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| Drug | Dosage/
g·kg-1/x(day) | Change in
body weight/g | Prolonged
survival/% |
| Whole prescription | 5.7/9 | -1.1 | 4.0 |
| Aloe + Indigo | 7.7/10 | -1.5 | 17.0 |
| Aloe | 7.6/10 | +0.3 | 3.8 |
| Indigo | 5.6/10 | +0.7 | 16.3 |
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Anticancer activity of different compositions for L7212 leukemia
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| Drug | Dosage/
g·kg-1/x(day) | Change in
body weight/g | Prolonged
survival/% |
| Whole prescription | 5.7/9 | -1.1 | 4.0 |
| Aloe + Indigo | 7.7/10 | -1.5 | 17.0 |
| Aloe | 7.6/10 | +0.3 | 3.8 |
| Indigo | 5.6/10 | +0.7 | 16.3 |
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| Tumor | Dosage
time | Body
wt/g | Tumor wt or survival day | Inhibition/% |
| Experiment | Control |
| S-180 | 10 | +1.0 | 1.29 g | 1.47 g | 12.1 |
| W-256 | 7 | +14.9 | 6.56 g | 7.14 g | 8.1 |
| EAC | 10 | +6.0 | 22.1 days | 19.8 days | 11.7 |
| L-615 | 6 | +0.5 | 7.3 days | 7.3 days | 0 |
| L-7212 | 10 | +0.7 | 12.1 days | 10.4 days | 16.3 (P < 0.01) |
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Inhibitory effect of indigo on various tumor models
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| Tumor | Dosage
time | Body
wt/g | Tumor wt or survival day | Inhibition/% |
| Experiment | Control |
| S-180 | 10 | +1.0 | 1.29 g | 1.47 g | 12.1 |
| W-256 | 7 | +14.9 | 6.56 g | 7.14 g | 8.1 |
| EAC | 10 | +6.0 | 22.1 days | 19.8 days | 11.7 |
| L-615 | 6 | +0.5 | 7.3 days | 7.3 days | 0 |
| L-7212 | 10 | +0.7 | 12.1 days | 10.4 days | 16.3 (P < 0.01) |
), ArticleFig(id=1201118435112608630, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1200500166454267983, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
| Drug sample | Dosage
/g·kg-1 | Change in
body wt/g | Prolonged
survival life/day | P
value |
| FI (hot water ext) | 15.5 | -1.6 | 0 | - |
| RI (water ext) | 28.5 | -1.2 | 0 | - |
| RI (alc. ext) | 22.9 | -0.4 | 5.0 | - |
| Indigo (powder) | 5.6 | -0.2 | 14.6 | < 0.01 |
| Indigo (water ext) | 30.4 | +1.7 | 0 | - |
| Indigo (alc. ext) | 28.5 | +0.7 | 1.9 | - |
Indigo (hot acid
water ext) | 2.7 | 0 | 18.7 | < 0.01 |
), ArticleFig(id=1201118435242632065, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1200500166454267983, language=CN, label=Table 3, caption=
Inhibitory effect of various extraction part of indigo on mouse leukemia 7212
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| Drug sample | Dosage
/g·kg-1 | Change in
body wt/g | Prolonged
survival life/day | P
value |
| FI (hot water ext) | 15.5 | -1.6 | 0 | - |
| RI (water ext) | 28.5 | -1.2 | 0 | - |
| RI (alc. ext) | 22.9 | -0.4 | 5.0 | - |
| Indigo (powder) | 5.6 | -0.2 | 14.6 | < 0.01 |
