Article(id=1222469708650107314, tenantId=1146029695717560320, journalId=1189982191388893191, issueId=1222469705873481976, articleNumber=null, orderNo=null, doi=10.16438/j.0513-4870.2019-0668, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=research-article, receivedDate=1566403200000, receivedDateStr=2019-08-22, revisedDate=1567353600000, revisedDateStr=2019-09-02, acceptedDate=null, acceptedDateStr=null, onlineDate=1769389090931, onlineDateStr=2026-01-26, pubDate=1570809600000, pubDateStr=2019-10-12, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1769389090931, onlineIssueDateStr=2026-01-26, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1769389090931, creator=13701087609, updateTime=1769389090931, updator=13701087609, issue=Issue{id=1222469705873481976, tenantId=1146029695717560320, journalId=1189982191388893191, year='2019', volume='54', issue='10', pageStart='1711', pageEnd='1880', issueExtLink='null', onlineDate='null', pubDate='1570809600000', pubDateStr='2019-10-12', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1769389090269, creator='13701087609', updateTime=1769389551199, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1222471639254683958, tenantId=1146029695717560320, journalId=1189982191388893191, issueId=1222469705873481976, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1222471639254683959, tenantId=1146029695717560320, journalId=1189982191388893191, issueId=1222469705873481976, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1851, endPage=1857, ext={EN=ArticleExt(id=1222469709128257978, articleId=1222469708650107314, tenantId=1146029695717560320, journalId=1189982191388893191, language=EN, title=The antitumor activity of STAT3 target inhibitor Bt354 and molecular mechanism of anti-prostate cancer, columnId=1190335348761793317, journalTitle=Acta Pharmaceutica Sinica, columnName=Original Articles, runingTitle=null, highlight=null, articleAbstract=
Signal transducer and activator of transcription 3 (STAT3) was found in an abnormal constitutively active status in certain cancer tissues, and under these circumstances the interruption of STAT3 signaling pathway was proposed with the potential anti-cancer efficacy. In this study, our previous reported STAT3 inhibitor Bt354 can inhibit tumor growth in DU145 xenograft mice without affecting body weight. In groups treated with Bt354, the inhibition rate of tumor weight was 58.8%, 62.7% and 73.5% in 10, 20, 40 mg·kg-1 group, respectively. Particularly, the number of Ki 67 positive cells in the tumor sections was significantly decreased in Bt354 groups. Furthermore, Bt354 inhibited the nuclear translocation of STAT3 and consequently induced cell growth inhibition, apoptosis in DU145 cells. These findings suggest that Bt354 may be a potent anticancer agent for STAT3 activated prostate cancer cells. Procedures for animal study were performed with approval of the Animal Care and Use Committee of the Chinese Academy of Medical Sciences and Peking Union Medical College.
, authors=null, authorsList=Yu-chen WANG, Yue CHEN, Ming JI, Ni-na XUE, Xiao-guang CHEN, authorCompany=null, correspAuthors=Xiao-guang CHEN, authorNote=null, correspAuthorsNote=null, copyrightStatement=Copyright ©2019 Acta Pharmaceutica Sinica. All rights reserved., copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1222469710621430265, articleId=1222469708650107314, tenantId=1146029695717560320, journalId=1189982191388893191, language=CN, title=STAT3靶点抑制剂Bt354抗前列腺癌作用及其分子机制研究, columnId=1190335348896011050, journalTitle=药学学报, columnName=研究论文, runingTitle=null, highlight=null, articleAbstract=
在某些肿瘤组织中，信号传导与活化转录因子3（STAT3）信号通路处于异常激活状态。在这种情况下，抑制STAT3信号通路被认为是一种潜在的肿瘤治疗方法。在体外，STAT3靶点抑制剂Bt354可以抑制癌细胞的增殖；在体内，Bt354还抑制了DU145异种移植小鼠的肿瘤生长，而不影响体重。在Bt354给药组中，10、20和40 mg·kg-1组的瘤重抑制率分别为58.8%、62.7%和73.5%。另外，Bt354给药组均可见DU145移植瘤组织中Ki 67阳性细胞的数量显著降低。这些研究结果表明，Bt354可能是一种对STAT3激活的前列腺癌细胞有效的抗癌剂。此外，Bt354抑制了STAT3的核转位，从而诱导了DU145细胞的生长抑制和凋亡。动物实验中对动物的处理均遵循中国医学科学院药物研究所动物实验中心标准操作规程。
, authors=null, authorsList=王雨辰, 陈越, 季鸣, 薛妮娜, 陈晓光, authorCompany=null, correspAuthors=陈晓光, authorNote=null, correspAuthorsNote=
, copyrightStatement=版权所有©《药学学报》编辑部2019, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=7dlY+evc2P+Kl/k6YouO3A==, magXml=a5XAEF14V4soy5Jmv+l6Eg==, pdfUrl=null, pdf=fdsWC/JDOV1kT+GCSLqMvg==, pdfFileSize=9490644, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=U1doH0h0saw1uFXtpPOp1g==, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=V5Vb2A0kNr2OUYgMok6iHQ==, mapNumber=null, fund=null)}, authors=[Author(id=1222469710923420172, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469708650107314, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1222469711019889173, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469708650107314, authorId=1222469710923420172, language=EN, stringName=Yu-chen WANG, firstName=Yu-chen, middleName=null, lastName=WANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=State Key Laboratory of Bioactive Substances and Functions of Natural Medicines/Beijing Key Laboratory of Non-clinical Drug Metabolism and PK/PD Study, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1222469711149912603, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469708650107314, authorId=1222469710923420172, language=CN, stringName=王雨辰, firstName=雨辰, middleName=null, lastName=王, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=中国医学科学院、北京协和医学院药物研究所, 天然药物活性物质与功能国家重点实验室/创新药物非临床药物代谢及PK/PD研究北京市重点实验室, 北京 100050, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1222469710826951170, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469708650107314, xref=null, ext=[AuthorCompanyExt(id=1222469710831145475, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469708650107314, companyId=1222469710826951170, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=State