Article(id=1198652615572681503, tenantId=1146029695717560320, journalId=1189982191388893191, issueId=1198652605778985059, articleNumber=null, orderNo=null, doi=10.16438/j.0513-4870.2023-0553, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1682870400000, receivedDateStr=2023-05-01, revisedDate=1689177600000, revisedDateStr=2023-07-13, acceptedDate=null, acceptedDateStr=null, onlineDate=1763710653441, onlineDateStr=2025-11-21, pubDate=1691769600000, pubDateStr=2023-08-12, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1763710653441, onlineIssueDateStr=2025-11-21, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1763710653441, creator=13701087609, updateTime=1763710653441, updator=13701087609, issue=Issue{id=1198652605778985059, tenantId=1146029695717560320, journalId=1189982191388893191, year='2023', volume='58', issue='8', pageStart='0', pageEnd='2540', issueExtLink='null', onlineDate='null', pubDate='1691769600000', pubDateStr='2023-08-12', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1763710651106, creator='13701087609', updateTime=1763710739504, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1198652976601596347, tenantId=1146029695717560320, journalId=1189982191388893191, issueId=1198652605778985059, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1198652976601596348, tenantId=1146029695717560320, journalId=1189982191388893191, issueId=1198652605778985059, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=2193, endPage=2202, ext={EN=ArticleExt(id=1198652616088580921, articleId=1198652615572681503, tenantId=1146029695717560320, journalId=1189982191388893191, language=EN, title=Research progress in controllable proteolysis targeting chimeras, columnId=null, journalTitle=Acta Pharmaceutica Sinica, columnName=null, runingTitle=null, highlight=null, articleAbstract=

Proteolysis targeting chimeras (PROTACs) is an innovative technique in targeted protein degradation. PROTACs is a heterobifunctional molecule which can bind to the E3 ligase and target protein to form a ubiquitination complex, resulting in the ubiquitin-proteasome system dependent degradation of target protein. PROTACs has been regarded as the promising method in drug discovery campaign, for its high commonality, potent degradation activity and unique selectivity profile. However, the catalytic mechanism also induces the uncontrollable protein degradation risk. Controllable PROTACs contain the responsive element in the molecular entity. In certain conditions, the element can be triggered to activate or terminate the degradation event. In this review, we will briefly summarize the strategies in controllable PROTACs and describe the representative examples according to the responsive mechanism. We hope this review could provide some insight into the further development of controllable PROTACs.

, authors=null, authorsList=Yi MOU, Shuai WEN, Yan WANG, Zheng-yu JIANG, authorCompany=null, correspAuthors=Zheng-yu JIANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=Copyright ©2023 Acta Pharmaceutica Sinica. All rights reserved., copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1198652623034347814, articleId=1198652615572681503, tenantId=1146029695717560320, journalId=1189982191388893191, language=CN, title=可控性蛋白降解靶向嵌合体(PROTACs) 技术研究进展, columnId=1190335349655180086, journalTitle=药学学报, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

蛋白降解靶向嵌合体(PROTACs) 是一类新型蛋白降解技术, 能同时结合E3连接酶与疾病相关蛋白, 利用内源性泛素-蛋白酶体系降解靶蛋白。PROTACs具有较佳的通用性、较强的蛋白降解活性和较好的目的蛋白选择性, 成为靶向蛋白降解领域的热点技术, 但具有降解不受控的风险。可控PROTACs引入了特定的刺激响应触发元件, 在特定的响应条件下可被触发, 产生/终止后续的蛋白质降解效应。本文概述了可控PROTACs设计策略, 并按照相应机制不同对代表化合物和研究进展进行了介绍, 从而为可控PROTACs的研究提供借鉴和思路。

, authors=null, authorsList=牟伊, 文帅, 王燕, 姜正羽, authorCompany=null, correspAuthors=姜正羽, authorNote=null, correspAuthorsNote=, copyrightStatement=版权所有©《药学学报》编辑部2023, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=Hsy6rIhnSyHwZMlQLeViSg==, magXml=4DpsNCiZLpkfq2o6g9/zAg==, pdfUrl=null, pdf=+UhphPgV0KMnhipwnvaGAg==, pdfFileSize=3107173, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=f68Y6KIQsuTJ3EGFOEqt1w==, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=koE8Xx2zHFoWh4dPknZ/lg==, mapNumber=null, fund=null)}, authors=[Author(id=1198960101244629878, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1198960101441762188, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, authorId=1198960101244629878, language=EN, stringName=Yi MOU, firstName=Yi, middleName=null, lastName=MOU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=1. College of Pharmacy and Chemistry & Chemical Engineering, Taizhou University, Taizhou 225300, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1198960101651477409, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, authorId=1198960101244629878, language=CN, stringName=牟伊, firstName=伊, middleName=null, lastName=牟, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=1.泰州学院医药与化学化工学院, 江苏 泰州 225300, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1198960100913279817, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, xref=null, ext=[AuthorCompanyExt(id=1198960100938445647, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, companyId=1198960100913279817, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1. College of Pharmacy and Chemistry & Chemical Engineering, Taizhou University, Taizhou 225300, China), AuthorCompanyExt(id=1198960100959417172, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, companyId=1198960100913279817, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.