Article(id=1221483550319231623, tenantId=1146029695717560320, journalId=1189982191388893191, issueId=1221483541674774769, articleNumber=null, orderNo=null, doi=10.16438/j.0513-4870.2020-0421, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=research-article, receivedDate=1585238400000, receivedDateStr=2020-03-27, revisedDate=1590508800000, revisedDateStr=2020-05-27, acceptedDate=null, acceptedDateStr=null, onlineDate=1769153972463, onlineDateStr=2026-01-23, pubDate=1605110400000, pubDateStr=2020-11-12, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1769153972463, onlineIssueDateStr=2026-01-23, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1769153972463, creator=13701087609, updateTime=1769153972463, updator=13701087609, issue=Issue{id=1221483541674774769, tenantId=1146029695717560320, journalId=1189982191388893191, year='2020', volume='55', issue='11', pageStart='2491', pageEnd='2750', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1769153970402, creator=13701087609, updateTime=1769154342560, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1221485102668890897, tenantId=1146029695717560320, journalId=1189982191388893191, issueId=1221483541674774769, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1221485102673085202, tenantId=1146029695717560320, journalId=1189982191388893191, issueId=1221483541674774769, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=2651, endPage=2656, ext={EN=ArticleExt(id=1221483550864491167, articleId=1221483550319231623, tenantId=1146029695717560320, journalId=1189982191388893191, language=EN, title=Therapeutic effects of artesunate on cytomegalovirus pneumonia in mice, columnId=1190335348761793317, journalTitle=Acta Pharmaceutica Sinica, columnName=Original Articles, runingTitle=null, highlight=null, articleAbstract=
To investigate the therapeutic effect of artesunate on mouse cytomegalovirus pneumonia, the BALB/c-nu mice were infected with murine cytomegalovirus-green fluorescent protein (MCMV-GFP) by nose dropping method. The experimental protocol was approved by the Medical Laboratory Animal Ethics Committee of Guangzhou Medical University. The BALB/c-nu mice were randomly divided into five groups:control group, MCMV pneumonia group, and artesunate (60, 120, and 240 mg·kg-1) groups. The survival rate, weights, and virus loads in lungs among the groups were observed. The degree of histopathologic changes in lungs was assessed directly by hematoxylin-eosin (HE) assay. MCMV-GFP expression was assessed by immunofluorescence. In addition, reverse transcription polymerase chain reaction (RT-PCR) analysis was performed to investigate the content of major immediate early 1 (Mie1) mRNA, and enzyme-linked immunosorbent assay (ELISA) was used to detect the changes of inflammatory factors, interleukin 10 (IL-10), IL-6, and tumor necrosis factor-α (TNF-α). Western blot analysis was used to detect the expression of the changes of nuclear factor-kappa B (NF-κB) signaling pathways in total proteins. Compared with MCMV group, artesunate (120 mg·kg-1) significantly increased body weights of MCMV-infected nude mice over 30 days, and decreased the viral titer in lung homogenate, lung inflammation, and histological severity. Moreover, the administration of artesunate (120 mg·kg-1) could downregulate the expression of phospho-NF-κB (p-NF-κB) p65 in the lungs of mice. The present study suggested that artesunate can protect the immunocompromised mice from MCMV-induced interstitial pneumonia via downregulating NF-κB signaling pathway, thus attenuating inflammation in the lungs.
, correspAuthors=Ai-ping QIN, Xi-yong YU, authorNote=null, correspAuthorsNote=null, copyrightStatement=Copyright ©2020 Acta Pharmaceutica Sinica. All rights reserved., copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, authorCompany=null, fund=null, authors=null, authorsList=Ping WANG, Sheng CHEN, Xiao-tao HUANG, Xiao-mei XIAO, Qing-ping ZHAN, Ai-ping QIN, Xi-yong YU), CN=ArticleExt(id=1221483552328303335, articleId=1221483550319231623, tenantId=1146029695717560320, journalId=1189982191388893191, language=CN, title=青蒿琥酯对小鼠巨细胞病毒性肺炎的治疗作用, columnId=1190335348896011050, journalTitle=药学学报, columnName=研究论文, runingTitle=null, highlight=null, articleAbstract=
为了探索青蒿琥酯对小鼠巨细胞病毒性肺炎的治疗作用及其机制，应用滴鼻法建立携带绿色荧光蛋白的小鼠巨细胞病毒（murine cytomegalovirus-green fluorescent protein，MCMV-GFP）感染的巨细胞病毒性肺炎模型。动物福利和实验过程均遵循广州医科大学动物伦理委员会的规定。将BALB/c-nu小鼠随机分为5组：空白对照组、巨细胞病毒肺炎模型组、青蒿琥酯60、120和240 mg·kg-1组。观察小鼠生存期和肺组织病理变化，并进一步进行分子机制研究。分别采用苏木精-伊红（hematoxylin-eosin，HE）染色法检测肺组织的病理变化；荧光定量PCR（polymerase chain reaction）方法检测肺组织中MCMV主要即刻早期基因1（major immediate early 1，Mie1）mRNA的表达；免疫荧光法检测MCMV-GFP的表达；ELISA法（enzyme-linked immunosorbent assay）检测肺上清炎症因子白细胞介素6（interleukin 6，IL-6）、IL-10和肿瘤坏死因子α（tumor necrosis factor α，TNF-α）的含量；Western blot法检测感染后肺组织NF-κB（nuclear factor-κB）通路的变化；绘制小鼠体重变化和生存曲线图。结果显示，MCMV感染模型组小鼠肺组织出现大量炎症细胞浸润，肺组织结构破坏。青蒿琥酯（120 mg·kg-1）治疗后的小鼠肺部炎症减轻，肺泡结构明显好转。与MCMV感染模型组相比，青蒿琥酯（120和240 mg·kg-1）剂量组治疗后，小鼠肺部病毒复制水平降低，青蒿琥酯（120 mg·kg-1）剂量组可显著降低促炎因子IL-6和TNF-α水平并增加抗炎因子IL-10的水平；磷酸化NF-κB蛋白表达明显下降，治疗组小鼠体重增加，生存期延长。上述结果表明，青蒿琥酯具有抑制MCMV感染小鼠肺炎的作用，通过抑制NF-κB炎症信号通路的激活，减轻肺组织炎症因子IL-6和TNF-α的释放，并增加抗炎因子IL-10的表达，从而实现减轻肺部组织炎症的作用。
, correspAuthors=秦爱萍, 余细勇, authorNote=null, correspAuthorsNote=