Key Laboratory of Bioactive Substances and Functions of Natural Medicines/Beijing Key Laboratory of Non-clinical Drug Metabolism and PK/PD Study, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China), AuthorCompanyExt(id=1222469710843728388, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469708650107314, companyId=1222469710826951170, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=中国医学科学院、北京协和医学院药物研究所, 天然药物活性物质与功能国家重点实验室/创新药物非临床药物代谢及PK/PD研究北京市重点实验室, 北京 100050)])]), Author(id=1222469711237992993, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469708650107314, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1222469711321879078, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469708650107314, authorId=1222469711237992993, language=EN, stringName=Yue CHEN, firstName=Yue, middleName=null, lastName=CHEN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=State Key Laboratory of Bioactive Substances and Functions of Natural Medicines/Beijing Key Laboratory of Non-clinical Drug Metabolism and PK/PD Study, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1222469711393182254, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469708650107314, authorId=1222469711237992993, language=CN, stringName=陈越, firstName=越, middleName=null, lastName=陈, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=中国医学科学院、北京协和医学院药物研究所, 天然药物活性物质与功能国家重点实验室/创新药物非临床药物代谢及PK/PD研究北京市重点实验室, 北京 100050, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1222469710826951170, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469708650107314, xref=null, ext=[AuthorCompanyExt(id=1222469710831145475, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469708650107314, companyId=1222469710826951170, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=State Key Laboratory of Bioactive Substances and Functions of Natural Medicines/Beijing Key Laboratory of Non-clinical Drug Metabolism and PK/PD Study, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China), AuthorCompanyExt(id=1222469710843728388, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469708650107314, companyId=1222469710826951170, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=中国医学科学院、北京协和医学院药物研究所, 天然药物活性物质与功能国家重点实验室/创新药物非临床药物代谢及PK/PD研究北京市重点实验室, 北京 100050)])]), Author(id=1222469711464485429, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469708650107314, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1222469711544177214, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469708650107314, authorId=1222469711464485429, language=EN, stringName=Ming JI, firstName=Ming, middleName=null, lastName=JI, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=State Key Laboratory of Bioactive Substances and Functions of Natural Medicines/Beijing Key Laboratory of Non-clinical Drug Metabolism and PK/PD Study, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1222469711632257605, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469708650107314, authorId=1222469711464485429, language=CN, stringName=季鸣, firstName=鸣, middleName=null, lastName=季, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=中国医学科学院、北京协和医学院药物研究所, 天然药物活性物质与功能国家重点实验室/创新药物非临床药物代谢及PK/PD研究北京市重点实验室, 北京 100050, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1222469710826951170, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469708650107314, xref=null, ext=[AuthorCompanyExt(id=1222469710831145475, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469708650107314, companyId=1222469710826951170, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=State Key Laboratory of Bioactive Substances and Functions of Natural Medicines/Beijing Key Laboratory of Non-clinical Drug Metabolism and PK/PD Study, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China), AuthorCompanyExt(id=1222469710843728388, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469708650107314, companyId=1222469710826951170, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=中国医学科学院、北京协和医学院药物研究所, 天然药物活性物质与功能国家重点实验室/创新药物非临床药物代谢及PK/PD研究北京市重点实验室, 北京 100050)])]), Author(id=1222469711745503822, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469708650107314, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1222469711854555735, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469708650107314, authorId=1222469711745503822, language=EN, stringName=Ni-na XUE, firstName=Ni-na, middleName=null, lastName=XUE, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=State Key Laboratory of Bioactive Substances and Functions of Natural Medicines/Beijing Key Laboratory of Non-clinical Drug Metabolism and PK/PD Study, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1222469711959413344, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469708650107314, authorId=1222469711745503822, language=CN, stringName=薛妮娜, firstName=妮娜, middleName=null, lastName=薛, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=中国医学科学院、北京协和医学院药物研究所, 天然药物活性物质与功能国家重点实验室/创新药物非临床药物代谢及PK/PD研究北京市重点实验室, 北京 100050, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1222469710826951170, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469708650107314, xref=null, ext=[AuthorCompanyExt(id=1222469710831145475, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469708650107314, companyId=1222469710826951170, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=State Key Laboratory of Bioactive Substances and Functions of Natural Medicines/Beijing Key Laboratory of Non-clinical Drug Metabolism and PK/PD Study, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China), AuthorCompanyExt(id=1222469710843728388, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469708650107314, companyId=1222469710826951170, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=中国医学科学院、北京协和医学院药物研究所, 天然药物活性物质与功能国家重点实验室/创新药物非临床药物代谢及PK/PD研究北京市重点实验室, 北京 100050)])]), Author(id=1222469712039105128, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469708650107314, orderNo=4, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=chxg@imm.ac.cn, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1222469712164934257, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469708650107314, authorId=1222469712039105128, language=EN, stringName=Xiao-guang CHEN, firstName=Xiao-guang, middleName=null, lastName=CHEN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