泰州学院医药与化学化工学院, 江苏 泰州 225300)])]), Author(id=1198960101819249581, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1198960102054130631, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, authorId=1198960101819249581, language=EN, stringName=Shuai WEN, firstName=Shuai, middleName=null, lastName=WEN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=1. College of Pharmacy and Chemistry & Chemical Engineering, Taizhou University, Taizhou 225300, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1198960102205125588, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, authorId=1198960101819249581, language=CN, stringName=文帅, firstName=帅, middleName=null, lastName=文, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=1.泰州学院医药与化学化工学院, 江苏 泰州 225300, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1198960100913279817, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, xref=null, ext=[AuthorCompanyExt(id=1198960100938445647, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, companyId=1198960100913279817, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1. College of Pharmacy and Chemistry & Chemical Engineering, Taizhou University, Taizhou 225300, China), AuthorCompanyExt(id=1198960100959417172, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, companyId=1198960100913279817, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.泰州学院医药与化学化工学院, 江苏 泰州 225300)])]), Author(id=1198960102494532581, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1198960102679081972, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, authorId=1198960102494532581, language=EN, stringName=Yan WANG, firstName=Yan, middleName=null, lastName=WANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=1. College of Pharmacy and Chemistry & Chemical Engineering, Taizhou University, Taizhou 225300, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1198960102796522495, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, authorId=1198960102494532581, language=CN, stringName=王燕, firstName=燕, middleName=null, lastName=王, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=1.泰州学院医药与化学化工学院, 江苏 泰州 225300, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1198960100913279817, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, xref=null, ext=[AuthorCompanyExt(id=1198960100938445647, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, companyId=1198960100913279817, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1. College of Pharmacy and Chemistry & Chemical Engineering, Taizhou University, Taizhou 225300, China), AuthorCompanyExt(id=1198960100959417172, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, companyId=1198960100913279817, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.泰州学院医药与化学化工学院, 江苏 泰州 225300)])]), Author(id=1198960102922350602, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=jiangzhengyucpu@163.com, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1198960103077539860, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, authorId=1198960102922350602, language=EN, stringName=Zheng-yu JIANG, firstName=Zheng-yu, middleName=null, lastName=JIANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^{2, *}, address=2. Jiangsu Key Laboratory of Drug Design and Optimization, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1198960103199174689, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, authorId=1198960102922350602, language=CN, stringName=姜正羽, firstName=正羽, middleName=null, lastName=姜, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^{2, *}, address=2.中国药科大学药学院, 江苏省药物分子设计与成药性优化重点实验室, 江苏 南京 210009, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1198960101127189351, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, xref=null, ext=[AuthorCompanyExt(id=1198960101131383655, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, companyId=1198960101127189351, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2. Jiangsu Key Laboratory of Drug Design and Optimization, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China), AuthorCompanyExt(id=1198960101143966569, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, companyId=1198960101127189351, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2.中国药科大学药学院, 江苏省药物分子设计与成药性优化重点实验室, 江苏 南京 210009)])])], keywords=[Keyword(id=1198960103509553205, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, language=EN, orderNo=1, keyword=proteolysis targeting chimeras), Keyword(id=1198960103677325373, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, language=EN, orderNo=2, keyword=targeted protein degradation), Keyword(id=1198960103857680461, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, language=EN, orderNo=3, keyword=controllable proteolysis targeting