, copyrightStatement=版权所有©《药学学报》编辑部2020, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=zeBRabMRzBmUfm6OAkg2Og==, magXml=tQ15JPKSAkRxB2EThn1a7Q==, pdfUrl=null, pdf=5p1OlkV9YlZrCxbGzKS96g==, pdfFileSize=967460, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=ETuhdodROgnCROL1riqV8g==, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=C7cei59+468883f8iBMvfw==, mapNumber=null, authorCompany=null, fund=null, authors=null, authorsList=王萍, 陈盛, 黄小桃, 肖小梅, 湛青平, 秦爱萍, 余细勇)}, authors=[Author(id=1221483552709985026, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1221483552802259722, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, authorId=1221483552709985026, language=EN, stringName=Ping WANG, firstName=Ping, middleName=null, lastName=WANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Guangdong Key Laboratory of Molecular Target and Clinical Pharmacology, State Key Laboratory of Respiratory Diseases Pharmacology Group, School of Pharmaceutical Sciences of Guangzhou Medical University, Guangzhou 511436, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1221483552915505935, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, authorId=1221483552709985026, language=CN, stringName=王萍, firstName=萍, middleName=null, lastName=王, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=广州医科大学药学院, 广东省分子靶标与临床药理学重点实验室, 呼吸疾病国家重点实验室药理学组, 广东 广州 511436, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1221483552579961592, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, xref=null, ext=[AuthorCompanyExt(id=1221483552588350202, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, companyId=1221483552579961592, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Guangdong Key Laboratory of Molecular Target and Clinical Pharmacology, State Key Laboratory of Respiratory Diseases Pharmacology Group, School of Pharmaceutical Sciences of Guangzhou Medical University, Guangzhou 511436, China), AuthorCompanyExt(id=1221483552600933115, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, companyId=1221483552579961592, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=广州医科大学药学院, 广东省分子靶标与临床药理学重点实验室, 呼吸疾病国家重点实验室药理学组, 广东 广州 511436)])]), Author(id=1221483553020363542, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1221483553150386974, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, authorId=1221483553020363542, language=EN, stringName=Sheng CHEN, firstName=Sheng, middleName=null, lastName=CHEN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Guangdong Key Laboratory of Molecular Target and Clinical Pharmacology, State Key Laboratory of Respiratory Diseases Pharmacology Group, School of Pharmaceutical Sciences of Guangzhou Medical University, Guangzhou 511436, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1221483553272021799, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, authorId=1221483553020363542, language=CN, stringName=陈盛, firstName=盛, middleName=null, lastName=陈, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=广州医科大学药学院, 广东省分子靶标与临床药理学重点实验室, 呼吸疾病国家重点实验室药理学组, 广东 广州 511436, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1221483552579961592, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, xref=null, ext=[AuthorCompanyExt(id=1221483552588350202, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, companyId=1221483552579961592, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Guangdong Key Laboratory of Molecular Target and Clinical Pharmacology, State Key Laboratory of Respiratory Diseases Pharmacology Group, School of Pharmaceutical Sciences of Guangzhou Medical University, Guangzhou 511436, China), AuthorCompanyExt(id=1221483552600933115, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, companyId=1221483552579961592, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=广州医科大学药学院, 广东省分子靶标与临床药理学重点实验室, 呼吸疾病国家重点实验室药理学组, 广东 广州 511436)])]), Author(id=1221483553376879404, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1221483553502708536, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, authorId=1221483553376879404, language=EN, stringName=Xiao-tao HUANG, firstName=Xiao-tao, middleName=null, lastName=HUANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Guangdong Key Laboratory of Molecular Target and Clinical Pharmacology, State Key Laboratory of Respiratory Diseases Pharmacology Group, School of Pharmaceutical Sciences of Guangzhou Medical University, Guangzhou 511436, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1221483553603371842, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, authorId=1221483553376879404, language=CN, stringName=黄小桃, firstName=小桃, middleName=null, lastName=黄, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=广州医科大学药学院, 广东省分子靶标与临床药理学重点实验室, 呼吸疾病国家重点实验室药理学组, 广东 广州 511436, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1221483552579961592, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, xref=null, ext=[AuthorCompanyExt(id=1221483552588350202, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, companyId=1221483552579961592, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Guangdong Key Laboratory of Molecular Target and Clinical Pharmacology, State Key Laboratory of Respiratory Diseases Pharmacology Group, School of Pharmaceutical Sciences of Guangzhou Medical University, Guangzhou 511436, China), AuthorCompanyExt(id=1221483552600933115, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, companyId=1221483552579961592, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=广州医科大学药学院, 广东省分子靶标与临床药理学重点实验室, 呼吸疾病国家重点实验室药理学组, 广东 广州 511436)])]), Author(id=1221483553733395273, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1221483553880195927, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, authorId=1221483553733395273, language=EN, stringName=Xiao-mei XIAO, firstName=Xiao-mei, middleName=null, lastName=XIAO, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Guangdong Key Laboratory of Molecular Target