Article(id=1222469636172538110, tenantId=1146029695717560320, journalId=1189982191388893191, issueId=1222469634733891832, articleNumber=null, orderNo=null, doi=10.16438/j.0513-4870.2019-0090, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=research-article, receivedDate=1548604800000, receivedDateStr=2019-01-28, revisedDate=1551542400000, revisedDateStr=2019-03-03, acceptedDate=null, acceptedDateStr=null, onlineDate=1769389073651, onlineDateStr=2026-01-26, pubDate=1565539200000, pubDateStr=2019-08-12, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1769389073651, onlineIssueDateStr=2026-01-26, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1769389073651, creator=13701087609, updateTime=1769389073651, updator=13701087609, issue=Issue{id=1222469634733891832, tenantId=1146029695717560320, journalId=1189982191388893191, year='2019', volume='54', issue='8', pageStart='1333', pageEnd='1530', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1769389073308, creator=13701087609, updateTime=1769389491233, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1222471387697111522, tenantId=1146029695717560320, journalId=1189982191388893191, issueId=1222469634733891832, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1222471387697111523, tenantId=1146029695717560320, journalId=1189982191388893191, issueId=1222469634733891832, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=1348, endPage=1355, ext={EN=ArticleExt(id=1222469637095285007, articleId=1222469636172538110, tenantId=1146029695717560320, journalId=1189982191388893191, language=EN, title=The roles of sphingosine-1-phosphate and its receptor in
Mycobacterium tuberculosis infection and novel antibiotics discovery, columnId=1190335348648547107, journalTitle=Acta Pharmaceutica Sinica, columnName=Reviews, runingTitle=null, highlight=null, articleAbstract=
Tuberculosis (TB) caused by Mycobacterium tuberculosis (M. tuberculosis) infection remains a major public health problem of global concern, largely due to antibiotics resistance, persistence and immune evasion. Sphingolipid bioactive molecules are involved in several important pathophysiological processes. Sphingosine-1-phosphate is a key product of sphingolipid metabolism, and can play a role in two manners:autocrine and/or paracrine. Sphingosine-1-phosphate regulates T cells and a variety of antigen-presenting cells during M. tuberculosis infection, promotes antigen processing and expression in monocytes, is involved in the maturation of phagolysosome, regulates Ca2+ homeostasis, participates in the autophagy of macrophages, inhibits the survival and proliferation of M. tuberculosis within host cells, and effectively reduces the necrosis of the mouse lungs infected by M. tuberculosis. Injection of 20 nmol per mouse sphingosine-1-phosphate inhibited up to 47% of mycobacterial growth in the lung and spleen of mice infected by M. tuberculosis. In this paper, sphingosine-1-phosphate, its receptors and regulatory network were reviewed, and the specific mechanism of sphingosine-1-phosphate inhibiting the survival of M. tuberculosis-infected host cells was elaborated. This will provide novel insights into the new targets for tuberculosis prevention and treatment.
, correspAuthors=Jian-ping XIE, authorNote=null, correspAuthorsNote=null, copyrightStatement=Copyright ©2019 Acta Pharmaceutica Sinica. All rights reserved., copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, authorCompany=null, fund=null, authors=null, authorsList=Jun-feng ZHEN, Shuang-quan YAN, Yu-zhu LI, Jian-ping XIE), CN=ArticleExt(id=1222469638001254699, articleId=1222469636172538110, tenantId=1146029695717560320, journalId=1189982191388893191, language=CN, title=鞘氨醇-1-磷酸及其受体在结核分枝杆菌感染和抗生素研发中的作用, columnId=1190335349655180086, journalTitle=药学学报, columnName=综述, runingTitle=null, highlight=null, articleAbstract=
结核病仍是全球关注的重大公共卫生问题，这与其耐药及感染后的持留和免疫逃逸有关。鞘脂类生物活性分子参与多个重要的病理生理过程。鞘氨醇-1-磷酸是鞘脂类代谢的关键产物，能够通过自分泌/旁分泌的方式发挥作用。鞘氨醇-1-磷酸调节T细胞和结核分枝杆菌感染过程中多种抗原呈递细胞，促进单核细胞抗原的加工和表达，促进吞噬溶酶体的成熟，还可以调控Ca2+稳态以及参与巨噬细胞自噬等过程，抑制结核分枝杆菌在宿主细胞内的存活和生长，有效降低结核菌感染小鼠肺的损伤。外源添加鞘氨醇-1-磷酸，能够减少结核分枝杆菌感染小鼠肺和脾的分枝杆菌量。本文综述了鞘氨醇-1-磷酸及其受体调控网络，阐述了鞘氨醇-1-磷酸在抑制结核分枝杆菌感染宿主细胞后存活过程的具体机制，旨在为结核病治疗寻找新的防控靶标。
, correspAuthors=谢建平, authorNote=null, correspAuthorsNote=
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https://apps.who.int/iris/handle/10665/274453., articleTitle=null, refAbstract=null), Reference(id=1222469642245890605, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=null, pmid=null, pmcid=null, year=2018, volume=18, issue=null, pageStart=e183, pageEnd=e198, url=http://d.old.wanfangdata.com.cn/Periodical/ysjxzz2014z1019, language=null, rfNumber=[2], rfOrder=1, authorNames=Tiberi S, du Plessis N, Walzl G, journalName=Lancet Infect Dis, refType=null, unstructuredReference=
Tiberi S ,
du Plessis N ,
Walzl G et al . Tuberculosis: progress and advances in development of new drugs, treatment regimens, and host-directed therapies[J].
Lancet Infect Dis,
2018,
18: e183-e198., articleTitle=Tuberculosis: progress and advances in development of new drugs, treatment regimens, and host-directed therapies, refAbstract=null), Reference(id=1222469642384302652, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=10.1016/S2213-2600(17)30079-6, pmid=null, pmcid=null, year=2017, volume=5, issue=null, pageStart=291, pageEnd=360, url=null, language=null, rfNumber=[3], rfOrder=2, authorNames=Dheda K, Gumbo T, Maartens G, journalName=Lancet Respir Med, refType=null, unstructuredReference=
Dheda K ,
Gumbo T ,
Maartens G et al . The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis[J].
Lancet Respir Med,
2017,
5: 291-360., articleTitle=The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis, refAbstract=null), Reference(id=1222469642476577349, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=10.1016/j.jep.2018.12.008, pmid=null, pmcid=null, year=2018, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[4], rfOrder=3, authorNames=Dwivedi VP, Bhattacharya D, Singh M, journalName=J Ethnopharmacol, refType=null, unstructuredReference=
Dwivedi VP ,
Bhattacharya D ,
Singh M et al . Allicin enhances antimicrobial activity of macrophages during
Mycobacterium tuberculosis infection[J].
J Ethnopharmacol,
2018. DOI:
10.1016/j.jep.2018.12.008., articleTitle=Allicin enhances antimicrobial activity of macrophages during
Mycobacterium tuberculosis infection, refAbstract=null), Reference(id=1222469642556269132, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=10.1016/j.micinf.2015.09.005, pmid=null, pmcid=null, year=2016, volume=18, issue=null, pageStart=11, pageEnd=20, url=null, language=null, rfNumber=[5], rfOrder=4, authorNames=Amaral EP, Lasunskaia EB, D'império-Lima MR, journalName=Microbes Infect, refType=null, unstructuredReference=
Amaral EP ,
Lasunskaia EB ,
D'império-Lima MR . Innate immunity in tuberculosis: how the sensing of mycobacteria and tissue damage modulates macrophage death[J].
Microbes Infect,
2016,
18: 11-20., articleTitle=Innate immunity in tuberculosis: how the sensing of mycobacteria and tissue damage modulates macrophage death, refAbstract=null), Reference(id=1222469642610795090, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=null, pmid=null, pmcid=null, year=2017, volume=8, issue=null, pageStart=623, pageEnd=null, url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389097/, language=null, rfNumber=[6], rfOrder=5, authorNames=da Costa AC, de Resende DP, Santos BPO, journalName=Front Microbiol, refType=null, unstructuredReference=
da Costa AC ,
de Resende DP ,
Santos BPO et al . Modulation of macrophage responses by CMX, a fusion protein composed of Ag85c, MPT51, and HspX from
Mycobacterium tuberculosis[J].
Front Microbiol,
2017,
8: 623., articleTitle=Modulation of macrophage responses by CMX, a fusion protein composed of Ag85c, MPT51, and HspX from
Mycobacterium tuberculosis, refAbstract=null), Reference(id=1222469642690486875, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=null, pmid=null, pmcid=null, year=2017, volume=12, issue=null, pageStart=162, pageEnd=183, url=http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=91cd003fecdd44ca6f2b39cb766a2bd2, language=null, rfNumber=[7], rfOrder=6, authorNames=Agnihotri J, Singh S, Wais M, journalName=Recent Pat Antiinfect Drug Discov, refType=null, unstructuredReference=
Agnihotri J ,
Singh S ,
Wais M et al . Macrophage targeted cellular carriers for effective delivery of anti-tubercular drugs[J].
Recent Pat Antiinfect Drug Discov,
2017,
12: 162-183., articleTitle=Macrophage targeted cellular carriers for effective delivery of anti-tubercular drugs, refAbstract=null), Reference(id=1222469642778567268, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=10.1111/j.1365-2567.2009.03145.x, pmid=null, pmcid=null, year=2010, volume=129, issue=null, pageStart=125, pageEnd=132, url=null, language=null, rfNumber=[8], rfOrder=7, authorNames=Emanuela G, Santucci MB, Michela S, journalName=Immunology, refType=null, unstructuredReference=
Emanuela G ,
Santucci MB ,
Michela S et al . Natural lysophospholipids reduce
Mycobacterium tuberculosis-induced cytotoxi-city and induce anti-mycobacterial activity by a phagolysosome maturation-dependent mechanism in A549 type Ⅱ alveolar epithelial cells[J].
