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Article(id=1308841126535192625, tenantId=1146029695717560320, journalId=1189982191388893191, issueId=1308840985296204417, articleNumber=null, orderNo=null, doi=10.16438/j.0513-4870.2025-1339, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1762790400000, receivedDateStr=2025-11-11, revisedDate=1766332800000, revisedDateStr=2025-12-22, acceptedDate=null, acceptedDateStr=null, onlineDate=1789981641658, onlineDateStr=2026-09-21, pubDate=1778515200000, pubDateStr=2026-05-12, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1789981641658, onlineIssueDateStr=2026-09-21, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1789981641658, creator=13701087609, updateTime=1789981641658, updator=13701087609, issue=Issue{id=1308840985296204417, tenantId=1146029695717560320, journalId=1189982191388893191, year='2026', volume='61', issue='5', pageStart='1435', pageEnd='1880', issueExtLink='null', onlineDate='null', pubDate='1778515200000', pubDateStr='2026-05-12', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1789981607984, creator='13701087609', updateTime=1789984207975, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1308851890515968861, tenantId=1146029695717560320, journalId=1189982191388893191, issueId=1308840985296204417, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1308851890515968862, tenantId=1146029695717560320, journalId=1189982191388893191, issueId=1308840985296204417, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1744, endPage=1748, ext={EN=ArticleExt(id=1308841126761685042, articleId=1308841126535192625, tenantId=1146029695717560320, journalId=1189982191388893191, language=EN, title=A new alkyne from the effective substance groups of Artemisia ordosica, columnId=1190335348761793317, journalTitle=Acta Pharmaceutica Sinica, columnName=Original Articles, runingTitle=null, highlight=null, articleAbstract=

This study employs silica gel column chromatography and thin-layer chromatography to study the chemical constituents of the effective substance groups from Artemisia ordosica, and analyze the spectral data of the separated compounds to determine their structures. Nine alkynes, including ordosin (1), capillene (2), capillin (3), capillinol (4), trans-dehydromatricaria ester (5), capillarin (6), o-hydroxycapillene (7), capillaridin (8), o-hydroxycapillin (9), and one dihydroflavone, 5-hydroxy-7,4′-dimethoxydihydroflavone (10), were isolated and identified from the effective substance groups of Artemisia ordosica. Among these, compound 1 is a new alkyne, while 2-4, 6, 8, and 9 were isolated for the first time from Artemisia ordosica. By examining the effects of compounds 1-4, 6, 8, and 9 on the release of nitric oxide (NO) in the culture medium of RAW264.7 macrophages induced by lipopolysaccharide (LPS), the inhibitory effect on inflammatory response was evaluated. The results revealed that compounds 1-4, 6, 8, and 9 exhibited NO inhibitory activity at a concentration of 10 μmol·L-1, with inhibition rates of 96.7%, 88.4%, 91.6%, 77.8%, 98.7%, 86.7% and 75.1%, respectively.

, authors=Qing-hu WANG*, Ya-wei SONG, Yi-li-qi, Yi-de-ri, Na-ren-chao-ke-tu, authorsList=Qing-hu WANG, Ya-wei SONG, Yi-li-qi, Yi-de-ri, Na-ren-chao-ke-tu, authorCompany=null, correspAuthors=Qing-hu WANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=Copyright ©2026 Acta Pharmaceutica Sinica. All rights reserved., copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1308841127474716727, articleId=1308841126535192625, tenantId=1146029695717560320, journalId=1189982191388893191, language=CN, title=黑沙蒿有效物质群中一个新的炔类化合物, columnId=1190335348896011050, journalTitle=药学学报, columnName=研究论文, runingTitle=null, highlight=null, articleAbstract=