and Clinical Pharmacology, State Key Laboratory of Respiratory Diseases Pharmacology Group, School of Pharmaceutical Sciences of Guangzhou Medical University, Guangzhou 511436, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1221483553968276319, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, authorId=1221483553733395273, language=CN, stringName=肖小梅, firstName=小梅, middleName=null, lastName=肖, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=广州医科大学药学院, 广东省分子靶标与临床药理学重点实验室, 呼吸疾病国家重点实验室药理学组, 广东 广州 511436, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1221483552579961592, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, xref=null, ext=[AuthorCompanyExt(id=1221483552588350202, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, companyId=1221483552579961592, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Guangdong Key Laboratory of Molecular Target and Clinical Pharmacology, State Key Laboratory of Respiratory Diseases Pharmacology Group, School of Pharmaceutical Sciences of Guangzhou Medical University, Guangzhou 511436, China), AuthorCompanyExt(id=1221483552600933115, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, companyId=1221483552579961592, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=广州医科大学药学院, 广东省分子靶标与临床药理学重点实验室, 呼吸疾病国家重点实验室药理学组, 广东 广州 511436)])]), Author(id=1221483554077328232, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, orderNo=4, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1221483554161214325, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, authorId=1221483554077328232, language=EN, stringName=Qing-ping ZHAN, firstName=Qing-ping, middleName=null, lastName=ZHAN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Guangdong Key Laboratory of Molecular Target and Clinical Pharmacology, State Key Laboratory of Respiratory Diseases Pharmacology Group, School of Pharmaceutical Sciences of Guangzhou Medical University, Guangzhou 511436, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1221483554257683324, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, authorId=1221483554077328232, language=CN, stringName=湛青平, firstName=青平, middleName=null, lastName=湛, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=广州医科大学药学院, 广东省分子靶标与临床药理学重点实验室, 呼吸疾病国家重点实验室药理学组, 广东 广州 511436, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1221483552579961592, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, xref=null, ext=[AuthorCompanyExt(id=1221483552588350202, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, companyId=1221483552579961592, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Guangdong Key Laboratory of Molecular Target and Clinical Pharmacology, State Key Laboratory of Respiratory Diseases Pharmacology Group, School of Pharmaceutical Sciences of Guangzhou Medical University, Guangzhou 511436, China), AuthorCompanyExt(id=1221483552600933115, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, companyId=1221483552579961592, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=广州医科大学药学院, 广东省分子靶标与临床药理学重点实验室, 呼吸疾病国家重点实验室药理学组, 广东 广州 511436)])]), Author(id=1221483554370929540, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, orderNo=5, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=qinaiping_2008@163.com, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1221483554488370066, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, authorId=1221483554370929540, language=EN, stringName=Ai-ping QIN, firstName=Ai-ping, middleName=null, lastName=QIN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
*, address=Guangdong Key Laboratory of Molecular Target and Clinical Pharmacology, State Key Laboratory of Respiratory Diseases Pharmacology Group, School of Pharmaceutical Sciences of Guangzhou Medical University, Guangzhou 511436, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1221483554605810586, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, authorId=1221483554370929540, language=CN, stringName=秦爱萍, firstName=爱萍, middleName=null, lastName=秦, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
*, address=广州医科大学药学院, 广东省分子靶标与临床药理学重点实验室, 呼吸疾病国家重点实验室药理学组, 广东 广州 511436, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1221483552579961592, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, xref=null, ext=[AuthorCompanyExt(id=1221483552588350202, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, companyId=1221483552579961592, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Guangdong Key Laboratory of Molecular Target and Clinical Pharmacology, State Key Laboratory of Respiratory Diseases Pharmacology Group, School of Pharmaceutical Sciences of Guangzhou Medical University, Guangzhou 511436, China), AuthorCompanyExt(id=1221483552600933115, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, companyId=1221483552579961592, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=广州医科大学药学院, 广东省分子靶标与临床药理学重点实验室, 呼吸疾病国家重点实验室药理学组, 广东 广州 511436)])]), Author(id=1221483554698085283, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, orderNo=6, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=yuxycn@aliyun.com, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1221483554823914414, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, authorId=1221483554698085283, language=EN, stringName=Xi-yong YU, firstName=Xi-yong, middleName=null, lastName=YU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
