Article(id=1222469715440689711, tenantId=1146029695717560320, journalId=1189982191388893191, issueId=1222469705873481976, articleNumber=null, orderNo=null, doi=10.16438/j.0513-4870.2019-0648, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=research-article, receivedDate=1565625600000, receivedDateStr=2019-08-13, revisedDate=1568649600000, revisedDateStr=2019-09-17, acceptedDate=null, acceptedDateStr=null, onlineDate=1769389092550, onlineDateStr=2026-01-26, pubDate=1570809600000, pubDateStr=2019-10-12, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1769389092550, onlineIssueDateStr=2026-01-26, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1769389092550, creator=13701087609, updateTime=1769389092550, updator=13701087609, issue=Issue{id=1222469705873481976, tenantId=1146029695717560320, journalId=1189982191388893191, year='2019', volume='54', issue='10', pageStart='1711', pageEnd='1880', issueExtLink='null', onlineDate='null', pubDate='1570809600000', pubDateStr='2019-10-12', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1769389090269, creator='13701087609', updateTime=1769389551199, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1222471639254683958, tenantId=1146029695717560320, journalId=1189982191388893191, issueId=1222469705873481976, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1222471639254683959, tenantId=1146029695717560320, journalId=1189982191388893191, issueId=1222469705873481976, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1818, endPage=1823, ext={EN=ArticleExt(id=1222469715973366363, articleId=1222469715440689711, tenantId=1146029695717560320, journalId=1189982191388893191, language=EN, title=Research progress of dendritic cells anti-tumor vaccine stimulated by mRNA, columnId=1190335348648547107, journalTitle=Acta Pharmaceutica Sinica, columnName=Reviews, runingTitle=null, highlight=null, articleAbstract=

Distinct from conventional cancer therapies focusing directly on local tumors, cancer immunotherapy aims to restore or enhance immune surveillance to fight against cancer, which bears the advantages of less side effects, lasting efficacy, substantial specificity and suitability for individualized treatment. As the most powerful antigen-presenting cell type, dendritic cells (DCs) can induce potent antigen-specific immune responses in vivo. DCs-based immunotherapy acts by loading DCs with cancer antigens in various ways to elicit specific anti-tumor immune responses. Currently, pulsing DCs with cancer antigen encoding mRNAs is an antigen loading approach under extensive study, registering encouraging results in relevant immunotherapeutic clinical trials. Thus, pulsing DCs with mRNAs is a new and highly promising modality in cancer immunotherapy.

, authors=null, authorsList=Xing ZHAO, Yang-zhuo GU, Xiang-rong SONG, authorCompany=null, correspAuthors=Xiang-rong SONG, authorNote=null, correspAuthorsNote=null, copyrightStatement=Copyright ©2019 Acta Pharmaceutica Sinica. All rights reserved., copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1222469716598317695, articleId=1222469715440689711, tenantId=1146029695717560320, journalId=1189982191388893191, language=CN, title=mRNA致敏的树突状细胞用于肿瘤免疫治疗的研究进展, columnId=1190335349655180086, journalTitle=药学学报, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

肿瘤免疫治疗旨在恢复或增强机体的免疫监视功能来对抗肿瘤，与传统的抗肿瘤治疗直接聚焦于肿瘤病灶局部不同，其具有不良反应小、作用持久、特异性强及适于个体化治疗等优势。树突状细胞（DCs）作为功能最强的抗原递呈细胞，能够在体内诱导强烈的特异性免疫应答。目前基于DCs的肿瘤免疫治疗，是将肿瘤抗原通过一定方法负载于DCs，从而激发特异性抗肿瘤免疫应答。用编码肿瘤抗原的mRNA致敏DCs是目前研究较为广泛的一种肿瘤抗原负载方式，对应的免疫治疗策略已在临床试验中显示出较好的抗肿瘤疗效。因此，mRNA致敏的DCs是一种极具潜力的肿瘤免疫治疗新模式。

, authors=null, authorsList=赵星, 顾杨卓, 宋相容, authorCompany=null, correspAuthors=宋相容, authorNote=null, correspAuthorsNote=, copyrightStatement=版权所有©《药学学报》编辑部2019, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=nnCRoBeqt6Vqsp72o5jmOg==, magXml=KFCrwM98039uZkf5OqHdRQ==, pdfUrl=null, pdf=83l+IwuBzAuAGt8wFNpqVg==, pdfFileSize=751924, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=thdSpgSiC+sFRTPeLyitow==, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=ObO8wMNZdXp6UwCwcM+ySg==, mapNumber=null, fund=null)}, authors=[Author(id=1222469717047108258, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1222469717160354474, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, authorId=1222469717047108258, language=EN, stringName=Xing ZHAO, firstName=Xing, middleName=null, lastName=ZHAO, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^{1, 2}, address=1. State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China
2. Stem Cell and Tissue Engineering Research Center/Key Laboratory of Adult Stem Cell Transformation Research, Chinese Academy of Medical Sciences, Department of Immunology, Guizhou Medical University, Guiyang 550004, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1222469717231657646, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, authorId=1222469717047108258, language=CN, stringName=赵星, firstName=星, middleName=null, lastName=赵, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^{1, 2}, address=1.四川大学华西医院生物治疗国家重点实验室, 四川 成都 610041
2.贵州医科大学, 组织工程与干细胞实验中心/中国医学科学院成体干细胞转化研究重点实验室, 免疫学教研室, 贵州 贵阳 550004, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1222469716837393034, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, xref=null, ext=[AuthorCompanyExt(id=1222469716841587339, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, companyId=1222469716837393034, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1. State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China), AuthorCompanyExt(id=1222469716849975948, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, companyId=1222469716837393034, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.四川大学华西医院生物治疗国家重点实验室, 四川 成都 610041)]), AuthorCompany(id=1222469716946444952, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, xref=null, ext=[AuthorCompanyExt(id=1222469716954833561, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, companyId=1222469716946444952, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2. Stem Cell and Tissue Engineering Research Center/Key Laboratory of Adult Stem Cell Transformation Research, Chinese Academy of Medical Sciences, Department of Immunology, Guizhou Medical University, Guiyang 550004, China), AuthorCompanyExt(id=1222469716959027866, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, companyId=1222469716946444952, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2.