采用经典硅胶柱色谱及薄层色谱对黑沙蒿有效物质群的化学成分进行分离, 并对分离得到化合物的波谱数据进行分析, 确定其结构。从黑沙蒿有效物质群中分离鉴定了9个炔类化合物, ordosin (1)、茵陈烯块(2)、茵陈二炔酮(3)、capillinol (4)、反-去氢母菊酯(5)、茵陈素(6)、邻羟基-茵陈烯块(7)、capillaridin (8)、邻羟基-茵陈二炔酮(9) 和1个二氢黄酮, 5-羟基-7,4′-二甲氧基二氢黄酮(10), 其中化合物1为新的炔烃, 2~4、6、8和9为从黑沙蒿中首次分离得到。通过测定化合物1~4、6、8和9对脂多糖(LPS) 诱导的小鼠RAW264.7巨噬细胞培养液中一氧化氮(NO) 释放量的影响, 评价其对炎症反应的抑制作用。活性筛选结果显示, 在10 μmol·L-1浓度下, 化合物1~4、6、8和9均具有明显的NO抑制活性, 其抑制率分别为96.7%、88.4%、91.6%、77.8%、98.7%、86.7%和75.1%。

, authors=王青虎*, 宋亚伟, 伊力奇, 伊德日, 那仁朝克图, authorsList=王青虎, 宋亚伟, 伊力奇, 伊德日, 那仁朝克图, authorCompany=null, correspAuthors=王青虎, authorNote=

作者贡献:

宋亚伟负责黑沙蒿有效物质群的制备及分离和稿件撰写; 伊力奇、伊德日负责协助制备及分离; 那仁朝克图负责实验的设计及测定核磁共振数据; 王青虎负责实验指导、结构鉴定及稿件修改。

, correspAuthorsNote=
王青虎,E-mail:
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No.δHδC
12.19 (3H, d, J = 2.5 Hz)5.41
2-73.9
3-101.9
2′-154.2
3′6.12 (1H, q, J = 2.5 Hz)95.1
4′-183.0
5′7.80 (1H, d, J = 7.5 Hz)124.9
6′7.24 (1H, t, J = 7.5 Hz)123.6
7′7.68 (1H, t, J = 7.5 Hz)137.3
8′7.32 (1H, d, J = 7.5 Hz)113.0
9′-165.9
10′-121.9
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1H (500 MHz) and 13C NMR (125 MHz) data of compound 1 in CDCl3

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No.δHδC
12.19 (3H, d, J = 2.5 Hz)5.41
2-73.9
3-101.9
2′-154.2
3′6.12 (1H, q, J = 2.5 Hz)95.1
4′-183.0
5′7.80 (1H, d, J = 7.5 Hz)124.9
6′7.24 (1H, t, J = 7.5 Hz)123.6
7′7.68 (1H, t, J = 7.5 Hz)137.3
8′7.32 (1H, d, J = 7.5 Hz)113.0
9′-165.9
10′-121.9
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黑沙蒿有效物质群中一个新的炔类化合物
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王青虎 * , 宋亚伟 , 伊力奇 , 伊德日 , 那仁朝克图
药学学报 | 研究论文 2026,61(5): 1744-1748
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药学学报 |研究论文 2026 , 61 (5) : 1744 -1748
黑沙蒿有效物质群中一个新的炔类化合物
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王青虎* , 宋亚伟, 伊力奇, 伊德日, 那仁朝克图
作者信息
  • 内蒙古民族大学蒙医药学院, 内蒙古 通辽 028000
通讯作者:
王青虎,E-mail:
作者简介:

作者贡献:

宋亚伟负责黑沙蒿有效物质群的制备及分离和稿件撰写; 伊力奇、伊德日负责协助制备及分离; 那仁朝克图负责实验的设计及测定核磁共振数据; 王青虎负责实验指导、结构鉴定及稿件修改。