Immunology,
2010,
129: 125-132., articleTitle=Natural lysophospholipids reduce
Mycobacterium tuberculosis-induced cytotoxi-city and induce anti-mycobacterial activity by a phagolysosome maturation-dependent mechanism in A549 type Ⅱ alveolar epithelial cells, refAbstract=null), Reference(id=1222469642896007791, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=10.1016/j.bbrc.2007.07.087, pmid=null, pmcid=null, year=2007, volume=361, issue=null, pageStart=687, pageEnd=693, url=null, language=null, rfNumber=[9], rfOrder=8, authorNames=Santucci MB, Greco E, Spirito MD, journalName=Biochem Biophys Res Commun, refType=null, unstructuredReference=
Santucci MB ,
Greco E ,
Spirito MD et al . Sphingosine 1-phosphate promotes antigen processing and presentation to CD4
+ T cells in
Mycobacterium tuberculosis-infected monocytes[J].
Biochem Biophys Res Commun,
2007,
361: 687-693., articleTitle=Sphingosine 1-phosphate promotes antigen processing and presentation to CD4
+ T cells in
Mycobacterium tuberculosis-infected monocytes, refAbstract=null), Reference(id=1222469643005059700, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=10.1371/journal.pone.0122771, pmid=null, pmcid=null, year=2015, volume=10, issue=null, pageStart=e0122771, pageEnd=null, url=null, language=null, rfNumber=[10], rfOrder=9, authorNames=Barnawi J, Tran H, Jersmann H, journalName=PLoS One, refType=null, unstructuredReference=
Barnawi J ,
Tran H ,
Jersmann H et al . Potential link between the sphingosine-1-phosphate (S1P) system and defective alveolar macrophage phagocytic function in chronic obstructive pulmonary disease (COPD)[J].
PLoS One,
2015,
10: e0122771., articleTitle=Potential link between the sphingosine-1-phosphate (S1P) system and defective alveolar macrophage phagocytic function in chronic obstructive pulmonary disease (COPD), refAbstract=null), Reference(id=1222469643156054652, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=10.1038/nrm.2017.107, pmid=null, pmcid=null, year=2018, volume=19, issue=null, pageStart=175, pageEnd=191, url=null, language=null, rfNumber=[11], rfOrder=10, authorNames=Hannun YA, Obeid LM, journalName=Nat Rev Mol Cell Biol, refType=null, unstructuredReference=
Hannun YA ,
Obeid LM . Sphingolipids and their metabolism in physiology and disease[J].
Nat Rev Mol Cell Biol,
2018,
19: 175-191., articleTitle=Sphingolipids and their metabolism in physiology and disease, refAbstract=null), Reference(id=1222469643298660999, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=10.1093/emboj/17.10.2830, pmid=null, pmcid=null, year=1998, volume=17, issue=null, pageStart=2830, pageEnd=2837, url=null, language=null, rfNumber=[12], rfOrder=11, authorNames=Meyer zu Heringdorf D, Lass H, Alemany R, journalName=EMBO J, refType=null, unstructuredReference=
Meyer zu Heringdorf D ,
Lass H ,
Alemany R et al . Sphingosine kinase-mediated Ca
2+ signalling by G-protein-coupled receptors[J].
EMBO J,
1998,
17: 2830-2837., articleTitle=Sphingosine kinase-mediated Ca
2+ signalling by G-protein-coupled receptors, refAbstract=null), Reference(id=1222469643474821775, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=10.3390/ijms18122721, pmid=null, pmcid=null, year=2017, volume=18, issue=null, pageStart=2721, pageEnd=null, url=null, language=null, rfNumber=[13], rfOrder=12, authorNames=Gonzalez L, Qian AS, Tahir U, journalName=Int J Mol Sci, refType=null, unstructuredReference=
Gonzalez L ,
Qian AS ,
Tahir U et al . Sphingosine-1-phosphate receptor 1, expressed in myeloid cells, slows diet-induced atherosclerosis and protects against macrophage apoptosis in
Ldlr KO mice[J].
Int J Mol Sci,
2017,
18: 2721., articleTitle=Sphingosine-1-phosphate receptor 1, expressed in myeloid cells, slows diet-induced atherosclerosis and protects against macrophage apoptosis in
Ldlr KO mice, refAbstract=null), Reference(id=1222469643567096476, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=10.1194/jlr.R046300, pmid=null, pmcid=null, year=2014, volume=55, issue=null, pageStart=1596, pageEnd=1608, url=null, language=null, rfNumber=[14], rfOrder=13, authorNames=Blaho VA, Hla T, journalName=J Lipid Res, refType=null, unstructuredReference=
Blaho VA ,
Hla T . An update on the biology of sphingosine 1-phosphate receptors[J].
J Lipid Res,
2014,
55: 1596-1608., articleTitle=An update on the biology of sphingosine 1-phosphate receptors, refAbstract=null), Reference(id=1222469643684536997, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=null, pmid=null, pmcid=null, year=2014, volume=8, issue=null, pageStart=283, pageEnd=null, url=http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=Doaj000003744431, language=null, rfNumber=[15], rfOrder=14, authorNames=Brunkhorst R, Vutukuri R, Pfeilschifter W, journalName=Front Cell Neurosci, refType=null, unstructuredReference=
Brunkhorst R ,
Vutukuri R ,
Pfeilschifter W . Fingolimod for the treatment of neurological diseases - state of play and future perspectives[J].
Front Cell Neurosci,
2014,
8: 283., articleTitle=Fingolimod for the treatment of neurological diseases - state of play and future perspectives, refAbstract=null), Reference(id=1222469643814560430, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=10.1186/s12879-016-1450-1, pmid=null, pmcid=null, year=2016, volume=16, issue=null, pageStart=123, pageEnd=null, url=null, language=null, rfNumber=[16], rfOrder=15, authorNames=Sinha P, Gupta A, Prakash P, journalName=BMC Infect Dis, refType=null, unstructuredReference=
Sinha P ,
Gupta A ,
Prakash P et al . Differentiation of
Mycobacterium tuberculosis complex from non-tubercular mycobacteria by nested multiplex PCR targeting IS6110, MTP40 and 32 kD alpha antigen encoding gene fragments[J].
BMC Infect Dis,
2016,
16: 123., articleTitle=Differentiation of
Mycobacterium tuberculosis complex from non-tubercular mycobacteria by nested multiplex PCR targeting IS6110, MTP40 and 32 kD alpha antigen encoding gene fragments, refAbstract=null), Reference(id=1222469643906835126, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=10.1111/mmi.13531, pmid=null, pmcid=null, year=2016, volume=102, issue=null, pageStart=1004, pageEnd=1019, url=null, language=null, rfNumber=[17], rfOrder=16, authorNames=Custódio R, McLean CJ, Scott AE, journalName=Mol Microbiol, refType=null, unstructuredReference=
Custódio R ,
McLean CJ ,
Scott AE et al . Characterization of secreted sphingosine-1-phosphate lyases required for virulence and intracellular survival of
Burkholderia pseudomallei[J].
Mol Microbiol,
2016,
102: 1004-1019., articleTitle=Characterization of secreted sphingosine-1-phosphate lyases required for virulence and intracellular survival of
Burkholderia pseudomallei, refAbstract=null), Reference(id=1222469644020081348, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=10.3390/ijms19030722, pmid=null, pmcid=null, year=2018, volume=19, issue=null, pageStart=722, pageEnd=null, url=null, language=null, rfNumber=[18], rfOrder=17, authorNames=Kleuser B, journalName=Int J Mol Sci, refType=null, unstructuredReference=
Kleuser B . Divergent role of sphingosine 1-phosphate in liver health and disease[J].
Int J Mol Sci,
2018,
19: 722., articleTitle=Divergent role of sphingosine 1-phosphate in liver health and disease, refAbstract=null), Reference(id=1222469644145910477, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=10.1016/j.cellsig.2011.02.009, pmid=null, pmcid=null, year=2011, volume=23, issue=null, pageStart=1144, pageEnd=1152, url=null, language=null, rfNumber=[19], rfOrder=18, authorNames=Kumar A, Byun HS, Bittman R, journalName=Cell Signal, refType=null, unstructuredReference=
Kumar A ,
Byun HS ,
Bittman R et al . The sphingolipid degradation product
trans-2-hexadecenal induces cytoskeletal reorganization and apoptosis in a JNK-dependent manner[J].
Cell Signal,
2011,
23: 1144-1152., articleTitle=The sphingolipid degradation product
trans-2-hexadecenal induces cytoskeletal reorganization and apoptosis in a JNK-dependent manner, refAbstract=null), Reference(id=1222469644242379481, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=10.1016/j.drudis.2015.09.013, pmid=null, pmcid=null, year=2016, volume=21, issue=null, pageStart=133, pageEnd=142, url=null, language=null, rfNumber=[20], rfOrder=19, authorNames=Arish M, Husein A, Kashif M, journalName=Drug Discov Today, refType=null, unstructuredReference=
Arish M ,
Husein A ,
Kashif M et al . Sphingosine-1-phosphate signaling: unraveling its role as a drug target against infectious diseases[J].
Drug Discov Today,
2016,
21: 133-142., articleTitle=Sphingosine-1-phosphate signaling: unraveling its role as a drug target against infectious diseases, refAbstract=null), Reference(id=1222469644334654180, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=10.1016/j.bbalip.2013.07.012, pmid=null, pmcid=null, year=2014, volume=1841, issue=null, pageStart=759, pageEnd=765, url=null, language=null, rfNumber=[21], rfOrder=20, authorNames=Nishi T, Kobayashi N, Hisano Y, journalName=Biochim Biophys Acta, refType=null, unstructuredReference=
Nishi T ,
Kobayashi N ,
Hisano Y et al . Molecular and physiological functions of sphingosine 1-phosphate transporters[J].