*, address=State Key Laboratory of Bioactive Substances and Functions of Natural Medicines/Beijing Key Laboratory of Non-clinical Drug Metabolism and PK/PD Study, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1222469712307540604, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469708650107314, authorId=1222469712039105128, language=CN, stringName=陈晓光, firstName=晓光, middleName=null, lastName=陈, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
*, address=中国医学科学院、北京协和医学院药物研究所, 天然药物活性物质与功能国家重点实验室/创新药物非临床药物代谢及PK/PD研究北京市重点实验室, 北京 100050, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1222469710826951170, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469708650107314, xref=null, ext=[AuthorCompanyExt(id=1222469710831145475, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469708650107314, companyId=1222469710826951170, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=State Key Laboratory of Bioactive Substances and Functions of Natural Medicines/Beijing Key Laboratory of Non-clinical Drug Metabolism and PK/PD Study, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China), AuthorCompanyExt(id=1222469710843728388, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469708650107314, companyId=1222469710826951170, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=中国医学科学院、北京协和医学院药物研究所, 天然药物活性物质与功能国家重点实验室/创新药物非临床药物代谢及PK/PD研究北京市重点实验室, 北京 100050)])])], keywords=[Keyword(id=1222469712450146950, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469708650107314, language=EN, orderNo=1, keyword=Bt354), Keyword(id=1222469712534033039, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469708650107314, language=EN, orderNo=2, keyword=prostate cancer), Keyword(id=1222469712659862164, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469708650107314, language=EN, orderNo=3, keyword=signal transducer and activator of transcription 3), Keyword(id=1222469712789885595, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469708650107314, language=EN, orderNo=4, keyword=apoptosis), Keyword(id=1222469712873771684, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469708650107314, language=EN, orderNo=5, keyword=inhibitor), Keyword(id=1222469712945074856, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469708650107314, language=CN, orderNo=1, keyword=Bt354), Keyword(id=1222469713083486895, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469708650107314, language=CN, orderNo=2, keyword=前列腺癌), Keyword(id=1222469713171567287, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469708650107314, language=CN, orderNo=3, keyword=信号传导与活化转录因子3), Keyword(id=1222469713272230594, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469708650107314, language=CN, orderNo=4, keyword=凋亡), Keyword(id=1222469713343533770, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469708650107314, language=CN, orderNo=5, keyword=抑制剂)], refs=[Reference(id=1222469715251942233, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469708650107314, doi=10.3322/caac.21551, pmid=null, pmcid=null, year=2019, volume=69, issue=null, pageStart=7, pageEnd=34, url=null, language=null, rfNumber=[1], rfOrder=0, authorNames=Siegel RL, Miller KD, Jemal A, journalName=CA Cancer J Clin, refType=null, unstructuredReference=
Siegel RL ,
Miller KD ,
Jemal A . Cancer statistics, 2019[J].
CA Cancer J Clin,
2019,
69: 7-34., articleTitle=Cancer statistics, 2019, refAbstract=null), Reference(id=1222469715344216928, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469708650107314, doi=null, pmid=null, pmcid=null, year=2018, volume=35, issue=null, pageStart=144, pageEnd=145, url=null, language=null, rfNumber=[2], rfOrder=1, authorNames=Wang YE, Wu JF, journalName=Chin Med J Metall Indus (中国冶金工业医学杂志), refType=null, unstructuredReference=
Wang YE ,
Wu JF . Advances in treatment of castration-resistant prostate cancer[J].
Chin Med J Metall Indus (中国冶金工业医学杂志),
2018,
35: 144-145., articleTitle=Advances in treatment of castration-resistant prostate cancer, refAbstract=null), Reference(id=1222469715440685928, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469708650107314, doi=10.1097/CCO.0b013e3283380939, pmid=null, pmcid=null, year=2010, volume=22, issue=null, pageStart=263, pageEnd=267, url=null, language=null, rfNumber=[3], rfOrder=2, authorNames=Lassi K, Dawson NA, journalName=Curr Opin Oncol, refType=null, unstructuredReference=
Lassi K ,
Dawson NA . Update on castrate-resistant prostate cancer:2010[J].
Curr Opin Oncol,
2010,
22: 263-267., articleTitle=Update on castrate-resistant prostate cancer:2010, refAbstract=null), Reference(id=1222469715558126446, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469708650107314, doi=10.1593/neo.07971, pmid=null, pmcid=null, year=2008, volume=10, issue=null, pageStart=287, pageEnd=297, url=null, language=null, rfNumber=[4], rfOrder=3, authorNames=Xiong H, Zhang ZG, Tian XQ, journalName=Neoplasia, refType=null, unstructuredReference=
Xiong H ,
Zhang ZG ,
Tian XQ et al . Inhibition of JAK1, 2/STAT3 signaling induces apoptosis, cell cycle arrest, and reduces tumor cell invasion in colorectal cancer cells[J].