*, address=Guangdong Key Laboratory of Molecular Target and Clinical Pharmacology, State Key Laboratory of Respiratory Diseases Pharmacology Group, School of Pharmaceutical Sciences of Guangzhou Medical University, Guangzhou 511436, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1221483554966520764, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, authorId=1221483554698085283, language=CN, stringName=余细勇, firstName=细勇, middleName=null, lastName=余, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
*, address=广州医科大学药学院, 广东省分子靶标与临床药理学重点实验室, 呼吸疾病国家重点实验室药理学组, 广东 广州 511436, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1221483552579961592, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, xref=null, ext=[AuthorCompanyExt(id=1221483552588350202, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, companyId=1221483552579961592, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Guangdong Key Laboratory of Molecular Target and Clinical Pharmacology, State Key Laboratory of Respiratory Diseases Pharmacology Group, School of Pharmaceutical Sciences of Guangzhou Medical University, Guangzhou 511436, China), AuthorCompanyExt(id=1221483552600933115, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, companyId=1221483552579961592, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=广州医科大学药学院, 广东省分子靶标与临床药理学重点实验室, 呼吸疾病国家重点实验室药理学组, 广东 广州 511436)])])], keywords=[Keyword(id=1221483555079766983, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, language=EN, orderNo=1, keyword=cytomegalovirus), Keyword(id=1221483555180430287, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, language=EN, orderNo=2, keyword=artesunate), Keyword(id=1221483555281093596, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, language=EN, orderNo=3, keyword=pneumonia), Keyword(id=1221483555377562599, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, language=EN, orderNo=4, keyword=inflammatory factor), Keyword(id=1221483555465642995, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, language=EN, orderNo=5, keyword=signaling pathway), Keyword(id=1221483555541140478, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, language=CN, orderNo=1, keyword=巨细胞病毒), Keyword(id=1221483555641802760, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, language=CN, orderNo=2, keyword=青蒿琥酯), Keyword(id=1221483555742466068, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, language=CN, orderNo=3, keyword=肺炎), Keyword(id=1221483555876683812, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, language=CN, orderNo=4, keyword=炎症因子), Keyword(id=1221483555989930031, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, language=CN, orderNo=5, keyword=信号通路)], refs=[Reference(id=1221483558116442349, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, doi=null, pmid=null, pmcid=null, year=2014, volume=20, issue=null, pageStart=19, pageEnd=26, url=null, language=null, rfNumber=[1], rfOrder=0, authorNames=Lumbreras C, Manuel O, Len O, journalName=Clin Microbiol Infect, refType=null, unstructuredReference=
Lumbreras C ,
Manuel O ,
Len O et al . Cytomegalovirus infection in solid organ transplant recipients[J].
Clin Microbiol Infect,
2014,
20: 19-26., articleTitle=Cytomegalovirus infection in solid organ transplant recipients, refAbstract=null), Reference(id=1221483558250660086, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, doi=10.1111/ajo.12408, pmid=null, pmcid=null, year=2016, volume=56, issue=null, pageStart=9, pageEnd=18, url=null, language=null, rfNumber=[2], rfOrder=1, authorNames=Naing ZW, Scott GM, Shand A, journalName=Aust N Z J Obstet Gynaecol, refType=null, unstructuredReference=
Naing ZW ,
Scott GM ,
Shand A et al . Congenital cytomegalovirus infection in pregnancy:a review of prevalence, clinical features, diagnosis and prevention[J].
Aust N Z J Obstet Gynaecol,
2016,
56: 9-18., articleTitle=Congenital cytomegalovirus infection in pregnancy:a review of prevalence, clinical features, diagnosis and prevention, refAbstract=null), Reference(id=1221483558393266434, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, doi=10.1159/000339714, pmid=null, pmcid=null, year=2012, volume=6, issue=null, pageStart=365, pageEnd=368, url=null, language=null, rfNumber=[3], rfOrder=2, authorNames=Ebisutani C, Kawamura A, Shibata N, journalName=Case Rep Gastroenterol, refType=null, unstructuredReference=
Ebisutani C ,
Kawamura A ,
Shibata N et al . Gastric ulcer associated with cytomegalovirus in an immunocompetent patient:method for diagnosis[J].
Case Rep Gastroenterol,
2012,
6: 365-368., articleTitle=Gastric ulcer associated with cytomegalovirus in an immunocompetent patient:method for diagnosis, refAbstract=null), Reference(id=1221483558535872782, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, doi=null, pmid=null, pmcid=null, year=2020, volume=55, issue=null, pageStart=585, pageEnd=596, url=null, language=null, rfNumber=[4], rfOrder=3, authorNames=LI J, Liu XY, Zhan P, journalName=Acta Pharm Sin (药学学报), refType=null, unstructuredReference=
LI J ,
Liu XY ,
Zhan P . Advances in human cytomegalovirus inhibitors[J].
Acta Pharm Sin (药学学报),
2020,
55: 585-596., articleTitle=Advances in human cytomegalovirus inhibitors, refAbstract=null), Reference(id=1221483558674284824, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, doi=10.3109/14767058.2015.1058774, pmid=null, pmcid=null, year=2016, volume=29, issue=null, pageStart=1657, pageEnd=1664, url=null, language=null, rfNumber=[5], rfOrder=4, authorNames=Mareri A, Lasorella S, Iapadre G, journalName=J Matern Fetal Neonatal Med, refType=null, unstructuredReference=
Mareri A ,
Lasorella S ,
Iapadre G et al . Anti-viral therapy for congenital cytomegalovirus infection:pharmacokinetics, efficacy and side effects[J].