Biochim Biophys Acta,
2014,
1841: 759-765., articleTitle=Molecular and physiological functions of sphingosine 1-phosphate transporters, refAbstract=null), Reference(id=1222469644426928881, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=10.1111/bph.14381, pmid=null, pmcid=null, year=2018, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[22], rfOrder=21, authorNames=Don-Doncow N, Zhang Y, Matuskova H, journalName=Br J Pharmacol, refType=null, unstructuredReference=
Don-Doncow N ,
Zhang Y ,
Matuskova H et al . The emerging alliance of sphingosine-1-phosphate signaling and immune cells: from basic mechanisms to implications in hypertension[J].
Br J Pharmacol,
2018. DOI:
10.1111/bph.14381., articleTitle=The emerging alliance of sphingosine-1-phosphate signaling and immune cells: from basic mechanisms to implications in hypertension, refAbstract=null), Reference(id=1222469644515009275, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=null, pmid=null, pmcid=null, year=2017, volume=8, issue=null, pageStart=378, pageEnd=null, url=http://cn.bing.com/academic/profile?id=457b2d16b50212c86fbe4187f12cc4bd&encoded=0&v=paper_preview&mkt=zh-cn, language=null, rfNumber=[23], rfOrder=22, authorNames=Sharma L, Prakash H, journalName=Front Immunol, refType=null, unstructuredReference=
Sharma L ,
Prakash H . Sphingolipids are dual specific drug targets for the management of pulmonary infections: perspective[J].
Front Immunol,
2017,
8: 378., articleTitle=Sphingolipids are dual specific drug targets for the management of pulmonary infections: perspective, refAbstract=null), Reference(id=1222469644632449798, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=10.1002/art.40558, pmid=null, pmcid=null, year=2018, volume=70, issue=null, pageStart=1879, pageEnd=1889, url=null, language=null, rfNumber=[24], rfOrder=23, authorNames=Burg N, Swendeman S, Worgall S, journalName=Arthritis Rheumatol, refType=null, unstructuredReference=
Burg N ,
Swendeman S ,
Worgall S et al . Sphingosine-1 phosphate receptor-1 signaling maintains endothelial cell barrier function and protects against immune complex-induced vascular injury[J].
Arthritis Rheumatol,
2018,
70: 1879-1889., articleTitle=Sphingosine-1 phosphate receptor-1 signaling maintains endothelial cell barrier function and protects against immune complex-induced vascular injury, refAbstract=null), Reference(id=1222469644733113104, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=10.3389/fphar.2017.00556, pmid=null, pmcid=null, year=2017, volume=8, issue=null, pageStart=556, pageEnd=null, url=null, language=null, rfNumber=[25], rfOrder=24, authorNames=Cannavo A, Liccardo D, Komici K, journalName=Front Pharmacol, refType=null, unstructuredReference=
Cannavo A ,
Liccardo D ,
Komici K et al . Sphingosine kinases and sphingosine 1-phosphate receptors: signaling and actions in the cardiovascular system[J].
Front Pharmacol,
2017,
8: 556., articleTitle=Sphingosine kinases and sphingosine 1-phosphate receptors: signaling and actions in the cardiovascular system, refAbstract=null), Reference(id=1222469644854747927, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=10.1016/j.jbior.2015.09.001, pmid=null, pmcid=null, year=2016, volume=60, issue=null, pageStart=151, pageEnd=159, url=null, language=null, rfNumber=[26], rfOrder=25, authorNames=Pyne NJ, McNaughton M, Boomkamp S, journalName=Adv Biol Regul, refType=null, unstructuredReference=
Pyne NJ ,
McNaughton M ,
Boomkamp S et al . Role of sphingosine 1-phosphate receptors, sphingosine kinases and sphingosine in cancer and inflammation[J].
Adv Biol Regul,
2016,
60: 151-159., articleTitle=Role of sphingosine 1-phosphate receptors, sphingosine kinases and sphingosine in cancer and inflammation, refAbstract=null), Reference(id=1222469644967994146, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=10.1016/j.plipres.2016.03.001, pmid=null, pmcid=null, year=2016, volume=62, issue=null, pageStart=93, pageEnd=106, url=null, language=null, rfNumber=[27], rfOrder=26, authorNames=Pyne S, Adams DR, Pyne NJ, journalName=Prog Lipid Res, refType=null, unstructuredReference=
Pyne S ,
Adams DR ,
Pyne NJ . Sphingosine 1-phosphate and sphingosine kinases in health and disease: recent advances[J].
Prog Lipid Res,
2016,
62: 93-106., articleTitle=Sphingosine 1-phosphate and sphingosine kinases in health and disease: recent advances, refAbstract=null), Reference(id=1222469645060268843, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=10.1016/j.intimp.2010.10.005, pmid=null, pmcid=null, year=2011, volume=11, issue=null, pageStart=366, pageEnd=372, url=null, language=null, rfNumber=[28], rfOrder=27, authorNames=Chiba K, Kataoka H, Seki N, journalName=Int Immunopharmacol, refType=null, unstructuredReference=
Chiba K ,
Kataoka H ,
Seki N et al . Fingolimod (FTY720), sphingosine 1-phosphate receptor modulator, shows superior efficacy as compared with interferon-
β in mouse experimental autoimmune encephalomyelitis[J].
Int Immunopharmacol,
2011,
11: 366-372., articleTitle=Fingolimod (FTY720), sphingosine 1-phosphate receptor modulator, shows superior efficacy as compared with interferon-
β in mouse experimental autoimmune encephalomyelitis, refAbstract=null), Reference(id=1222469645173515055, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=null, pmid=null, pmcid=null, year=2018, volume=17, issue=null, pageStart=7409, pageEnd=7414, url=http://cn.bing.com/academic/profile?id=e26c971484f13fc60c46c29fefc1ff7c&encoded=0&v=paper_preview&mkt=zh-cn, language=null, rfNumber=[29], rfOrder=28, authorNames=Huang JK, Zhang T, Wang HM, journalName=Mol Med Rep, refType=null, unstructuredReference=
Huang JK ,
Zhang T ,
Wang HM et al . Treatment of experimental autoimmune myasthenia gravis rats with FTY720 and its effect on Th1/Th2 cells[J].
Mol Med Rep,
2018,
17: 7409-7414., articleTitle=Treatment of experimental autoimmune myasthenia gravis rats with FTY720 and its effect on Th1/Th2 cells, refAbstract=null), Reference(id=1222469645290955575, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=null, pmid=null, pmcid=null, year=2018, volume=39, issue=null, pageStart=565, pageEnd=572, url=http://cn.bing.com/academic/profile?id=2e730be8e34742d40bee01c57efd4f4b&encoded=0&v=paper_preview&mkt=zh-cn, language=null, rfNumber=[30], rfOrder=29, authorNames=Li Y, Hu TH, Chen TJ, journalName=Oncol Rep, refType=null, unstructuredReference=
Li Y ,
Hu TH ,
Chen TJ et al . Combination treatment of FTY720 and cisplatin exhibits enhanced antitumour effects on cisplatin-resistant non-small lung cancer cells[J].
Oncol Rep,
2018,
39: 565-572., articleTitle=Combination treatment of FTY720 and cisplatin exhibits enhanced antitumour effects on cisplatin-resistant non-small lung cancer cells, refAbstract=null), Reference(id=1222469645416784705, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=10.1016/j.bbi.2018.03.009, pmid=null, pmcid=null, year=2018, volume=70, issue=null, pageStart=293, pageEnd=304, url=null, language=null, rfNumber=[31], rfOrder=30, authorNames=Shi DY, Tian TG, Yao S, journalName=Brain Behav Immun, refType=null, unstructuredReference=
Shi DY ,
Tian TG ,
Yao S et al . FTY720 attenuates behavioral deficits in a murine model of systemic lupus erythematosus[J].
Brain Behav Immun,
2018,
70: 293-304., articleTitle=FTY720 attenuates behavioral deficits in a murine model of systemic lupus erythematosus, refAbstract=null), Reference(id=1222469645525836620, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=10.1002/jcp.26001, pmid=null, pmcid=null, year=2018, volume=233, issue=null, pageStart=1300, pageEnd=1311, url=null, language=null, rfNumber=[32], rfOrder=31, authorNames=Velmurugan BK, Lee CH, Chiang SL, journalName=J Cell Physiol, refType=null, unstructuredReference=
Velmurugan BK ,
Lee CH ,
Chiang SL et al . PP2A deactivation is a common event in oral cancer and reactivation by FTY720 shows promising therapeutic potential[J].
J Cell Physiol,
2018,
233: 1300-1311., articleTitle=PP2A deactivation is a common event in oral cancer and reactivation by FTY720 shows promising therapeutic potential, refAbstract=null), Reference(id=1222469645618111315, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=10.1016/j.it.2018.01.006, pmid=null, pmcid=null, year=2018, volume=39, issue=null, pageStart=419, pageEnd=433, url=null, language=null, rfNumber=[33], rfOrder=32, authorNames=Jeyanathan M, Yao YS, Afkhami S, journalName=Trends Immunol, refType=null, unstructuredReference=
Jeyanathan M ,
Yao YS ,
Afkhami S et al . New tuberculosis vaccine strategies: taking aim at un-natural immunity[J].
Trends Immunol,
2018,
39: 419-433., articleTitle=New tuberculosis vaccine strategies: taking aim at un-natural immunity, refAbstract=null), Reference(id=1222469645697803094, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=10.1371/journal.pone.0168252, pmid=null, pmcid=null, year=2016, volume=11, issue=null, pageStart=e0168252, pageEnd=null, url=null, language=null, rfNumber=[34], rfOrder=33, authorNames=Bigaud M, Dincer Z, Bollbuck B, journalName=PLoS One, refType=null, unstructuredReference=
Bigaud M ,
Dincer Z ,
Bollbuck B et al . Pathophysiological consequences of a break in S1P1-dependent homeostasis of vascular permeability revealed by S1P1 competitive antagonism[J].
