Article(id=1222466823665209534, tenantId=1146029695717560320, journalId=1189982191388893191, issueId=1222466818573324401, articleNumber=null, orderNo=null, doi=10.16438/j.0513-4870.2019-0061, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=research-article, receivedDate=1547654400000, receivedDateStr=2019-01-17, revisedDate=1552924800000, revisedDateStr=2019-03-19, acceptedDate=null, acceptedDateStr=null, onlineDate=1769388403096, onlineDateStr=2026-01-26, pubDate=1560268800000, pubDateStr=2019-06-12, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1769388403096, onlineIssueDateStr=2026-01-26, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1769388403096, creator=13701087609, updateTime=1769388403096, updator=13701087609, issue=Issue{id=1222466818573324401, tenantId=1146029695717560320, journalId=1189982191388893191, year='2019', volume='54', issue='6', pageStart='963', pageEnd='1144', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1769388401883, creator=13701087609, updateTime=1769389420159, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1222471089591149021, tenantId=1146029695717560320, journalId=1189982191388893191, issueId=1222466818573324401, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1222471089591149022, tenantId=1146029695717560320, journalId=1189982191388893191, issueId=1222466818573324401, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=1088, endPage=1091, ext={EN=ArticleExt(id=1222466824395018458, articleId=1222466823665209534, tenantId=1146029695717560320, journalId=1189982191388893191, language=EN, title=Pharmacokinetics of two types of dipropofol crystal tablets in Beagle dogs, columnId=1190335348761793317, journalTitle=Acta Pharmaceutica Sinica, columnName=Original Articles, runingTitle=null, highlight=null, articleAbstract=
A method for determining dipropofol in the plasma of Beagle dogs was established by HPLC-MS/MS. We also studied the pharmacokinetic characteristics of two different forms of crystal tablets of dipropofol in Beagle dogs. All animal experiments were approved by the Animal Experimental Management, Welfare and Ethics Committee of Pharmacology Evaluation Research Center, Shanghai Institute of Pharmaceutical Industry. The results indicate that the maximum plasma concentration (Cmax) of dipropofol was 69.02 ±20.16 μg·L-1 after 20 mg·kg-1 crystal form Ⅰ tablet taken orally, and the AUC0-t was 160.49 ±55.26 μg·L-1·h. After 20 mg·kg-1 crystal form Ⅱ tablet taken, the Cmax of dipropofol was 92.58 ±60.26 μg·L-1, and the AUC0-t was 243.59 ±148.36 μg·L-1·h. The AUC0-t and Cmax of crystal form Ⅱ were significantly different from that of crystal form Ⅰ (P < 0.05). Crystal form Ⅱ was the dominant crystal form. The results suggest that we should control crystal form during the development of dipropofol oral tablets.
, correspAuthors=Shu-pan GUO, authorNote=null, correspAuthorsNote=null, copyrightStatement=Copyright ©2019 Acta Pharmaceutica Sinica. All rights reserved., copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, authorCompany=null, fund=null, authors=null, authorsList=Shu-pan GUO, Ru-tao WANG, Yi ZHAO, Long AN, Sa XIAO, Yan QIN), CN=ArticleExt(id=1222466825699447098, articleId=1222466823665209534, tenantId=1146029695717560320, journalId=1189982191388893191, language=CN, title=两种晶型异丙双酚片剂的比格犬药代动力学研究, columnId=1190335348896011050, journalTitle=药学学报, columnName=研究论文, runingTitle=null, highlight=null, articleAbstract=
本研究利用HPLC-MS/MS建立了比格犬血浆中异丙双酚的测定方法，并研究了异丙双酚两种晶型片剂在比格犬体内的药代动力学特性。本研究所涉及的动物实验获得了上海医药工业研究院药理评价研究中心实验动物管理和福利、伦理委员会批准。结果显示比格犬口服异丙双酚晶型Ⅰ和Ⅱ片剂各20 mg·kg-1后，血浆中异丙双酚最大血药浓度（Cmax）分别为69.02 ±20.16和92.58 ±60.26 μg·L-1。药时曲线下面积（AUC0-t）分别为160.49 ±55.26和243.59 ±148.36 μg·L-1·h。晶型Ⅱ的AUC0-t和Cmax与晶型Ⅰ相比有显著差异（P < 0.05），晶型Ⅱ为优势晶型，提示在异丙双酚口服剂型制备时要注意晶型的控制。
, correspAuthors=郭树攀, authorNote=null, correspAuthorsNote=
, copyrightStatement=版权所有©《药学学报》编辑部2019, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=VgJ6QydWTA4rzbsipXYnwQ==, magXml=xAkt3HoZiDcSN8DZqfCdUA==, pdfUrl=null, pdf=4j40Thjpr7nod1QQ0VJyXA==, pdfFileSize=952133, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=4bxurBL1Jx05KoY1IXolbA==, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=LuqFzQoMf0c0Y+/RkxI3lw==, mapNumber=null, authorCompany=null, fund=null, authors=null, authorsList=郭树攀, 王汝涛, 赵熠, 安龙, 肖飒, 秦燕)}, authors=[Author(id=1222466942347235858, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222466823665209534, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=guoshupang2589@163.com, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1222466942506619419, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222466823665209534, authorId=1222466942347235858, language=EN, stringName=Shu-pan GUO, firstName=Shu-pan, middleName=null, lastName=GUO, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, *, address=1. Xi'an Libang Zhaoxin Biological Technology Co., Ltd, Xi'an 710077, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1222466942707946021, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222466823665209534, authorId=1222466942347235858, language=CN, stringName=郭树攀, firstName=树攀, middleName=null, lastName=郭, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, *, address=1.