J Matern Fetal Neonatal Med,
2016,
29: 1657-1664., articleTitle=Anti-viral therapy for congenital cytomegalovirus infection:pharmacokinetics, efficacy and side effects, refAbstract=null), Reference(id=1221483558791725346, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, doi=10.1097/QCO.0b013e32834cfb58, pmid=null, pmcid=null, year=2011, volume=24, issue=null, pageStart=605, pageEnd=611, url=null, language=null, rfNumber=[6], rfOrder=5, authorNames=Hakki M, Chou S, journalName=Curr Opin Infect Dis, refType=null, unstructuredReference=
Hakki M ,
Chou S . The biology of cytomegalovirus drug resistance[J].
Curr Opin Infect Dis,
2011,
24: 605-611., articleTitle=The biology of cytomegalovirus drug resistance, refAbstract=null), Reference(id=1221483558909165867, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, doi=10.1093/jac/dkt346, pmid=null, pmcid=null, year=2014, volume=69, issue=null, pageStart=34, pageEnd=40, url=null, language=null, rfNumber=[7], rfOrder=6, authorNames=Flobinus A, Taudon N, Desbordes M, journalName=J Antimicrob Chemother, refType=null, unstructuredReference=
Flobinus A ,
Taudon N ,
Desbordes M et al . Stability and antiviral activity against human cytomegalovirus of artemisinin derivatives[J].
J Antimicrob Chemother,
2014,
69: 34-40., articleTitle=Stability and antiviral activity against human cytomegalovirus of artemisinin derivatives, refAbstract=null), Reference(id=1221483559081132338, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, doi=null, pmid=null, pmcid=null, year=2014, volume=29, issue=null, pageStart=1703, pageEnd=1707, url=null, language=null, rfNumber=[8], rfOrder=7, authorNames=Zeng AH, Ouyang Y, Guo MM, journalName=Chin J Appl Clin Pediatr (中华实用儿科临床杂志), refType=null, unstructuredReference=
Zeng AH ,
Ouyang Y ,
Guo MM et al . Antiviral activity research of artesunate against human eytomegalovirus by fractionation dosage method in vitro[J].
Chin J Appl Clin Pediatr (中华实用儿科临床杂志),
2014,
29: 1703-1707., articleTitle=Antiviral activity research of artesunate against human eytomegalovirus by fractionation dosage method in vitro, refAbstract=null), Reference(id=1221483559202767167, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, doi=null, pmid=null, pmcid=null, year=2015, volume=14, issue=null, pageStart=611, pageEnd=614, url=null, language=null, rfNumber=[9], rfOrder=8, authorNames=Luo Q, Lin J, journalName=Chin J Respir Crit Care Med (中国呼吸与危重监护杂志), refType=null, unstructuredReference=
Luo Q ,
Lin J . Research progress of artesunate in lung diseases[J].
Chin J Respir Crit Care Med (中国呼吸与危重监护杂志),
2015,
14: 611-614., articleTitle=Research progress of artesunate in lung diseases, refAbstract=null), Reference(id=1221483559374733644, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[10], rfOrder=9, authorNames=null, journalName=null, refType=null, unstructuredReference=Redwood AJ, Shellam GR, Smith LM. Molecular evolution of murine cytomegalovirus genomes[M]//Reddehase MJ. Cytomegaloviruses: From Molecular Pathogenesis to Intervention (Vol.1). Norfolk: Caister Academic Press, 2013: 23-37., articleTitle=null, refAbstract=null), Reference(id=1221483559450231122, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, doi=10.1007/s00430-015-0400-7, pmid=null, pmcid=null, year=2015, volume=204, issue=null, pageStart=461, pageEnd=469, url=null, language=null, rfNumber=[11], rfOrder=10, authorNames=Ostermann E, Pawletko K, Indenbirken D, journalName=Med Microbiol Immunol, refType=null, unstructuredReference=
Ostermann E ,
Pawletko K ,
Indenbirken D et al . Stepwise adaptation of murine cytomegalovirus to cells of a foreign host for identification of host range determinants[J].
Med Microbiol Immunol,
2015,
204: 461-469., articleTitle=Stepwise adaptation of murine cytomegalovirus to cells of a foreign host for identification of host range determinants, refAbstract=null), Reference(id=1221483559571865947, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[12], rfOrder=11, authorNames=null, journalName=null, refType=null, unstructuredReference=Boppana SB, Britt WJ. Synopsis of clinical aspects of human cytomegalovirus disease[M]//Reddehase MJ. Cytomegaloviruses: From Molecular Pathogenesis to Intervention (Vol.2). Norfolk: Caister Academic Press, 2013: 1-25., articleTitle=null, refAbstract=null), Reference(id=1221483559714472290, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, doi=10.1517/14656560802678138, pmid=null, pmcid=null, year=2009, volume=10, issue=null, pageStart=191, pageEnd=209, url=null, language=null, rfNumber=[13], rfOrder=12, authorNames=Schreiber A, Härter G, Schubert A, journalName=Expert Opin Pharmacother, refType=null, unstructuredReference=
Schreiber A ,
Härter G ,
Schubert A et al . Antiviral treatment of cytomegalovirus infection and resistant strains[J].