Neoplasia,
2008,
10: 287-297., articleTitle=Inhibition of JAK1, 2/STAT3 signaling induces apoptosis, cell cycle arrest, and reduces tumor cell invasion in colorectal cancer cells, refAbstract=null), Reference(id=1222469715683955570, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469708650107314, doi=10.1196/annals.1378.063, pmid=null, pmcid=null, year=2006, volume=1091, issue=null, pageStart=151, pageEnd=169, url=null, language=null, rfNumber=[5], rfOrder=4, authorNames=Aggarwal BB, Sethi G, Ahn KS, journalName=Ann N Y Acad Sci, refType=null, unstructuredReference=
Aggarwal BB ,
Sethi G ,
Ahn KS et al . Targeting signal-transducer-and-activator-of-transcription-3 for prevention and therapy of cancer:modern target but ancient solution[J].
Ann N Y Acad Sci,
2006,
1091: 151-169., articleTitle=Targeting signal-transducer-and-activator-of-transcription-3 for prevention and therapy of cancer:modern target but ancient solution, refAbstract=null), Reference(id=1222469715793007477, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469708650107314, doi=10.1038/sj.onc.1208469, pmid=null, pmcid=null, year=2005, volume=24, issue=null, pageStart=3397, pageEnd=3408, url=null, language=null, rfNumber=[6], rfOrder=5, authorNames=Dauer DJ, Ferraro B, Song L, journalName=Oncogene, refType=null, unstructuredReference=
Dauer DJ ,
Ferraro B ,
Song L et al . STAT3 regulates genes common to both wound healing and cancer[J].
Oncogene,
2005,
24: 3397-3408., articleTitle=STAT3 regulates genes common to both wound healing and cancer, refAbstract=null), Reference(id=1222469715881087865, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469708650107314, doi=10.1016/j.molimm.2007.04.031, pmid=null, pmcid=null, year=2008, volume=45, issue=null, pageStart=137, pageEnd=143, url=null, language=null, rfNumber=[7], rfOrder=6, authorNames=Song Y, Qian L, Song S, journalName=Mol Immunol, refType=null, unstructuredReference=
Song Y ,
Qian L ,
Song S et al . FRA-1 and STAT3 synergistically regulate activation of human MMP-9 gene[J].
Mol Immunol,
2008,
45: 137-143., articleTitle=FRA-1 and STAT3 synergistically regulate activation of human MMP-9 gene, refAbstract=null), Reference(id=1222469715969168253, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469708650107314, doi=10.1038/onc.2012.546, pmid=null, pmcid=null, year=2013, volume=32, issue=null, pageStart=5144, pageEnd=5155, url=null, language=null, rfNumber=[8], rfOrder=7, authorNames=Kesanakurti D, Chetty C, Rajasekhar Maddirela D, journalName=Oncogene, refType=null, unstructuredReference=
Kesanakurti D ,
Chetty C ,
Rajasekhar Maddirela D et al . Essential role of cooperative NF-
κB and STAT3 recruitment to ICAM-1 intronic consensus elements in the regulation of radiation-induced invasion and migration in glioma[J].
Oncogene,
2013,
32: 5144-5155., articleTitle=Essential role of cooperative NF-
κB and STAT3 recruitment to ICAM-1 intronic consensus elements in the regulation of radiation-induced invasion and migration in glioma, refAbstract=null), Reference(id=1222469716057248643, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469708650107314, doi=10.1038/sj.onc.1207383, pmid=null, pmcid=null, year=2004, volume=23, issue=null, pageStart=3550, pageEnd=3560, url=null, language=null, rfNumber=[9], rfOrder=8, authorNames=Xie TX, Wei D, Liu M, journalName=Oncogene, refType=null, unstructuredReference=
Xie TX ,
Wei D ,
Liu M et al . STAT3 activation regulates the expression of matrix metalloproteinase-2 and tumor invasion and metastasis[J].
Oncogene,
2004,
23: 3550-3560., articleTitle=STAT3 activation regulates the expression of matrix metalloproteinase-2 and tumor invasion and metastasis, refAbstract=null), Reference(id=1222469716136940423, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469708650107314, doi=null, pmid=null, pmcid=null, year=2012, volume=33, issue=null, pageStart=150, pageEnd=154, url=http://d.old.wanfangdata.com.cn/Periodical/dejydxxb201202007, language=null, rfNumber=[10], rfOrder=9, authorNames=Han H, Li CY, Liu X, journalName=Acad J Sec Mil Med Uni (第二军医大学学报), refType=null, unstructuredReference=
Han H ,
Li CY ,
Liu X et al . Relationship of STAT3 activity with chemosensitivity to cisplatin in prostate cancer cell lines[J].