西安力邦肇新生物科技有限公司, 陕西 西安 710077, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1222466941944582654, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222466823665209534, xref=null, ext=[AuthorCompanyExt(id=1222466941965554175, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222466823665209534, companyId=1222466941944582654, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1. Xi'an Libang Zhaoxin Biological Technology Co., Ltd, Xi'an 710077, China), AuthorCompanyExt(id=1222466941973942784, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222466823665209534, companyId=1222466941944582654, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.西安力邦肇新生物科技有限公司, 陕西 西安 710077)])]), Author(id=1222466942842163759, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222466823665209534, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1222466942963798582, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222466823665209534, authorId=1222466942842163759, language=EN, stringName=Ru-tao WANG, firstName=Ru-tao, middleName=null, lastName=WANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, address=1. Xi'an Libang Zhaoxin Biological Technology Co., Ltd, Xi'an 710077, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1222466943085433407, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222466823665209534, authorId=1222466942842163759, language=CN, stringName=王汝涛, firstName=汝涛, middleName=null, lastName=王, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, address=1.西安力邦肇新生物科技有限公司, 陕西 西安 710077, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1222466941944582654, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222466823665209534, xref=null, ext=[AuthorCompanyExt(id=1222466941965554175, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222466823665209534, companyId=1222466941944582654, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1. Xi'an Libang Zhaoxin Biological Technology Co., Ltd, Xi'an 710077, China), AuthorCompanyExt(id=1222466941973942784, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222466823665209534, companyId=1222466941944582654, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.西安力邦肇新生物科技有限公司, 陕西 西安 710077)])]), Author(id=1222466943202873927, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222466823665209534, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1222466943307731536, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222466823665209534, authorId=1222466943202873927, language=EN, stringName=Yi ZHAO, firstName=Yi, middleName=null, lastName=ZHAO, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, address=1. Xi'an Libang Zhaoxin Biological Technology Co., Ltd, Xi'an 710077, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1222466943416783452, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222466823665209534, authorId=1222466943202873927, language=CN, stringName=赵熠, firstName=熠, middleName=null, lastName=赵, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, address=1.西安力邦肇新生物科技有限公司, 陕西 西安 710077, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1222466941944582654, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222466823665209534, xref=null, ext=[AuthorCompanyExt(id=1222466941965554175, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222466823665209534, companyId=1222466941944582654, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1. Xi'an Libang Zhaoxin Biological Technology Co., Ltd, Xi'an 710077, China), AuthorCompanyExt(id=1222466941973942784, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222466823665209534, companyId=1222466941944582654, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.西安力邦肇新生物科技有限公司, 陕西 西安 710077)])]), Author(id=1222466943534223975, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222466823665209534, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1222466943651664494, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222466823665209534, authorId=1222466943534223975, language=EN, stringName=Long AN, firstName=Long, middleName=null, lastName=AN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, address=1. Xi'an Libang Zhaoxin Biological Technology Co., Ltd, Xi'an 710077, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1222466943752327794, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222466823665209534, authorId=1222466943534223975, language=CN, stringName=安龙, firstName=龙, middleName=null, lastName=安, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, address=1.