Expert Opin Pharmacother,
2009,
10: 191-209., articleTitle=Antiviral treatment of cytomegalovirus infection and resistant strains, refAbstract=null), Reference(id=1221483559869661546, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, doi=10.1084/jem.193.4.471, pmid=null, pmcid=null, year=2001, volume=193, issue=null, pageStart=471, pageEnd=481, url=null, language=null, rfNumber=[14], rfOrder=13, authorNames=Suzuki A, Hanada T, Mitsuyama K, journalName=J Exp Med, refType=null, unstructuredReference=
Suzuki A ,
Hanada T ,
Mitsuyama K et al . CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammation[J].
J Exp Med,
2001,
193: 471-481., articleTitle=CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammation, refAbstract=null), Reference(id=1221483559991296372, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, doi=10.5483/BMBRep.2017.50.2.011, pmid=null, pmcid=null, year=2017, volume=50, issue=null, pageStart=55, pageEnd=57, url=null, language=null, rfNumber=[15], rfOrder=14, authorNames=Kim SJ, Kim HM, journalName=BMB Rep, refType=null, unstructuredReference=
Kim SJ ,
Kim HM . Dynamic lipopolysaccharide transfer cascade to TLR4/MD2 complex via LBP and CD14[J].
BMB Rep,
2017,
50: 55-57., articleTitle=Dynamic lipopolysaccharide transfer cascade to TLR4/MD2 complex via LBP and CD14, refAbstract=null), Reference(id=1221483560108736891, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, doi=10.1038/nri2448, pmid=null, pmcid=null, year=2008, volume=8, issue=null, pageStart=958, pageEnd=969, url=null, language=null, rfNumber=[16], rfOrder=15, authorNames=Mosser DM, Edwards JP, journalName=Nat Rev Immunol, refType=null, unstructuredReference=
Mosser DM ,
Edwards JP . Exploring the full spectrum of macrophage activation[J].
Nat Rev Immunol,
2008,
8: 958-969., articleTitle=Exploring the full spectrum of macrophage activation, refAbstract=null)], funds=[Fund(id=1221483557772509391, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, awardId=U1601227, language=CN, fundingSource=国家自然科学基金重点项目(U1601227), fundOrder=null, country=null), Fund(id=1221483557873172697, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, awardId=81330007, language=CN, fundingSource=国家自然科学基金重点项目(81330007), fundOrder=null, country=null), Fund(id=1221483557961253091, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, awardId=GD2015B020225006, language=CN, fundingSource=广东省重大科技计划资助项目(GD2015B020225006), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1221483552579961592, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, xref=null, ext=[AuthorCompanyExt(id=1221483552588350202, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, companyId=1221483552579961592, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Guangdong Key Laboratory of Molecular Target and Clinical Pharmacology, State Key Laboratory of Respiratory Diseases Pharmacology Group, School of Pharmaceutical Sciences of Guangzhou Medical University, Guangzhou 511436, China), AuthorCompanyExt(id=1221483552600933115, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, companyId=1221483552579961592, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=广州医科大学药学院, 广东省分子靶标与临床药理学重点实验室, 呼吸疾病国家重点实验室药理学组, 广东 广州 511436)])], figs=[ArticleFig(id=1221483556262559821, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, language=EN, label=null, caption=null, figureFileSmall=IrGZQrYVsaiAin+8w1GZDg==, figureFileBig=ETuhdodROgnCROL1riqV8g==, tableContent=null), ArticleFig(id=1221483556405166171, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, language=CN, label=Figure 1, caption=
Effects of artesunate (ART) on weight and mortality of murine cytomegalovirus (MCMV) infected mice. A: Body weight change was monitored following infection for 40 days. Median with interquartile range of 10 mice per experimental group; B: Survival time of mice was recorded over 40 days. <i>n</i> = 10, <i><span class="mag-xml-overline" style="border-top:1px solid black">x</span></i>±<i>s</i>. <sup>***</sup><i>P</i> < 0.001 <i>vs</i> MCMV group. Ctrl: Control , figureFileSmall=IrGZQrYVsaiAin+8w1GZDg==, figureFileBig=ETuhdodROgnCROL1riqV8g==, tableContent=null), ArticleFig(id=1221483556824596594, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, language=EN, label=null, caption=null, figureFileSmall=uk8ugeFkrcAlf+ODiERTZw==, figureFileBig=mdrYVXJylg99IhJOOwjQ5g==, tableContent=null), ArticleFig(id=1221483556904288381, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, language=CN, label=Figure 2, caption=
Hematoxylin-eosin (HE)-stained sections of MCMV infected-mice lungs at 21 days post-infection compared to the phosphate buffered saline (PBS)-infected mice lungs. A: Control group; B: MCMV group; C: ART group (60 mg·kg<sup>-1</sup>); D: ART group (120 mg·kg<sup>-1</sup>); E: ART group (240 mg·kg<sup>-1</sup>). Scale bar: 200 μm , figureFileSmall=uk8ugeFkrcAlf+ODiERTZw==, figureFileBig=mdrYVXJylg99IhJOOwjQ5g==, tableContent=null), ArticleFig(id=1221483557030117517, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, language=EN, label=null, caption=null, figureFileSmall=FSeOaH82bFWCtO4+jyjqPA==, figureFileBig=Bxjh41mB4yz98CaGYELIDg==, tableContent=null), ArticleFig(id=1221483557143363737, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, language=CN, label=Figure 3, caption=
