Article(id=1221483546858934555, tenantId=1146029695717560320, journalId=1189982191388893191, issueId=1221483541674774769, articleNumber=null, orderNo=null, doi=10.16438/j.0513-4870.2020-0554, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=research-article, receivedDate=1586966400000, receivedDateStr=2020-04-16, revisedDate=1590422400000, revisedDateStr=2020-05-26, acceptedDate=null, acceptedDateStr=null, onlineDate=1769153971638, onlineDateStr=2026-01-23, pubDate=1605110400000, pubDateStr=2020-11-12, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1769153971638, onlineIssueDateStr=2026-01-23, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1769153971638, creator=13701087609, updateTime=1769153971638, updator=13701087609, issue=Issue{id=1221483541674774769, tenantId=1146029695717560320, journalId=1189982191388893191, year='2020', volume='55', issue='11', pageStart='2491', pageEnd='2750', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1769153970402, creator=13701087609, updateTime=1769154342560, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1221485102668890897, tenantId=1146029695717560320, journalId=1189982191388893191, issueId=1221483541674774769, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1221485102673085202, tenantId=1146029695717560320, journalId=1189982191388893191, issueId=1221483541674774769, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=2529, endPage=2534, ext={EN=ArticleExt(id=1221483550243737950, articleId=1221483546858934555, tenantId=1146029695717560320, journalId=1189982191388893191, language=EN, title=Progress and perspective of potential anti-coronavirus activity of phenothiazines, columnId=1190335348648547107, journalTitle=Acta Pharmaceutica Sinica, columnName=Reviews, runingTitle=null, highlight=null, articleAbstract=

Coronaviruses (CoVs) are associated with some mammalian infectious diseases, which have caused several outbreaks of respiratory system infectious diseases in recent years. There is no effective vaccine or approved drug treatment against coronaviruses, and the development of anti-coronavirus agents is an urgent priority. Phenothiazines are a class of antipsychotic drugs, which were found that they have some other biological activities, like promising antibacterial, antifungal, anticancer, antiviral, etc. They can be used for drug repurposing. This review summarizes current researches on the potential anti-coronavirus activity of phenothiazine, discusses the mechanisms and some research difficulties, and provides a foundation for developing anti-coronavirus drugs which use phenothiazine as the lead compound.

, correspAuthors=Hua CHEN, authorNote=null, correspAuthorsNote=null, copyrightStatement=Copyright ©2020 Acta Pharmaceutica Sinica. All rights reserved., copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, authorCompany=null, fund=null, authors=null, authorsList=Jun-yue WAN, Hua CHEN, Jie YIN), CN=ArticleExt(id=1221483551749493184, articleId=1221483546858934555, tenantId=1146029695717560320, journalId=1189982191388893191, language=CN, title=吩噻嗪类化合物潜在抗冠状病毒活性的研究进展, columnId=1190335349655180086, journalTitle=药学学报, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

冠状病毒（coronaviruses，CoVs）与哺乳类动物的多种疾病的产生有关，近年来造成了多起人类呼吸系统传染病的暴发。目前为止还没有相关治疗药物或疫苗被批准用于治疗冠状病毒，因此开发抗冠状病毒药物是当务之急。吩噻嗪类化合物是一类抗精神病药物，近年来发现其具有抗肿瘤、抗菌及抗病毒活性等其他生物活性，是一类可以老药新用的化合物。本文针对吩噻嗪类化合物的抗冠状病毒活性研究进行了综述，探讨了其作用机制及研究难点，并对将吩噻嗪结构作为先导化合物进行抗冠状病毒药物的合理开发提出展望。

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Drug name	Structure	MERS-CoV EC50/μmol·L-1	SARS-CoV EC50/μmol·L-1
Triflupromazine hydrochloride		5.758	6.398
Chlorpromazine hydrochloride		9.514	12.971
Promethazine hydrochloride		11.802	7.545

), ArticleFig(id=1221483555062993619, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1221483546858934555, language=CN, label=Table 1, caption=

Phenothiazines with activity against Middle East respiratory syndrome coronavirus (MERS-CoV) and severe acute respiratory syndrome coronavirus (SARS-CoV). EC₅₀: Median effective concentration

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Drug name	Structure	MERS-CoV EC50/μmol·L-1	SARS-CoV EC50/μmol·L-1
Triflupromazine hydrochloride		5.758	6.398
Chlorpromazine hydrochloride		9.514	12.971
Promethazine hydrochloride		11.802	7.545

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