西安力邦肇新生物科技有限公司, 陕西 西安 710077, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1222466941944582654, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222466823665209534, xref=null, ext=[AuthorCompanyExt(id=1222466941965554175, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222466823665209534, companyId=1222466941944582654, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1. Xi'an Libang Zhaoxin Biological Technology Co., Ltd, Xi'an 710077, China), AuthorCompanyExt(id=1222466941973942784, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222466823665209534, companyId=1222466941944582654, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.西安力邦肇新生物科技有限公司, 陕西 西安 710077)])]), Author(id=1222466943836213883, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222466823665209534, orderNo=4, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1222466943941071493, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222466823665209534, authorId=1222466943836213883, language=EN, stringName=Sa XIAO, firstName=Sa, middleName=null, lastName=XIAO, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, address=1. Xi'an Libang Zhaoxin Biological Technology Co., Ltd, Xi'an 710077, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1222466944066900620, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222466823665209534, authorId=1222466943836213883, language=CN, stringName=肖飒, firstName=飒, middleName=null, lastName=肖, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, address=1.西安力邦肇新生物科技有限公司, 陕西 西安 710077, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1222466941944582654, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222466823665209534, xref=null, ext=[AuthorCompanyExt(id=1222466941965554175, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222466823665209534, companyId=1222466941944582654, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1. Xi'an Libang Zhaoxin Biological Technology Co., Ltd, Xi'an 710077, China), AuthorCompanyExt(id=1222466941973942784, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222466823665209534, companyId=1222466941944582654, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.西安力邦肇新生物科技有限公司, 陕西 西安 710077)])]), Author(id=1222466944163369624, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222466823665209534, orderNo=5, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1222466944289198747, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222466823665209534, authorId=1222466944163369624, language=EN, stringName=Yan QIN, firstName=Yan, middleName=null, lastName=QIN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
2, address=2. Shanghai Institute of Pharmaceutical Industry, Shanghai 200437, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1222466944389862051, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222466823665209534, authorId=1222466944163369624, language=CN, stringName=秦燕, firstName=燕, middleName=null, lastName=秦, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
2, address=2.上海医药工业研究院, 上海 200437, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1222466942183657990, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222466823665209534, xref=null, ext=[AuthorCompanyExt(id=1222466942200435208, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222466823665209534, companyId=1222466942183657990, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2. Shanghai Institute of Pharmaceutical Industry, Shanghai 200437, China), AuthorCompanyExt(id=1222466942217212424, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222466823665209534, companyId=1222466942183657990, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2.上海医药工业研究院, 上海 200437)])])], keywords=[Keyword(id=1222466944641520301, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222466823665209534, language=EN, orderNo=1, keyword=dipropofol), Keyword(id=1222466944767349428, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222466823665209534, language=EN, orderNo=2, keyword=crystal tablets), Keyword(id=1222466944888984249, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222466823665209534, language=EN, orderNo=3, keyword=pharmacokinetics), Keyword(id=1222466945060950725, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222466823665209534, language=EN, orderNo=4, keyword=HPLC-MS/MS), Keyword(id=1222466945211945679, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222466823665209534, language=CN, orderNo=1, keyword=异丙双酚), Keyword(id=1222466945337774807, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222466823665209534, language=CN, orderNo=2, keyword=晶型), Keyword(id=1222466945430049502, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222466823665209534, language=CN, orderNo=3, keyword=药代动力学), Keyword(id=1222466945522324199, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222466823665209534, language=CN, orderNo=4, keyword=HPLC-MS/MS)], refs=[Reference(id=1222466946893861670, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222466823665209534, doi=10.1039/an9952002435, pmid=null, pmcid=null, year=1995, volume=120, issue=null, pageStart=2435, pageEnd=2460, url=null, language=null, rfNumber=[1], rfOrder=0, authorNames=Threlfall TL, journalName=Analyst, refType=null, unstructuredReference=
Threlfall TL . Analysis of organic polymorphs[J].
