Article(id=1208402596470043279, tenantId=1146029695717560320, journalId=1189982191388893191, issueId=1208402587812999387, articleNumber=null, orderNo=null, doi=10.16438/j.0513-4870.2020-1831, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=research-article, receivedDate=1606752000000, receivedDateStr=2020-12-01, revisedDate=1608825600000, revisedDateStr=2020-12-25, acceptedDate=null, acceptedDateStr=null, onlineDate=1766035230033, onlineDateStr=2025-12-18, pubDate=1615478400000, pubDateStr=2021-03-12, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1766035230033, onlineIssueDateStr=2025-12-18, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1766035230033, creator=13701087609, updateTime=1766035230033, updator=13701087609, issue=Issue{id=1208402587812999387, tenantId=1146029695717560320, journalId=1189982191388893191, year='2021', volume='56', issue='3', pageStart='643', pageEnd='894', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1766035227968, creator=13701087609, updateTime=1766137227354, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1208830404333794090, tenantId=1146029695717560320, journalId=1189982191388893191, issueId=1208402587812999387, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1208830404333794091, tenantId=1146029695717560320, journalId=1189982191388893191, issueId=1208402587812999387, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=703, endPage=710, ext={EN=ArticleExt(id=1208402596872696501, articleId=1208402596470043279, tenantId=1146029695717560320, journalId=1189982191388893191, language=EN, title=Research progress on STAT protein inhibitors in the treatment of lymphoma, columnId=1190335348648547107, journalTitle=Acta Pharmaceutica Sinica, columnName=Reviews, runingTitle=null, highlight=null, articleAbstract=
The abnormal activation and mutation of signal transducer and activator transcription (STAT) proteins has been implicated in multiple lymphomas. The research discovery and clinical application of STATs inhibitors have become an important strategy for treating lymphoma. This review introduces the abnormal activation and mutation of STATs in multiple malignant lymphomas, and focuses on reviewing the latest screening strategies targeting STATs and its clinical application in the treatment of lymphoma, providing references for the further development of STATs inhibitors.
, correspAuthors=Li LI, authorNote=null, correspAuthorsNote=null, copyrightStatement=Copyright ©2021 Acta Pharmaceutica Sinica. All rights reserved., copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, authorCompany=null, fund=null, authors=null, authorsList=Qi-hong DENG, Zheng WANG, Xian-ming DENG, Li LI), CN=ArticleExt(id=1208402598063878957, articleId=1208402596470043279, tenantId=1146029695717560320, journalId=1189982191388893191, language=CN, title=靶向STAT蛋白的抑制剂在淋巴瘤治疗中的研究进展, columnId=1190335349655180086, journalTitle=药学学报, columnName=综述, runingTitle=null, highlight=null, articleAbstract=
信号转导和转录激活蛋白（signal transducer and activator of transcription，STAT）家族在多种恶性淋巴瘤中普遍存在异常激活和突变，其抑制剂的研究发现与临床应用成为淋巴瘤的一个重要治疗策略。本文介绍了STATs蛋白在多种恶性淋巴瘤中的异常激活突变，并着重综述了靶向STATs蛋白的最新筛选策略及其在淋巴瘤治疗中的临床应用研究，为STATs抑制剂的进一步研发提供借鉴。
, correspAuthors=李莉, authorNote=null, correspAuthorsNote=
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Protein domains of signal transducers and activators of transcription (STATs). DNA: Deoxyribonucleic acid; SH2 domain: Src homology domain , figureFileSmall=qM8zlsBY2cDnwFEyLEiPmg==, figureFileBig=DjGOPu2u3qfS06vXH6frxQ==, tableContent=null), ArticleFig(id=1208478662832275677, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208402596470043279, language=EN, label=null, caption=null, figureFileSmall=FA02/gAyOOx4X2sVsb6v7g==, figureFileBig=4GVbEhy4KEFzL73ub0PrpQ==, tableContent=null), ArticleFig(id=1208478662928744679, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208402596470043279, language=CN, label=Figure 2, caption=
JAK/STAT signaling pathway. JAK: Janus protein tyrosine kinase; PY: Phosphorylated tyrosine residue; Bcl-xL: B cell lymphoma 2-like 1; Bcl-2: B-cell lymphoma-2; Mcl-1: Myeloid cell leukemia-1; VEGF: Vascular endothelial growth factor; MMP: Matrix metalloproteinase , figureFileSmall=FA02/gAyOOx4X2sVsb6v7g==, figureFileBig=4GVbEhy4KEFzL73ub0PrpQ==, tableContent=null), ArticleFig(id=1208478663121682683, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208402596470043279, language=EN, label=null, caption=null, figureFileSmall=mqakxCDNnJOfed7VlvjI+Q==, figureFileBig=5WOvOtco7PnCShYjZGNsMg==, tableContent=null), ArticleFig(id=1208478663243317509, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208402596470043279, language=CN, label=Figure 3, caption=