贵州医科大学, 组织工程与干细胞实验中心/中国医学科学院成体干细胞转化研究重点实验室, 免疫学教研室, 贵州 贵阳 550004)])]), Author(id=1222469717323932343, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1222469717432984253, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, authorId=1222469717323932343, language=EN, stringName=Yang-zhuo GU, firstName=Yang-zhuo, middleName=null, lastName=GU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=1. State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1222469717516870337, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, authorId=1222469717323932343, language=CN, stringName=顾杨卓, firstName=杨卓, middleName=null, lastName=顾, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=1.四川大学华西医院生物治疗国家重点实验室, 四川 成都 610041, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1222469716837393034, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, xref=null, ext=[AuthorCompanyExt(id=1222469716841587339, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, companyId=1222469716837393034, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1. State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China), AuthorCompanyExt(id=1222469716849975948, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, companyId=1222469716837393034, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.四川大学华西医院生物治疗国家重点实验室, 四川 成都 610041)])]), Author(id=1222469717655282377, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=songxr@scu.edu.cn, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1222469717802083025, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, authorId=1222469717655282377, language=EN, stringName=Xiang-rong SONG, firstName=Xiang-rong, middleName=null, lastName=SONG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^{1, *}, address=1. State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1222469717911134935, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, authorId=1222469717655282377, language=CN, stringName=宋相容, firstName=相容, middleName=null, lastName=宋, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^{1, *}, address=1.四川大学华西医院生物治疗国家重点实验室, 四川 成都 610041, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1222469716837393034, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, xref=null, ext=[AuthorCompanyExt(id=1222469716841587339, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, companyId=1222469716837393034, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1. State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China), AuthorCompanyExt(id=1222469716849975948, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, companyId=1222469716837393034, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.四川大学华西医院生物治疗国家重点实验室, 四川 成都 610041)])])], keywords=[Keyword(id=1222469718045352673, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, language=EN, orderNo=1, keyword=dendritic cell), Keyword(id=1222469718166987496, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, language=EN, orderNo=2, keyword=mRNA), Keyword(id=1222469718238290674, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, language=EN, orderNo=3, keyword=vaccine), Keyword(id=1222469718343148280, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, language=EN, orderNo=4, keyword=tumor immunotherapy), Keyword(id=1222469718460588798, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, language=CN, orderNo=1, keyword=树突状细胞), Keyword(id=1222469718536086270, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, language=CN, orderNo=2, keyword=信使RNA), Keyword(id=1222469718649332483, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, language=CN, orderNo=3, keyword=疫苗), Keyword(id=1222469718741607175, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, language=CN, orderNo=4, keyword=肿瘤免疫治疗)], refs=[Reference(id=1222469719370752798, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, doi=10.1038/nrd.2017.243, pmid=null, pmcid=null, year=2018, volume=17, issue=null, pageStart=261, pageEnd=279, url=null, language=null, rfNumber=[1], rfOrder=0, authorNames=Pardi N, Hogan MJ, Porter FW, journalName=Nat Rev Drug Discov, refType=null, unstructuredReference= Pardi N , Hogan MJ , Porter FW et al . mRNA vaccines - a new era in vaccinology[J]. Nat Rev Drug Discov, 2018, 17: 261-279., articleTitle=mRNA vaccines - a new era in vaccinology, refAbstract=null), Reference(id=1222469719450444579, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, doi=10.4155/fsoa-2017-0151, pmid=null, pmcid=null, year=2018, volume=4, issue=null, pageStart=FSO300, pageEnd=null, url=null, language=null, rfNumber=[2], rfOrder=1, authorNames=Lundstrom K, journalName=Future Sci OA, refType=null, unstructuredReference= Lundstrom K . Latest development on RNA-based drugs and vaccines[J]. Future Sci OA, 2018, 4: FSO300., articleTitle=Latest development on RNA-based drugs and vaccines, refAbstract=null), Reference(id=1222469719546913574, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, doi=10.1038/nature18300, pmid=null, pmcid=null, year=2016, volume=534, issue=null, pageStart=396, pageEnd=401, url=null, language=null, rfNumber=[3], rfOrder=2, authorNames=Kranz LM, Diken M, Haas H, journalName=Nature, refType=null, unstructuredReference= Kranz LM , Diken M , Haas H et al . Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy[J]. Nature, 2016, 534: 396-401., articleTitle=Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy, refAbstract=null), Reference(id=1222469719647576876, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, doi=10.1084/jem.137.5.1142, pmid=null, pmcid=null, year=1973, volume=137, issue=null, pageStart=1142, pageEnd=1162, url=null, language=null, rfNumber=[4], rfOrder=3, authorNames=Steinman RM, Cohn ZA, journalName=J Exp Med, refType=null, unstructuredReference= Steinman RM , Cohn ZA . Identification of a novel cell type in peripheral lymphoid organs of mice. Ⅰ. Morphology, quantitation, tissue distribution[J]. J Exp Med, 1973, 137: 1142-1162., articleTitle=Identification of a novel cell type in peripheral lymphoid organs of mice. Ⅰ. Morphology, quantitation, tissue distribution, refAbstract=null), Reference(id=1222469719752434483, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, doi=10.1111/imm.12888, pmid=null, pmcid=null, year=2018, volume=154, issue=null, pageStart=3, pageEnd=20, url=null, language=null, rfNumber=[5], rfOrder=4, authorNames=Collin M, Bigley V, journalName=Immunology, refType=null, unstructuredReference= Collin M , Bigley V . Human dendritic cell subsets: an update[J]. Immunology, 2018, 154: 3-20., articleTitle=Human dendritic cell subsets: an update, refAbstract=null), Reference(id=1222469719911818040, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, doi=10.1124/pr.114.009456, pmid=null, pmcid=null, year=2015, volume=67, issue=null, pageStart=731, pageEnd=753, url=null, language=null, rfNumber=[6], rfOrder=5, authorNames=Anguille S, Smits EL, Bryant C, journalName=Pharmacol Rev, refType=null, unstructuredReference= Anguille S , Smits EL , Bryant C et al . Dendritic cells as pharmacological tools for