Analyst,
1995,
120: 2435-2460., articleTitle=Analysis of organic polymorphs, refAbstract=null), Reference(id=1222466947023885100, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222466823665209534, doi=null, pmid=null, pmcid=null, year=2003, volume=6, issue=null, pageStart=550, pageEnd=560, url=http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=10.1177/001698626801200304, language=null, rfNumber=[2], rfOrder=1, authorNames=Clas SD, journalName=Curr Opin Drug Discov Devel, refType=null, unstructuredReference=
Clas SD . The importance of characterizing the crystal form of the drug substance during drug development[J].
Curr Opin Drug Discov Devel,
2003,
6: 550-560., articleTitle=The importance of characterizing the crystal form of the drug substance during drug development, refAbstract=null), Reference(id=1222466947120354092, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222466823665209534, doi=10.1023/A:1023285627778, pmid=null, pmcid=null, year=2003, volume=20, issue=null, pageStart=531, pageEnd=536, url=null, language=null, rfNumber=[3], rfOrder=2, authorNames=Yu LX, Furness MS, Raw A, journalName=Pharm Res, refType=null, unstructuredReference=
Yu LX ,
Furness MS ,
Raw A et al . Scientific considerations of pharmaceutical solid polymorphism in abbreviated new drug applications[J].
Pharm Res,
2003,
20: 531-536., articleTitle=Scientific considerations of pharmaceutical solid polymorphism in abbreviated new drug applications, refAbstract=null), Reference(id=1222466947221017391, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222466823665209534, doi=10.1023/A:1016241927429, pmid=null, pmcid=null, year=1995, volume=12, issue=null, pageStart=945, pageEnd=954, url=null, language=null, rfNumber=[4], rfOrder=3, authorNames=Byrn S, Pfeiffer R, Ganey M, journalName=Pharm Res, refType=null, unstructuredReference=
Byrn S ,
Pfeiffer R ,
Ganey M et al . Pharmaceutical solids: a strategic approach to regulatory considerations[J].
Pharm Res,
1995,
12: 945-954., articleTitle=Pharmaceutical solids: a strategic approach to regulatory considerations, refAbstract=null), Reference(id=1222466947338457907, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222466823665209534, doi=null, pmid=null, pmcid=null, year=2011, volume=46, issue=null, pageStart=896, pageEnd=903, url=http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=yxxb201108004, language=null, rfNumber=[5], rfOrder=4, authorNames=Ma LW, Du W, Zhao CS, journalName=Acta Pharm Sin (药学学报), refType=null, unstructuredReference=
Ma LW ,
Du W ,
Zhao CS . Advances in the quantitative analytical methods of drug polymorphism[J].
Acta Pharm Sin (药学学报),
2011,
46: 896-903., articleTitle=Advances in the quantitative analytical methods of drug polymorphism, refAbstract=null), Reference(id=1222466947443315514, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222466823665209534, doi=null, pmid=null, pmcid=null, year=2010, volume=45, issue=null, pageStart=5, pageEnd=11, url=null, language=null, rfNumber=[6], rfOrder=5, authorNames=Du GH, Lv Y, journalName=Chin Pharm J (中国药学杂志), refType=null, unstructuredReference=
Du GH ,
Lv Y . Optimal drug polymorphism of solid compound[J].