PLoS One,
2016,
11: e0168252., articleTitle=Pathophysiological consequences of a break in S1P1-dependent homeostasis of vascular permeability revealed by S1P1 competitive antagonism, refAbstract=null), Reference(id=1222469645815243615, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=10.1111/cmi.12836, pmid=null, pmcid=null, year=2018, volume=20, issue=null, pageStart=e12836, pageEnd=null, url=null, language=null, rfNumber=[35], rfOrder=34, authorNames=Bryan AM, Del Poeta M, journalName=Cell Microbiol, refType=null, unstructuredReference=
Bryan AM ,
Del Poeta M . Sphingosine-1-phosphate receptors and innate immunity[J].
Cell Microbiol,
2018,
20: e12836., articleTitle=Sphingosine-1-phosphate receptors and innate immunity, refAbstract=null), Reference(id=1222469645932684134, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=10.1007/s10928-014-9362-4, pmid=null, pmcid=null, year=2014, volume=41, issue=null, pageStart=261, pageEnd=278, url=null, language=null, rfNumber=[36], rfOrder=35, authorNames=Krause A, Brossard P, D'Ambrosio D, journalName=J Pharmacokinet Pharmacodyn, refType=null, unstructuredReference=
Krause A ,
Brossard P ,
D'Ambrosio D et al . Population pharmacokinetics and pharmacodynamics of ponesimod, a selective S1P1 receptor modulator[J].
J Pharmacokinet Pharmacodyn,
2014,
41: 261-278., articleTitle=Population pharmacokinetics and pharmacodynamics of ponesimod, a selective S1P1 receptor modulator, refAbstract=null), Reference(id=1222469646083679088, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=null, pmid=null, pmcid=null, year=2017, volume=11, issue=null, pageStart=S265, pageEnd=S266, url=http://cn.bing.com/academic/profile?id=d6d43812c941f674511e9e17700c6ddf&encoded=0&v=paper_preview&mkt=zh-cn, language=null, rfNumber=[37], rfOrder=36, authorNames=Peyrin-Biroulet L, Christopher R, Trokan L, journalName=J Crohns Colitis, refType=null, unstructuredReference=
Peyrin-Biroulet L ,
Christopher R ,
Trokan L et al . P369 safety and lymphocyte-lowering properties of etrasimod (APD334), an oral, potent, next-generation, selective S1P receptor modulator, after dose escalation in healthy volunteers[J].
J Crohns Colitis,
2017,
11: S265-S266., articleTitle=P369 safety and lymphocyte-lowering properties of etrasimod (APD334), an oral, potent, next-generation, selective S1P receptor modulator, after dose escalation in healthy volunteers, refAbstract=null), Reference(id=1222469646150787961, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=10.1007/s12975-016-0477-3, pmid=null, pmcid=null, year=2016, volume=7, issue=null, pageStart=420, pageEnd=438, url=null, language=null, rfNumber=[38], rfOrder=37, authorNames=Sun N, Keep RF, Hua Y, journalName=Transl Stroke Res, refType=null, unstructuredReference=
Sun N ,
Keep RF ,
Hua Y et al . Critical role of the sphingolipid pathway in stroke: a review of current utility and potential therapeutic targets[J].
Transl Stroke Res,
2016,
7: 420-438., articleTitle=Critical role of the sphingolipid pathway in stroke: a review of current utility and potential therapeutic targets, refAbstract=null), Reference(id=1222469646238868349, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=10.1111/bph.13820, pmid=null, pmcid=null, year=2017, volume=174, issue=null, pageStart=2085, pageEnd=2101, url=null, language=null, rfNumber=[39], rfOrder=38, authorNames=Yamamoto R, Aoki T, Koseki H, journalName=Br J Pharmacol, refType=null, unstructuredReference=
Yamamoto R ,
Aoki T ,
Koseki H et al . A sphingosine‐1‐phosphate receptor type 1 agonist, ASP4058, suppresses intracranial aneurysm through promoting endothelial integrity and blocking macrophage transmigration[J].
Br J Pharmacol,
2017,
174: 2085-2101., articleTitle=A sphingosine‐1‐phosphate receptor type 1 agonist, ASP4058, suppresses intracranial aneurysm through promoting endothelial integrity and blocking macrophage transmigration, refAbstract=null), Reference(id=1222469646356308873, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=10.1016/j.thromres.2017.06.001, pmid=null, pmcid=null, year=2017, volume=156, issue=null, pageStart=91, pageEnd=100, url=null, language=null, rfNumber=[40], rfOrder=39, authorNames=Onuma T, Tanabe K, Kito Y, journalName=Thromb Res, refType=null, unstructuredReference=
Onuma T ,
Tanabe K ,
Kito Y et al . Sphingosine 1-phosphate (S1P) suppresses the collagen-induced activation of human platelets
via S1P4 receptor[J].
Thromb Res,
2017,
156: 91-100., articleTitle=Sphingosine 1-phosphate (S1P) suppresses the collagen-induced activation of human platelets
via S1P4 receptor, refAbstract=null), Reference(id=1222469646456972177, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=10.1021/acs.jmedchem.7b00785, pmid=null, pmcid=null, year=2017, volume=60, issue=null, pageStart=9508, pageEnd=9530, url=null, language=null, rfNumber=[41], rfOrder=40, authorNames=Kurata H, Kusumi K, Otsuki K, journalName=J Med Chem, refType=null, unstructuredReference=
Kurata H ,
Kusumi K ,
Otsuki K et al . Discovery of a 1-methyl-3, 4-dihydronaphthalene-based sphingosine-1-phosphate (S1P) receptor agonist ceralifimod (ONO-4641). A S1P1 and S1P5 selective agonist for the treatment of autoimmune diseases[J].
J Med Chem,
2017,
60: 9508-9530., articleTitle=Discovery of a 1-methyl-3, 4-dihydronaphthalene-based sphingosine-1-phosphate (S1P) receptor agonist ceralifimod (ONO-4641). A S1P1 and S1P5 selective agonist for the treatment of autoimmune diseases, refAbstract=null), Reference(id=1222469646616355738, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=10.1371/journal.pone.0110819, pmid=null, pmcid=null, year=2014, volume=9, issue=null, pageStart=e110819, pageEnd=null, url=null, language=null, rfNumber=[42], rfOrder=41, authorNames=Yamamoto R, Okada Y, Hirose J, journalName=PLoS One, refType=null, unstructuredReference=
Yamamoto R ,
Okada Y ,
Hirose J et al . ASP4058, a novel agonist for sphingosine 1-phosphate receptors 1 and 5, ameliorates rodent experimental autoimmune encephalomyelitis with a favorable safety profile[J].
PLoS One,
2014,
9: e110819., articleTitle=ASP4058, a novel agonist for sphingosine 1-phosphate receptors 1 and 5, ameliorates rodent experimental autoimmune encephalomyelitis with a favorable safety profile, refAbstract=null), Reference(id=1222469646750573473, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=10.1172/JCI200423704, pmid=null, pmcid=null, year=2004, volume=114, issue=null, pageStart=1531, pageEnd=1537, url=null, language=null, rfNumber=[43], rfOrder=42, authorNames=Goetzl EJ, Rosen H, journalName=J Clin Invest, refType=null, unstructuredReference=
Goetzl EJ ,
Rosen H . Regulation of immunity by lysosphingolipids and their G protein-coupled receptors[J].
J Clin Invest,
2004,
114: 1531-1537., articleTitle=Regulation of immunity by lysosphingolipids and their G protein-coupled receptors, refAbstract=null), Reference(id=1222469646868013995, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=10.1016/j.ijpharm.2018.03.029, pmid=null, pmcid=null, year=2018, volume=542, issue=null, pageStart=253, pageEnd=265, url=null, language=null, rfNumber=[44], rfOrder=43, authorNames=Tran TH, Tran TTP, Nguyen HT, journalName=Int J Pharm, refType=null, unstructuredReference=
Tran TH ,
Tran TTP ,
Nguyen HT et al . Nanoparticles for dendritic cell-based immunotherapy[J].
Int J Pharm,
2018,
542: 253-265., articleTitle=Nanoparticles for dendritic cell-based immunotherapy, refAbstract=null), Reference(id=1222469646998037424, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=null, pmid=null, pmcid=null, year=2017, volume=820, issue=null, pageStart=8, pageEnd=17, url=https://www.sciencedirect.com/science/article/pii/S0014299917307926, language=null, rfNumber=[45], rfOrder=44, authorNames=Jin H, Han J, Resing D, journalName=Eur J Pharmacol, refType=null, unstructuredReference=
Jin H ,
Han J ,
Resing D et al . Synthesis and
in vitro characterization of a P2×7 radioligand[
123I]TZ6019 and its response to neuroinflammation in a mouse model of Alzheimer disease[J].
Eur J Pharmacol,
2017,
820: 8-17., articleTitle=Synthesis and
in vitro characterization of a P2×7 radioligand[
123I]TZ6019 and its response to neuroinflammation in a mouse model of Alzheimer disease, refAbstract=null), Reference(id=1222469647132255157, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=10.1016/j.apsb.2017.12.002, pmid=null, pmcid=null, year=2018, volume=8, issue=null, pageStart=23, pageEnd=33, url=null, language=null, rfNumber=[46], rfOrder=45, authorNames=Jin K, Luo ZM, Zhang B, journalName=Acta Pharm Sin B, refType=null, unstructuredReference=
Jin K ,
Luo ZM ,
Zhang B et al . Biomimetic nanoparticles for inflammation targeting[J].