Acad J Sec Mil Med Uni (第二军医大学学报),
2012,
33: 150-154., articleTitle=Relationship of STAT3 activity with chemosensitivity to cisplatin in prostate cancer cell lines, refAbstract=null), Reference(id=1222469716237603723, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469708650107314, doi=10.1080/1061186X.2018.1452244, pmid=null, pmcid=null, year=2018, volume=26, issue=null, pageStart=920, pageEnd=930, url=null, language=null, rfNumber=[11], rfOrder=10, authorNames=Chen Y, Ji M, Zhang S, journalName=J Drug Target, refType=null, unstructuredReference=
Chen Y ,
Ji M ,
Zhang S et al . Bt354 as a new STAT3 signaling pathway inhibitor against triple negative breast cancer[J].
J Drug Target,
2018,
26: 920-930., articleTitle=Bt354 as a new STAT3 signaling pathway inhibitor against triple negative breast cancer, refAbstract=null), Reference(id=1222469716321489808, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469708650107314, doi=null, pmid=null, pmcid=null, year=2010, volume=21, issue=null, pageStart=274, pageEnd=281, url=http://d.old.wanfangdata.com.cn/NSTLQK/10.1002-ijc.2910210305/, language=null, rfNumber=[12], rfOrder=11, authorNames=Stone KR, Mickey DD, Wunderli H, journalName=Int J Cancer, refType=null, unstructuredReference=
Stone KR ,
Mickey DD ,
Wunderli H et al . Isolation of a human prostate carcinoma cell line (DU 145)[J].
Int J Cancer,
2010,
21: 274-281., articleTitle=Isolation of a human prostate carcinoma cell line (DU 145), refAbstract=null), Reference(id=1222469716459901843, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469708650107314, doi=null, pmid=null, pmcid=null, year=2018, volume=53, issue=null, pageStart=938, pageEnd=943, url=http://www.yxxb.com.cn:8081/aps/CN/abstract/abstract17188.shtml, language=null, rfNumber=[13], rfOrder=12, authorNames=Ji M, Yao HP, Zhou J, journalName=Acta Pharm Sin (药学学报), refType=null, unstructuredReference=
Ji M ,
Yao HP ,
Zhou J et al . Antitumor activity of a novel PARP1/2 inhibitor YHP-743[J].
Acta Pharm Sin (药学学报),
2018,
53: 938-943., articleTitle=Antitumor activity of a novel PARP1/2 inhibitor YHP-743, refAbstract=null), Reference(id=1222469716573148055, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469708650107314, doi=null, pmid=null, pmcid=null, year=2014, volume=49, issue=null, pageStart=861, pageEnd=868, url=http://www.yxxb.com.cn:8081/aps/CN/abstract/abstract14904.shtml, language=null, rfNumber=[14], rfOrder=13, authorNames=Tang K, Yang HZ, Li Y, journalName=Acta Pharm Sin (药学学报), refType=null, unstructuredReference=
Tang K ,
Yang HZ ,
Li Y et al . Anti-tumor activity and mechanism of T03
in vitro and
in vivo[J].
Acta Pharm Sin (药学学报),
2014,
49: 861-868., articleTitle=Anti-tumor activity and mechanism of T03
in vitro and
in vivo, refAbstract=null), Reference(id=1222469716686394268, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469708650107314, doi=10.2174/092986708783955464, pmid=null, pmcid=null, year=2008, volume=15, issue=null, pageStart=834, pageEnd=843, url=null, language=null, rfNumber=[15], rfOrder=14, authorNames=Costantino L, Barlocco D, journalName=Curr Med Chem, refType=null, unstructuredReference=
Costantino L ,
Barlocco D . STAT3 as a target for cancer drug discovery[J].
Curr Med Chem,
2008,
15: 834-843., articleTitle=STAT3 as a target for cancer drug discovery, refAbstract=null), Reference(id=1222469716778668961, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469708650107314, doi=10.1172/JCI0215650, pmid=null, pmcid=null, year=2002, volume=109, issue=null, pageStart=1143, pageEnd=1148, url=null, language=null, rfNumber=[16], rfOrder=15, authorNames=Levy DE, Lee CK, journalName=J Clin Invest, refType=null, unstructuredReference=
Levy DE ,
Lee CK . What does STAT3 do?[J].
J Clin Invest,
2002,
109: 1143-1148., articleTitle=What does STAT3 do?, refAbstract=null), Reference(id=1222469716858360743, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469708650107314, doi=null, pmid=null, pmcid=null, year=2017, volume=52, issue=null, pageStart=1351, pageEnd=1358, url=http://www.yxxb.com.cn:8081/aps/CN/abstract/abstract16945.shtml, language=null, rfNumber=[17], rfOrder=16, authorNames=Chen Y, Ji M, Chen XG, journalName=Acta Pharm Sin (药学学报), refType=null, unstructuredReference=
Chen Y ,
Ji M ,
Chen XG . Research progress of relationship between STAT3 and tumor[J].