Chin Pharm J (中国药学杂志),
2010,
45: 5-11., articleTitle=Optimal drug polymorphism of solid compound, refAbstract=null), Reference(id=1222466947552367422, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222466823665209534, doi=null, pmid=null, pmcid=null, year=2013, volume=48, issue=null, pageStart=497, pageEnd=500, url=null, language=null, rfNumber=[7], rfOrder=6, authorNames=Fang LH, He GR, Wang HY, journalName=Chin Pharm J (中国药学杂志), refType=null, unstructuredReference=
Fang LH ,
He GR ,
Wang HY . Strategy of compound polymorph bioactivity study in early druggability evaluation[J].
Chin Pharm J (中国药学杂志),
2013,
48: 497-500., articleTitle=Strategy of compound polymorph bioactivity study in early druggability evaluation, refAbstract=null), Reference(id=1222466947707556672, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222466823665209534, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[8], rfOrder=7, authorNames=null, journalName=null, refType=null, unstructuredReference=Wang RT, Chen T, Hu HJ, et al. Application of dipropofol and its derivatives in the treat of epilepsy: CN, ZL201010160034.9 [P]. 2010-08-08 [2018-10-10]., articleTitle=null, refAbstract=null), Reference(id=1222466947862745925, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222466823665209534, doi=null, pmid=null, pmcid=null, year=2018, volume=120, issue=null, pageStart=1404, pageEnd=1414, url=http://cn.bing.com/academic/profile?id=71d1c2b19a8d0a1af4c5fd4f17163456&encoded=0&v=paper_preview&mkt=zh-cn, language=null, rfNumber=[9], rfOrder=8, authorNames=Zhang JL, Chen XL, K M, journalName=Nervous System Pathophysiol, refType=null, unstructuredReference=
Zhang JL ,
Chen XL ,
K M et al . Anticonvulsant effect of dipropofol by enhancing native GABA currents in cortical neurons in mice[J].
Nervous System Pathophysiol,
2018,
120: 1404-1414., articleTitle=Anticonvulsant effect of dipropofol by enhancing native GABA currents in cortical neurons in mice, refAbstract=null), Reference(id=1222466947975992137, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222466823665209534, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[10], rfOrder=9, authorNames=null, journalName=null, refType=null, unstructuredReference=Wang RT, Chen T, Wang WJ. The crystal forms and preparation methods of 3, 3', 5, 5'-tetraisopropyl-4, 4'-diphenyl: CN, ZL201310055828.2 [P]. 2013-07-03 [2018-10-10]., articleTitle=null, refAbstract=null), Reference(id=1222466948059878220, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222466823665209534, doi=null, pmid=null, pmcid=null, year=2012, volume=32, issue=null, pageStart=1136, pageEnd=1142, url=http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=ywfxzz201207005, language=null, rfNumber=[11], rfOrder=10, authorNames=Shi JM, Han WL, Chen LY, journalName=Pharm Anal, refType=null, unstructuredReference=
Shi JM ,
Han WL ,
Chen LY et al . HPLC-MS/MS determination and pharmacokinetic study of propofol in human plasma[J].
Pharm Anal,
2012,
32: 1136-1142., articleTitle=HPLC-MS/MS determination and pharmacokinetic study of propofol in human plasma, refAbstract=null), Reference(id=1222466948156347215, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222466823665209534, doi=null, pmid=null, pmcid=null, year=2016, volume=19, issue=null, pageStart=1826, pageEnd=1830, url=http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=zgys201610005, language=null, rfNumber=[12], rfOrder=11, authorNames=Sun XQ, Ma JS, journalName=China Pharm (中国药师), refType=null, unstructuredReference=
Sun XQ ,
Ma JS . Simultaneous determination of carbamazepine and phenobarbital in human plasma by UPLC-MS/MS[J].