A new alkyne from the effective substance groups of Artemisia ordosica
Qing-hu WANG* , Ya-wei SONG, Yi-li-qi, Yi-de-ri, Na-ren-chao-ke-tu
Affiliations
  • College of Traditional Mongolian Medicine, Inner Mongolia Minzu University, Tongliao 028000, China
出版时间: 2026-05-12 doi: 10.16438/j.0513-4870.2025-1339
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采用经典硅胶柱色谱及薄层色谱对黑沙蒿有效物质群的化学成分进行分离, 并对分离得到化合物的波谱数据进行分析, 确定其结构。从黑沙蒿有效物质群中分离鉴定了9个炔类化合物, ordosin (1)、茵陈烯块(2)、茵陈二炔酮(3)、capillinol (4)、反-去氢母菊酯(5)、茵陈素(6)、邻羟基-茵陈烯块(7)、capillaridin (8)、邻羟基-茵陈二炔酮(9) 和1个二氢黄酮, 5-羟基-7,4′-二甲氧基二氢黄酮(10), 其中化合物1为新的炔烃, 2~4、6、8和9为从黑沙蒿中首次分离得到。通过测定化合物1~4、6、8和9对脂多糖(LPS) 诱导的小鼠RAW264.7巨噬细胞培养液中一氧化氮(NO) 释放量的影响, 评价其对炎症反应的抑制作用。活性筛选结果显示, 在10 μmol·L-1浓度下, 化合物1~4、6、8和9均具有明显的NO抑制活性, 其抑制率分别为96.7%、88.4%、91.6%、77.8%、98.7%、86.7%和75.1%。

黑沙蒿  /  有效物质群  /  炔类  /  结构鉴定  /  抗炎活性

This study employs silica gel column chromatography and thin-layer chromatography to study the chemical constituents of the effective substance groups from Artemisia ordosica, and analyze the spectral data of the separated compounds to determine their structures. Nine alkynes, including ordosin (1), capillene (2), capillin (3), capillinol (4), trans-dehydromatricaria ester (5), capillarin (6), o-hydroxycapillene (7), capillaridin (8), o-hydroxycapillin (9), and one dihydroflavone, 5-hydroxy-7,4′-dimethoxydihydroflavone (10), were isolated and identified from the effective substance groups of Artemisia ordosica. Among these, compound 1 is a new alkyne, while 2-4, 6, 8, and 9 were isolated for the first time from Artemisia ordosica. By examining the effects of compounds 1-4, 6, 8, and 9 on the release of nitric oxide (NO) in the culture medium of RAW264.7 macrophages induced by lipopolysaccharide (LPS), the inhibitory effect on inflammatory response was evaluated. The results revealed that compounds 1-4, 6, 8, and 9 exhibited NO inhibitory activity at a concentration of 10 μmol·L-1, with inhibition rates of 96.7%, 88.4%, 91.6%, 77.8%, 98.7%, 86.7% and 75.1%, respectively.