Effects of ART on MCMV replication in lung tissues. Mice were infected with MCMV-GFP. After treatment for 3 days with artesunate, lung sections were stained for MCMV-expressed GFP (green in the merge images). Nuclei were stained with DAPI (blue). Scale bar: 50 μm. A: Control group; B: MCMV group; C: ART group (60 mg·kg<sup>-1</sup>); D: ART group (120 mg·kg<sup>-1</sup>); E: ART group (240 mg·kg<sup>-1</sup>); F: Immune fluorescence identification of mice lungs was analyzed; G: The expression of <i>Mie1</i> mRNA in lung tissues of MCMV-infected mice. <i>n</i> = 5, <i><span class="mag-xml-overline" style="border-top:1px solid black">x</span></i>±<i>s</i>. <sup>##</sup><i>P</i> < 0.01, <sup>####</sup><i>P</i> < 0.000 1 <i>vs</i> control; <sup>*</sup><i>P</i> < 0.05, <sup>**</sup><i>P</i> < 0.01, <sup>***</sup><i>P</i> < 0.001 <i>vs</i> MCMV group. GFP: Green fluorescent protein; DAPI: 4', 6-Diamidino-2-phenylindole; <i>Mie1</i>: Major immediate early 1 , figureFileSmall=FSeOaH82bFWCtO4+jyjqPA==, figureFileBig=Bxjh41mB4yz98CaGYELIDg==, tableContent=null), ArticleFig(id=1221483557227249823, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, language=EN, label=null, caption=null, figureFileSmall=v6/a6fxtb5mtoEC6fY+KAA==, figureFileBig=LTqJltrvvJHcmN0DGL9AvA==, tableContent=null), ArticleFig(id=1221483557365661868, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, language=CN, label=Figure 4, caption=
Effects of ART on inflammatory factors in lung tissues. The expression levels of interleukin 10 (IL-10), tumor necrosis factor <i>α</i> (TNF-<i>α</i>), and IL-6 in lung supernatants were measured by enzyme-linked immunosorbent assay (ELISA). <i>n</i> = 5, <i><span class="mag-xml-overline" style="border-top:1px solid black">x</span></i>±<i>s</i>. <sup>#</sup><i>P</i> < 0.05, <sup>####</sup><i>P</i> < 0.000 1 <i>vs</i> control; <sup>*</sup><i>P</i> < 0.05, <sup>***</sup><i>P</i> < 0.001 <i>vs</i> MCMV group , figureFileSmall=v6/a6fxtb5mtoEC6fY+KAA==, figureFileBig=LTqJltrvvJHcmN0DGL9AvA==, tableContent=null), ArticleFig(id=1221483557487296694, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, language=EN, label=null, caption=null, figureFileSmall=LpmFnzNxi8uN5LKPCPiGyA==, figureFileBig=4kBP86M+NrKU8J8zrElyeg==, tableContent=null), ArticleFig(id=1221483557617320126, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483550319231623, language=CN, label=Figure 5, caption=
Expression of nuclear factor-kappa B (NF-<i>κ</i>B) and phospho-NF-<i>κ</i>B (p-NF-<i>κ</i>B) in MCMV-infected mice lungs after ART treatment (60, 120, and 240 mg·kg<sup>-1</sup>) were detected. Representative Western blot images of NF-<i>κ</i>B and p-NF-<i>κ</i>B were presented and analyzed. <i>n</i> = 5, <i><span class="mag-xml-overline" style="border-top:1px solid black">x</span></i> ± <i>s</i>.<sup>*</sup><i>P</i> < 0.05, <sup>**</sup><i>P</i> < 0.01 <i>vs</i> MCMV group. GAPDH: Glyceraldehyde-3-phosphate dehydrogenase , figureFileSmall=LpmFnzNxi8uN5LKPCPiGyA==, figureFileBig=4kBP86M+NrKU8J8zrElyeg==, tableContent=null)], attaches=null, journal=Journal(id=1189982048455397383, delFlag=0, nameCn=药学学报, nameEn=Acta Pharmaceutica Sinica, nameHistory1=null, nameHistory2=null, issn=0513-4870, eissn=null, cn=11-2163/R, coden=null, periodic=0, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=BTxjudbJDVO4PqdBR6On6Q==, journalPrice=null, startedYear=null, abbrevIsoEn=null, journalRemark=null, publicationField=null, createdTime=1761643429151, updatedTime=1761735768113, createdBy=18614031015, updatedBy=13701087609, firstLetterCn=A, firstLetterEn=A, subjectCode=Life Sciences, subjectName=Life Sciences, subjectCodeEn=Life Sciences, subjectNameEn=null, picCn=BTxjudbJDVO4PqdBR6On6Q==, picEn=c4l1ckL55nWbhl1KrFdWIA==, jcr=null, cjcr=null, exts=[JournalExt(id=1190369346338783397, language=CN, name=药学学报, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1761735768160, updatedTime=1761735768160, createdBy=13701087609, updatedBy=13701087609, submissionGuidelinesUrl=, submissionAuthorUrl=https://www.yxxb.com.cn/journalx_yxxb/authorLogOn.action, submissionEditorUrl=https://www.yxxb.com.cn/journalx_yxxb/editorLogOn.action, submissionReviewUrl=https://www.yxxb.com.cn/journalx_yxxb/expertLogOn.action, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""}), JournalExt(id=1190369346376532134, language=EN, name=Acta Pharmaceutica Sinica, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1761735768169, updatedTime=1761735768169, createdBy=13701087609, updatedBy=13701087609, submissionGuidelinesUrl=, submissionAuthorUrl=https://www.yxxb.com.cn/journalx_yxxb/authorLogOn.action, submissionEditorUrl=https://www.yxxb.com.cn/journalx_yxxb/editorLogOn.action, submissionReviewUrl=https://www.yxxb.com.cn/journalx_yxxb/expertLogOn.action, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""})], databaseList=null, tenantJournalId=1189982191388893191, websiteList=[Website(id=1189982271588340489, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1189982191388893191, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/yxxb/CN, language=CN, createTime=1761643482348, createBy=18614031015, updateTime=1761643498101, updateBy=18614031015, name=药学学报-中文, tplId=1146099689490845704, title=药学学报, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1189982873114448678, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271588340489, code=articleTextType, value=kx, createTime=1761643625763, updateTime=1761643625763, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982873093477155, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271588340489, code=banner, value=null, createTime=1761643625758