China Pharm (中国药师),
2016,
19: 1826-1830., articleTitle=Simultaneous determination of carbamazepine and phenobarbital in human plasma by UPLC-MS/MS, refAbstract=null), Reference(id=1222466948298953553, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222466823665209534, doi=10.1111/jvp.2012.35.issue-4, pmid=null, pmcid=null, year=2012, volume=35, issue=null, pageStart=329, pageEnd=341, url=null, language=null, rfNumber=[13], rfOrder=12, authorNames=Lee SH, Park HW, Kim MJ, journalName=Vet Pharmacol Ther, refType=null, unstructuredReference=
Lee SH ,
Park HW ,
Kim MJ . External validation of pharmacokinetic and pharmacodynamic models of microemulsion and long-chain triglyceride emulsion propofol in Beagle dogs[J].
Vet Pharmacol Ther,
2012,
35: 329-341., articleTitle=External validation of pharmacokinetic and pharmacodynamic models of microemulsion and long-chain triglyceride emulsion propofol in Beagle dogs, refAbstract=null)], funds=[Fund(id=1222466946692535073, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222466823665209534, awardId=2014ZX09507003-005, language=CN, fundingSource=国家科技重大专项“重大新药创制”“以离子通道为靶标的重大新药创制”(2014ZX09507003-005), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1222466941944582654, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222466823665209534, xref=null, ext=[AuthorCompanyExt(id=1222466941965554175, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222466823665209534, companyId=1222466941944582654, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1. Xi'an Libang Zhaoxin Biological Technology Co., Ltd, Xi'an 710077, China), AuthorCompanyExt(id=1222466941973942784, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222466823665209534, companyId=1222466941944582654, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.西安力邦肇新生物科技有限公司, 陕西 西安 710077)]), AuthorCompany(id=1222466942183657990, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222466823665209534, xref=null, ext=[AuthorCompanyExt(id=1222466942200435208, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222466823665209534, companyId=1222466942183657990, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2. Shanghai Institute of Pharmaceutical Industry, Shanghai 200437, China), AuthorCompanyExt(id=1222466942217212424, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222466823665209534, companyId=1222466942183657990, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2.上海医药工业研究院, 上海 200437)])], figs=[ArticleFig(id=1222466945761399543, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222466823665209534, language=EN, label=null, caption=null, figureFileSmall=60AnISftI1NNoWA9DaDVgA==, figureFileBig=4bxurBL1Jx05KoY1IXolbA==, tableContent=null), ArticleFig(id=1222466945845285625, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222466823665209534, language=CN, label=Figure 1, caption=
Structure of dipropofol , figureFileSmall=60AnISftI1NNoWA9DaDVgA==, figureFileBig=4bxurBL1Jx05KoY1IXolbA==, tableContent=null), ArticleFig(id=1222466945958531842, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222466823665209534, language=EN, label=null, caption=null, figureFileSmall=y52uW0PtghQTCIZj3Lqkcg==, figureFileBig=5Ovl8LT1x2PUuBtUAzDWdw==, tableContent=null), ArticleFig(id=1222466946055000838, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222466823665209534, language=CN, label=Figure 2, caption=
HPLC chromatograms of biological samples with dipropofol. A: Blank plasma; B: Standard solution; C: Plasma sample in 1 hour. IS: Internal standard , figureFileSmall=y52uW0PtghQTCIZj3Lqkcg==, figureFileBig=5Ovl8LT1x2PUuBtUAzDWdw==, tableContent=null), ArticleFig(id=1222466946172441353, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222466823665209534, language=EN, label=null, caption=null, figureFileSmall=HKm+8rX269YpWkzlzovZNw==, figureFileBig=+g2usjvQQ0rX3Tmk7tXhKQ==, tableContent=null), ArticleFig(id=1222466946273104653, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222466823665209534, language=CN, label=Figure 3, caption=
Blood concentration-time curves of dipropofol crystal tablets after oral administration (<i>n</i> = 6, $\bar{x}\pm s$) , figureFileSmall=HKm+8rX269YpWkzlzovZNw==, figureFileBig=+g2usjvQQ0rX3Tmk7tXhKQ==, tableContent=null), ArticleFig(id=1222466946373767956, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222466823665209534, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
| Parameter | Crystal Ⅰ | Crystal Ⅱ |
| MRT0-t/h | 2.12 ± 0.37 | 2.15 ± 0.41 |