Artemisia ordosica  /  effective substance group  /  alkyne  /  structural identification  /  anti-inflammatory activity
王青虎, 宋亚伟, 伊力奇, 伊德日, 那仁朝克图. 黑沙蒿有效物质群中一个新的炔类化合物. 药学学报, 2026 , 61 (5) : 1744 -1748 . DOI: 10.16438/j.0513-4870.2025-1339
Qing-hu WANG, Ya-wei SONG, Yi-li-qi, Yi-de-ri, Na-ren-chao-ke-tu. A new alkyne from the effective substance groups of Artemisia ordosica[J]. Acta Pharmaceutica Sinica, 2026 , 61 (5) : 1744 -1748 . DOI: 10.16438/j.0513-4870.2025-1339
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黑沙蒿(Artemisia ordosica Krasch.) 是菊科蒿属小灌木, 又名沙蒿、鄂尔多斯蒿、油蒿、籽蒿, 蒙语名哈拉一沙巴嘎, 分布于我国内蒙古、河北北部、山西北部等华北干旱半干旱地区, 防风固沙性能良好, 现宁夏、陕西北部、新疆和甘肃均有引种[1]。《中华本草》中记载, 黑沙蒿具有祛风、除湿、解毒、消肿等功效, 主治风湿性关节炎、痈肿疮疖、咽喉肿痛、感冒头痛等症。蒙医认为本品味苦, 性凉, 具有杀黏、清热、燥黄水、愈伤、生肌、合脉止血、消肿、软便之功效[2]。现代药理研究表明, 黑沙蒿具有提高免疫力、抗炎、抗氧化、降胆固醇等广泛的药理活性[3-6]。查阅文献[7-10]发现黑沙蒿的化学成分主要有黄酮、苯丙素及炔类等化合物。近年来, 黑沙蒿有效物质群的类风湿性关节炎治疗作用被广泛关注, 但是其药效物质还不够明确[11,12]。为了进一步摸清黑沙蒿有效物质群的化学成分及其抗炎活性, 本研究采用经典硅胶柱色谱及薄层色谱对其进行分离鉴定, 从中得到9个炔类化合物和1个二氢黄酮, 包括一个新的色原酮炔类化合物, 结构见图1。通过考察化合物1~4、6、8、9对脂多糖(LPS) 诱导的小鼠RAW264.7巨噬细胞培养液中一氧化氮(NO) 释放量的影响, 评价其对炎症反应的抑制作用。
结果与讨论
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1　结构鉴定
化合物1为淡黄色固体, 易溶于二氯甲烷、乙酸乙酯等有机溶剂。HR-ESI-MS图谱中给出一个[M+H]+的准分子离子峰为m/z 185.061 3 (calcd. for C12H9O2 185.060 3), 确定其分子式为C12H8O2, 不饱和度为9。
1H NMR谱(500 MHz, CDCl3, 表1) 中给出了4个芳香质子信号δH 7.24 (1H, t, J = 7.5 Hz, H-6′)、7.32 (1H, d, J = 7.5 Hz, H-8′)、7.68 (1H, t, J = 7.5 Hz, H-7′) 和7.80 (1H, d, J = 7.5 Hz, H-5′) 推测结构中存在1个不对称的邻二取代苯环。此外, 1H NMR中还给出了1个甲基质子信号δH 2.19 (3H, d, J = 2.5 Hz, H-1) 和1个特殊的色原酮3位质子信号δH 6.12 (1H, q, J = 2.5 Hz, H-3′), 提示H-3′与H-1存在远程偶合。1H NMR中这些质子和质子化碳通过HSQC实验明确指定。
13C NMR谱(125 MHz, CDCl3, 表1) 中给出了一组色原酮碳信号δC 154.2 (C-2′)、95.1 (C-3′)、183.0 (C-4′)、124.9 (C-5′)、123.6 (C-6′)、137.3 (C-7′)、113.0 (C-8′)、165.9 (C-9′)、121.9 (C-10′), 并在HMBC谱(图2) 中δH 6.12 (H-3′) 与C-10′相关, δH 7.32 (H-8′) 与C-6′和C-10′相关, δH 7.80 (H-5′) 与C-4′、C-7′和C-9′相关, 进一步证实了结构中色原酮的存在。另外, 13C NMR谱中还给出1个丙炔基碳信号δC 5.41 (C-1)、73.9 (C-2) 和101.9 (C-3), 并在HMBC谱(图2) 中δH 2.19 (H-1) 与C-2、C-3和C-2′相关, 提示丙炔基连接于色原酮的2′位。经文献检索为未见文献报道的新化合物, 命名为ordosin, 是一个色原酮炔类化合物。