chimeras), Keyword(id=1198960104071589977, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, language=CN, orderNo=1, keyword=蛋白降解靶向嵌合体), Keyword(id=1198960104189030497, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, language=CN, orderNo=2, keyword=靶向蛋白降解), Keyword(id=1198960104319053931, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, language=CN, orderNo=3, keyword=可控性蛋白降解靶向嵌合体)], refs=[Reference(id=1198960110086222342, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, doi=10.1016/j.molcel.2020.01.010, pmid=null, pmcid=null, year=2020, volume=77, issue=null, pageStart=446, pageEnd=460, url=null, language=null, rfNumber=[1], rfOrder=0, authorNames=null, journalName=Mol Cell, refType=null, unstructuredReference=Verma R, Mohl D, Deshaies RJ. Harnessing the power of proteolysis for targeted protein inactivation[J]. Mol Cell, 2020, 77: 446-460., articleTitle=Harnessing the power of proteolysis for targeted protein inactivation, refAbstract=null), Reference(id=1198960110191079950, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, doi=10.1038/nrd.2016.211, pmid=null, pmcid=null, year=2017, volume=16, issue=null, pageStart=101, pageEnd=114, url=null, language=null, rfNumber=[2], rfOrder=1, authorNames=null, journalName=Nat Rev Drug Discov, refType=null, unstructuredReference=Lai AC, Crews CM. Induced protein degradation: an emerging drug discovery paradigm[J]. Nat Rev Drug Discov, 2017, 16: 101-114., articleTitle=Induced protein degradation: an emerging drug discovery paradigm, refAbstract=null), Reference(id=1198960110455321117, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, doi=10.3390/molecules27248828, pmid=null, pmcid=null, year=2022, volume=27, issue=null, pageStart=8828, pageEnd=null, url=null, language=null, rfNumber=[3], rfOrder=2, authorNames=null, journalName=Molecules, refType=null, unstructuredReference=Li R, Liu M, Yang Z, et al. Proteolysis-targeting chimeras (PROTACs) in cancer therapy: present and future[J]. Molecules, 2022, 27: 8828., articleTitle=Proteolysis-targeting chimeras (PROTACs) in cancer therapy: present and future, refAbstract=null), Reference(id=1198960110656647723, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, doi=10.1186/s13046-020-01672-1, pmid=null, pmcid=null, year=2020, volume=39, issue=null, pageStart=189, pageEnd=null, url=null, language=null, rfNumber=[4], rfOrder=3, authorNames=null, journalName=J Exp Clin Cancer Res, refType=null, unstructuredReference=Ocana A, Pandiella A. Proteolysis targeting chimeras (PROTACs) in cancer therapy[J]. J Exp Clin Cancer Res, 2020, 39: 189., articleTitle=Proteolysis targeting chimeras (PROTACs) in cancer therapy, refAbstract=null), Reference(id=1198960110904111679, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, doi=10.1093/nar/gkaa807, pmid=null, pmcid=null, year=2021, volume=49, issue=null, pageStart=D1381, pageEnd=D1387, url=null, language=null, rfNumber=[5], rfOrder=4, authorNames=null, journalName=Nucleic Acids Res, refType=null, unstructuredReference=Weng G, Shen C, Cao D, et al. PROTAC-DB: an online database of PROTACs[J]. Nucleic Acids Res, 2021, 49: D1381-D1387., articleTitle=PROTAC-DB: an online database of PROTACs, refAbstract=null), Reference(id=1198960111097049681, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, doi=10.1021/acsmedchemlett.9b00219, pmid=null, pmcid=null, year=2019, volume=10, issue=null, pageStart=1081, pageEnd=1085, url=null, language=null, rfNumber=[6], rfOrder=5, authorNames=null, journalName=ACS Med Chem Lett, refType=null, unstructuredReference=Nunes J, Mcgonagle GA, Eden J, et al. Targeting IRAK4 for degradation with PROTACs[J]. ACS Med Chem Lett, 2019, 10: 1081-1085., articleTitle=Targeting IRAK4 for degradation with PROTACs, refAbstract=null), Reference(id=1198960111264821854, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, doi=10.1002/med.21877, pmid=null, pmcid=null, year=2022, volume=42, issue=null, pageStart=1280, pageEnd=1342, url=null, language=null, rfNumber=[7], rfOrder=6, authorNames=null, journalName=Med Res Rev, refType=null, unstructuredReference=He S, Dong G, Cheng J, et al. Strategies for designing proteolysis targeting chimaeras (PROTACs)[J]. Med Res Rev, 2022, 42: 1280-1342., articleTitle=Strategies for designing proteolysis targeting chimaeras (PROTACs), refAbstract=null), Reference(id=1198960111457759857, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, doi=10.1016/j.ddtec.2019.01.002, pmid=null, pmcid=null, year=2019, volume=31, issue=null, pageStart=15, pageEnd=27, url=null, language=null, rfNumber=[8], rfOrder=7, authorNames=null, journalName=Drug Discov Today Technol, refType=null, unstructuredReference=Pettersson M, Crews CM. Proteolysis targeting chimeras (PROTACs) - past, present and future[J]. Drug Discov Today Technol, 2019, 31: 15-27., articleTitle=Proteolysis targeting chimeras (PROTACs) - past, present and future, refAbstract=null), Reference(id=1198960111596171902, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, doi=10.3390/ijms231810328, pmid=null, pmcid=null, year=2022, volume=23, issue=null, pageStart=10328, pageEnd=null, url=null, language=null, rfNumber=[9], rfOrder=8, authorNames=null, journalName=Int J Mol Sci, refType=null, unstructuredReference=Yao T, Xiao H, Wang H, et al. Recent advances in PROTACs for drug targeted protein research[J]. Int J Mol Sci, 2022, 23: 10328., articleTitle=Recent advances in PROTACs for drug targeted protein