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药学学报
| 2023, 58(5): 0-0
中药活性成分与作用机制——专栏致辞
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出版时间: 2023-05-12
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中药活性成分与作用机制——专栏致辞.
药学学报,
2023
, 58
(5)
: 0
-0
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Acta Pharmaceutica Sinica ,
2023
, 58
(5)
: 0
-0
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近年来，药物分析学作为药物研究的“眼睛科学”，在与化学、生物学、医学及药学相关学科的交叉融合过程中实现了创新性发展。它的应用已经涵盖药物早期发现、临床研究、制药过程以及生物体内和代谢过程等的综合评价和动态分析。当前中药现代化研究成为热点，各种药物分析技术已成为中药活性成分分析和作用机制研究的有力手段，其发展面临更大的挑战和机遇。
中药是中华民族数千年来与疾病斗争的智慧结晶，是中华民族的瑰宝，其中的天然活性成分及代谢产物是中药发挥药理作用的物质基础，也是制药工业中新药研发的重要来源之一。依靠各种药物分析技术深入挖掘中医药宝库的科学内涵、明确其发挥药效的活性成分、了解活性成分在体内的作用位点以及其作用的分子机制、建立与生物活性相关的质量控制与评价方法、加快实现中医药现代化，是当前我国中药行业及科学研究急需解决的关键问题。
本专栏聚焦药物分析新技术的开发和应用，针对中药活性成分与作用机制研究热点问题，以邀请业内专家和公开征集方式进行组稿，收录了11篇与主题相关的论文，包括4篇综述和7篇研究论文。参与稿件撰写单位和人员有江西中医药大学陈颖翀博士，西安交通大学包涛副教授和卢闻教授，杭州师范大学周建良教授，暨南大学江正瑾教授，中国中医科学院中医基础理论研究所柏冬副研究员，中国中医科学院西苑医院刘建勋研究员，安徽中医药大学吴虹教授，以及海军军医大学吕狄亚副教授和曹岩副教授等。稿件主要内容涉及中药活性成分筛选技术研究；中药活性成分研究与中药现代化；中药活性成分药理作用研究新方法；中药活性成分作用机制研究；肠道菌群与中药相互作用；中药体内作用过程及代谢；中药分析新方法等。本专栏内容丰富、涉足广泛，希望本专栏的推出为从事中药活性成分与作用机制研究的读者提供借鉴和参考，促进中药现代化的发展。
王嗣岑 教授，博士生导师，西藏大学校长助理（援藏），西安交通大学药学院院长。主要从事药物分析新方法的研究。主持国家自然科学基金、十二五“重大新药创制”重大专项课题等7项。发表SCI论文100余篇，获授权国家发明专利50件。获国家技术发明二等奖1项。享受国务院特殊津贴，入选教育部新世纪优秀人才支持计划，陕西省中青年科技创新领军人才、陕西省青年科技标兵。担任中国药学会药物分析专业委员会副主任委员，陕西省药学会副理事长，陕西省药学会药物分析专业委员会主任委员。主编《分析化学》（科学出版社）1部，参编教材4部；合著专著4部。
解笑瑜 西安交通大学药学院教授，博士生导师，入选国家级青年人才计划。主要从事药物复杂体系成分与活性分析研究。主持国家自然科学基金等多个项目。获陕西省科学技术二等奖1项。以第一/通讯发表SCI收录论文40余篇。担任陕西省心血管药物工程技术研究中心副主任、中国药学会药物分析专业委员会委员、陕西省药学会青年工作委员会副主任委员、陕西省药学会药物分析专业委员会委员。同时，担任《药学学报》中英文两刊、Journal of Pharmaceutical Analysis和《沈阳药科大学学报》等期刊青年编委。
2023年第58卷第5期
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首发时间：2025-11-21
出版时间：2023-05-12
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2种不同金属材料的力学参数
科 属数 种数 占总种数比例 属 种数 占总种数比例 鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78 小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39 多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39 红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87 小菇属 Mycena 11 5.26 光柄菇属 Pluteus 5 2.39 红菇属 Russula 17 8.13 栓菌属 Trametes 5 2.39
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