cancer immunotherapy[J]. Pharmacol Rev, 2015, 67: 731-753., articleTitle=Dendritic cells as pharmacological tools for cancer immunotherapy, refAbstract=null), Reference(id=1222469720020869949, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, doi=10.3390/vaccines1040527, pmid=null, pmcid=null, year=2013, volume=1, issue=null, pageStart=527, pageEnd=549, url=null, language=null, rfNumber=[7], rfOrder=6, authorNames=Terhune J, Berk E, Czerniecki BJ, journalName=Vaccines, refType=null, unstructuredReference= Terhune J , Berk E , Czerniecki BJ . Dendritic cell-induced Th1 and Th17 cell differentiation for cancer therapy[J]. Vaccines, 2013, 1: 527-549., articleTitle=Dendritic cell-induced Th1 and Th17 cell differentiation for cancer therapy, refAbstract=null), Reference(id=1222469720205419330, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, doi=10.3389/fimmu.2017.00971, pmid=null, pmcid=null, year=2017, volume=8, issue=null, pageStart=971, pageEnd=null, url=null, language=null, rfNumber=[8], rfOrder=7, authorNames=Leal Rojas IM, Mok WH, Pearson FE, journalName=Front Immunol, refType=null, unstructuredReference= Leal Rojas IM , Mok WH , Pearson FE et al . Human blood CD1c⁺ dendritic cells promote Th1 and Th17 effector function in memory CD4⁺ T cells[J]. Front Immunol, 2017, 8: 971., articleTitle=Human blood CD1c⁺ dendritic cells promote Th1 and Th17 effector function in memory CD4⁺ T cells, refAbstract=null), Reference(id=1222469720318665544, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, doi=10.4049/jimmunol.1501202, pmid=null, pmcid=null, year=2016, volume=196, issue=null, pageStart=624, pageEnd=636, url=null, language=null, rfNumber=[9], rfOrder=8, authorNames=Chow KV, Lew AM, Sutherland RM, journalName=J Immunol, refType=null, unstructuredReference= Chow KV , Lew AM , Sutherland RM et al . Monocyte-derived dendritic cells promote Th polarization, whereas conventional dendritic cells promote Th proliferation[J]. J Immunol, 2016, 196: 624-636., articleTitle=Monocyte-derived dendritic cells promote Th polarization, whereas conventional dendritic cells promote Th proliferation, refAbstract=null), Reference(id=1222469720423523151, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, doi=null, pmid=null, pmcid=null, year=2016, volume=2016, issue=null, pageStart=6374379, pageEnd=null, url=http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=a69551f3a6727787f1206527c090a982, language=null, rfNumber=[10], rfOrder=9, authorNames=Thomas R, Yang X, journalName=J Immunol Res, refType=null, unstructuredReference= Thomas R , Yang X . NK-DC crosstalk in immunity to microbial infection[J]. J Immunol Res, 2016, 2016: 6374379, articleTitle=NK-DC crosstalk in immunity to microbial infection, refAbstract=null), Reference(id=1222469720553546576, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, doi=null, pmid=null, pmcid=null, year=2016, volume=128, issue=null, pageStart=5723, pageEnd=null, url=https://www.researchgate.net/publication/313910489_Dendritic_cell_production_from_allogenenic_donor_Cd34stem_cells_and_mononuclear_cells_Cancer_vaccine, language=null, rfNumber=[11], rfOrder=10, authorNames=Unal A, Birekul A, Unal MC, journalName=Blood, refType=null, unstructuredReference= Unal A , Birekul A , Unal MC et al . Dendritic cell production from allogeneic donor CD34⁺ stem cells and mononuclear cells; cancer vaccine[J]. Blood, 2016, 128: 5723, articleTitle=Dendritic cell production from allogeneic donor CD34⁺ stem cells and mononuclear cells; cancer vaccine, refAbstract=null), Reference(id=1222469720641626964, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, doi=10.3390/cancers11020181, pmid=null, pmcid=null, year=2019, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[12], rfOrder=11, authorNames=Plantinga M, de Haar CG, Dünnebach E, journalName=Cancers, refType=null, unstructuredReference= Plantinga M , de Haar CG , Dünnebach E et al . Cord-blood-stem-cell-derived conventional dendritic cells specifically originate from CD115-expressing precursors[J]. Cancers, 2019. DOI:10.3390/cancers11020181., articleTitle=Cord-blood-stem-cell-derived conventional dendritic cells specifically originate from CD115-expressing precursors, refAbstract=null), Reference(id=1222469720767456089, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, doi=10.1084/jem.180.1.83, pmid=null, pmcid=null, year=1994, volume=180, issue=null, pageStart=83, pageEnd=93, url=null, language=null, rfNumber=[13], rfOrder=12, authorNames=Romani N, Gruner S, Brang D, journalName=J Exp Med, refType=null, unstructuredReference= Romani N , Gruner S , Brang D et al . Proliferating dendritic cell progenitors in human blood[J]. J Exp Med, 1994, 180: 83-93., articleTitle=Proliferating dendritic cell progenitors in human blood, refAbstract=null), Reference(id=1222469720880702302, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, doi=10.1084/jem.179.4.1109, pmid=null, pmcid=null, year=1994, volume=179, issue=null, pageStart=1109, pageEnd=1118, url=null, language=null, rfNumber=[14], rfOrder=13, authorNames=Sallusto F, Lanzavecchia A, journalName=J Exp Med, refType=null, unstructuredReference= Sallusto F , Lanzavecchia A . Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha[J]. J Exp Med, 1994, 179: 1109-1118., articleTitle=Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha, refAbstract=null), Reference(id=1222469720977171299, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, doi=10.1016/0022-1759(96)00078-6, pmid=null, pmcid=null, year=1996, volume=196, issue=null, pageStart=137, pageEnd=151, url=null, language=null, rfNumber=[15], rfOrder=14, authorNames=Romani N, Reider D, Heuer M, journalName=J Immunol Methods, refType=null, unstructuredReference= Romani N , Reider D , Heuer M et al . Generation of mature dendritic cells from human blood an improved method with special regard to clinical applicability[J]. J Immunol Methods, 1996, 196: 137-151., articleTitle=Generation of mature dendritic cells from human blood an improved method with special regard to clinical applicability, refAbstract=null), Reference(id=1222469721090417512, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, doi=10.1073/pnas.93.6.2588, pmid=null, pmcid=null, year=1996, volume=93, issue=null, pageStart=2588, pageEnd=2592, url=null, language=null, rfNumber=[16], rfOrder=15, authorNames=Zhou LJ, Tedder TF, journalName=Proc Natl Acad Sci U S A, refType=null, unstructuredReference= Zhou LJ , Tedder TF . CD14⁺ blood monocytes can differentiate into functionally mature CD83⁺ dendritic cells[J]. Proc Natl Acad Sci U S A, 1996, 93: 2588-2592., articleTitle=CD14⁺ blood monocytes can differentiate into functionally mature CD83⁺ dendritic