research, refAbstract=null), Reference(id=1198960111763944079, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, doi=10.1016/j.ebiom.2018.09.005, pmid=null, pmcid=null, year=2018, volume=36, issue=null, pageStart=553, pageEnd=562, url=null, language=null, rfNumber=[10], rfOrder=9, authorNames=null, journalName=EBioMedicine, refType=null, unstructuredReference=An S, Fu L. Small-molecule PROTACs: an emerging and promising approach for the development of targeted therapy drugs[J]. EBioMedicine, 2018, 36: 553-562., articleTitle=Small-molecule PROTACs: an emerging and promising approach for the development of targeted therapy drugs, refAbstract=null), Reference(id=1198960111910744728, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, doi=10.2174/1871520621666210308100327, pmid=null, pmcid=null, year=2022, volume=22, issue=null, pageStart=406, pageEnd=417, url=null, language=null, rfNumber=[11], rfOrder=10, authorNames=null, journalName=Anticancer Agents Med Chem, refType=null, unstructuredReference=Kaur R, Chaudhary G, Kaur A, et al. PROTACs: a hope for breast cancer patients?[J]. Anticancer Agents Med Chem, 2022, 22: 406-417., articleTitle=PROTACs: a hope for breast cancer patients?, refAbstract=null), Reference(id=1198960112061739683, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, doi=10.1080/14756366.2022.2081164, pmid=null, pmcid=null, year=2022, volume=37, issue=null, pageStart=1694, pageEnd=1703, url=null, language=null, rfNumber=[12], rfOrder=11, authorNames=null, journalName=J Enzyme Inhib Med Chem, refType=null, unstructuredReference=Wang C, Zhang Y, Yang S, et al. PROTACs for BRDs proteins in cancer therapy: a review[J]. J Enzyme Inhib Med Chem, 2022, 37: 1694-1703., articleTitle=PROTACs for BRDs proteins in cancer therapy: a review, refAbstract=null), Reference(id=1198960112183374510, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, doi=10.2174/1568009621666210203110857, pmid=null, pmcid=null, year=2021, volume=21, issue=null, pageStart=306, pageEnd=325, url=null, language=null, rfNumber=[13], rfOrder=12, authorNames=null, journalName=Curr Cancer Drug Targets, refType=null, unstructuredReference=Giardina SF, Valdambrini E, Warren JD, et al. PROTACs: promising approaches for epigenetic strategies to overcome drug resistance[J]. Curr Cancer Drug Targets, 2021, 21: 306-325., articleTitle=PROTACs: promising approaches for epigenetic strategies to overcome drug resistance, refAbstract=null), Reference(id=1198960112305009333, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, doi=10.1021/acs.jmedchem.1c00649, pmid=null, pmcid=null, year=2021, volume=64, issue=null, pageStart=7839, pageEnd=7852, url=null, language=null, rfNumber=[14], rfOrder=13, authorNames=null, journalName=J Med Chem, refType=null, unstructuredReference=Zheng M, Huo J, Gu X, et al. Rational design and synthesis of novel dual PROTACs for simultaneous degradation of EGFR and PARP[J]. J Med Chem, 2021, 64: 7839-7852., articleTitle=Rational design and synthesis of novel dual PROTACs for simultaneous degradation of EGFR and PARP, refAbstract=null), Reference(id=1198960112447615683, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, doi=10.1016/j.ejmech.2022.115037, pmid=null, pmcid=null, year=2023, volume=247, issue=null, pageStart=115037, pageEnd=null, url=null, language=null, rfNumber=[15], rfOrder=14, authorNames=null, journalName=Eur J Med Chem, refType=null, unstructuredReference=Wang YW, Lan L, Wang M, et al. PROTACS: a technology with a gold rush-like atmosphere[J]. Eur J Med Chem, 2023, 247: 115037., articleTitle=PROTACS: a technology with a gold rush-like atmosphere, refAbstract=null), Reference(id=1198960112594416342, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, doi=10.3389/fchem.2021.679120, pmid=null, pmcid=null, year=2021, volume=9, issue=null, pageStart=679120, pageEnd=null, url=null, language=null, rfNumber=[16], rfOrder=15, authorNames=null, journalName=Front Chem, refType=null, unstructuredReference=Yu F, Cai M, Shao L, et al. Targeting protein kinases degradation by PROTACs[J]. Front Chem, 2021, 9: 679120., articleTitle=Targeting protein kinases degradation by PROTACs, refAbstract=null), Reference(id=1198960112770577129, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, doi=10.1002/cbic.202100270, pmid=null, pmcid=null, year=2022, volume=23, issue=null, pageStart=e202100270, pageEnd=null, url=null, language=null, rfNumber=[17], rfOrder=16, authorNames=null, journalName=Chembiochem, refType=null, unstructuredReference=Hu Z, Crews CM. Recent developments in PROTAC-mediated protein degradation: from bench to clinic[J]. Chembiochem, 2022, 23: e202100270., articleTitle=Recent developments in PROTAC-mediated protein degradation: from bench to clinic, refAbstract=null), Reference(id=1198960112900600568, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, doi=10.3390/molecules28031217, pmid=null, pmcid=null, year=2023, volume=28, issue=null, pageStart=1217, pageEnd=null, url=null, language=null, rfNumber=[18], rfOrder=17, authorNames=null, journalName=Molecules, refType=null, unstructuredReference=Liu X, Wang A, Shi Y, et al. PROTACs in epigenetic cancer therapy: current status and future opportunities[J]. Molecules, 2023, 28: 1217., articleTitle=PROTACs in epigenetic cancer therapy: current status and future