6-methylflavan (2a), (2R,3R)-2-ethoxy-3,7-dihydroxy-5-methoxy-6-methylflavan (2b), (2R,3S)-2-ethoxy-3,7-dihydroxy-5-methoxy-6-methylflavan (3a) and (2S,3R)-2-ethoxy-3,7-dihydroxy-5-methoxy-6-methylflavan (3b). Compounds 1b and 2b demonstrated protective effects against OGD-induced H9c2 cell injury, which increased cell viability by (6.36 ±1.26)% and (10.78 ±0.76)% at a concentration of 20 μmol/L, respectively. Conclusion Compounds 1a/1b, 2a/2b, and 3a/3b are three pairs of enantiomers, and they are all new compounds, named as dracoropin I₁, dracoropin I₂, dracoropin J₁, dracoropin J₂, dracoropin K₁, dracoropin K₂. Among them, compounds 1b and 2b exhibited protective effects on myocardial cells., authors=SUN Yunjiao, PANG Daoran, YIN Jiaojiao, WANG Yuan, ZHANG Yuyan, LI Junjun, LIN Yue, WU Zihao, HUO Huixia, LI Jun, authorsList=SUN Yunjiao, PANG Daoran, YIN Jiaojiao, WANG Yuan, ZHANG Yuyan, LI Junjun, LIN Yue, WU Zihao, HUO Huixia, LI Jun, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1304406821305864656, articleId=1304406819431010766, tenantId=1146029695717560320, journalId=1302319053441957962, language=CN, title=麒麟竭中黄烷类化合物及其对心肌细胞损伤保护作用, columnId=1304140187169214944, journalTitle=中草药, columnName=化学成分, runingTitle=null, highlight=null, articleAbstract=目的 研究麒麟竭Daemonorops draco果实的化学成分及其心肌细胞保护活性。方法 采用硅胶、ODS、Sephadex LH-20凝胶柱色谱以及半制备高效液相色谱技术进行分离、纯化，通过其理化性质及UV、IR、HRESIMS、NMR等谱学数据鉴定化合物的结构。采用缺糖缺氧（oxygen-glucosedeprivation，OGD）损伤的H9c2心肌细胞模型对分离得到的化合物进行心肌损伤保护活性筛选。结果 从麒麟竭果实乙醇提取物醋酸乙酯部位中共分离鉴定了3对新黄烷类化合物，分别为 (2S)-2-乙氧基-7-羟基-5-甲氧基-6-甲基黄烷（1a）、(2R)-2-乙氧基-7-羟基-5-甲氧基-6-甲基黄烷（1b）、(2S,3S)-2-乙氧基-3,7-二羟基-5-甲氧基-6-甲基黄烷（2a）、(2R,3R)-2-乙氧基-3,7-二羟基-5-甲氧基-6-甲基黄烷（2b）、(2R,3S)-2-乙氧基-3,7-二羟基-5-甲氧基-6-甲基黄烷（3a）和 (2S,3R)-2-乙氧基-3,7-二羟基-5-甲氧基-6-甲基黄烷（3b）。化合物1b和2b在20 μmol/L的浓度下对OGD损伤的H9c2细胞存活率分别提高了（6.36±1.26）%和（10.78±0.76）%。结论 化合物1a/1b、2a/2b和3a/3b为3对对映异构体，均为新化合物，分别命名为麒麟竭素I₁、麒麟竭素I₂、麒麟竭素J₁、麒麟竭素J₂、麒麟竭素K₁和麒麟竭素K₂，其中化合物1b和2b有一定的保护心肌细胞损伤活性。, authors=孙云娇^1,2, 庞道然^1,2, 尹娇娇^1,2, 王圆^1,2, 张玉艳^1,2, 李俊俊^1,2, 林悦^1,2, 吴梓豪¹, 霍会霞², 李军^1,2, authorsList=孙云娇, 庞道然, 尹娇娇, 王圆, 张玉艳, 李俊俊, 林悦, 吴梓豪, 霍会霞, 李军, authorCompany=1 北京中医药大学中药学院, 北京 102488;
2 北京中医药大学 北京中医药研究院 中药现代研究中心, 北京 102488, correspAuthors=李军, authorNote=孙云娇: 孙云娇,硕士研究生,研究方向为中药药效物质。E-mail:syunjiao0106@163.com, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=MDxfIZGaVdWcbxDGOQyyow==, pdfFileSize=1335747, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=国家自然科学基金重点项目 (82030114); 国家中医药管理局青年岐黄学者培养项目 ([2022]256))}, authors=[Author(id=1307464632646525357, tenantId=1146029695717560320, journalId=null, articleId=1304406819431010766, orderNo=null, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=null, email=null, emailSecond=null, emailThird=null, correspondingAuthor=null, authorType=null, ext={EN=AuthorExt(id=null, tenantId=null, 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