cells, refAbstract=null), Reference(id=1222469721191080811, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, doi=10.3389/fimmu.2018.00658, pmid=null, pmcid=null, year=2018, volume=9, issue=null, pageStart=658, pageEnd=null, url=null, language=null, rfNumber=[17], rfOrder=16, authorNames=Van Acker HH, Anguille S, De Reu H, journalName=Front Immunol, refType=null, unstructuredReference= Van Acker HH , Anguille S , De Reu H et al . Interleukin-15-cultured dendritic cells enhance anti-tumor gamma delta T cell functions through IL-15 secretion[J]. Front Immunol, 2018, 9: 658., articleTitle=Interleukin-15-cultured dendritic cells enhance anti-tumor gamma delta T cell functions through IL-15 secretion, refAbstract=null), Reference(id=1222469721287549809, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, doi=null, pmid=null, pmcid=null, year=2019, volume=7, issue=null, pageStart=B137, pageEnd=null, url=null, language=null, rfNumber=[18], rfOrder=17, authorNames=Versteven M, Damoiseaux D, Campillo-Davo D, journalName=Cancer Immunol Res, refType=null, unstructuredReference= Versteven M , Damoiseaux D , Campillo-Davo D et al . Preclinical evaluation of a Wilms' tumor protein 1-targeted interleukin-15 dendritic cell vaccine: T-cell activity and batch production[J]. Cancer Immunol Res, 2019, 7: B137., articleTitle=Preclinical evaluation of a Wilms' tumor protein 1-targeted interleukin-15 dendritic cell vaccine: T-cell activity and batch production, refAbstract=null), Reference(id=1222469721363047284, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, doi=10.1016/j.jcyt.2018.06.006, pmid=null, pmcid=null, year=2018, volume=20, issue=null, pageStart=1164, pageEnd=1181, url=null, language=null, rfNumber=[19], rfOrder=18, authorNames=Brabants E, Heyns K, Smet SD, journalName=Cytotherapy, refType=null, unstructuredReference= Brabants E , Heyns K , Smet SD et al . An accelerated, clinical-grade protocol to generate high yields of type 1-polarizing messenger RNA-loaded dendritic cells for cancer vaccination[J]. Cytotherapy, 2018, 20: 1164-1181., articleTitle=An accelerated, clinical-grade protocol to generate high yields of type 1-polarizing messenger RNA-loaded dendritic cells for cancer vaccination, refAbstract=null), Reference(id=1222469721442739064, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, doi=null, pmid=null, pmcid=null, year=2001, volume=61, issue=null, pageStart=6451, pageEnd=6458, url=http://www.ncbi.nlm.nih.gov/pubmed/11522640, language=null, rfNumber=[20], rfOrder=19, authorNames=Banchereau J, Palucka AK, Dhodapkar M, journalName=Cancer Res, refType=null, unstructuredReference= Banchereau J , Palucka AK , Dhodapkar M et al . Immune and clinical responses in patients with metastatic melanoma to CD34⁺ progenitor-derived dendritic cell vaccine[J]. Cancer Res, 2001, 61: 6451-6458., articleTitle=Immune and clinical responses in patients with metastatic melanoma to CD34⁺ progenitor-derived dendritic cell vaccine, refAbstract=null), Reference(id=1222469721564373881, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, doi=10.3389/fimmu.2019.01079, pmid=null, pmcid=null, year=2019, volume=10, issue=null, pageStart=1079, pageEnd=null, url=null, language=null, rfNumber=[21], rfOrder=20, authorNames=Shinde P, Melinkeri S, Santra MK, journalName=Front Immunol, refType=null, unstructuredReference= Shinde P , Melinkeri S , Santra MK et al . Autologous hematopoietic stem cells are a preferred source to generate dendritic cells for immunotherapy in multiple myeloma patients[J]. Front Immunol, 2019, 10: 1079., articleTitle=Autologous hematopoietic stem cells are a preferred source to generate dendritic cells for immunotherapy in multiple myeloma patients, refAbstract=null), Reference(id=1222469721715368828, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, doi=10.1016/S1470-2045(13)70585-0, pmid=null, pmcid=null, year=2014, volume=15, issue=null, pageStart=e257, pageEnd=e267, url=null, language=null, rfNumber=[22], rfOrder=21, authorNames=Anguille S, Smits EL, Lion E, journalName=Lancet Oncol, refType=null, unstructuredReference= Anguille S , Smits EL , Lion E et al . Clinical use of dendritic cells for cancer therapy[J]. Lancet Oncol, 2014, 15: e257-e267., articleTitle=Clinical use of dendritic cells for cancer therapy, refAbstract=null), Reference(id=1222469721811837825, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, doi=10.1186/s12967-018-1507-6, pmid=null, pmcid=null, year=2018, volume=16, issue=null, pageStart=142, pageEnd=null, url=null, language=null, rfNumber=[23], rfOrder=22, authorNames=Liau LM, Ashkan K, Tran DD, journalName=J Transl Med, refType=null, unstructuredReference= Liau LM , Ashkan K , Tran DD et al . First results on survival from a large phase 3 clinical trial of an autologous dendritic cell vaccine in newly diagnosed glioblastoma[J]. J Transl Med, 2018, 16: 142., articleTitle=First results on survival from a large phase 3 clinical trial of an autologous dendritic cell vaccine in newly diagnosed glioblastoma, refAbstract=null), Reference(id=1222469721933472644, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, doi=10.1111/imcb.12170, pmid=null, pmcid=null, year=2018, volume=96, issue=null, pageStart=683, pageEnd=693, url=null, language=null, rfNumber=[24], rfOrder=23, authorNames=Leone DA, Rees AJ, Kain R, journalName=Immunol Cell Biol, refType=null, unstructuredReference= Leone DA , Rees AJ , Kain R . Dendritic cells and routing cargo into exosomes[J]. Immunol Cell Biol, 2018, 96: 683-693., articleTitle=Dendritic cells and routing cargo into exosomes, refAbstract=null), Reference(id=1222469722038330246, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, doi=10.1016/j.trecan.2017.12.007, pmid=null, pmcid=null, year=2018, volume=4, issue=null, pageStart=119, pageEnd=137, url=null, language=null, rfNumber=[25], rfOrder=24, authorNames=Saxena M, Bhardwaj N, journalName=Trends Cancer, refType=null, unstructuredReference= Saxena M , Bhardwaj N . Re-emergence of dendritic cell vaccines for cancer treatment[J]. Trends Cancer, 2018, 4: 119-137., articleTitle=Re-emergence of dendritic cell vaccines for cancer treatment, refAbstract=null), Reference(id=1222469722109633417, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, doi=10.1186/s40425-019-0580-6, pmid=null, pmcid=null, year=2019, volume=7, issue=null, pageStart=109, pageEnd=null, url=null, language=null, rfNumber=[26], rfOrder=25, authorNames=Bol KF, Schreibelt G, Rabold K, journalName=J Immunother Cancer, refType=null, unstructuredReference= Bol KF , Schreibelt G , Rabold K et al . The clinical application of cancer immunotherapy based on naturally circulating dendritic cells[J]. J Immunother Cancer, 2019, 7: 109., articleTitle=The clinical application of cancer