Article(id=1308840486610240311, tenantId=1146029695717560320, journalId=1189982191388893191, issueId=1308840287129141340, articleNumber=null, orderNo=null, doi=10.16438/j.0513-4870.2025-1108, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1758124800000, receivedDateStr=2025-09-18, revisedDate=1760284800000, revisedDateStr=2025-10-13, acceptedDate=null, acceptedDateStr=null, onlineDate=1789981489087, onlineDateStr=2026-09-21, pubDate=1775923200000, pubDateStr=2026-04-12, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1789981489087, onlineIssueDateStr=2026-09-21, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1789981489087, creator=13701087609, updateTime=1789981489087, updator=13701087609, issue=Issue{id=1308840287129141340, tenantId=1146029695717560320, journalId=1189982191388893191, year='2026', volume='61', issue='4', pageStart='1001', pageEnd='1434', issueExtLink='null', onlineDate='null', pubDate='1775923200000', pubDateStr='2026-04-12', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1789981441528, creator='13701087609', updateTime=1789984228828, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1308851977992368434, tenantId=1146029695717560320, journalId=1189982191388893191, issueId=1308840287129141340, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1308851977992368435, tenantId=1146029695717560320, journalId=1189982191388893191, issueId=1308840287129141340, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1276, endPage=1282, ext={EN=ArticleExt(id=1308840486811566904, articleId=1308840486610240311, tenantId=1146029695717560320, journalId=1189982191388893191, language=EN, title=The direct target and synergistic action of sulbactam against Acinetobacter baumannii, columnId=1190335348761793317, journalTitle=Acta Pharmaceutica Sinica, columnName=Original Articles, runingTitle=null, highlight=null, articleAbstract=

β-Lactamase inhibitor sulbactam has unique activity against Acinetobacter baumannii, but its direct target protein has not been fully elucidated. In this research, thermal proteome profiling and surface plasmon resonance technologies were applied to identify and validate RNA 5′ pyrophosphohydrolase (RppH) as the direct target of sulbactam against A. baumannii. And further, using the checkerboard method, we found that sulbactam could synergize with carbapenem antibiotics to battle A. baumannii. The research results supplement the new molecular mechanism of action of sulbactam and provide an effective combined regimen for its combination with other antibiotics to combat clinical intractable drug-resistant bacteria infections.

, authors=Xin-yi LI, Qiong-lu DUAN, Xi ZHU, Ya-nan NI, Dan-qing SONG, Ying-hong LI^*, authorsList=Xin-yi LI, Qiong-lu DUAN, Xi ZHU, Ya-nan NI, Dan-qing SONG, Ying-hong LI, authorCompany=null, correspAuthors=Ying-hong LI, authorNote=null, correspAuthorsNote=null, copyrightStatement=Copyright ©2026 Acta Pharmaceutica Sinica. All rights reserved., copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1308840487923057475, articleId=1308840486610240311, tenantId=1146029695717560320, journalId=1189982191388893191, language=CN, title=舒巴坦抗鲍曼不动杆菌直接靶点及协同增敏抗生素的研究, columnId=1190335348896011050, journalTitle=药学学报, columnName=研究论文, runingTitle=null, highlight=null, articleAbstract=

β-内酰胺酶抑制剂舒巴坦具有独特的抗鲍曼不动杆菌活性, 但其直接靶蛋白尚未完全阐明。本研究运用包括热蛋白质组分析、表面等离子共振等化学蛋白组学技术, 发现并验证RNA 5′焦磷酸水解酶为舒巴坦抗鲍曼不动杆菌的直接靶点。并进一步通过棋盘法筛选发现, 舒巴坦可以协同碳青霉烯类抗生素对抗鲍曼不动杆菌的活性。研究结果补充了舒巴坦新的分子作用机制, 并为其配伍对抗临床棘手耐药菌感染提供了有效联合治疗方案。

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MIC used alone/µg·mL-1		MIC of SUL /µg·mL-1	MICs in combination/µg·mL-1		FIC
Antibiotic	MIC		Antibiotic	MIC (MICSUL)
Meropenem	8.	1	Meropenem (SUL)	2 (0.125)	0.375
Imipenem	4.	1	Imipenem (SUL)	1 (0.25)	0.5
Faropenem	16.	1	Faropenem (SUL)	4 (0.125)	0.375
Amikacin	4.	1	Amikacin (SUL)	> 16 (0.063)	> 2.06
Clarithromycin	16.	1	Clarithromycin (SUL)	0.062 5 (0.5)	0.504
Azithromycin	4.	1	Azithromycin (SUL)	0.25 (0.5)	0.56
Ceftazidime	16.	1	Ceftazidime (SUL)	4 (0.5)	0.75
Tigecycline	0.25	1	Tigecycline (SUL)	0.5 (0.03)	2.03
Minocycline	1.	1	Minocycline (SUL)	0.5 (0.015)	0.53
Polymyxin B	16.	1	Polymyxin B (SUL)	32 (0.063)	2.06
Polymyxin E	2.	1	Polymyxin E (SUL)	4 (0.125)	2.125
Levofloxacin	0.5	1	Levofloxacin (SUL)	0.03 (0.5)	0.56
Ciprofloxacin	0.5	1	Ciprofloxacin (SUL)	0.5 (0.03)	1.03
Linezolid	> 1 024.	1	Linezolid (SUL)	1 024 (0.125)	< 0.675

), ArticleFig(id=1308840496777233277, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1308840486610240311, language=CN, label=Tab.1, caption=

In vitro antibacterial activities of sulbactam combined with 14 antibiotics against A. baumannii. MIC: Minimal inhibitory concentration; FIC: Fractional inhibitory concentration

, figureFileSmall=null, figureFileBig=null, tableContent=

MIC used alone/µg·mL-1		MIC of SUL /µg·mL-1	MICs in combination/µg·mL-1		FIC
Antibiotic	MIC		Antibiotic	MIC (MICSUL)
Meropenem	8.	1	Meropenem (SUL)	2 (0.125)	0.375
Imipenem	4.	1	Imipenem (SUL)	1 (0.25)	0.5
Faropenem	16.	1	Faropenem (SUL)	4 (0.125)	0.375
Amikacin	4.	1	Amikacin (SUL)	> 16 (0.063)	> 2.06
Clarithromycin	16.	1	Clarithromycin (SUL)	0.062 5 (0.5)	0.504
Azithromycin	4.	1	Azithromycin (SUL)	0.25 (0.5)	0.56
Ceftazidime	16.	1	Ceftazidime (SUL)	4 (0.5)	0.75
Tigecycline	0.25	1	Tigecycline (SUL)	0.5 (0.03)	2.03
Minocycline	1.	1	Minocycline (SUL)	0.5 (0.015)	0.53
Polymyxin B	16.	1	Polymyxin B (SUL)	32 (0.063)	2.06
Polymyxin E	2.	1	Polymyxin E (SUL)	4 (0.125)	2.125
Levofloxacin	0.5	1	Levofloxacin (SUL)	0.03 (0.5)	0.56
Ciprofloxacin	0.5	1	Ciprofloxacin (SUL)	0.5 (0.03)	1.03
Linezolid	> 1 024.	1	Linezolid (SUL)	1 024 (0.125)	< 0.675

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