opportunities, refAbstract=null), Reference(id=1198960113026429705, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, doi=10.1016/j.semcancer.2022.07.001, pmid=null, pmcid=null, year=2022, volume=86, issue=null, pageStart=269, pageEnd=279, url=null, language=null, rfNumber=[19], rfOrder=18, authorNames=null, journalName=Semin Cancer Biol, refType=null, unstructuredReference=Liu J, Peng Y, Inuzuka H, et al. Targeting micro-environmental pathways by PROTACs as a therapeutic strategy[J]. Semin Cancer Biol, 2022, 86: 269-279., articleTitle=Targeting micro-environmental pathways by PROTACs as a therapeutic strategy, refAbstract=null), Reference(id=1198960113160647448, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, doi=10.2174/0929867327666201117141611, pmid=null, pmcid=null, year=2021, volume=28, issue=null, pageStart=4893, pageEnd=4909, url=null, language=null, rfNumber=[20], rfOrder=19, authorNames=null, journalName=Curr Med Chem, refType=null, unstructuredReference=Li W, Elhassan RM, Hou X, et al. Recent advances in small molecule PROTACs for the treatment of cancer[J]. Curr Med Chem, 2021, 28: 4893-4909., articleTitle=Recent advances in small molecule PROTACs for the treatment of cancer, refAbstract=null), Reference(id=1198960113265505061, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, doi=10.1073/pnas.141230798, pmid=null, pmcid=null, year=2001, volume=98, issue=null, pageStart=8554, pageEnd=8559, url=null, language=null, rfNumber=[21], rfOrder=20, authorNames=null, journalName=Proc Natl Acad Sci U S A, refType=null, unstructuredReference=Sakamoto KM, Kim KB, Kumagai A, et al. PROTACs: chimeric molecules that target proteins to the Skp1-Cullin-F box complex for ubiquitination and degradation[J]. Proc Natl Acad Sci U S A, 2001, 98: 8554-8559., articleTitle=PROTACs: chimeric molecules that target proteins to the Skp1-Cullin-F box complex for ubiquitination and degradation, refAbstract=null), Reference(id=1198960113382945581, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, doi=null, pmid=null, pmcid=null, year=2021, volume=23, issue=null, pageStart=115, pageEnd=133, url=null, language=null, rfNumber=[22], rfOrder=21, authorNames=null, journalName=Methods Mol Biol, refType=null, unstructuredReference=Bartoschik T, Zoephel A, Rumpel K, et al. MST and TRIC technology to reliably study PROTACs binary and ternary binding in drug development[J]. Methods Mol Biol, 2021, 23: 115-133., articleTitle=MST and TRIC technology to reliably study PROTACs binary and ternary binding in drug development, refAbstract=null), Reference(id=1198960113479414584, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, doi=10.1002/cbf.3369, pmid=null, pmcid=null, year=2019, volume=37, issue=null, pageStart=21, pageEnd=30, url=null, language=null, rfNumber=[23], rfOrder=22, authorNames=null, journalName=Cell Biochem Funct, refType=null, unstructuredReference=Zou Y, Ma D, Wang Y. The PROTAC technology in drug development[J]. Cell Biochem Funct, 2019, 37: 21-30., articleTitle=The PROTAC technology in drug development, refAbstract=null), Reference(id=1198960113605243719, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, doi=10.1021/acschembio.6b01068, pmid=null, pmcid=null, year=2017, volume=12, issue=null, pageStart=892, pageEnd=898, url=null, language=null, rfNumber=[24], rfOrder=23, authorNames=null, journalName=ACS Chem Biol, refType=null, unstructuredReference=Ottis P, Crews CM. Proteolysis-targeting chimeras: induced protein degradation as a therapeutic strategy[J]. ACS Chem Biol, 2017, 12: 892-898., articleTitle=Proteolysis-targeting chimeras: induced protein degradation as a therapeutic strategy, refAbstract=null), Reference(id=1198960113701712722, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, doi=10.1038/s41392-022-00999-9, pmid=null, pmcid=null, year=2022, volume=7, issue=null, pageStart=181, pageEnd=null, url=null, language=null, rfNumber=[25], rfOrder=24, authorNames=null, journalName=Signal Transduct Target Ther, refType=null, unstructuredReference=He M, Cao C, Ni Z, et al. PROTACs: great opportunities for academia and industry (an update from 2020 to 2021)[J]. Signal Transduct Target Ther, 2022, 7: 181., articleTitle=PROTACs: great opportunities for academia and industry (an update from 2020 to 2021), refAbstract=null), Reference(id=1198960113823347549, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, doi=null, pmid=null, pmcid=null, year=2022, volume=12, issue=null, pageStart=2990, pageEnd=3005, url=https://www.cnki.com.cn/Article/CJFDTOTAL-YXBY202306025.htm, language=null, rfNumber=[26], rfOrder=25, authorNames=null, journalName=Acta Pharm Sin (药学学报), refType=null, unstructuredReference=Ma S, Ji J, Tong Y, et al. Non-small molecule PROTACs (NSM-PROTACs): protein degradation kaleidoscope[J]. Acta Pharm Sin (药学学报), 2022, 12: 2990-3005., articleTitle=Non-small molecule PROTACs (NSM-PROTACs): protein degradation kaleidoscope, refAbstract=null), Reference(id=1198960113944982378, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, doi=10.1016/j.cell.2019.11.031, pmid=null, pmcid=null, year=2020, volume=181, issue=null, pageStart=102, pageEnd=114, url=null, language=null, rfNumber=[27], rfOrder=26, authorNames=null, journalName=Cell, refType=null, unstructuredReference=Burslem GM, Crews CM. Proteolysis-targeting chimeras as therapeutics and tools for biological