Acta Pharm Sin B,
2018,
8: 23-33., articleTitle=Biomimetic nanoparticles for inflammation targeting, refAbstract=null), Reference(id=1222469647232918455, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=10.1097/j.pain.0000000000000965, pmid=null, pmcid=null, year=2017, volume=158, issue=null, pageStart=1733, pageEnd=1742, url=null, language=null, rfNumber=[47], rfOrder=46, authorNames=Grenald SA, Doyle TM, Zhang H, journalName=Pain, refType=null, unstructuredReference=
Grenald SA ,
Doyle TM ,
Zhang H et al . Targeting the S1P/S1PR1 axis mitigates cancer-induced bone pain and neuroinflammation[J].
Pain,
2017,
158: 1733-1742., articleTitle=Targeting the S1P/S1PR1 axis mitigates cancer-induced bone pain and neuroinflammation, refAbstract=null), Reference(id=1222469647350358972, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=10.1158/0008-5472.CAN-17-1423, pmid=null, pmcid=null, year=2018, volume=78, issue=null, pageStart=1713, pageEnd=1725, url=null, language=null, rfNumber=[48], rfOrder=47, authorNames=Nagahashi M, Yamada A, Katsuta E, journalName=Cancer Res, refType=null, unstructuredReference=
Nagahashi M ,
Yamada A ,
Katsuta E et al . Targeting the SphK1/S1P/S1PR1 axis that links obesity, chronic inflammation and breast cancer metastasis[J].
Cancer Res,
2018,
78: 1713-1725., articleTitle=Targeting the SphK1/S1P/S1PR1 axis that links obesity, chronic inflammation and breast cancer metastasis, refAbstract=null), Reference(id=1222469647459410882, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=null, pmid=null, pmcid=null, year=2015, volume=4, issue=null, pageStart=469, pageEnd=483, url=http://cn.bing.com/academic/profile?id=cb22590cf3c705610caeca880f441cd2&encoded=0&v=paper_preview&mkt=zh-cn, language=null, rfNumber=[49], rfOrder=48, authorNames=Suh JH, Saba JD, journalName=Transl Cancer Res, refType=null, unstructuredReference=
Suh JH ,
Saba JD . Sphingosine-1-phosphate in inflammatory bowel disease and colitis-associated colon cancer: the fat's in the fire[J].
Transl Cancer Res,
2015,
4: 469-483., articleTitle=Sphingosine-1-phosphate in inflammatory bowel disease and colitis-associated colon cancer: the fat's in the fire, refAbstract=null), Reference(id=1222469647555879883, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=10.1038/srep24939, pmid=null, pmcid=null, year=2016, volume=6, issue=null, pageStart=24939, pageEnd=null, url=null, language=null, rfNumber=[50], rfOrder=49, authorNames=Aytan N, Choi JK, Carreras I, journalName=Sci Rep, refType=null, unstructuredReference=
Aytan N ,
Choi JK ,
Carreras I et al . Fingolimod modulates multiple neuroinflammatory markers in a mouse model of Alzheimer's disease[J].
Sci Rep,
2016,
6: 24939., articleTitle=Fingolimod modulates multiple neuroinflammatory markers in a mouse model of Alzheimer's disease, refAbstract=null), Reference(id=1222469647669126094, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=10.1089/neu.2017.5391, pmid=null, pmcid=null, year=2018, volume=35, issue=null, pageStart=1452, pageEnd=1466, url=null, language=null, rfNumber=[51], rfOrder=50, authorNames=Cuzzocrea S, Doyle T, Campolo M, journalName=J Neurotrauma, refType=null, unstructuredReference=
Cuzzocrea S ,
Doyle T ,
Campolo M et al . Sphingosine 1-phosphate receptor subtype 1 as a therapeutic target for brain trauma[J].
J Neurotrauma,
2018,
35: 1452-1466., articleTitle=Sphingosine 1-phosphate receptor subtype 1 as a therapeutic target for brain trauma, refAbstract=null), Reference(id=1222469647769789398, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=10.1186/s12957-016-0884-7, pmid=null, pmcid=null, year=2016, volume=14, issue=null, pageStart=131, pageEnd=null, url=null, language=null, rfNumber=[52], rfOrder=51, authorNames=Jin L, Liu WR, Tian MX, journalName=World J Surg Oncol, refType=null, unstructuredReference=
Jin L ,
Liu WR ,
Tian MX et al . The SphKs/S1P/S1PR1 axis in immunity and cancer: more ore to be mined[J].
World J Surg Oncol,
2016,
14: 131., articleTitle=The SphKs/S1P/S1PR1 axis in immunity and cancer: more ore to be mined, refAbstract=null), Reference(id=1222469647899812828, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=10.1007/s11307-016-0944-y, pmid=null, pmcid=null, year=2016, volume=18, issue=null, pageStart=724, pageEnd=732, url=null, language=null, rfNumber=[53], rfOrder=52, authorNames=Liu H, Jin HJ, Yue XY, journalName=Mol Imaging Biol, refType=null, unstructuredReference=
Liu H ,
Jin HJ ,
Yue XY et al . PET imaging study of S1PR1 expression in a rat model of multiple sclerosis[J].
Mol Imaging Biol,
2016,
18: 724-732., articleTitle=PET imaging study of S1PR1 expression in a rat model of multiple sclerosis, refAbstract=null), Reference(id=1222469648046613478, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=10.1084/jem.20160392, pmid=null, pmcid=null, year=2017, volume=214, issue=null, pageStart=2695, pageEnd=2713, url=null, language=null, rfNumber=[54], rfOrder=53, authorNames=Weichand B, Popp R, Dziumbla S, journalName=J Exp Med, refType=null, unstructuredReference=
Weichand B ,
Popp R ,
Dziumbla S et al . S1PR1 on tumor-associated macrophages promotes lymphangiogenesis and metastasis
via NLRP3/IL-1
β[J].
J Exp Med,
2017,
214: 2695-2713., articleTitle=S1PR1 on tumor-associated macrophages promotes lymphangiogenesis and metastasis
via NLRP3/IL-1
β, refAbstract=null), Reference(id=1222469648168248304, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=10.1002/dvdy.21852, pmid=null, pmcid=null, year=2009, volume=238, issue=null, pageStart=487, pageEnd=500, url=null, language=null, rfNumber=[55], rfOrder=54, authorNames=Meng H, Lee VM, journalName=Dev Dyn, refType=null, unstructuredReference=
Meng H ,
Lee VM . Differential expression of sphingosine-1-phosphate receptors 1-5 in the developing nervous system[J].
Dev Dyn,
2009,
238: 487-500., articleTitle=Differential expression of sphingosine-1-phosphate receptors 1-5 in the developing nervous system, refAbstract=null), Reference(id=1222469648294077434, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=null, pmid=null, pmcid=null, year=2018, volume=15, issue=null, pageStart=334, pageEnd=345, url=http://cn.bing.com/academic/profile?id=37de47d00fc6fdf5832544cce9d88271&encoded=0&v=paper_preview&mkt=zh-cn, language=null, rfNumber=[56], rfOrder=55, authorNames=Chen YZ, Wang F, Wang HJ, journalName=J Geriatr Cardiol, refType=null, unstructuredReference=
Chen YZ ,
Wang F ,
Wang HJ et al . Sphingosine 1 phosphate receptor-1 (S1PR1) signaling protects cardiac function by inhibiting cardiomyocyte autophagy[J].
J Geriatr Cardiol,
2018,
15: 334-345., articleTitle=Sphingosine 1 phosphate receptor-1 (S1PR1) signaling protects cardiac function by inhibiting cardiomyocyte autophagy, refAbstract=null), Reference(id=1222469648415711234, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=10.1016/j.mvr.2008.09.005, pmid=null, pmcid=null, year=2009, volume=77, issue=null, pageStart=39, pageEnd=45, url=null, language=null, rfNumber=[57], rfOrder=56, authorNames=Wang LC, Dudek SM, journalName=Microvasc Res, refType=null, unstructuredReference=
Wang LC ,
Dudek SM . Regulation of vascular permeability by sphingosine 1-phosphate[J].
Microvasc Res,
2009,
77: 39-45., articleTitle=Regulation of vascular permeability by sphingosine 1-phosphate, refAbstract=null), Reference(id=1222469648520568841, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=10.1164/rccm.200405-684OC, pmid=null, pmcid=null, year=2004, volume=170, issue=null, pageStart=987, pageEnd=993, url=null, language=null, rfNumber=[58], rfOrder=57, authorNames=McVerry BJ, Peng XQ, Hassoun PM, journalName=Am J Respir Crit Care Med, refType=null, unstructuredReference=
McVerry BJ ,
Peng XQ ,
Hassoun PM et al . Sphingosine 1-phosphate reduces vascular leak in murine and canine models of acute lung injury[J].
Am J Respir Crit Care Med,
2004,
170: 987-993., articleTitle=Sphingosine 1-phosphate reduces vascular leak in murine and canine models of acute lung injury, refAbstract=null), Reference(id=1222469648638009356, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=10.1016/j.apsb.2016.06.001, pmid=null, pmcid=null, year=2016, volume=6, issue=null, pageStart=576, pageEnd=583, url=null, language=null, rfNumber=[59], rfOrder=58, authorNames=Mi JQ, Zhao MM, Yang S, journalName=Acta Pharm Sin B, refType=null, unstructuredReference=
Mi JQ ,
Zhao MM ,
Yang S et al . Pharmacokinetics of H002, a novel S1PR1 modulator, and its metabolites in rat blood using liquid chromatography–tandem mass spectrometry[J].