Acta Pharm Sin (药学学报),
2017,
52: 1351-1358., articleTitle=Research progress of relationship between STAT3 and tumor, refAbstract=null)], funds=[Fund(id=1222469715151278929, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469708650107314, awardId=2017-I2M-1-010, language=CN, fundingSource=中国医学科学院医学与健康科技创新工程重大协同创新项目(2017-I2M-1-010), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1222469710826951170, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469708650107314, xref=null, ext=[AuthorCompanyExt(id=1222469710831145475, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469708650107314, companyId=1222469710826951170, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=State Key Laboratory of Bioactive Substances and Functions of Natural Medicines/Beijing Key Laboratory of Non-clinical Drug Metabolism and PK/PD Study, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China), AuthorCompanyExt(id=1222469710843728388, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469708650107314, companyId=1222469710826951170, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=中国医学科学院、北京协和医学院药物研究所, 天然药物活性物质与功能国家重点实验室/创新药物非临床药物代谢及PK/PD研究北京市重点实验室, 北京 100050)])], figs=[ArticleFig(id=1222469713469362901, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469708650107314, language=EN, label=null, caption=null, figureFileSmall=nT+GBR2WlDyQw2/joaiS/w==, figureFileBig=U1doH0h0saw1uFXtpPOp1g==, tableContent=null), ArticleFig(id=1222469713570026203, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469708650107314, language=CN, label=Figure 1, caption=
Bt354 inhibited the proliferation of DU145 cancer cells. A: Chemical structure of Bt354; B: Anti-proliferative effects of Bt354 in DU145 evaluated by using immunofluorescence staining with EdU; C: Change in the number of EdU-labeled DU145 cells. The results are representative of three independent experiments. <sup>***</sup><i>P</i> < 0.001 <i>vs</i> Ctrl group , figureFileSmall=nT+GBR2WlDyQw2/joaiS/w==, figureFileBig=U1doH0h0saw1uFXtpPOp1g==, tableContent=null), ArticleFig(id=1222469713804907246, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469708650107314, language=EN, label=null, caption=null, figureFileSmall=MVXILnIBkjoeZf9/9pmbzQ==, figureFileBig=W8zHKyo4HvU6gwbsq4My4w==, tableContent=null), ArticleFig(id=1222469713897181941, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469708650107314, language=CN, label=Figure 2, caption=
Antitumor activity of Bt354 in DU145 xenograft mice model. A, B: Change of tumor volume and body weight; C: Tumor weight of the stripped tumors of DU145 xenograft mice; D: White blood cell (WBC), red blood cell (RBC) and blood platelet (PLT) count of mice treated with docetaxel and different doses of Bt354. <i>n</i> = 7, <span class="mag-xml-overline" style="border-top:1px solid black"><i>x</i></span> ± <i>s</i> , figureFileSmall=MVXILnIBkjoeZf9/9pmbzQ==, figureFileBig=W8zHKyo4HvU6gwbsq4My4w==, tableContent=null), ArticleFig(id=1222469714002039551, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469708650107314, language=EN, label=null, caption=null, figureFileSmall=W65r4ZTsACbLoLID6EU+kg==, figureFileBig=pMJkhfPvjq0mwkXUGYuBGA==, tableContent=null), ArticleFig(id=1222469714119480071, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469708650107314, language=CN, label=Figure 3, caption=
The number of Ki 67 positive cells in the tumor sections. A: Sections of individual tumors from 6 groups immunohistochemically stained with Ki 67 to evaluate cell proliferation (×200); B: Change in the number of Ki 67 positive cells. <sup>**</sup><i>P</i> < 0.01, <sup>***</sup><i>P</i> < 0.001 <i>vs</i> Ctrl group , figureFileSmall=W65r4ZTsACbLoLID6EU+kg==, figureFileBig=pMJkhfPvjq0mwkXUGYuBGA==, tableContent=null), ArticleFig(id=1222469714207560462, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469708650107314, language=EN, label=null, caption=null, figureFileSmall=l9BOYaLPt35oopJhn2rEIg==, figureFileBig=V3XPGJrzptABkzXxNeqYSQ==, tableContent=null), ArticleFig(id=1222469714400498462, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469708650107314, language=CN, label=Figure 4, caption=
Tumor sections from DU145 cells to detect apoptosis in tumor tissue. Scale length is 50 μm , figureFileSmall=l9BOYaLPt35oopJhn2rEIg==, figureFileBig=V3XPGJrzptABkzXxNeqYSQ==, tableContent=null), ArticleFig(id=1222469714496967458, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469708650107314, language=EN, label=null, caption=null, figureFileSmall=r9xY3flrQY8wSRYbzamqEg==, figureFileBig=eqcvVMrgvJRCfx3MegVg9g==, tableContent=null), ArticleFig(id=1222469714606019372, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469708650107314, language=CN, label=Figure 5, caption=
Effect of Bt354 on the invasion and metastasis of tumor cells. A: DU145 cells treated with different concentrations of Bt354 were detected by wound healing assay; B: DU145 cells treated with different concentrations of Bt354 were detected by cell migration assay; C: Change in the population of DU145 cells. <sup>***</sup><i>P</i> < 0.001 <i>vs</i> Ctrl group , figureFileSmall=r9xY3flrQY8wSRYbzamqEg==, figureFileBig=eqcvVMrgvJRCfx3MegVg9g==, tableContent=null), ArticleFig(id=1222469714702488369, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469708650107314, language=EN, label=null, caption=null, figureFileSmall=1tkpbmS3F7T3qd8zkr7m2A==, figureFileBig=5gr2zRGwPW9akC9cft6Ssg==, tableContent=null), ArticleFig(id=1222469714798957371, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469708650107314, language=CN, label=Figure 6, caption=