discovery[J]. Cell, 2020, 181: 102-114., articleTitle=Proteolysis-targeting chimeras as therapeutics and tools for biological discovery, refAbstract=null), Reference(id=1198960114116948852, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, doi=10.1016/j.chembiol.2020.07.020, pmid=null, pmcid=null, year=2020, volume=27, issue=null, pageStart=998, pageEnd=1014, url=null, language=null, rfNumber=[28], rfOrder=27, authorNames=null, journalName=Cell Chem Biol, refType=null, unstructuredReference=Nalawansha DA, Crews CM. PROTACs: an emerging therapeutic modality in precision medicine[J]. Cell Chem Biol, 2020, 27: 998-1014., articleTitle=PROTACs: an emerging therapeutic modality in precision medicine, refAbstract=null), Reference(id=1198960114238583675, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, doi=10.1038/s41467-018-08027-7, pmid=null, pmcid=null, year=2019, volume=10, issue=null, pageStart=131, pageEnd=null, url=null, language=null, rfNumber=[29], rfOrder=28, authorNames=null, journalName=Nat Commun, refType=null, unstructuredReference=Smith BE, Wang SL, Jaime-Figueroa S, et al. Differential PROTAC substrate specificity dictated by orientation of recruited E3 ligase[J]. Nat Commun, 2019, 10: 131., articleTitle=Differential PROTAC substrate specificity dictated by orientation of recruited E3 ligase, refAbstract=null), Reference(id=1198960114360218505, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, doi=10.1016/j.chembiol.2017.09.010, pmid=null, pmcid=null, year=2018, volume=25, issue=null, pageStart=78, pageEnd=87, url=null, language=null, rfNumber=[30], rfOrder=29, authorNames=null, journalName=Cell Chem Biol, refType=null, unstructuredReference=Bondeson DP, Smith BE, Burslem GM, et al. Lessons in PROTAC design from selective degradation with a promiscuous warhead[J]. Cell Chem Biol, 2018, 25: 78-87., articleTitle=Lessons in PROTAC design from selective degradation with a promiscuous warhead, refAbstract=null), Reference(id=1198960114465076114, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, doi=10.1038/nchembio.2538, pmid=null, pmcid=null, year=2018, volume=14, issue=null, pageStart=163, pageEnd=170, url=null, language=null, rfNumber=[31], rfOrder=30, authorNames=null, journalName=Nat Chem Biol, refType=null, unstructuredReference=Olson CM, Jiang B, Erb MA, et al. Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation[J]. Nat Chem Biol, 2018, 14: 163-170., articleTitle=Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation, refAbstract=null), Reference(id=1198960114578322333, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, doi=null, pmid=null, pmcid=null, year=2018, volume=115, issue=null, pageStart=E7285, pageEnd=E7292, url=null, language=null, rfNumber=[32], rfOrder=31, authorNames=null, journalName=Proc Natl Acad Sci U S A, refType=null, unstructuredReference=Zorba A, Nguyen C, Xu Y, et al. Delineating the role of cooperativity in the design of potent PROTACs for BTK[J]. Proc Natl Acad Sci U S A, 2018, 115: E7285-E7292., articleTitle=Delineating the role of cooperativity in the design of potent PROTACs for BTK, refAbstract=null), Reference(id=1198960114771260338, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, doi=10.1038/s41573-021-00371-6, pmid=null, pmcid=null, year=2022, volume=21, issue=null, pageStart=181, pageEnd=200, url=null, language=null, rfNumber=[33], rfOrder=32, authorNames=null, journalName=Nat Rev Drug Discov, refType=null, unstructuredReference=Bekes M, Langley DR, Crews CM. PROTAC targeted protein degraders: the past is prologue[J]. Nat Rev Drug Discov, 2022, 21: 181-200., articleTitle=PROTAC targeted protein degraders: the past is prologue, refAbstract=null), Reference(id=1198960114913866686, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, doi=10.1039/D2CS00200K, pmid=null, pmcid=null, year=2022, volume=51, issue=null, pageStart=5740, pageEnd=5756, url=null, language=null, rfNumber=[34], rfOrder=33, authorNames=null, journalName=Chem Soc Rev, refType=null, unstructuredReference=Guenette RG, Yang SW, Min J, et al. Target and tissue selectivity of PROTAC degraders[J]. Chem Soc Rev, 2022, 51: 5740-5756., articleTitle=Target and tissue selectivity of PROTAC degraders, refAbstract=null), Reference(id=1198960115048084422, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, doi=10.1016/j.cellsig.2022.110446, pmid=null, pmcid=null, year=2022, volume=99, issue=null, pageStart=110446, pageEnd=null, url=null, language=null, rfNumber=[35], rfOrder=34, authorNames=null, journalName=Cell Signal, refType=null, unstructuredReference=Graham H. The mechanism of action and clinical value of PROTACs: a graphical review[J]. Cell Signal, 2022, 99: 110446., articleTitle=The mechanism of action and clinical value of PROTACs: a graphical review, refAbstract=null), Reference(id=1198960115186496470, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, doi=10.1007/s40291-022-00586-2, pmid=null, pmcid=null, year=2022, volume=26, issue=null, pageStart=283, pageEnd=291, url=null, language=null, rfNumber=[36], rfOrder=35, authorNames=null, journalName=Mol Diagn Ther, refType=null, unstructuredReference=Chen L, Wan X, Shan X, et al. Smart PROTACs enable controllable protein degradation for precision cancer therapy[J]. Mol Diagn Ther, 2022, 26: 