2　化合物1~4、6、8和9的活性测试
以LPS诱导的小鼠巨噬细胞RAW 264.7为炎症模型, 评价了化合物1~4、6、8和9的抑制NO生成活性。实验结果显示, 在10 μmol·L-1浓度下, 化合物1~4、6、8和9均具有明显的NO抑制活性, 其抑制率分别为96.7%、88.4%、91.6%、77.8%、98.7%、86.7%和75.1%。
实验部分
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Bruker AVAIVCEⅢ-500型核磁共振波谱仪(TMS内标, 德国Bruker公司); Waters xevo G2S Q-TOF-MS质谱仪(美国Waters公司); IRXross红外光谱仪和AUW220D型电子天平(日本岛津公司); UV-1300PC型紫外可见分光光度计(上海美析仪器有限公司); NU-5710型二氧化碳培养箱(美国NuAire公司); Spark多功能酶标仪(瑞士Tecan公司); DMi1倒置显微镜[徕卡显微系统(上海) 有限公司]; LC-4012低速离心机(安徽中科中佳科学仪器有限公司); SX-700高压蒸汽灭菌锅(日本TOMY公司)。RAW264.7巨噬细胞(中国科学院上海细胞库); LPS (北京索莱宝科技有限公司, 818E035); 胎牛血清(美国Hyclone公司, SH30406.05); DMEM高糖培养基(美国Gibco公司, 812557); Griess试剂(碧云天生物技术有限公司, S0021S); 薄层色谱硅胶、柱色谱硅胶(青岛海洋化工厂); 分析纯石油醚(60~90 ℃)、乙酸乙酯、环己烷(天津大茂化学试剂厂)。
黑沙蒿采集于内蒙古通辽市科左后旗伊胡塔, 经内蒙古民族大学蒙医药学院蒙药学白金亮副教授鉴定为菊科蒿属植物黑沙蒿的全草(编号: 20220702)。样品保存于内蒙古民族大学蒙医药学院蒙药学博士生实验室备用。
1　提取分离
黑沙蒿药材5 kg, 用10倍量的95%乙醇回流提取3次, 每次2 h, 合并提取液, 减压回收乙醇, 得到95%乙醇提取物(1 095 g), 其得率为21.9%。称取95%乙醇提取物1 kg, 按文献[7]方法制备黑沙蒿有效物质群。
称取黑沙蒿有效物质群30 g, 放入烧杯中加二氯甲烷适量, 溶解, 溶解后加少量硅胶, 拌样均匀, 自然晾干。用湿法拌样后的样品装入已装好的硅胶柱色谱, 采用石油醚-乙酸乙酯(100∶1~10∶1) 进行梯度洗脱, 洗脱液以500 mL为一份, 减压回收溶剂至干, 用二氯甲烷溶解, 溶液经TLC检测合并相同部分, 得到6个流分(Fr. 1~6)。Fr. 1 (1.2 g) 拌样后装入已装好的硅胶柱色谱, 以石油醚-乙酸乙酯(100∶1) 为洗脱剂, 洗脱, 洗脱液以100 mL为一份, 减压回收溶剂至干, 用二氯甲烷溶解, 溶液经TLC检测, 分段为两份(Fr. 1A和Fr. 1B)。Fr. 1A (289 mg) 加二氯甲烷适量, 溶解, 以环己烷-乙酸乙酯(21∶1) 为展开剂, 用薄层色谱进行制备, 得到化合物2 (31 mg); Fr. 1B (193 mg) 加二氯甲烷适量, 溶解, 以环己烷-乙酸乙酯(19∶1) 为展开剂, 用薄层色谱进行制备, 得到化合物3 (19 mg)。Fr. 2 (0.3 g) 拌样后装入已装好的硅胶柱色谱, 以石油醚-乙酸乙酯(90∶1) 为洗脱剂, 洗脱, 洗脱液经TLC检测合并相同部分, 自然晾干, 得到化合物4 (13 mg)。Fr. 3 (1.6 g) 拌样后装入已装好的硅胶柱色谱, 以石油醚-乙酸乙酯(80∶1) 为洗脱剂, 洗脱, 洗脱液以100 mL为一份, 减压回收溶剂至干, 用二氯甲烷溶解, 溶液经TLC检测, 分段为两份(Fr. 3A和Fr. 3B)。Fr. 3A (0.2 g) 拌样后装入已装好的硅胶柱色谱, 以环己烷-乙酸乙酯(80∶1) 洗脱, 洗脱液经TLC检测合并相同部分, 自然晾干, 得到化合物5 (15 mg); Fr. 3B (0.5 g) 加二氯甲烷适量, 溶解, 以环己烷-乙酸乙酯(17∶1) 为展开剂, 用薄层色谱进行制备, 得到化合物1 (46 mg)。