| CLz/F /L·h-1·kg-1 | 122.58 ± 48.30 | 96.73 ± 56.35 |
| Cmax /μg·L-1 | 69.02 ± 20.16 | 92.58 ± 60.26* |
| tmax /h | 1.33 ± 0.26 | 1.33 ± 0.41 |
| t1/2 /h | 1.64 ± 0.59 | 1.75 ± 0.58 |
| AUC0-t /μg·L-1·h | 160.49 ± 55.26 | 243.59 ± 148.36* |
), ArticleFig(id=1222466946461848345, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222466823665209534, language=CN, label=Table 1, caption=
Main pharmacokinetic parameters of dipropofol crystal tablets in beagle dogs after orally administration. *P < 0.05 vs Crystal Ⅰ
, figureFileSmall=null, figureFileBig=null, tableContent=
| Parameter | Crystal Ⅰ | Crystal Ⅱ |
| MRT0-t/h | 2.12 ± 0.37 | 2.15 ± 0.41 |
| CLz/F /L·h-1·kg-1 | 122.58 ± 48.30 | 96.73 ± 56.35 |
| Cmax /μg·L-1 | 69.02 ± 20.16 | 92.58 ± 60.26* |
| tmax /h | 1.33 ± 0.26 | 1.33 ± 0.41 |
| t1/2 /h | 1.64 ± 0.59 | 1.75 ± 0.58 |
| AUC0-t /μg·L-1·h | 160.49 ± 55.26 | 243.59 ± 148.36* |
)], attaches=null, journal=Journal(id=1189982048455397383, delFlag=0, nameCn=药学学报, nameEn=Acta Pharmaceutica Sinica, nameHistory1=null, nameHistory2=null, issn=0513-4870, eissn=null, cn=11-2163/R, coden=null, periodic=0, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=BTxjudbJDVO4PqdBR6On6Q==, journalPrice=null, startedYear=null, abbrevIsoEn=null, journalRemark=null, publicationField=null, createdTime=1761643429151, updatedTime=1761735768113, createdBy=18614031015, updatedBy=13701087609, firstLetterCn=A, firstLetterEn=A, subjectCode=Life Sciences, subjectName=Life Sciences, subjectCodeEn=Life Sciences, subjectNameEn=null, picCn=BTxjudbJDVO4PqdBR6On6Q==, picEn=c4l1ckL55nWbhl1KrFdWIA==, jcr=null, cjcr=null, exts=[JournalExt(id=1190369346338783397, language=CN, name=药学学报, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1761735768160, updatedTime=1761735768160, createdBy=13701087609, updatedBy=13701087609, submissionGuidelinesUrl=, submissionAuthorUrl=https://www.yxxb.com.cn/journalx_yxxb/authorLogOn.action, submissionEditorUrl=https://www.yxxb.com.cn/journalx_yxxb/editorLogOn.action, submissionReviewUrl=https://www.yxxb.com.cn/journalx_yxxb/expertLogOn.action, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""}), JournalExt(id=1190369346376532134, language=EN, name=Acta Pharmaceutica Sinica, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1761735768169, updatedTime=1761735768169, createdBy=13701087609, updatedBy=13701087609, submissionGuidelinesUrl=, submissionAuthorUrl=https://www.yxxb.com.cn/journalx_yxxb/authorLogOn.action, submissionEditorUrl=https://www.yxxb.com.cn/journalx_yxxb/editorLogOn.action, submissionReviewUrl=https://www.yxxb.com.cn/journalx_yxxb/expertLogOn.action, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""})], databaseList=null, tenantJournalId=1189982191388893191, websiteList=[Website(id=1189982271588340489, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1189982191388893191, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/yxxb/CN, language=CN, createTime=1761643482348, createBy=18614031015, updateTime=1761643498101, updateBy=18614031015, name=药学学报-中文, tplId=1146099689490845704, title=药学学报, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1189982873114448678, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271588340489, code=articleTextType, value=kx, createTime=1761643625763, updateTime=1761643625763, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982873093477155, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271588340489, code=banner, value=null, createTime=1761643625758, updateTime=1761643625758, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982873135420201, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271588340489, code=grayFlag, value=0, createTime=1761643625768, updateTime=1761643625768, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982873085088546, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271588340489, code=logo, value=https://castjournals.cast.org.cn/joweb/yxxb/CN/file/pic?fileId=w+t2v8bJnX5lh3+hRRJcDA==, createTime=1761643625756, updateTime=1761643625756, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982873152197419, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271588340489, code=minRunFlag, value=0, createTime=1761643625772, updateTime=1761643625772, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982873110254373, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271588340489, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/yxxb/CN/file/pic, createTime=1761643625762, updateTime=1761