Acta Pharm Sin B,
2016,
6: 576-583., articleTitle=Pharmacokinetics of H002, a novel S1PR1 modulator, and its metabolites in rat blood using liquid chromatography–tandem mass spectrometry, refAbstract=null), Reference(id=1222469648751255572, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=10.1152/ajpregu.00085.2006, pmid=null, pmcid=null, year=2007, volume=292, issue=null, pageStart=R440, pageEnd=R446, url=null, language=null, rfNumber=[60], rfOrder=59, authorNames=Lorenz JN, Arend LJ, Robitz R, journalName=Am J Physiol Regul Integr Comp Physiol, refType=null, unstructuredReference=
Lorenz JN ,
Arend LJ ,
Robitz R et al . Vascular dysfunction in S1P2 sphingosine 1-phosphate receptor knockout mice[J].
Am J Physiol Regul Integr Comp Physiol,
2007,
292: R440-R446., articleTitle=Vascular dysfunction in S1P2 sphingosine 1-phosphate receptor knockout mice, refAbstract=null), Reference(id=1222469648868696088, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=10.1172/JCI31123, pmid=null, pmcid=null, year=2007, volume=117, issue=null, pageStart=2506, pageEnd=2516, url=null, language=null, rfNumber=[61], rfOrder=60, authorNames=Skoura A, Sanchez T, Claffey K, journalName=J Clin Invest, refType=null, unstructuredReference=
Skoura A ,
Sanchez T ,
Claffey K et al . Essential role of sphingosine 1-phosphate receptor 2 in pathological angiogenesis of the mouse retina[J].
J Clin Invest,
2007,
117: 2506-2516., articleTitle=Essential role of sphingosine 1-phosphate receptor 2 in pathological angiogenesis of the mouse retina, refAbstract=null), Reference(id=1222469648969359393, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=10.1074/jbc.M700370200, pmid=null, pmcid=null, year=2007, volume=282, issue=null, pageStart=10690, pageEnd=10696, url=null, language=null, rfNumber=[62], rfOrder=61, authorNames=Kono M, Belyantseva IA, Skoura A, journalName=J Biol Chem, refType=null, unstructuredReference=
Kono M ,
Belyantseva IA ,
Skoura A et al . Deafness and stria vascularis defects in S1P2 receptor-null mice[J].
J Biol Chem,
2007,
282: 10690-10696., articleTitle=Deafness and stria vascularis defects in S1P2 receptor-null mice, refAbstract=null), Reference(id=1222469649082605604, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=10.1016/j.etp.2009.02.068, pmid=null, pmcid=null, year=2010, volume=62, issue=null, pageStart=53, pageEnd=60, url=null, language=null, rfNumber=[63], rfOrder=62, authorNames=Imasawa T, Kitamura HR, Ohkawa R, journalName=Exp Toxicol Pathol, refType=null, unstructuredReference=
Imasawa T ,
Kitamura HR ,
Ohkawa R et al . Unbalanced expression of sphingosine 1-phosphate receptors in diabetic nephropathy[J].
Exp Toxicol Pathol,
2010,
62: 53-60., articleTitle=Unbalanced expression of sphingosine 1-phosphate receptors in diabetic nephropathy, refAbstract=null), Reference(id=1222469649216823337, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=10.1084/jem.20091513, pmid=null, pmcid=null, year=2010, volume=207, issue=null, pageStart=465, pageEnd=474, url=null, language=null, rfNumber=[64], rfOrder=63, authorNames=Oskeritzian CA, Price MM, Hait NC, journalName=J Exp Med, refType=null, unstructuredReference=
Oskeritzian CA ,
Price MM ,
Hait NC et al . Essential roles of sphingosine-1-phosphate receptor 2 in human mast cell activation, anaphylaxis, and pulmonary edema[J].
J Exp Med,
2010,
207: 465-474., articleTitle=Essential roles of sphingosine-1-phosphate receptor 2 in human mast cell activation, anaphylaxis, and pulmonary edema, refAbstract=null), Reference(id=1222469649351041069, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=10.1172/JCI40659, pmid=null, pmcid=null, year=2010, volume=120, issue=null, pageStart=1429, pageEnd=1440, url=null, language=null, rfNumber=[65], rfOrder=64, authorNames=Olivera A, Eisner C, Kitamura Y, journalName=J Clin Invest, refType=null, unstructuredReference=
Olivera A ,
Eisner C ,
Kitamura Y et al . Sphingosine kinase 1 and sphingosine-1-phosphate receptor 2 are vital to recovery from anaphylactic shock in mice[J].
J Clin Invest,
2010,
120: 1429-1440., articleTitle=Sphingosine kinase 1 and sphingosine-1-phosphate receptor 2 are vital to recovery from anaphylactic shock in mice, refAbstract=null), Reference(id=1222469649464287286, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=10.1002/glia.20324, pmid=null, pmcid=null, year=2006, volume=53, issue=null, pageStart=621, pageEnd=630, url=null, language=null, rfNumber=[66], rfOrder=65, authorNames=Bassi R, Anelli V, Giussani P, journalName=Glia, refType=null, unstructuredReference=
Bassi R ,
Anelli V ,
Giussani P et al . Sphingosine-1-phosphate is released by cerebellar astrocytes in response to bFGF and induces astrocyte proliferation through G
i-protein-coupled receptors[J].
Glia,
2006,
53: 621-630., articleTitle=Sphingosine-1-phosphate is released by cerebellar astrocytes in response to bFGF and induces astrocyte proliferation through G
i-protein-coupled receptors, refAbstract=null), Reference(id=1222469649573339196, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=null, pmid=null, pmcid=null, year=2009, volume=82, issue=null, pageStart=193, pageEnd=200, url=http://d.old.wanfangdata.com.cn/OAPaper/oai_pubmedcentral.nih.gov_2721649, language=null, rfNumber=[67], rfOrder=66, authorNames=Means CK, Brown JH, journalName=Cardiovasc Res, refType=null, unstructuredReference=
Means CK ,
Brown JH . Sphingosine-1-phosphate receptor signalling in the heart[J].
Cardiovasc Res,
2009,
82: 193-200., articleTitle=Sphingosine-1-phosphate receptor signalling in the heart, refAbstract=null), Reference(id=1222469649665613887, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=10.1016/j.bbrc.2008.04.037, pmid=null, pmcid=null, year=2008, volume=371, issue=null, pageStart=159, pageEnd=162, url=null, language=null, rfNumber=[68], rfOrder=67, authorNames=Li QF, Wu CT, Guo Q, journalName=Biochem Biophys Res Commun, refType=null, unstructuredReference=
Li QF ,
Wu CT ,
Guo Q et al . Sphingosine 1-phosphate induces Mcl-1 upregulation and protects multiple myeloma cells against apoptosis[J].
Biochem Biophys Res Commun,
2008,
371: 159-162., articleTitle=Sphingosine 1-phosphate induces Mcl-1 upregulation and protects multiple myeloma cells against apoptosis, refAbstract=null), Reference(id=1222469649757888578, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=10.1016/j.jhep.2009.01.028, pmid=null, pmcid=null, year=2009, volume=50, issue=null, pageStart=1174, pageEnd=1183, url=null, language=null, rfNumber=[69], rfOrder=68, authorNames=Li CY, Kong YX, Wang H, journalName=J Hepatol, refType=null, unstructuredReference=
Li CY ,
Kong YX ,
Wang H et al . Homing of bone marrow mesenchymal stem cells mediated by sphingosine 1-phosphate contributes to liver fibrosis[J].
J Hepatol,
2009,
50: 1174-1183., articleTitle=Homing of bone marrow mesenchymal stem cells mediated by sphingosine 1-phosphate contributes to liver fibrosis, refAbstract=null), Reference(id=1222469649879523400, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=10.1152/ajplung.00162.2017, pmid=null, pmcid=null, year=2017, volume=313, issue=null, pageStart=L218, pageEnd=L229, url=null, language=null, rfNumber=[70], rfOrder=69, authorNames=Lam A, Prabhu R, Gross CM, journalName=Am J Physiol Lung Cell Mol Physiol, refType=null, unstructuredReference=
Lam A ,
Prabhu R ,
Gross CM et al . Role of apoptosis and autophagy in tuberculosis[J].
Am J Physiol Lung Cell Mol Physiol,
2017,
313: L218-L229., articleTitle=Role of apoptosis and autophagy in tuberculosis, refAbstract=null), Reference(id=1222469649996963919, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=10.1038/s41419-018-0599-5, pmid=null, pmcid=null, year=2018, volume=9, issue=null, pageStart=521, pageEnd=null, url=null, language=null, rfNumber=[71], rfOrder=70, authorNames=Moruno-Manchon JF, Uzor NE, Ambati CR, journalName=Cell Death Dis, refType=null, unstructuredReference=
Moruno-Manchon JF ,
Uzor NE ,
Ambati CR et al . Sphingosine kinase 1-associated autophagy differs between neurons and astrocytes[J].
Cell Death Dis,
2018,
9: 521., articleTitle=Sphingosine kinase 1-associated autophagy differs between neurons and astrocytes, refAbstract=null), Reference(id=1222469650093432915, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=10.1086/386286, pmid=null, pmcid=null, year=2004, volume=189, issue=null, pageStart=2129, pageEnd=2138, url=null, language=null, rfNumber=[72], rfOrder=71, authorNames=Garg SK, Volpe E, Palmieri G, journalName=J Infect Dis, refType=null, unstructuredReference=
Garg SK ,
Volpe E ,
Palmieri G et al . Sphingosine 1-phosphate induces antimicrobial activity both
in vitro and
in vivo[J].
J Infect Dis,
2004,
189: 2129-2138., articleTitle=Sphingosine 1-phosphate induces antimicrobial activity both
in vitro and
in vivo, refAbstract=null), Reference(id=1222469650198290522, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=10.1016/j.clim.2006.09.002, pmid=null, pmcid=null, year=2006, volume=121, issue=null, pageStart=260, pageEnd=264, url=null, language=null, rfNumber=[73], rfOrder=72, authorNames=Garg SK, Santucci MB, Panitti M, journalName=Clin Immunol, refType=null, unstructuredReference=
Garg SK ,
Santucci MB ,
Panitti M et al . Does sphingosine 1-phosphate play a protective role in the course of pulmonary tuberculosis?[J].
