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儿童哮喘中医药防治的机制与转化研究
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儿童哮喘中医药防治的机制与转化研究
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. 儿童哮喘中医药防治的机制与转化研究. 药学学报, 2026 , 61 (9) : 1 -2 .
. Acta Pharmaceutica Sinica, 2026 , 61 (9) : 1 -2 .
儿童哮喘是全球范围内严重影响儿童身心健康的慢性呼吸系统疾病, 发病率呈逐年上升趋势, 给患儿家庭和社会带来了沉重负担。中医药在儿童哮喘防治中具有独特优势, 众多临床有效方药在缓解症状、改善肺功能、减少急性发作等方面发挥了重要作用。在国家重点研发计划“中医药现代化”重点专项“儿童哮喘中医药防治策略及技术方案优化” (2024YFC3505900) 的支持下, 该项目组围绕儿童哮喘的中医药防治开展了系统研究, 在哮喘发病机制解析、中药复方药效物质与作用机制阐释、病证结合动物模型构建等方面取得了一系列进展。本专栏收录的四篇论文正是该专项阶段性研究成果的代表性展示。
从现代医学与传统医学双重视角出发, 系统综述了哮喘不同免疫表型(T2-high、T2-low及非免疫机制) 及中医核心证候(寒性哮喘、热性哮喘、外寒内热证、气虚痰恋证、肾虚痰恋证、肺脾气虚证、脾肾阳虚证、肺肾阴虚证) 对应的动物模型, 深入剖析了各类模型的建模依据、机制关联及应用中存在的问题, 并提出机制导向的模型优化与中西医融合建模策略, 为提升哮喘动物模型在精准研究和临床转化中的应用价值提供了理论框架。基于HPLC-Q-TOF-MS/MS技术首次对XKZ2305颗粒的化学成分进行系统解析, 共鉴定出174个化合物, 结合网络药理学与动物实验验证, 揭示了该复方通过黄芩素、汉黄芩素、槲皮素、钩藤碱等多成分协同作用于TP53、IL6、HIF1A等核心靶点, 经HIF-1、PI3K/AKT等多条信号通路发挥抗炎、缓解气道重塑的作用机制。运用基于特征的分子网络策略与非靶标成分谱分析, 系统表征了降气平哮方的237种化学成分, 首次揭示了合剂与传统水煎液在环烯醚萜类和萜类等成分溶出上的显著差异, 并发现麻黄碱、黄芩苷、芍药苷等24种成分具有较高的肺内分布特征, 原儿茶酸、钩藤碱等48种成分在结肠内容物中呈延迟暴露, 为“肺肠同治”理论提供了直接的化学证据。整合哮喘患者鼻刷样本与哮喘小鼠肺组织转录组数据, 采用机器学习与免疫细胞浸润分析, 筛选出IL-1RL1/IL-13等7个核心基因, 证实小儿降气平哮合剂可通过精准阻断“C1QA/C1QC-LRP1”补体递呈轴与“IL-1RL1/IL-13” 2型免疫通路, 系统性纠正Th2型免疫微环境失衡。
上述研究从“机制阐释—物质基础—体内过程—靶点验证”多个维度, 初步构建了儿童哮喘中医药防治的现代科学证据链。四篇论文虽研究角度各异、技术方法不同, 但共同指向一个核心命题, 即中医药治疗哮喘的优势在于“多成分、多靶点、多通路”的系统调控, 而这一优势的充分彰显, 有赖于现代分析技术、系统生物学方法与中医药理论的深度融合。从动物模型的机制导向优化, 到复方化学成分的系统解析, 再到体内暴露谱与核心靶点的精确刻画, 每一步都在为“中药复方如何整体调节哮喘免疫微环境”这一根本问题提供越来越清晰的答案。
展望未来, 儿童哮喘的中医药研究仍需在以下几个方向持续深耕: 其一, 加强非T2型哮喘动物模型的开发与标准化, 弥补当前模型体系的短板; 其二, 推动“病−证−机制”多重对应的复合动物模型构建, 使中医证候的生物学基础得以在更完整的病理背景下被揭示; 其三, 深化化学成分体内代谢过程与药效物质之间的关联研究, 阐明多成分协同作用的动态规律; 其四, 开展多中心、大样本的随机对照临床试验, 系统评估中医药治疗儿童哮喘的疗效与安全性, 为中医药循证决策提供高质量证据。
儿童是国家的未来, 儿童健康是“健康中国”战略的重要基石。本专栏所展示的研究成果, 既是对国家重点研发计划阶段性进展的集中呈现, 也是对中医药现代化研究路径的一次积极探索。期待这些工作能够为儿童哮喘的精准防治提供新的思路, 为中医药在儿科呼吸系统疾病领域的传承创新与国际化发展贡献一份力量。

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占总种数比例
Percentage of
total species (%)
属
Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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