643625762, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982873143808810, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271588340489, code=silenceFlag, value=0, createTime=1761643625770, updateTime=1761643625770, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982873101865764, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271588340489, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1761643625760, updateTime=1761643625760, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982873122837287, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271588340489, code=themeColor, value=null, createTime=1761643625765, updateTime=1761643625765, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982873127031592, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271588340489, code=themeStyle, value=null, createTime=1761643625766, updateTime=1761643625766, creator=18614031015, updator=18614031015)]), Website(id=1189982271655449355, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1189982191388893191, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/yxxb/EN, language=EN, createTime=1761643482364, createBy=18614031015, updateTime=1761643514085, updateBy=18614031015, name=药学学报-英文, tplId=1146101810881728533, title=Acta Pharmaceutica Sinica, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1189982903015633534, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271655449355, code=articleTextType, value=kx, createTime=1761643632892, updateTime=1761643632892, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982902990467707, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271655449355, code=banner, value=null, createTime=1761643632886, updateTime=1761643632886, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982903036605057, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271655449355, code=grayFlag, value=0, createTime=1761643632897, updateTime=1761643632897, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982902982079098, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271655449355, code=logo, value=https://castjournals.cast.org.cn/joweb/yxxb/EN/file/pic?fileId=w+t2v8bJnX5lh3+hRRJcDA==, createTime=1761643632884, updateTime=1761643632884, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982903053382275, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271655449355, code=minRunFlag, value=0, createTime=1761643632901, updateTime=1761643632901, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982903007244925, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271655449355, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/yxxb/EN/file/pic, createTime=1761643632890, updateTime=1761643632890, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982903044993666, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271655449355, code=silenceFlag, value=0, createTime=1761643632899, updateTime=1761643632899, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982902998856316, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271655449355, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1761643632888, updateTime=1761643632888, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982903019827839, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271655449355, code=themeColor, value=null, createTime=1761643632893, updateTime=1761643632893, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982903028216448, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271655449355, code=themeStyle, value=null, createTime=1761643632895, updateTime=1761643632895, creator=18614031015, updator=18614031015)])], journalTitle=药学学报, weixinUrl=null, journalUrl=https://www.yxxb.com.cn/aps, iacademicId=null, status=1, seqNo=null, journalTitleEn=Acta Pharmaceutica Sinica, journalPhotoCn=BTxjudbJDVO4PqdBR6On6Q==, journalPhotoEn=c4l1ckL55nWbhl1KrFdWIA==, journalFirstLetter=A, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false), detailUrlCn=https://castjournals.cast.org.cn/joweb/yxxb/CN/10.16438/j.0513-4870.2019-0061, detailUrlEn=https://castjournals.cast.org.cn/joweb/yxxb/EN/10.16438/j.0513-4870.2019-0061, pdfUrlCn=https://castjournals.cast.org.cn/joweb/yxxb/CN/PDF/10.16438/j.0513-4870.2019-0061, pdfUrlEn=https://castjournals.cast.org.cn/joweb/yxxb/EN/PDF/10.16438/j.0513-4870.2019-0061, aliStartDate=null, aliEndDate=null, collectionFlag=false, citedCount=null, citedUrl=null, reference=null)
全屏
文章导航
PDF下载
154
58
关闭全屏
北京市海淀区学院南路86号
010-62199257
qkjq@cast.org.cn