immunotherapy based on naturally circulating dendritic cells, refAbstract=null), Reference(id=1222469722193519500, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, doi=10.1172/jci.insight.91438, pmid=null, pmcid=null, year=2017, volume=2, issue=null, pageStart=e91438, pageEnd=null, url=null, language=null, rfNumber=[27], rfOrder=26, authorNames=Gross S, Erdmann M, Haendle I, journalName=JCI Insight, refType=null, unstructuredReference= Gross S , Erdmann M , Haendle I et al . Twelve-year survival and immune correlates in dendritic cell-vaccinated melanoma patients[J]. JCI Insight, 2017, 2: e91438., articleTitle=Twelve-year survival and immune correlates in dendritic cell-vaccinated melanoma patients, refAbstract=null), Reference(id=1222469722289988495, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, doi=10.3389/fimmu.2019.00766, pmid=null, pmcid=null, year=2019, volume=10, issue=null, pageStart=766, pageEnd=null, url=null, language=null, rfNumber=[28], rfOrder=27, authorNames=Mastelic-Gavillet B, Balint K, Boudousquie C, journalName=Front Immunol, refType=null, unstructuredReference= Mastelic-Gavillet B , Balint K , Boudousquie C et al . Personalized dendritic cell vaccines-recent breakthroughs and encouraging clinical results[J]. Front Immunol, 2019, 10: 766., articleTitle=Personalized dendritic cell vaccines-recent breakthroughs and encouraging clinical results, refAbstract=null), Reference(id=1222469722386457491, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, doi=10.1046/j.1523-1747.2000.00084.x, pmid=null, pmcid=null, year=2000, volume=115, issue=null, pageStart=449, pageEnd=453, url=null, language=null, rfNumber=[29], rfOrder=28, authorNames=Kukutsch NA, Roßner S, Austyn JM, journalName=J Invest Dermatol, refType=null, unstructuredReference= Kukutsch NA , Roßner S , Austyn JM et al . Formation and kinetics of MHC class Ⅰ-ovalbumin peptide complexes on immature and mature murine dendritic cells[J]. J Invest Dermatol, 2000, 115: 449-453., articleTitle=Formation and kinetics of MHC class Ⅰ-ovalbumin peptide complexes on immature and mature murine dendritic cells, refAbstract=null), Reference(id=1222469722491315095, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, doi=10.1158/2326-6066.CIR-14-0177, pmid=null, pmcid=null, year=2015, volume=3, issue=null, pageStart=196, pageEnd=205, url=null, language=null, rfNumber=[30], rfOrder=29, authorNames=Zhang H, Tang K, Zhang Y, journalName=Cancer Immunol Res, refType=null, unstructuredReference= Zhang H , Tang K , Zhang Y et al . Cell-free tumor microparticle vaccines stimulate dendritic cells via cGAS/STING signaling[J]. Cancer Immunol Res, 2015, 3: 196-205., articleTitle=Cell-free tumor microparticle vaccines stimulate dendritic cells via cGAS/STING signaling, refAbstract=null), Reference(id=1222469722575201178, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, doi=10.1002/ijc.29100, pmid=null, pmcid=null, year=2015, volume=136, issue=null, pageStart=E74, pageEnd=E84, url=null, language=null, rfNumber=[31], rfOrder=30, authorNames=Gu X, Erb U, Büchler MW, journalName=Int J Cancer, refType=null, unstructuredReference= Gu X , Erb U , Büchler MW et al . Improved vaccine efficacy of tumor exosome compared to tumor lysate loaded dendritic cells in mice[J]. Int J Cancer, 2015, 136: E74-E84., articleTitle=Improved vaccine efficacy of tumor exosome compared to tumor lysate loaded dendritic cells in mice, refAbstract=null), Reference(id=1222469722659087262, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, doi=10.4161/hv.22661, pmid=null, pmcid=null, year=2013, volume=9, issue=null, pageStart=265, pageEnd=274, url=null, language=null, rfNumber=[32], rfOrder=31, authorNames=Van Lint S, Heirman C, Thielemans K, journalName=Hum Vaccin Immunother, refType=null, unstructuredReference= Van Lint S , Heirman C , Thielemans K et al . mRNA: from a chemical blueprint for protein production to an off-the-shelf therapeutic[J]. Hum Vaccin Immunother, 2013, 9: 265-274., articleTitle=mRNA: from a chemical blueprint for protein production to an off-the-shelf therapeutic, refAbstract=null), Reference(id=1222469722730390435, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, doi=null, pmid=null, pmcid=null, year=2017, volume=1499, issue=null, pageStart=89, pageEnd=107, url=http://link.springer.com/protocol/10.1007/978-1-4939-6481-9_5, language=null, rfNumber=[33], rfOrder=32, authorNames=Rauch S, Lutz J, Kowalczyk A, journalName=Methods Mol Biol, refType=null, unstructuredReference= Rauch S , Lutz J , Kowalczyk A et al . RNActive(R) technology: generation and testing of stable and immunogenic mRNA vaccines[J]. Methods Mol Biol, 2017, 1499: 89-107., articleTitle=RNActive(R) technology: generation and testing of stable and immunogenic mRNA vaccines, refAbstract=null), Reference(id=1222469722835248040, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, doi=10.1080/14760584.2017.1355245, pmid=null, pmcid=null, year=2017, volume=16, issue=null, pageStart=871, pageEnd=881, url=null, language=null, rfNumber=[34], rfOrder=33, authorNames=Iavarone C, O'Hagan DT, Yu D, journalName=Expert Rev Vaccines, refType=null, unstructuredReference= Iavarone C , O'Hagan DT , Yu D et al . Mechanism of action of mRNA-based vaccines[J]. Expert Rev Vaccines, 2017, 16: 871-881., articleTitle=Mechanism of action of mRNA-based vaccines, refAbstract=null), Reference(id=1222469722923328424, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, doi=10.4161/rna.22269, pmid=null, pmcid=null, year=2012, volume=9, issue=null, pageStart=1319, pageEnd=1330, url=null, language=null, rfNumber=[35], rfOrder=34, authorNames=Schlake T, Thess A, Fotin-Mleczek M, journalName=RNA Biol, refType=null, unstructuredReference= Schlake T , Thess A , Fotin-Mleczek M et al . Developing mRNA-vaccine technologies[J]. RNA Biol, 2012, 9: 1319-1330., articleTitle=Developing mRNA-vaccine technologies, refAbstract=null), Reference(id=1222469723028186027, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, doi=null, pmid=null, pmcid=null, year=2018, volume=15, issue=null, pageStart=756, pageEnd=762, url=https://www.ncbi.nlm.nih.gov/pubmed/29578372, language=null, rfNumber=[36], rfOrder=35, authorNames=Asrani KH, Farelli JD, Stahley MR, journalName=RNA Biol, refType=null, unstructuredReference= Asrani KH , Farelli JD , Stahley MR et al . Optimization of mRNA untranslated regions for improved expression of therapeutic mRNA[J]. RNA Biol, 2018, 15: 756-762., articleTitle=Optimization of mRNA untranslated regions for improved expression of therapeutic