Article(id=1222469707249213691, tenantId=1146029695717560320, journalId=1189982191388893191, issueId=1222469705873481976, articleNumber=null, orderNo=null, doi=10.16438/j.0513-4870.2019-0670, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=research-article, receivedDate=1566403200000, receivedDateStr=2019-08-22, revisedDate=1567699200000, revisedDateStr=2019-09-06, acceptedDate=null, acceptedDateStr=null, onlineDate=1769389090596, onlineDateStr=2026-01-26, pubDate=1570809600000, pubDateStr=2019-10-12, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1769389090596, onlineIssueDateStr=2026-01-26, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1769389090596, creator=13701087609, updateTime=1769389090596, updator=13701087609, issue=Issue{id=1222469705873481976, tenantId=1146029695717560320, journalId=1189982191388893191, year='2019', volume='54', issue='10', pageStart='1711', pageEnd='1880', issueExtLink='null', onlineDate='null', pubDate='1570809600000', pubDateStr='2019-10-12', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1769389090269, creator='13701087609', updateTime=1769389551199, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1222471639254683958, tenantId=1146029695717560320, journalId=1189982191388893191, issueId=1222469705873481976, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1222471639254683959, tenantId=1146029695717560320, journalId=1189982191388893191, issueId=1222469705873481976, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1863, endPage=1867, ext={EN=ArticleExt(id=1222469707685421313, articleId=1222469707249213691, tenantId=1146029695717560320, journalId=1189982191388893191, language=EN, title=The effects of different stimulators on the activation of human lymphocytes, columnId=1190335348761793317, journalTitle=Acta Pharmaceutica Sinica, columnName=Original Articles, runingTitle=null, highlight=null, articleAbstract=

The research aims to study the effects of different stimulants on the activation of human lymphocytes. Human peripheral blood mononuclear cells were prepared by density centrifugation. The blood's sample was provided by National Institutes for Food and Drug Control and approved by its Ethics Committee. The expressions of CD69 in CD3⁺CD4⁺ and CD3⁺CD8⁺ human T cells were detected by flow cytometry after administrated with CD3/CD28 antibody, phytohaemagglutinin (PHA), Staphylococcus auresus enterooxin B (SEB), interleukin (IL27) and PMA plus ionomycin for 24 h. The proliferation of lymphocyte was detected by CellTiter-Glo kit. The secreted IFNγ in supernatant of medium was examined by ELISA kit. The proliferation of lymphocytes had no change after exposed of CD3/CD28 antibody, SEB, IL27 and PMA plus ionomycin for 24 h. However, the CD69 expressions in CD3⁺CD4⁺ and CD3⁺CD8⁺ T cells and IFNγ productions were significantly increased by CD3/CD28 antibody, SEB, IL27 and PMA plus ionomycin at 24 h, indicating that CD3⁺CD4⁺ and CD3⁺CD8⁺ T cells were activated under above-mentioned stimulated condition. CD3/CD28 antibody, SEB, IL27 and PMA plus ionomycin were valid stimulants for T cell activation.

, authors=null, authorsList=Zheng YAN, Ni-na XUE, Ming JI, Fang-fang LAI, Xiao-guang CHEN, authorCompany=null, correspAuthors=Xiao-guang CHEN, authorNote=null, correspAuthorsNote=null, copyrightStatement=Copyright ©2019 Acta Pharmaceutica Sinica. All rights reserved., copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1222469708620751140, articleId=1222469707249213691, tenantId=1146029695717560320, journalId=1189982191388893191, language=CN, title=不同刺激剂对人淋巴细胞活化的影响, columnId=1190335348896011050, journalTitle=药学学报, columnName=研究论文, runingTitle=null, highlight=null, articleAbstract=

本文研究不同刺激剂在体外对人淋巴细胞活化的影响。采用梯度离心法分离获得人外周血单个核细胞（peripheral blood mononuclear cells，PBMC），血液样本由中国食品药品检定研究院提供，并通过伦理委员会批准。用CD3/CD28抗体（anti-CD3/CD28 antibody）、植物血凝素（phytohaemagglutinin，PHA）、金黄色葡萄球菌B型肠毒素（Staphylococcus auresus enterooxin B，SEB）、白介素27（interleukin 27，IL27）、佛波酯（phorbol myristrate acetate，PMA）+离子霉素（ionomycin）在体外分别刺激24 h，观察CD3⁺CD4⁺和CD3⁺CD8⁺ T细胞亚群CD69表达。同时采用CellTiter-Glo发光法和ELISA法检测淋巴细胞增殖和IFNγ的分泌。CD3/CD28抗体、PMA+ionomycin、SEB和IL27作用PBMC 24 h不影响淋巴细胞增殖，但可以很好地活化CD3⁺CD4⁺和CD3⁺CD8⁺ T细胞，表现为CD69的平均荧光强度显著右移，并促进淋巴细胞IFNγ的分泌。CD3/CD28抗体、PMA+ionomycin、SEB和IL27是T细胞活化的有效刺激剂。

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