| Indigo (water ext) | 30.4 | +1.7 | 0 | - |
| Indigo (alc. ext) | 28.5 | +0.7 | 1.9 | - |
Indigo (hot acid
water ext) | 2.7 | 0 | 18.7 | < 0.01 |
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 |
| Compd. | R | Dosage mg·kg-1/x (days) | TWI/% |
| 1 | H | 100/9 | 45.4 |
| 3 | CH3 | 105/9 | 41.5 |
| 4 | C2H5 | 110/9 | 57.9 |
| 5 | n-C3H7 | 116/9 | 53.9 |
| 6 | n-C4H9 | 121/9 | 41.1 |
| 7 | n-C5H11 | 134/9 | 15.7 |
| 8 | n-C10H21 | 150/9 | 19.8 |
| 9 | n-C14H29 | 174/9 | 25.2 |
| 10 | n-C18H37 | 195/9 | 12.7 |
| 11 |  | 121/9 | -6.0 |
| 12 | COOC2H5 | 127/9 | 48.7 |
| 13 | CH2COOH | 20/9 (ip) | 38.7 |
| 14 | Benzyl | 136/9 | 35.1 |
| 15 | Acetyl | 116/9 | 47.7 |
| 16 | Formyl | 111/9 | 29.0 |
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Structure and activity of N1′-substituted indirubins
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|
| Compd. | R | Dosage mg·kg-1/x (days) | TWI/% |
| 1 | H | 100/9 | 45.4 |
| 3 | CH3 | 105/9 | 41.5 |
| 4 | C2H5 | 110/9 | 57.9 |
| 5 | n-C3H7 | 116/9 | 53.9 |
| 6 | n-C4H9 | 121/9 | 41.1 |
| 7 | n-C5H11 | 134/9 | 15.7 |
| 8 | n-C10H21 | 150/9 | 19.8 |
| 9 | n-C14H29 | 174/9 | 25.2 |
| 10 | n-C18H37 | 195/9 | 12.7 |
| 11 | | 121/9 | -6.0 |
| 12 | COOC2H5 | 127/9 | 48.7 |
| 13 | CH2COOH | 20/9 (ip) | 38.7 |
| 14 | Benzyl | 136/9 | 35.1 |
| 15 | Acetyl | 116/9 | 47.7 |
| 16 | Formyl | 111/9 | 29.0 |
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 |
| Compd. | R | R′ | Inhibition/% | Compd. | R | R′ | Inhibition/% |
| W-256a | LLCb | W-256a | LLCb |
| 3 | H | CH3 | 41.5 | 50.0 | 20 | CH3 | H | 51.5 | 38.2 |
| 4 | H | C2H5 | 57.9 | 38.2 | 21 | C2H5 | H | 54.6 | 44.1 |
| 5 | H | n-C3H7 | 53.9 | 27.5 | 22 | n-C3H7 | H | 15.0 | - |
| 17 | CH3 | H | 15.0 | - | 23 | CH3 | H | 67.6 | 50.0 |
| 18 | C2H5 | H | 16.3 | - | 24 | C2H5 | H | 48.5 | 38.2 |
| 19 | CH3 | CH3 | 46.9 | 42.9 | 25 | n-C3H7 | H | 12.5 | - |
), ArticleFig(id=1201118435834028978, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1200500166454267983, language=CN, label=Table 5, caption=
Structure and activity of compounds of substituted indirubin, indigotin and isoindigotin. a: Walker 256 carcinosarcoma; b: Lewis lung carcinoma
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|
| Compd. | R | R′ | Inhibition/% | Compd. | R | R′ | Inhibition/% |
| W-256a | LLCb | W-256a | LLCb |
| 3 | H | CH3 | 41.5 | 50.0 | 20 | CH3 | H | 51.5 | 38.2 |
| 4 | H | C2H5 | 57.9 | 38.2 | 21 | C2H5 | H | 54.6 | 44.1 |
| 5 | H | n-C3H7 | 53.9 | 27.5 | 22 | n-C3H7 | H | 15.0 | - |
| 17 | CH3 | H | 15.0 | - | 23 | CH3 | H | 67.6 | 50.0 |
| 18 | C2H5 | H | 16.3 | - | 24 | C2H5 | H | 48.5 | 38.2 |
| 19 | CH3 | CH3 | 46.9 | 42.9 | 25 | n-C3H7 | H | 12.5 | - |
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