mRNA, refAbstract=null), Reference(id=1222469723116266414, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, doi=null, pmid=null, pmcid=null, year=2018, volume=19, issue=null, pageStart=2, pageEnd=3, url=http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=d7f7dd6ac5358a2525d99e2b0088e9c9, language=null, rfNumber=[37], rfOrder=36, authorNames=Zlotorynski E, journalName=Nat Rev Mol Cell Biol, refType=null, unstructuredReference= Zlotorynski E . The short tail that wags the mRNA[J]. Nat Rev Mol Cell Biol, 2018, 19: 2-3., articleTitle=The short tail that wags the mRNA, refAbstract=null), Reference(id=1222469723195958193, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, doi=10.1182/blood-2006-04-015024, pmid=null, pmcid=null, year=2006, volume=108, issue=null, pageStart=4009, pageEnd=4017, url=null, language=null, rfNumber=[38], rfOrder=37, authorNames=Holtkamp S, Kreiter S, Selmi A, journalName=Blood, refType=null, unstructuredReference= Holtkamp S , Kreiter S , Selmi A et al . Modification of antigen-encoding RNA increases stability, translational efficacy, and T-cell stimulatory capacity of dendritic cells[J]. Blood, 2006, 108: 4009-4017., articleTitle=Modification of antigen-encoding RNA increases stability, translational efficacy, and T-cell stimulatory capacity of dendritic cells, refAbstract=null), Reference(id=1222469723284038582, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, doi=10.3390/vaccines3030490, pmid=null, pmcid=null, year=2015, volume=3, issue=null, pageStart=490, pageEnd=502, url=null, language=null, rfNumber=[39], rfOrder=38, authorNames=Galaine J, Borg C, Godet Y, journalName=Vaccines, refType=null, unstructuredReference= Galaine J , Borg C , Godet Y et al . Interest of tumor-specific CD4 T helper 1 cells for therapeutic anticancer vaccine[J]. Vaccines, 2015, 3: 490-502., articleTitle=Interest of tumor-specific CD4 T helper 1 cells for therapeutic anticancer vaccine, refAbstract=null), Reference(id=1222469723359536056, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, doi=10.4049/jimmunol.172.11.6649, pmid=null, pmcid=null, year=2004, volume=172, issue=null, pageStart=6649, pageEnd=6657, url=null, language=null, rfNumber=[40], rfOrder=39, authorNames=Bonehill A, Heirman C, Tuyaerts S, journalName=J Immunol, refType=null, unstructuredReference= Bonehill A , Heirman C , Tuyaerts S et al . Messenger RNA-electroporated dendritic cells presenting MAGE-A3 simultaneously in HLA class Ⅰ and class Ⅱ molecules[J]. J Immunol, 2004, 172: 6649-6657., articleTitle=Messenger RNA-electroporated dendritic cells presenting MAGE-A3 simultaneously in HLA class Ⅰ and class Ⅱ molecules, refAbstract=null), Reference(id=1222469723460199355, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, doi=10.1158/1078-0432.CCR-11-3368, pmid=null, pmcid=null, year=2012, volume=18, issue=null, pageStart=5460, pageEnd=5470, url=null, language=null, rfNumber=[41], rfOrder=40, authorNames=Aarntzen EH, Schreibelt G, Bol K, journalName=Clin Cancer Res, refType=null, unstructuredReference= Aarntzen EH , Schreibelt G , Bol K et al . Vaccination with mRNA-electroporated dendritic cells induces robust tumor antigen-specific CD4⁺ and CD8⁺ T cells responses in stage Ⅲ and Ⅳ melanoma patients[J]. Clin Cancer Res, 2012, 18: 5460-5470., articleTitle=Vaccination with mRNA-electroporated dendritic cells induces robust tumor antigen-specific CD4⁺ and CD8⁺ T cells responses in stage Ⅲ and Ⅳ melanoma patients, refAbstract=null), Reference(id=1222469723535696831, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, doi=10.1038/mt.2008.77, pmid=null, pmcid=null, year=2008, volume=16, issue=null, pageStart=1170, pageEnd=1180, url=null, language=null, rfNumber=[42], rfOrder=41, authorNames=Bonehill A, Tuyaerts S, Van Nuffel AMT, journalName=Mol Ther, refType=null, unstructuredReference= Bonehill A , Tuyaerts S , Van Nuffel AMT et al . Enhancing the T-cell stimulatory capacity of human dendritic cells by co-electroporation with CD40L, CD70 and constitutively active TLR4 encoding mRNA[J]. Mol Ther, 2008, 16: 1170-1180., articleTitle=Enhancing the T-cell stimulatory capacity of human dendritic cells by co-electroporation with CD40L, CD70 and constitutively active TLR4 encoding mRNA, refAbstract=null), Reference(id=1222469723602805699, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, doi=10.1200/jco.2011.29.15_suppl.2519, pmid=null, pmcid=null, year=2011, volume=29, issue=null, pageStart=2519, pageEnd=null, url=null, language=null, rfNumber=[43], rfOrder=42, authorNames=Neyns B, Wilgenhof S, Nuffel AMTV, journalName=J Clin Oncol, refType=null, unstructuredReference= Neyns B , Wilgenhof S , Nuffel AMTV et al . A phase Ⅰ clinical trial on the combined intravenous (Ⅳ) and intradermal (ID) administration of autologous TriMix-DC cellular therapy in patients with pretreated melanoma (TriMixIDIV)[J]. J Clin Oncol, 2011, 29: 2519., articleTitle=A phase Ⅰ clinical trial on the combined intravenous (Ⅳ) and intradermal (ID) administration of autologous TriMix-DC cellular therapy in patients with pretreated melanoma (TriMixIDIV), refAbstract=null), Reference(id=1222469723707663301, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, doi=10.1093/annonc/mdt245, pmid=null, pmcid=null, year=2013, volume=24, issue=null, pageStart=2686, pageEnd=2693, url=null, language=null, rfNumber=[44], rfOrder=43, authorNames=Wilgenhof S, Van Nuffel AM, Benteyn D, journalName=Ann Oncol, refType=null, unstructuredReference= Wilgenhof S , Van Nuffel AM , Benteyn D et al . A phase IB study on intravenous synthetic mRNA electroporated dendritic cell immunotherapy in pretreated advanced melanoma patients[J]. Ann Oncol, 2013, 24: 2686-2693., articleTitle=A phase IB study on intravenous synthetic mRNA electroporated dendritic cell immunotherapy in pretreated advanced melanoma patients, refAbstract=null), Reference(id=1222469723808326601, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, doi=10.1084/jem.184.2.465, pmid=null, pmcid=null, year=1996, volume=184, issue=null, pageStart=465, pageEnd=472, url=null, language=null, rfNumber=[45], rfOrder=44, authorNames=Boczkowski D, Nair SK, Snyder D, journalName=J Exp Med, refType=null, unstructuredReference= Boczkowski D , Nair SK , Snyder D et al . Dendritic cells pulsed with RNA are potent antigen-presenting cells in vitro and in vivo[J]. J Exp Med, 1996, 184: 465-472., articleTitle=Dendritic cells pulsed with RNA are potent antigen-presenting cells in vitro and in vivo, refAbstract=null), Reference(id=1222469723896406988, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, doi=10.1038/gt.2011.17, pmid=null, pmcid=null, year=2011, volume=18, issue=null, pageStart=702, pageEnd=708, url=null, language=null, rfNumber=[46], rfOrder=45, authorNames=Diken M, Kreiter S, Selmi A, journalName=Gene Ther, refType=null, unstructuredReference= Diken M , Kreiter S , Selmi A et al . Selective uptake of