Fr. 4 (1.4 g) 拌样后装入已装好的硅胶柱色谱, 以石油醚-乙酸乙酯(60∶1) 为洗脱剂, 洗脱, 洗脱液以100 mL为一份, 减压回收溶剂至干, 用二氯甲烷溶解, 溶液放置过夜, 得到化合物6 (208 mg); 母液浓缩至1 mL, 以环己烷: 乙酸乙酯(15∶1) 为展开剂, 用薄层色谱进行制备, 得到化合物7 (12 mg)。Fr. 5 (1.3 g) 拌样后装入已装好的硅胶柱色谱, 以石油醚-乙酸乙酯(40∶1) 为洗脱剂, 洗脱, 洗脱液以100 mL为一份, 减压回收溶剂至干, 用二氯甲烷溶解, 溶液经TLC检测合并相同部分, 并浓缩至2 mL, 以环己烷-乙酸乙酯(10∶1) 为展开剂, 用薄层色谱进行制备, 得到化合物8 (20 mg) 和化合物9 (11 mg)。Fr. 6 (0.6 g) 拌样后装入已装好的硅胶柱色谱, 以石油醚-乙酸乙酯(20∶1) 为洗脱剂, 洗脱, 洗脱液以100 mL为一份, 减压回收溶剂至干, 用二氯甲烷溶解, 溶液经TLC检测合并相同部分, 自然晾干, 得到化合物10 (38 mg)。
2　波谱数据
化合物1为淡黄色液体; UV (MeOH) λmax: 213 nm; IR (iTR) νmax 2 926, 1 708, 1 614, 1 573, 1 468, 1 384, 1 143 cm-1; HRESIMS m/z 185.061 3 [M+H] + (C12H9O2, 计算值为185.060 3); 1H NMR (CDCl3, 500 MHz) 和 13C NMR (CDCl3, 125 MHz) 数据见表1。
化合物2为淡黄色液体; 1H NMR (500 MHz, CDCl3) δH: 1.95 (3H, s, H-1), 3.69 (2H, s, H-6), 7.28 (1H, br s, H-4′), 7.33 (2H, br s, H-3′, 5′), 7.35 (2H, br s, H-2′, 6′); 13C NMR (125 MHz, CDCl3) δC: 4.20 (C-1), 64.4 (C-2), 67.5 (C-3), 73.8 (C-4), 74.1 (C-5), 25.5 (C-6), 135.5 (C-1′), 127.9 (C-2′), 128.6 (C-3′), 126.8 (C-4′), 128.6 (C-5′), 127.9 (C-6′)。与文献[13]对照, 鉴定化合物2为茵陈烯块。
化合物3为淡黄色液体; 1H NMR (500 MHz, CDCl3) δH: 2.11 (3H, s, H-1), 7.53 (2H, t, J = 8.0 Hz, H-3′,5′), 7.64 (1H, t, J = 8.0 Hz, H-4′), 8.15 (2H, d, J = 8.0 Hz, H-2′,6′); 13C NMR (125 MHz, CDCl3) δC: 4.89 (C-1), 63.4 (C-2), 70.9 (C-3), 78.4 (C-4), 86.4 (C-5), 177.2 (C-6), 136.7 (C-1′), 128.6 (C-2′), 129.6 (C-3′), 134.3 (C-4′), 129.6 (C-5′), 128.6 (C-6′)。与文献[14]对照, 鉴定化合物3为茵陈二炔酮。
化合物4为淡黄色液体; 1H NMR (500 MHz, CDCl3) δH: 1.98 (3H, s, H-1), 5.52 (1H, s, H-6), 7.37 (1H, t, J = 7.5 Hz, H-4′), 7.42 (2H, t, J = 7.5 Hz, H-3′,5′), 7.55 (2H, d, J = 7.5 Hz, H-2′,6′); 13C NMR (125 MHz, CDCl3) δC: 4.34 (C-1), 63.6 (C-2), 71.8 (C-3), 74.2 (C-4), 78.2 (C-5), 65.0 (C-6), 139.9 (C-1′), 126.6 (C-2′), 128.7 (C-3′), 128.6 (C-4′), 128.7 (C-5′), 125.6 (C-6′)。与文献[15]对照, 鉴定化合物4为capillinol。