Bt354 inhibited the nuclear translocation of STAT3 in DU145 cells , figureFileSmall=1tkpbmS3F7T3qd8zkr7m2A==, figureFileBig=5gr2zRGwPW9akC9cft6Ssg==, tableContent=null), ArticleFig(id=1222469714887037760, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469708650107314, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
| Group | Dose
/mg·kg-1 | Number of animals | Body weight/g | | Tumor volume/mm3 | T/C
/% | Tumor
weigh/g | TGI
/% |
| Begin | End | Begin | End |
| Control | - | | 21.6 ± 1.6 | 20.1 ± 0.9 | | 116.8 ± 37.0 | 1 349.8 ± 161.3 | NA | 1.02 ± 0.13 | NA |
| Docetaxel ip | 10 | 4 | 20.6 ± 0.9 | 17.4 ± 1.8 | 120.8 ± 46.8 | 244.7 ± 99.8 | 18.1*** | 0.23 ± 0.16 | 77.4*** |
| Napabucasin ip | 20 | 5 | 20.5 ± 0.6 | 19.1 ± 1.4 | 118.2 ± 20.9 | 784.1 ± 259.0 | 58.9*** | 0.43 ± 0.05 | 57.8*** |
| Bt354 po | 10 | 7 | 20.5 ± 0.5 | 18.9 ± 1.6 | 119.8 ± 33.0 | 609.7 ± 207.4 | 45.2*** | 0.42 ± 0.15 | 58.8*** |
| 20 | 7 | 20.9 ± 0.9 | 18.9 ± 1.7 | 117.1 ± 29.6 | 557.9 ± 173.8 | 41.3*** | 0.38 ± 0.15 | 62.7*** |
| 40 | 7 | 20.8 ± 0.9 | 19.1 ± 1.5 | 117.1 ± 16.3 | 405.8 ± 156.5 | 30.0*** | 0.27 ± 0.09 | 73.5*** |
), ArticleFig(id=1222469715004478280, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469708650107314, language=CN, label=Table 1, caption=
Antitumor activity of Bt354 in DU145 xenograft mice model. One-way ANOVA, ***P < 0.001 vs Ctrl group. TGI: Tumor growth inhibition; T/C: Mean tumor volume of treated group/mean tumor volume of vehicle group. n = 7, x ± s
, figureFileSmall=null, figureFileBig=null, tableContent=
| Group | Dose
/mg·kg-1 | Number of animals | Body weight/g | | Tumor volume/mm3 | T/C
/% | Tumor
weigh/g | TGI
/% |
| Begin | End | Begin | End |
| Control | - | | 21.6 ± 1.6 | 20.1 ± 0.9 | | 116.8 ± 37.0 | 1 349.8 ± 161.3 | NA | 1.02 ± 0.13 | NA |
| Docetaxel ip | 10 | 4 | 20.6 ± 0.9 | 17.4 ± 1.8 | 120.8 ± 46.8 | 244.7 ± 99.8 | 18.1*** | 0.23 ± 0.16 | 77.4*** |
| Napabucasin ip | 20 | 5 | 20.5 ± 0.6 | 19.1 ± 1.4 | 118.2 ± 20.9 | 784.1 ± 259.0 | 58.9*** | 0.43 ± 0.05 | 57.8*** |
| Bt354 po | 10 | 7 | 20.5 ± 0.5 | 18.9 ± 1.6 | 119.8 ± 33.0 | 609.7 ± 207.4 | 45.2*** | 0.42 ± 0.15 | 58.8*** |
| 20 | 7 | 20.9 ± 0.9 | 18.9 ± 1.7 | 117.1 ± 29.6 | 557.9 ± 173.8 | 41.3*** | 0.38 ± 0.15 | 62.7*** |
| 40 | 7 | 20.8 ± 0.9 | 19.1 ± 1.5 | 117.1 ± 16.3 | 405.8 ± 156.5 | 30.0*** | 0.27 ± 0.09 | 73.5*** |
)], attaches=null, journal=Journal(id=1189982048455397383, delFlag=0, nameCn=药学学报, nameEn=Acta Pharmaceutica Sinica, nameHistory1=null, nameHistory2=null, issn=0513-4870, eissn=null, cn=11-2163/R, coden=null, periodic=0, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=BTxjudbJDVO4PqdBR6On6Q==, journalPrice=null, startedYear=null, abbrevIsoEn=null, journalRemark=null, publicationField=null, createdTime=1761643429151, updatedTime=1788948913902, createdBy=18614031015, updatedBy=13041195026, firstLetterCn=Y, firstLetterEn=Y, subjectCode=Medical and Pharmaceutical Sciences, subjectName=Life Sciences, subjectCodeEn=Medical and Pharmaceutical Sciences, subjectNameEn=null, picCn=BTxjudbJDVO4PqdBR6On6Q==, picEn=c4l1ckL55nWbhl1KrFdWIA==, jcr=null, cjcr=null, exts=[JournalExt(id=1304509553505227679, language=CN, name=药学学报, nameHistory1=null, nameHistory2=null, managedBy=中国科学技术协会, sponsoredBy=中国药学会、中国医学科学院药物研究所, publishedBy=《药学学报》编辑委员会编辑出版, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788948914171, updatedTime=1788948914171, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://www.yxxb.com.cn/journalx_yxxb/authorLogOn.action, submissionEditorUrl=https://www.yxxb.com.cn/journalx_yxxb/editorLogOn.action, submissionReviewUrl=https://www.yxxb.com.cn/journalx_yxxb/expertLogOn.action, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""}), JournalExt(id=1304509553559753632, language=EN, name=Acta Pharmaceutica Sinica, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788948914184, updatedTime=1788948914184, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://www.yxxb.com.cn/journalx_yxxb/authorLogOn.action, submissionEditorUrl=https://www.yxxb.com.cn/journalx_yxxb/editorLogOn.action, submissionReviewUrl=https://www.yxxb.com.cn/journalx_yxxb/expertLogOn.action, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""})], databaseList=null, tenantJournalId=1189982191388893191, websiteList=[Website(id=1189982271588340489, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1189982191388893191, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/yxxb/CN, language=CN, createTime=1761643482348, createBy=18614031015, updateTime=1761643498101, updateBy=18614031015, name=药学学报-中文, tplId=1146099689490845704, title=药学学报, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1189982873114448678, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271588340489, code=articleTextType, value=kx, createTime=1761643625763, updateTime=1761643625763, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982873093477155, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271588340489, code=banner, value=null, createTime=1761643625758, updateTime=1761643625758, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982873135420201, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271588340489, code=grayFlag, value=0, createTime=1761643625768, updateTime=1761643625768, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982873085088546, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271588340489, code=logo, value=https://castjournals.cast.org.cn/joweb/yxxb/CN/file/pic?fileId=w+t2v8bJnX5lh3+hRRJcDA==, createTime=1761643625756, updateTime=1761643625756, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982873152197419, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271588340489, code=minRunFlag, value=0, createTime=1761643625772, updateTime=1761643625772, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982873110254373, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271588340489, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/yxxb/CN/file/pic, createTime=1761643625762, updateTime=1761643625762, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982873143808810, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271588340489, code=silenceFlag, value=0, createTime=1761643625770, updateTime=1761643625770, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982873101865764, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271588340489, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1761643625760, updateTime=1761643625760, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982873122837287, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271588340489, code=themeColor, value=null, createTime=1761643625765, updateTime=1761643625765, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982873127031592, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271588340489, code=themeStyle, value=null, createTime=1761643625766, updateTime=1761643625766, creator=18614031015, updator=18614031015)]), Website(id=1189982271655449355, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1189982191388893191, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/yxxb/EN, language=EN, createTime=1761643482364, createBy=18614031015, updateTime=1761643514085, updateBy=18614031015, name=药学学报-英文, tplId=1146101810881728533, title=Acta Pharmaceutica Sinica, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1189982903015633534, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271655449355, code=articleTextType, value=kx, createTime=1761643632892, updateTime=1761643632892, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982902990467707, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271655449355, code=banner, value=null, createTime=1761643632886, updateTime=1761643632886, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982903036605057, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271655449355, code=grayFlag, value=0, createTime=1761643632897, updateTime=1761643632897, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982902982079098, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271655449355, code=logo, value=https://castjournals.cast.org.cn/joweb/yxxb/EN/file/pic?fileId=w+t2v8bJnX5lh3+hRRJcDA==, createTime=1761643632884, updateTime=1761643632884, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982903053382275, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271655449355, code=minRunFlag, value=0, createTime=1761643632901, updateTime=1761643632901, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982903007244925, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271655449355, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/yxxb/EN/file/pic, createTime=1761643632890, updateTime=1761643632890, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982903044993666, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271655449355, code=silenceFlag, value=0, createTime=1761643632899, updateTime=1761643632899, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982902998856316, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271655449355, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1761643632888, updateTime=1761643632888, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982903019827839, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271655449355, code=themeColor, value=null, createTime=1761643632893, updateTime=1761643632893, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982903028216448, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271655449355, code=themeStyle, value=null, createTime=1761643632895, updateTime=1761643632895, creator=18614031015, updator=18614031015)])], journalTitle=药学学报, weixinUrl=null, journalUrl=https://www.yxxb.com.cn/aps, iacademicId=null, status=1, seqNo=null, journalTitleEn=Acta Pharmaceutica Sinica, journalPhotoCn=BTxjudbJDVO4PqdBR6On6Q==, journalPhotoEn=c4l1ckL55nWbhl1KrFdWIA==, journalFirstLetter=Y, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false, interPubPlatform=, interPubPlatformUrl=null), detailUrlCn=https://castjournals.cast.org.cn/joweb/yxxb/CN/10.16438/j.0513-4870.2019-0668, detailUrlEn=https://castjournals.cast.org.cn/joweb/yxxb/EN/10.16438/j.0513-4870.2019-0668, pdfUrlCn=https://castjournals.cast.org.cn/joweb/yxxb/CN/PDF/10.16438/j.0513-4870.2019-0668, pdfUrlEn=https://castjournals.cast.org.cn/joweb/yxxb/EN/PDF/10.16438/j.0513-4870.2019-0668, aliStartDate=null, aliEndDate=null, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=1, orderTime=1570809600000, fullTextJson=null, articleText=null, reference=null)
全屏
文章导航
PDF下载
409
207
关闭全屏
北京市海淀区学院南路86号
010-62199257（仅加盟咨询）
qkjq@cast.org.cn