naked vaccine RNA by dendritic cells is driven by macropinocytosis and abrogated upon DC maturation[J]. Gene Ther, 2011, 18: 702-708., articleTitle=Selective uptake of naked vaccine RNA by dendritic cells is driven by macropinocytosis and abrogated upon DC maturation, refAbstract=null), Reference(id=1222469723984487375, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, doi=10.2147/OTT.S171019, pmid=null, pmcid=null, year=2018, volume=11, issue=null, pageStart=5763, pageEnd=5775, url=null, language=null, rfNumber=[47], rfOrder=46, authorNames=Tu J, Zhang H, Yu J, journalName=Onco Targets Ther, refType=null, unstructuredReference= Tu J , Zhang H , Yu J et al . Ultrasound-mediated microbubble destruction: a new method in cancer immunotherapy[J]. Onco Targets Ther, 2018, 11: 5763-5775., articleTitle=Ultrasound-mediated microbubble destruction: a new method in cancer immunotherapy, refAbstract=null), Reference(id=1222469724055790547, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, doi=10.1200/JCO.2015.63.4121, pmid=null, pmcid=null, year=2016, volume=34, issue=null, pageStart=1330, pageEnd=1338, url=null, language=null, rfNumber=[48], rfOrder=47, authorNames=Wilgenhof S, Corthals J, Heirman C, journalName=J Clin Oncol, refType=null, unstructuredReference= Wilgenhof S , Corthals J , Heirman C et al . Phase Ⅱ study of autologous monocyte-derived mRNA electroporated dendritic cells (TriMixDC-MEL) plus ipilimumab in patients with pretreated advanced melanoma[J]. J Clin Oncol, 2016, 34: 1330-1338., articleTitle=Phase Ⅱ study of autologous monocyte-derived mRNA electroporated dendritic cells (TriMixDC-MEL) plus ipilimumab in patients with pretreated advanced melanoma, refAbstract=null), Reference(id=1222469724127093718, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, doi=10.1158/0008-5472.CAN-11-2957, pmid=null, pmcid=null, year=2012, volume=72, issue=null, pageStart=1661, pageEnd=1671, url=null, language=null, rfNumber=[49], rfOrder=48, authorNames=Van Lint S, Goyvaerts C, Maenhout S, journalName=Cancer Res, refType=null, unstructuredReference= Van Lint S , Goyvaerts C , Maenhout S et al . Preclinical evaluation of TriMix and antigen mRNA-based antitumor therapy[J]. Cancer Res, 2012, 72: 1661-1671., articleTitle=Preclinical evaluation of TriMix and antigen mRNA-based antitumor therapy, refAbstract=null), Reference(id=1222469724236145627, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, doi=null, pmid=null, pmcid=null, year=2016, volume=1428, issue=null, pageStart=277, pageEnd=283, url=https://link.springer.com/protocol/10.1007/978-1-4939-3625-0_18, language=null, rfNumber=[50], rfOrder=49, authorNames=Coosemans A, Tuyaerts S, Morias K, journalName=Methods Mol Biol, refType=null, unstructuredReference= Coosemans A , Tuyaerts S , Morias K et al . mRNA electroporation of dendritic cells with WT1, survivin, and TriMix (a Mixture of caTLR4, CD40L, and CD70)[J]. Methods Mol Biol, 2016, 1428: 277-283., articleTitle=mRNA electroporation of dendritic cells with WT1, survivin, and TriMix (a Mixture of caTLR4, CD40L, and CD70), refAbstract=null)], funds=[Fund(id=1222469719148454678, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, awardId=2018ZX09201018-024, language=CN, fundingSource=国家科技重大专项重大新药创制计划(2018ZX09201018-024), fundOrder=null, country=null), Fund(id=1222469719211369242, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, awardId=SY（2013）3010, language=CN, fundingSource=贵州省科技厅社会发展攻关项目(SY（2013）3010), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1222469716837393034, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, xref=null, ext=[AuthorCompanyExt(id=1222469716841587339, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, companyId=1222469716837393034, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1. State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China), AuthorCompanyExt(id=1222469716849975948, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, companyId=1222469716837393034, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.四川大学华西医院生物治疗国家重点实验室, 四川 成都 610041)]), AuthorCompany(id=1222469716946444952, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, xref=null, ext=[AuthorCompanyExt(id=1222469716954833561, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, companyId=1222469716946444952, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2. Stem Cell and Tissue Engineering Research Center/Key Laboratory of Adult Stem Cell Transformation Research, Chinese Academy of Medical Sciences, Department of Immunology, Guizhou Medical University, Guiyang 550004, China), AuthorCompanyExt(id=1222469716959027866, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, companyId=1222469716946444952, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2.贵州医科大学, 组织工程与干细胞实验中心/中国医学科学院成体干细胞转化研究重点实验室, 免疫学教研室, 贵州 贵阳 550004)])], figs=[ArticleFig(id=1222469718880019212, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, language=EN, label=null, caption=null, figureFileSmall=1SbLIoJwORVpWUuODBhSDw==, figureFileBig=thdSpgSiC+sFRTPeLyitow==, tableContent=null), ArticleFig(id=1222469718972293904, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469715440689711, language=CN, label=Figure 1, caption= , figureFileSmall=1SbLIoJwORVpWUuODBhSDw==, figureFileBig=thdSpgSiC+sFRTPeLyitow==, tableContent=null)], attaches=null, journal=Journal(id=1189982048455397383, delFlag=0, nameCn=药学学报, nameEn=Acta Pharmaceutica Sinica, nameHistory1=null, nameHistory2=null, issn=0513-4870, eissn=null, cn=11-2163/R, coden=null, periodic=0, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=BTxjudbJDVO4PqdBR6On6Q==, journalPrice=null, startedYear=null, abbrevIsoEn=null, journalRemark=null, publicationField=null, createdTime=1761643429151, updatedTime=1788948913902, createdBy=18614031015, updatedBy=13041195026, firstLetterCn=Y, firstLetterEn=Y, subjectCode=Medical and Pharmaceutical Sciences, subjectName=Life Sciences, subjectCodeEn=Medical and Pharmaceutical Sciences, subjectNameEn=null, picCn=BTxjudbJDVO4PqdBR6On6Q==, picEn=c4l1ckL55nWbhl1KrFdWIA==, jcr=null, cjcr=null, exts=[JournalExt(id=1304509553505227679, language=CN, name=药学学报, nameHistory1=null, nameHistory2=null, managedBy=中国科学技术协会, sponsoredBy=中国药学会、中国医学科学院药物研究所, publishedBy=《药学学报》编辑委员会编辑出版, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788948914171, updatedTime=1788948914171, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://www.yxxb.com.cn/journalx_yxxb/authorLogOn.action, submissionEditorUrl=https://www.yxxb.com.cn/journalx_yxxb/editorLogOn.action, submissionReviewUrl=https://www.yxxb.com.cn/journalx_yxxb/expertLogOn.action, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""}), JournalExt(id=1304509553559753632, language=EN, name=Acta