, updateTime=1761643625758, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982873135420201, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271588340489, code=grayFlag, value=0, createTime=1761643625768, updateTime=1761643625768, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982873085088546, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271588340489, code=logo, value=https://castjournals.cast.org.cn/joweb/yxxb/CN/file/pic?fileId=w+t2v8bJnX5lh3+hRRJcDA==, createTime=1761643625756, updateTime=1761643625756, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982873152197419, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271588340489, code=minRunFlag, value=0, createTime=1761643625772, updateTime=1761643625772, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982873110254373, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271588340489, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/yxxb/CN/file/pic, createTime=1761643625762, updateTime=1761643625762, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982873143808810, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271588340489, code=silenceFlag, value=0, createTime=1761643625770, updateTime=1761643625770, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982873101865764, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271588340489, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1761643625760, updateTime=1761643625760, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982873122837287, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271588340489, code=themeColor, value=null, createTime=1761643625765, updateTime=1761643625765, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982873127031592, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271588340489, code=themeStyle, value=null, createTime=1761643625766, updateTime=1761643625766, creator=18614031015, updator=18614031015)]), Website(id=1189982271655449355, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1189982191388893191, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/yxxb/EN, language=EN, createTime=1761643482364, createBy=18614031015, updateTime=1761643514085, updateBy=18614031015, name=药学学报-英文, tplId=1146101810881728533, title=Acta Pharmaceutica Sinica, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1189982903015633534, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271655449355, code=articleTextType, value=kx, createTime=1761643632892, updateTime=1761643632892, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982902990467707, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271655449355, code=banner, value=null, createTime=1761643632886, updateTime=1761643632886, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982903036605057, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271655449355, code=grayFlag, value=0, createTime=1761643632897, updateTime=1761643632897, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982902982079098, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271655449355, code=logo, value=https://castjournals.cast.org.cn/joweb/yxxb/EN/file/pic?fileId=w+t2v8bJnX5lh3+hRRJcDA==, createTime=1761643632884, updateTime=1761643632884, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982903053382275, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271655449355, code=minRunFlag, value=0, createTime=1761643632901, updateTime=1761643632901, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982903007244925, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271655449355, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/yxxb/EN/file/pic, createTime=1761643632890, updateTime=1761643632890, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982903044993666, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271655449355, code=silenceFlag, value=0, createTime=1761643632899, updateTime=1761643632899, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982902998856316, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271655449355, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1761643632888, updateTime=1761643632888, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982903019827839, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271655449355, code=themeColor, value=null, createTime=1761643632893, updateTime=1761643632893, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982903028216448, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271655449355, code=themeStyle, value=null, createTime=1761643632895, updateTime=1761643632895, creator=18614031015, updator=18614031015)])], journalTitle=药学学报, weixinUrl=null, journalUrl=https://www.yxxb.com.cn/aps, iacademicId=null, status=1, seqNo=null, journalTitleEn=Acta Pharmaceutica Sinica, journalPhotoCn=BTxjudbJDVO4PqdBR6On6Q==, journalPhotoEn=c4l1ckL55nWbhl1KrFdWIA==, journalFirstLetter=A, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false), detailUrlCn=https://castjournals.cast.org.cn/joweb/yxxb/CN/10.16438/j.0513-4870.2020-0421, detailUrlEn=https://castjournals.cast.org.cn/joweb/yxxb/EN/10.16438/j.0513-4870.2020-0421, pdfUrlCn=https://castjournals.cast.org.cn/joweb/yxxb/CN/PDF/10.16438/j.0513-4870.2020-0421, pdfUrlEn=https://castjournals.cast.org.cn/joweb/yxxb/EN/PDF/10.16438/j.0513-4870.2020-0421, aliStartDate=null, aliEndDate=null, collectionFlag=false, citedCount=null, citedUrl=null, reference=null)
全屏
文章导航
PDF下载
89
30
关闭全屏
北京市海淀区学院南路86号
010-62199257
qkjq@cast.org.cn