Clin Immunol,
2006,
121: 260-264., articleTitle=Does sphingosine 1-phosphate play a protective role in the course of pulmonary tuberculosis?, refAbstract=null), Reference(id=1222469650307342430, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=10.1016/j.clim.2006.06.003, pmid=null, pmcid=null, year=2006, volume=121, issue=null, pageStart=23, pageEnd=28, url=null, language=null, rfNumber=[74], rfOrder=73, authorNames=Garg SK, Valente E, Greco E, journalName=Clin Immunol, refType=null, unstructuredReference=
Garg SK ,
Valente E ,
Greco E et al . Lysophosphatidic acid enhances antimycobacterial activity both
in vitro and
ex vivo[J].
Clin Immunol,
2006,
121: 23-28., articleTitle=Lysophosphatidic acid enhances antimycobacterial activity both
in vitro and
ex vivo, refAbstract=null), Reference(id=1222469650391228514, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=10.1006/abio.2000.4580, pmid=null, pmcid=null, year=2000, volume=282, issue=null, pageStart=115, pageEnd=120, url=null, language=null, rfNumber=[75], rfOrder=74, authorNames=Murata N, Sato K, Kon J, journalName=Anal Biochem, refType=null, unstructuredReference=
Murata N ,
Sato K ,
Kon J et al . Quantitative measurement of sphingosine 1-phosphate by radioreceptor-binding assay[J].
Anal Biochem,
2000,
282: 115-120., articleTitle=Quantitative measurement of sphingosine 1-phosphate by radioreceptor-binding assay, refAbstract=null), Reference(id=1222469650504474726, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=10.1164/rccm.200508-1294OC, pmid=null, pmcid=null, year=2006, volume=173, issue=null, pageStart=803, pageEnd=810, url=null, language=null, rfNumber=[76], rfOrder=75, authorNames=Guyot-Revol V, Innes JA, Hackforth S, journalName=Am J Respir Crit Care Med, refType=null, unstructuredReference=
Guyot-Revol V ,
Innes JA ,
Hackforth S et al . Regulatory T cells are expanded in blood and disease sites in patients with tuberculosis[J].
Am J Respir Crit Care Med,
2006,
173: 803-810., articleTitle=Regulatory T cells are expanded in blood and disease sites in patients with tuberculosis, refAbstract=null), Reference(id=1222469650600943723, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=10.1126/science.1070238, pmid=null, pmcid=null, year=2002, volume=296, issue=null, pageStart=346, pageEnd=349, url=null, language=null, rfNumber=[77], rfOrder=76, authorNames=Mandala S, Hajdu R, Bergstrom J, journalName=Science, refType=null, unstructuredReference=
Mandala S ,
Hajdu R ,
Bergstrom J et al . Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists[J].
Science,
2002,
296: 346-349., articleTitle=Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists, refAbstract=null), Reference(id=1222469650722578543, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=10.1164/rccm.200309-1258OC, pmid=null, pmcid=null, year=2004, volume=169, issue=null, pageStart=1245, pageEnd=1251, url=null, language=null, rfNumber=[78], rfOrder=77, authorNames=Peng XQ, Hassoun PM, Sammani S, journalName=Am J Respir Crit Care Med, refType=null, unstructuredReference=
Peng XQ ,
Hassoun PM ,
Sammani S et al . Protective effects of sphingosine 1-phosphate in murine endotoxin-induced inflammatory lung injury[J].
Am J Respir Crit Care Med,
2004,
169: 1245-1251., articleTitle=Protective effects of sphingosine 1-phosphate in murine endotoxin-induced inflammatory lung injury, refAbstract=null), Reference(id=1222469650819047542, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=10.1038/nature09247, pmid=null, pmcid=null, year=2010, volume=466, issue=null, pageStart=973, pageEnd=977, url=null, language=null, rfNumber=[79], rfOrder=78, authorNames=Berry MPR, Graham CM, McNab FW, journalName=Nature, refType=null, unstructuredReference=
Berry MPR ,
Graham CM ,
McNab FW et al . An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis[J].
Nature,
2010,
466: 973-977., articleTitle=An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis, refAbstract=null), Reference(id=1222469650902933625, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=10.1177/039463200902200120, pmid=null, pmcid=null, year=2009, volume=22, issue=null, pageStart=175, pageEnd=181, url=null, language=null, rfNumber=[80], rfOrder=79, authorNames=Sali M, Delogu G, Greco E, journalName=Int J Immunopathol Pharmacol, refType=null, unstructuredReference=
Sali M ,
Delogu G ,
Greco E et al . Exploiting immunotherapy in
Mycobacterium tuberculosis-infected mice: sphingosine 1-phosphate treatment results in a protective or detrimental effect depending on the stage of infection[J].
Int J Immunopathol Pharmacol,
2009,
22: 175-181., articleTitle=Exploiting immunotherapy in
Mycobacterium tuberculosis-infected mice: sphingosine 1-phosphate treatment results in a protective or detrimental effect depending on the stage of infection, refAbstract=null), Reference(id=1222469650986819712, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=10.4049/jimmunol.170.6.2811, pmid=null, pmcid=null, year=2003, volume=170, issue=null, pageStart=2811, pageEnd=2815, url=null, language=null, rfNumber=[81], rfOrder=80, authorNames=Malik ZA, Thompson CR, Hashimi S, journalName=J Immunol, refType=null, unstructuredReference=
Malik ZA ,
Thompson CR ,
Hashimi S et al . Cutting edge:
Mycobacterium tuberculosis blocks Ca
2+ signaling and phagosome maturation in human macrophages
via specific inhibition of sphingosine kinase[J].
J Immunol,
2003,
170: 2811-2815., articleTitle=Cutting edge:
Mycobacterium tuberculosis blocks Ca
2+ signaling and phagosome maturation in human macrophages
via specific inhibition of sphingosine kinase, refAbstract=null), Reference(id=1222469651074900103, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=10.3389/fimmu.2017.01316, pmid=null, pmcid=null, year=2017, volume=8, issue=null, pageStart=1316, pageEnd=null, url=null, language=null, rfNumber=[82], rfOrder=81, authorNames=Chandrasekaran P, Saravanan N, Bethunaickan R, journalName=Front Immunol, refType=null, unstructuredReference=
Chandrasekaran P ,
Saravanan N ,
Bethunaickan R et al . Malnutrition: modulator of immune responses in tuberculosis[J].
Front Immunol,
2017,
8: 1316., articleTitle=Malnutrition: modulator of immune responses in tuberculosis, refAbstract=null), Reference(id=1222469651150397579, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=10.3389/fimmu.2017.01836, pmid=null, pmcid=null, year=2017, volume=8, issue=null, pageStart=1836, pageEnd=null, url=null, language=null, rfNumber=[83], rfOrder=82, authorNames=Teng O, Ang CKE, Guan XL, journalName=Front Immunol, refType=null, unstructuredReference=
Teng O ,
Ang CKE ,
Guan XL . Macrophage - bacteria interactions - a lipid-centric relationship[J].
Front Immunol,
2017,
8: 1836., articleTitle=Macrophage - bacteria interactions - a lipid-centric relationship, refAbstract=null), Reference(id=1222469651238477967, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=10.1016/j.apsb.2016.11.001, pmid=null, pmcid=null, year=2017, volume=7, issue=null, pageStart=3, pageEnd=17, url=null, language=null, rfNumber=[84], rfOrder=83, authorNames=Cui CC, Merritt R, Fu LW, journalName=Acta Pharm Sin B, refType=null, unstructuredReference=
Cui CC ,
Merritt R ,
Fu LW et al . Targeting calcium signaling in cancer therapy[J].
Acta Pharm Sin B,
2017,
7: 3-17., articleTitle=Targeting calcium signaling in cancer therapy, refAbstract=null), Reference(id=1222469651330752662, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=null, pmid=null, pmcid=null, year=1992, volume=267, issue=null, pageStart=23122, pageEnd=23128, url=http://cn.bing.com/academic/profile?id=e38239da23e03115e76c728eb7ed53d9&encoded=0&v=paper_preview&mkt=zh-cn, language=null, rfNumber=[85], rfOrder=84, authorNames=Desai NN, Zhang H, Olivera A, journalName=J Biol Chem, refType=null, unstructuredReference=
Desai NN ,
Zhang H ,
Olivera A et al . Sphingosine-1-phosphate, a metabolite of sphingosine, increases phosphatidic acid levels by phospholipase D activation[J].
J Biol Chem,
1992,
267: 23122-23128., articleTitle=Sphingosine-1-phosphate, a metabolite of sphingosine, increases phosphatidic acid levels by phospholipase D activation, refAbstract=null), Reference(id=1222469651423027356, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=10.1038/srep45120, pmid=null, pmcid=null, year=2017, volume=7, issue=null, pageStart=45120, pageEnd=null, url=null, language=null, rfNumber=[86], rfOrder=85, authorNames=Poerio N, Bugli F, Taus F, journalName=Sci Rep, refType=null, unstructuredReference=
Poerio N ,
Bugli F ,
Taus F et al . Liposomes loaded with bioactive lipids enhance antibacterial innate immunity irrespective of drug resistance[J].
Sci Rep,
2017,
7: 45120., articleTitle=Liposomes loaded with bioactive lipids enhance antibacterial innate immunity irrespective of drug resistance, refAbstract=null), Reference(id=1222469651523690655, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=10.1165/ajrcmb.23.6.4227, pmid=null, pmcid=null, year=2000, volume=23, issue=null, pageStart=748, pageEnd=754, url=null, language=null, rfNumber=[87], rfOrder=86, authorNames=Girón-Calle J, Forman HJ, journalName=Am J Respir Cell Mol Biol, refType=null, unstructuredReference=
Girón-Calle J ,
Forman HJ . Phospholipase D and priming of the respiratory burst by H
2O
2 in NR8383 alveolar macrophages[J].