Pharmaceutica Sinica, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788948914184, updatedTime=1788948914184, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://www.yxxb.com.cn/journalx_yxxb/authorLogOn.action, submissionEditorUrl=https://www.yxxb.com.cn/journalx_yxxb/editorLogOn.action, submissionReviewUrl=https://www.yxxb.com.cn/journalx_yxxb/expertLogOn.action, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""})], databaseList=null, tenantJournalId=1189982191388893191, websiteList=[Website(id=1189982271588340489, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1189982191388893191, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/yxxb/CN, language=CN, createTime=1761643482348, createBy=18614031015, updateTime=1761643498101, updateBy=18614031015, name=药学学报-中文, tplId=1146099689490845704, title=药学学报, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1189982873114448678, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271588340489, code=articleTextType, value=kx, createTime=1761643625763, updateTime=1761643625763, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982873093477155, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271588340489, code=banner, value=null, createTime=1761643625758, updateTime=1761643625758, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982873135420201, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271588340489, code=grayFlag, value=0, createTime=1761643625768, updateTime=1761643625768, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982873085088546, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271588340489, code=logo, value=https://castjournals.cast.org.cn/joweb/yxxb/CN/file/pic?fileId=w+t2v8bJnX5lh3+hRRJcDA==, createTime=1761643625756, updateTime=1761643625756, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982873152197419, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271588340489, code=minRunFlag, value=0, createTime=1761643625772, updateTime=1761643625772, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982873110254373, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271588340489, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/yxxb/CN/file/pic, createTime=1761643625762, updateTime=1761643625762, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982873143808810, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271588340489, code=silenceFlag, value=0, createTime=1761643625770, updateTime=1761643625770, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982873101865764, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271588340489, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1761643625760, updateTime=1761643625760, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982873122837287, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271588340489, code=themeColor, value=null, createTime=1761643625765, updateTime=1761643625765, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982873127031592, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271588340489, code=themeStyle, value=null, createTime=1761643625766, updateTime=1761643625766, creator=18614031015, updator=18614031015)]), Website(id=1189982271655449355, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1189982191388893191, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/yxxb/EN, language=EN, createTime=1761643482364, createBy=18614031015, updateTime=1761643514085, updateBy=18614031015, name=药学学报-英文, tplId=1146101810881728533, title=Acta Pharmaceutica Sinica, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1189982903015633534, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271655449355, code=articleTextType, value=kx, createTime=1761643632892, updateTime=1761643632892, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982902990467707, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271655449355, code=banner, value=null, createTime=1761643632886, updateTime=1761643632886, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982903036605057, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271655449355, code=grayFlag, value=0, createTime=1761643632897, updateTime=1761643632897, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982902982079098, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271655449355, code=logo, value=https://castjournals.cast.org.cn/joweb/yxxb/EN/file/pic?fileId=w+t2v8bJnX5lh3+hRRJcDA==, createTime=1761643632884, updateTime=1761643632884, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982903053382275, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271655449355, code=minRunFlag, value=0, createTime=1761643632901, updateTime=1761643632901, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982903007244925, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271655449355, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/yxxb/EN/file/pic, createTime=1761643632890, updateTime=1761643632890, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982903044993666, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271655449355, code=silenceFlag, value=0, createTime=1761643632899, updateTime=1761643632899, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982902998856316, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271655449355, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1761643632888, updateTime=1761643632888, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982903019827839, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271655449355, code=themeColor, value=null, createTime=1761643632893, updateTime=1761643632893, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982903028216448, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271655449355, code=themeStyle, value=null, createTime=1761643632895, updateTime=1761643632895, creator=18614031015, updator=18614031015)])], journalTitle=药学学报, weixinUrl=null, journalUrl=https://www.yxxb.com.cn/aps, iacademicId=null, status=1, seqNo=null, journalTitleEn=Acta Pharmaceutica Sinica, journalPhotoCn=BTxjudbJDVO4PqdBR6On6Q==, journalPhotoEn=c4l1ckL55nWbhl1KrFdWIA==, journalFirstLetter=Y, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false, interPubPlatform=, interPubPlatformUrl=null), detailUrlCn=https://castjournals.cast.org.cn/joweb/yxxb/CN/10.16438/j.0513-4870.2019-0648, detailUrlEn=https://castjournals.cast.org.cn/joweb/yxxb/EN/10.16438/j.0513-4870.2019-0648, pdfUrlCn=https://castjournals.cast.org.cn/joweb/yxxb/CN/PDF/10.16438/j.0513-4870.2019-0648, pdfUrlEn=https://castjournals.cast.org.cn/joweb/yxxb/EN/PDF/10.16438/j.0513-4870.2019-0648, aliStartDate=null, aliEndDate=null, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=1, orderTime=1570809600000, fullTextJson=null, articleText=null, reference=null)