283-291., articleTitle=Smart PROTACs enable controllable protein degradation for precision cancer therapy, refAbstract=null), Reference(id=1198960115282965475, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, doi=10.4155/fmc-2021-0199, pmid=null, pmcid=null, year=2022, volume=14, issue=null, pageStart=139, pageEnd=141, url=null, language=null, rfNumber=[37], rfOrder=36, authorNames=null, journalName=Future Med Chem, refType=null, unstructuredReference=Mou Y, Wen S, Gao X, et al. Proteolysis-targeting chimeras: a kaleidoscope of targeted protein degradation[J]. Future Med Chem, 2022, 14: 139-141., articleTitle=Proteolysis-targeting chimeras: a kaleidoscope of targeted protein degradation, refAbstract=null), Reference(id=1198960115387823087, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, doi=10.3389/fcell.2021.678077, pmid=null, pmcid=null, year=2021, volume=9, issue=null, pageStart=678077, pageEnd=null, url=null, language=null, rfNumber=[38], rfOrder=37, authorNames=null, journalName=Front Cell Dev Biol, refType=null, unstructuredReference=Liu J, Peng Y, Wei W. Light-controllable PROTACs for temporospatial control of protein degradation[J]. Front Cell Dev Biol, 2021, 9: 678077., articleTitle=Light-controllable PROTACs for temporospatial control of protein degradation, refAbstract=null), Reference(id=1198960115501069312, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, doi=10.1021/cr300177k, pmid=null, pmcid=null, year=2013, volume=113, issue=null, pageStart=119, pageEnd=191, url=null, language=null, rfNumber=[39], rfOrder=38, authorNames=null, journalName=Chem Rev, refType=null, unstructuredReference=Klan P, Solomek T, Bochet CG, et al. Photoremovable protecting groups in chemistry and biology: reaction mechanisms and efficacy[J]. Chem Rev, 2013, 113: 119-191., articleTitle=Photoremovable protecting groups in chemistry and biology: reaction mechanisms and efficacy, refAbstract=null), Reference(id=1198960115681423380, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, doi=10.1021/jacs.9b06422, pmid=null, pmcid=null, year=2019, volume=141, issue=null, pageStart=18370, pageEnd=18374, url=null, language=null, rfNumber=[40], rfOrder=39, authorNames=null, journalName=J Am Chem Soc, refType=null, unstructuredReference=Xue G, Wang K, Zhou D, et al. Light-induced protein degradation with photocaged PROTACs[J]. J Am Chem Soc, 2019, 141: 18370-18374., articleTitle=Light-induced protein degradation with photocaged PROTACs, refAbstract=null), Reference(id=1198960115794669593, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, doi=10.1126/sciadv.aay5154, pmid=null, pmcid=null, year=2020, volume=6, issue=null, pageStart=eaay5154, pageEnd=null, url=null, language=null, rfNumber=[41], rfOrder=40, authorNames=null, journalName=Sci Adv, refType=null, unstructuredReference=Liu J, Chen H, Ma L, et al. Light-induced control of protein destruction by opto-PROTAC[J]. Sci Adv, 2020, 6: eaay5154., articleTitle=Light-induced control of protein destruction by opto-PROTAC, refAbstract=null), Reference(id=1198960115949858861, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, doi=10.1039/D0CC00523A, pmid=null, pmcid=null, year=2020, volume=56, issue=null, pageStart=5532, pageEnd=5535, url=null, language=null, rfNumber=[42], rfOrder=41, authorNames=null, journalName=Chem Commun (Camb), refType=null, unstructuredReference=Kounde CS, Shchepinova MM, Saunders CN, et al. A caged E3 ligase ligand for PROTAC-mediated protein degradation with light[J]. Chem Commun (Camb), 2020, 56: 5532-5535., articleTitle=A caged E3 ligase ligand for PROTAC-mediated protein degradation with light, refAbstract=null), Reference(id=1198960116109242432, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, doi=10.1021/jacs.9b12718, pmid=null, pmcid=null, year=2020, volume=142, issue=null, pageStart=2193, pageEnd=2197, url=null, language=null, rfNumber=[43], rfOrder=42, authorNames=null, journalName=J Am Chem Soc, refType=null, unstructuredReference=Naro Y, Darrah K, Deiters A. Optical control of small molecule-induced protein degradation[J]. J Am Chem Soc, 2020, 142: 2193-2197., articleTitle=Optical control of small molecule-induced protein degradation, refAbstract=null), Reference(id=1198960116243460175, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, doi=10.1021/acs.chemrev.0c00663, pmid=null, pmcid=null, year=2020, volume=120, issue=null, pageStart=13135, pageEnd=13272, url=null, language=null, rfNumber=[44], rfOrder=43, authorNames=null, journalName=Chem Rev, refType=null, unstructuredReference=Weinstain R, Slanina T, Kand D, et al. Visible-to-NIR-light activated release: from small molecules to nanomaterials[J]. Chem Rev, 2020, 120: 13135-13272., articleTitle=Visible-to-NIR-light activated release: from small molecules to nanomaterials, refAbstract=null), Reference(id=1198960116348317791, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, doi=10.1073/pnas.1714499115, pmid=null, pmcid=null, year=2018, volume=115, issue=null, pageStart=9414, pageEnd=9422, url=null, language=null, rfNumber=[45], rfOrder=44, authorNames=null, journalName=Proc Natl Acad Sci U S A, refType=null, unstructuredReference=Harris JD, Moran MJ, Aprahamian I. New molecular switch architectures[J]. Proc Natl Acad Sci U S A, 2018, 115: 