化合物5为淡黄色液体; 1H NMR (500 MHz, CDCl3) δH: 2.04 (3H, s, H-10), 3.80 (3H, s, -OCH3), 6.20 (1H, d, J = 11.0 Hz, H-3), 6.31 (1H, d, J = 11.0 Hz, H-2); 13C NMR (125 MHz, CDCl3) δC: 164.6 (C-1), 132.5 (C-2), 121.5 (C-3), 86.1 (C-4), 64.9 (C-5), 58.4 (C-6), 71.0 (C-7), 72.2 (C-8), 80.8 (C-9), 4.78 (C-10), 51.7 (-OCH3)。与文献[16,17]对照, 鉴定化合物5为反-去氢母菊酯。
化合物6为淡黄色液体; 1H NMR (500 MHz, CDCl3) δH: 1.92 (3H, s, H-1), 3.48 (2H, s, H-4), 6.64 (1H, s, H-4′), 7.45 (1H, d, J = 7.5 Hz, H-5′), 7.52 (1H, t, J = 7.5 Hz, H-7′), 7.74 (1H, t, J = 7.5 Hz, H-6′), 8.29 (1H, d, J = 7.5 Hz, H-8′); 13C NMR (125 MHz, CDCl3) δC: 3.66 (C-1), 71.8 (C-2), 79.9 (C-3), 23.8 (C-4), 162.5 (C-1′), 153.8 (C-3′), 103.1 (C-4′), 125.4 (C-5′), 134.8 (C-6′), 128.0 (C-7′), 129.6 (C-8′), 137.3 (C-9′), 120.2 (C-10′)。与文献[18,19]对照, 鉴定化合物6为茵陈素。
化合物7为淡黄色液体; 1H NMR (500 MHz, CDCl3) δH: 1.95 (3H, s, H-1), 3.59 (2H, s, H-6), 6.71 (1H, d, J = 8.0 Hz, H-3′), 6.87 (1H, t, J = 8.0 Hz, H-5′), 7.11 (1H, t, J = 8.0 Hz, H-4′), 7.29 (1H, d, J = 8.0 Hz, H-6′); 13C NMR (125 MHz, CDCl3) δC: 4.27 (C-1), 72.7 (C-2), 64.3 (C-3), 67.9 (C-4), 74.1 (C-5), 21.0 (C-6), 120.1 (C-1′), 155.6 (C-2′), 113.6 (C-3′), 128.1 (C-4′), 121.8 (C-5′), 129.6 (C-6′)。与文献[17]对照, 鉴定化合物7为邻羟基-茵陈烯块。
化合物8为淡黄色液体; 1H NMR (500 MHz, CDCl3) δH: 2.01 (3H, s, H-1), 3.87 (3H, s, 2′-OCH3), 6.82 (1H, d, J = 7.5 Hz, H-3′), 7.09 (1H, t, J = 8.0 Hz, H-4′), 7.42 (1H, t, J = 8.0 Hz, H-5′), 7.83 (1H, d, J = 8.0 Hz, H-6′); 13C NMR (125 MHz, CDCl3) δC: 4.87 (C-1), 77.1 (C-2), 64.0 (C-3), 85.3 (C-4), 72.1 (C-5), 175.0 (C-6), 123.2 (C-1′), 159.2 (C-2′), 113.0 (C-3′), 130.8 (C-4′), 120.8 (C-5′), 131.5 (C-6′)。与文献[15]对照, 鉴定化合物8为capillaridin。
化合物9为淡黄色液体; 1H NMR (500 MHz, CDCl3) δH: 1.99 (3H, s, H-1), 6.77 (1H, d, J = 7.5 Hz, H-3′), 7.16 (1H, t, J = 8.0 Hz, H-4′), 7.58 (1H, t, J = 8.0 Hz, H-5′), 7.91 (1H, d, J = 8.0 Hz, H-6′); 13C NMR (125 MHz, CDCl3) δC: 4.95 (C-1), 78.4 (C-2), 63.4 (C-3), 86.4 (C-4), 70.9 (C-5), 177.1 (C-6), 120.9 (C-1′), 162.1 (C-2′), 118.0 (C-3′), 132.6 (C-4′), 122.9 (C-5′), 134.1 (C-6′)。与文献[17]对照, 鉴定化合物9为邻羟基-茵陈二炔酮。