Classification of STATs inhibitors , figureFileSmall=mqakxCDNnJOfed7VlvjI+Q==, figureFileBig=5WOvOtco7PnCShYjZGNsMg==, tableContent=null), ArticleFig(id=1208478663364952339, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208402596470043279, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
| Inhibitor | Targeted protein | Phase | ClinicalTrials.gov identifier | Disease | Reference |
| Sttatic | STAT3 | | | Nasal NK/T cell lymphoma | [29] |
| OPB-31121 | STAT3 | Ⅰ
Ⅰ/Ⅱ | NCT00955812
NCT1406574 | Burkitt lymphoma | [30] |
| Ⅰ | NCT00511082 | Non-Hodgkin lymphoma | |
| OPB-51602 | STAT3 | Ⅰ | NCT01344876 | Non-Hodgkin lymphoma | [31] |
| Niclosamide | Tax and STAT3 | | | Adult T-cell leukemia and lymphoma | [32] |
| Atiprimod | Apoptosis inducing factor and STAT3 | | | Mantle cell lymphoma | [33] |
| BP-1-102 | STAT3 | | | Anaplastic large cell lymphoma | [34] |
| STA-21 | STAT3 | | | Diffuse large B cell lymphoma | [35] |
| SD-36 | STAT3 | | | Anaplastic large cell lymphoma | [36, 37] |
| S31-201 | STAT3 | | | NK/T cell lymphoma | [38] |
| WP1066 | STAT3 | | | Mantle cell lymphoma, nasal NK/T cell lymphoma, adult T
cell leukemia/lymphoma, B cell lymphoma, and human brain malignant lymphoma | [39-41] |
| AZD9150 | STAT3 | Ⅰ | NCT02549651
NCT03527147 | Diffuse large B cell lymphoma and relapsed/refractory aggressive non-Hodgkin lymphoma | [42] |
| Cryptotanshinone | STAT3 | | | Burkitt lymphoma | [43] |
| Cucurbitacin I | STAT3 | | | Dalton Lymphoma, anaplastic large cell lymphoma | [44] |
| Lestaurtinib | STAT3 and STAT5 | Ⅲ | NCT01150669
NCT00557193 | Lymphocytic leukemia and Hodgkin's lymphoma | [45] |
| CMD178 | IL-2 and STAT5 | | | B-cell non-Hodgkin lymphoma | [46] |
| SH-4-54 | STAT3 and STAT5 | | | Classic Hodgkin lymphoma | [47] |
| Pimozide | STAT5 | | | Peripheral blood T cell lymphoma | [48] |
| TNX-650 | STAT6 | Ⅰ/Ⅱ | NCT00441818 | Refractory Hodgkin lymphoma | |
| Panobinostat | STAT5 and STAT6 | Ⅰ/Ⅱ
Ⅰ
Ⅰ | NCT00967044
NCT01504776
NCT01032148 | Hodgkin's lymphoma, relapsed and refractory lymphoma, etc. | [49, 50] |
| Fludarabine | STAT1 | Ⅱ | NCT03016988
NCT00117156 | Burkitt lymphoma, mantle cell lymphoma, marginal zone non-Hodgkin lymphoma, etc. | [51] |
), ArticleFig(id=1208478663486587167, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208402596470043279, language=CN, label=Table 1, caption=
The clinical application of STATs inhibitors in lymphomas. NK: Natural killer; IL-2: Interleukin-2
, figureFileSmall=null, figureFileBig=null, tableContent=
| Inhibitor | Targeted protein | Phase | ClinicalTrials.gov identifier | Disease | Reference |
| Sttatic | STAT3 | | | Nasal NK/T cell lymphoma | [29] |
| OPB-31121 | STAT3 | Ⅰ
Ⅰ/Ⅱ | NCT00955812
NCT1406574 | Burkitt lymphoma | [30] |
| Ⅰ | NCT00511082 | Non-Hodgkin lymphoma | |
| OPB-51602 | STAT3 | Ⅰ | NCT01344876 | Non-Hodgkin lymphoma | [31] |
| Niclosamide | Tax and STAT3 | | | Adult T-cell leukemia and lymphoma | [32] |
| Atiprimod | Apoptosis inducing factor and STAT3 | | | Mantle cell lymphoma | [33] |
| BP-1-102 | STAT3 | | | Anaplastic large cell lymphoma | [34] |
| STA-21 | STAT3 | | | Diffuse large B cell lymphoma | [35] |
| SD-36 | STAT3 | | | Anaplastic large cell lymphoma | [36, 37] |
| S31-201 | STAT3 | | | NK/T cell lymphoma | [38] |
| WP1066 | STAT3 | | | Mantle cell lymphoma, nasal NK/T cell lymphoma, adult T
cell leukemia/lymphoma, B cell lymphoma, and human brain malignant lymphoma | [39-41] |
| AZD9150 | STAT3 | Ⅰ | NCT02549651
NCT03527147 | Diffuse large B cell lymphoma and relapsed/refractory aggressive non-Hodgkin lymphoma | [42] |
| Cryptotanshinone | STAT3 | | | Burkitt lymphoma | [43] |
| Cucurbitacin I | STAT3 | | | Dalton Lymphoma, anaplastic large cell lymphoma | [44] |
| Lestaurtinib | STAT3 and STAT5 | Ⅲ | NCT01150669
NCT00557193 | Lymphocytic leukemia and Hodgkin's lymphoma | [45] |
| CMD178 | IL-2 and STAT5 | | | B-cell non-Hodgkin lymphoma | [46] |
| SH-4-54 | STAT3 and STAT5 | | | Classic Hodgkin lymphoma | [47] |
| Pimozide | STAT5 | | | Peripheral blood T cell lymphoma | [48] |
| TNX-650 | STAT6 | Ⅰ/Ⅱ | NCT00441818 | Refractory Hodgkin lymphoma | |
| Panobinostat | STAT5 and STAT6 | Ⅰ/Ⅱ
Ⅰ
Ⅰ | NCT00967044
NCT01504776
NCT01032148 | Hodgkin's lymphoma, relapsed and refractory lymphoma, etc. | [49, 50] |
| Fludarabine | STAT1 | Ⅱ | NCT03016988
NCT00117156 | Burkitt lymphoma, mantle cell lymphoma, marginal zone non-Hodgkin lymphoma, etc. | [51] |
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