Am J Respir Cell Mol Biol,
2000,
23: 748-754., articleTitle=Phospholipase D and priming of the respiratory burst by H
2O
2 in NR8383 alveolar macrophages, refAbstract=null), Reference(id=1222469651599188130, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=10.4049/jimmunol.167.6.3300, pmid=null, pmcid=null, year=2001, volume=167, issue=null, pageStart=3300, pageEnd=3307, url=null, language=null, rfNumber=[88], rfOrder=87, authorNames=Fairbairn IP, Stober CB, Kumararatne DS, journalName=J Immunol, refType=null, unstructuredReference=
Fairbairn IP ,
Stober CB ,
Kumararatne DS et al . ATP-mediated killing of intracellular mycobacteria by macrophages is a P2X
7-dependent process inducing bacterial death by phagosome-lysosome fusion[J].
J Immunol,
2001,
167: 3300-3307., articleTitle=ATP-mediated killing of intracellular mycobacteria by macrophages is a P2X
7-dependent process inducing bacterial death by phagosome-lysosome fusion, refAbstract=null), Reference(id=1222469651699851427, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=10.1111/mmi.13073, pmid=null, pmcid=null, year=2015, volume=97, issue=null, pageStart=881, pageEnd=897, url=null, language=null, rfNumber=[89], rfOrder=88, authorNames=Speer A, Sun J, Danilchanka O, journalName=Mol Microbiol, refType=null, unstructuredReference=
Speer A ,
Sun J ,
Danilchanka O et al . Surface hydrolysis of sphingomyelin by the outer membrane protein Rv0888 supports replication of
Mycobacterium tuberculosis in macrophages[J].
Mol Microbiol,
2015,
97: 881-897., articleTitle=Surface hydrolysis of sphingomyelin by the outer membrane protein Rv0888 supports replication of
Mycobacterium tuberculosis in macrophages, refAbstract=null), Reference(id=1222469651783737511, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=10.3892/ijmm.2014.1882, pmid=null, pmcid=null, year=2014, volume=34, issue=null, pageStart=1169, pageEnd=1174, url=null, language=null, rfNumber=[90], rfOrder=89, authorNames=Ishitsuka A, Fujine E, Mizutani Y, journalName=Int J Mol Med, refType=null, unstructuredReference=
Ishitsuka A ,
Fujine E ,
Mizutani Y et al . FTY720 and cisplatin synergistically induce the death of cisplatin-resistant melanoma cells through the downregulation of the PI3K pathway and the decrease in epidermal growth factor receptor expression[J].
Int J Mol Med,
2014,
34: 1169-1174., articleTitle=FTY720 and cisplatin synergistically induce the death of cisplatin-resistant melanoma cells through the downregulation of the PI3K pathway and the decrease in epidermal growth factor receptor expression, refAbstract=null), Reference(id=1222469651901178026, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, doi=10.1016/j.cellsig.2008.10.016, pmid=null, pmcid=null, year=2009, volume=21, issue=null, pageStart=293, pageEnd=300, url=null, language=null, rfNumber=[91], rfOrder=90, authorNames=Maeurer C, Holland S, Pierre S, journalName=Cell Signal, refType=null, unstructuredReference=
Maeurer C ,
Holland S ,
Pierre S et al . Sphingosine-1-phosphate induced mTOR-activation is mediated by the E3-ubiquitin ligase PAM[J].
Cell Signal,
2009,
21: 293-300., articleTitle=Sphingosine-1-phosphate induced mTOR-activation is mediated by the E3-ubiquitin ligase PAM, refAbstract=null)], funds=[Fund(id=1222469641948094996, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, awardId=81871182, language=CN, fundingSource=国家自然科学基金资助项目(81871182), fundOrder=null, country=null), Fund(id=1222469642048758301, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, awardId=81371851, language=CN, fundingSource=国家自然科学基金资助项目(81371851), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1222469638261301549, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, xref=null, ext=[AuthorCompanyExt(id=1222469638269690158, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, companyId=1222469638261301549, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, School of Life Sciences, Southwest University, Chongqing 400715, China), AuthorCompanyExt(id=1222469638278078768, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, companyId=1222469638261301549, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=西南大学生命科学学院, 现代生物医药研究所, 三峡库区生态环境与生物资源省部共建国家重点实验室培育基地, 重庆 400715)])], figs=[ArticleFig(id=1222469641105039833, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, language=EN, label=null, caption=null, figureFileSmall=VSiGsUd0YKmebPk7yRzWNQ==, figureFileBig=MuVzxJ+HH6uaQ9QOWQAI0Q==, tableContent=null), ArticleFig(id=1222469641193120225, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, language=CN, label=Figure 1, caption=
S1P metabolism and signaling pathways mediated by S1P receptors. ER: Endoplasmic reticulum; Sph: Sphingosine; CerS: Ceramide synthase; CDase: Ceramidase; SMS: Sphingomyelin; SMase: Sphingomyelinases; Ras: Ras family small GTPase; PLC: Phospholipase C; PI3K: Phosphatidylinositide 3 kinases; AC: Adenylate cyclase; Rho: Rho family of small GTPases; Akt: Protein kinase B; ROCK: Rho-associated kinase; ERK: Extracellular receptor kinase; eNOS: Endothelial nitric oxide synthase; Nox2: NADPH oxidase; PTEN: Phosphatase and tensin homolog; PKC: Protein kinase C; Camp: Cyclic adenosine monophosphate , figureFileSmall=VSiGsUd0YKmebPk7yRzWNQ==, figureFileBig=MuVzxJ+HH6uaQ9QOWQAI0Q==, tableContent=null), ArticleFig(id=1222469641465749998, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, language=EN, label=null, caption=null, figureFileSmall=tBt1zVZPS9DHgUXN9Bey3A==, figureFileBig=MTIC3oD/cv6y3oF6sdrdEg==, tableContent=null), ArticleFig(id=1222469641570607609, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, language=CN, label=Figure 2, caption=
S1P mediates the mechanism of macrophage action during <i>Mycobacterium tuberculosis</i> (Mtb) infection. A: Pathogenic Mtb inhibits the generation of S1P and promotes its survival in macrophages; B: The generation of S1P promotes the killing of Mtb in macrophages. PRR: Pattern recognition receptor; hVPS34: Vacuolar protein sorting-associated protein 34 homolog; COX2: Cycoloxygenase 2; PGE<sub>2</sub>: Prostaglandin E<sub>2</sub>; PLD: Phospholipase D; PA: Phosphatidic acid; ROIs: Reactive oxygen intermediates , figureFileSmall=tBt1zVZPS9DHgUXN9Bey3A==, figureFileBig=MTIC3oD/cv6y3oF6sdrdEg==, tableContent=null), ArticleFig(id=1222469641679659520, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
| Receptor | G alpha subunit | Distribution | Agonist | Antagonist | Reference |
| S1PR1 (EDG1) | Gi | Brain, heart, liver, lung, kidney,
spleen, thymus, lymphoid,
skeletal muscle | FTY720, BAF312, KRP203,
AUY954, AFD(R), CS-0777,
SEW2871, RCP1063, ASP4058,
CYM5442, ACT128800,
ONO-4641 | W146, W123, NI-
BR0213, VPC23019,
VPC44116, APD334 | [34-39] |
| S1PR2 (EDG5) | Gi, G12/13, Gq | Brain, heart, liver, lung, kidney,
spleen, thymus, skeletal muscle | CYM5520 | JTE013 | [38] |
| S1PR3 (EDG3) | Gi, G12/13, Gq | Brain, heart, liver, lung, kidney, spleen, thymus, testis, skeletal
muscle | FTY720, CYM5541 | VPC23019, VPC44116,
SPM202, SPM354 | [35, 38] |
| S1PR4 (EDG6) | Gi, G12/13 | Lymphoid, lung | FTY720, CYM50138,
CYM50308, CYM50260 | CYM50358, CYM50374 | [35, 38, 40] |
| S1PR5 (EDG8) | Gi, G12/13 | Brain, skin, spleen | FTY720, RPC1063, BAF312,
ASP4058 | | [35, 41, 42] |
), ArticleFig(id=1222469641780322824, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469636172538110, language=CN, label=Table 1, caption=
S1P receptors and its regulator
, figureFileSmall=null, figureFileBig=null, tableContent=
| Receptor | G alpha subunit | Distribution | Agonist | Antagonist | Reference |
| S1PR1 (EDG1) | Gi | Brain, heart, liver, lung, kidney,
spleen, thymus, lymphoid,
skeletal muscle | FTY720, BAF312, KRP203,
AUY954, AFD(R), CS-0777,
SEW2871, RCP1063, ASP4058,
CYM5442, ACT128800,
ONO-4641 | W146, W123, NI-
BR0213, VPC23019,
VPC44116, APD334 | [34-39] |
| S1PR2 (EDG5) | Gi, G12/13, Gq | Brain, heart, liver, lung, kidney,
spleen, thymus, skeletal muscle | CYM5520 | JTE013 | [38] |
| S1PR3 (EDG3) | Gi, G12/13, Gq | Brain, heart, liver, lung, kidney, spleen, thymus, testis, skeletal
muscle | FTY720, CYM5541 | VPC23019, VPC44116,
SPM202, SPM354 | [35, 38] |
| S1PR4 (EDG6) | Gi, G12/13 | Lymphoid, lung | FTY720, CYM50138,
CYM50308, CYM50260 | CYM50358, CYM50374 | [35, 38, 40] |
| S1PR5 (EDG8) | Gi, G12/13 | Brain, skin, spleen | FTY720, RPC1063, BAF312,
ASP4058 | | [35, 41, 42] |
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