化合物10为淡黄色固体; 1H NMR (500 MHz, CDCl3) δH: 2.81 (1H, dd, J = 17.0, 3.0 Hz, H-3a), 3.13 (1H, dd, J = 17.0, 13.0 Hz, H-3b), 3.81 (3H, s, 7-OCH3), 3.83 (3H, s, 4′-OCH3), 5.39 (1H, dd, J = 13.0, 3.0 Hz, H-2), 6.05 (1H, d, J = 2.5 Hz, H-8), 6.07 (1H, d, J = 2.5 Hz, H-6), 6.97 (2H, t, J = 8.0 Hz, H-3′,5′), 7.40 (2H, d, J = 7.0 Hz, H-2′,6′); 13C NMR (125 MHz, CDCl3) δC: 79.0 (C-2), 43.2 (C-3), 196.0 (C-4), 164.2 (C-5), 94.2 (C-6), 168.0 (C-7), 95.1 (C-8), 162.9 (C-9), 103.1 (C-10), 130.4 (C-1′), 127.7 (C-2′), 114.2 (C-3′), 160.1 (C-4′), 114.2 (C-5′), 127.7 (C-6′)。与文献[3]对照, 鉴定化合物10为5-羟基-7,4′-二甲氧基二氢黄酮。
3　抗炎活性测定
按文献[20]方法建立LPS诱导RAW 264.7细胞炎症模型。用6孔板每孔加入2 mL细胞悬液(即4×105个细胞/孔), 轻轻晃动平板使细胞均匀分布。放入37 ℃、5% CO2培养箱, 静置培养24 h (让细胞完全贴壁, 恢复生长状态)。24 h后给细胞进行分组, 空白组、模型组、样品组。将6孔板放回37 ℃、5% CO2培养箱, 同一浓度设3个复孔(每组平行3次), 模型组、样品组每孔加LPS诱导(终浓度为20 μg·mL-1), 孵育24 h。取出6孔板, 将每孔上清液轻轻转移至15 mL离心管(避免触碰孔底贴壁细胞), 4 ℃、1 500 r·min-1离心10 min (去除少量漂浮细胞碎片)。用移液枪吸取离心后的上清液2 mL, 转移至无菌EP管, 标记组别。取另一96孔板, 依次加入50 μL不同浓度的NaNO2标准品, 每组3个复孔。每孔加50 μL细胞上清液, 加50 μL Griess Ⅰ试剂, 再加50 μL Griess Ⅱ试剂, 混匀, 用酶标仪在540 nm波长处测定吸光度(A) 值, 按文献[21]方法计算细胞上清液中NO浓度。

文献
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2026年第61卷第5期
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doi: 10.16438/j.0513-4870.2025-1339
  • 接收时间：2025-11-11
  • 首发时间：2026-09-21
  • 出版时间：2026-05-12
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  • 收稿日期：2025-11-11
  • 修回日期：2025-12-22
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    内蒙古民族大学蒙医药学院, 内蒙古 通辽 028000

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王青虎,E-mail:
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2种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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