9414-9422., articleTitle=New molecular switch architectures, refAbstract=null), Reference(id=1198960116495118445, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, doi=10.1126/sciadv.aay5064, pmid=null, pmcid=null, year=2020, volume=6, issue=null, pageStart=eaay5064, pageEnd=null, url=null, language=null, rfNumber=[46], rfOrder=45, authorNames=null, journalName=Sci Adv, refType=null, unstructuredReference=Reynders M, Matsuura BS, Bérouti M, et al. PROTACs enable optical control of protein degradation[J]. Sci Adv, 2020, 6: eaay5064., articleTitle=PROTACs enable optical control of protein degradation, refAbstract=null), Reference(id=1198960116616753274, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, doi=10.1021/acscentsci.9b00713, pmid=null, pmcid=null, year=2019, volume=5, issue=null, pageStart=1682, pageEnd=1690, url=null, language=null, rfNumber=[47], rfOrder=46, authorNames=null, journalName=ACS Cent Sci, refType=null, unstructuredReference=Pfaff P, Samarasinghek TG, Crews CM, et al. Reversible spatiotemporal control of induced protein degradation by bistable photoPROTACs[J]. ACS Cent Sci, 2019, 5: 1682-1690., articleTitle=Reversible spatiotemporal control of induced protein degradation by bistable photoPROTACs, refAbstract=null), Reference(id=1198960116721610886, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, doi=10.1021/acs.jmedchem.9b02058, pmid=null, pmcid=null, year=2020, volume=63, issue=null, pageStart=4644, pageEnd=4654, url=null, language=null, rfNumber=[48], rfOrder=47, authorNames=null, journalName=J Med Chem, refType=null, unstructuredReference=Jin YH, Lu MC, Wang Y, et al. Azo-PROTAC: novel light-controlled small-molecule tool for protein knockdown[J]. J Med Chem, 2020, 63: 4644-4654., articleTitle=Azo-PROTAC: novel light-controlled small-molecule tool for protein knockdown, refAbstract=null), Reference(id=1198960116847440020, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, doi=10.1021/jacs.2c12809, pmid=null, pmcid=null, year=2023, volume=145, issue=null, pageStart=7218, pageEnd=7229, url=null, language=null, rfNumber=[49], rfOrder=48, authorNames=null, journalName=J Am Chem Soc, refType=null, unstructuredReference=Jin Y, Fan J, Wang R, et al. Ligation to scavenging strategy enables on-demand termination of targeted protein degradation[J]. J Am Chem Soc, 2023, 145: 7218-7229., articleTitle=Ligation to scavenging strategy enables on-demand termination of targeted protein degradation, refAbstract=null), Reference(id=1198960116973269155, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, doi=null, pmid=null, pmcid=null, year=2021, volume=27, issue=null, pageStart=e934116, pageEnd=null, url=null, language=null, rfNumber=[50], rfOrder=49, authorNames=null, journalName=Med Sci Monit, refType=null, unstructuredReference=Bouleetour W, Rowinski E, Louati S, et al. A review of the role of hypoxia in radioresistance in cancer therapy[J]. Med Sci Monit, 2021, 27: e934116., articleTitle=A review of the role of hypoxia in radioresistance in cancer therapy, refAbstract=null), Reference(id=1198960117090709677, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, doi=10.1146/annurev-med-060619-022830, pmid=null, pmcid=null, year=2022, volume=73, issue=null, pageStart=251, pageEnd=265, url=null, language=null, rfNumber=[51], rfOrder=50, authorNames=null, journalName=Annu Rev Med, refType=null, unstructuredReference=Jayaprakasn P, Vignalip DA, Delgoffe GM, et al. Hypoxia reduction sensitizes refractory cancers to immunotherapy[J]. Annu Rev Med, 2022, 73: 251-265., articleTitle=Hypoxia reduction sensitizes refractory cancers to immunotherapy, refAbstract=null), Reference(id=1198960117220733110, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, doi=10.1016/j.jpba.2021.114199, pmid=null, pmcid=null, year=2021, volume=203, issue=null, pageStart=114199, pageEnd=null, url=null, language=null, rfNumber=[52], rfOrder=51, authorNames=null, journalName=J Pharm Biomed Anal, refType=null, unstructuredReference=Qiao J, Wang M, Cui M, et al. Small-molecule probes for fluorescent detection of cellular hypoxia-related nitroreductase[J]. J Pharm Biomed Anal, 2021, 203: 114199., articleTitle=Small-molecule probes for fluorescent detection of cellular hypoxia-related nitroreductase, refAbstract=null), Reference(id=1198960117392699591, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, doi=10.1042/BJ20150650, pmid=null, pmcid=null, year=2015, volume=471, issue=null, pageStart=131, pageEnd=153, url=null, language=null, rfNumber=[53], rfOrder=52, authorNames=null, journalName=Biochem J, refType=null, unstructuredReference=Williams EM, Little RF, Mowday AM, et al. Nitroreductase gene-directed enzyme prodrug therapy: insights and advances toward clinical utility[J]. Biochem J, 2015, 471: 131-153., articleTitle=Nitroreductase gene-directed enzyme prodrug therapy: insights and advances toward clinical utility, refAbstract=null), Reference(id=1198960117552083162, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, doi=10.1128/AEM.01758-21, pmid=null, pmcid=null, year=2021, volume=87, issue=null, pageStart=e0175821, pageEnd=null, url=null, language=null, rfNumber=[54], rfOrder=53, authorNames=null, journalName=Appl Environ Microbiol, refType=null, unstructuredReference=Zhou Y, Lv H, Li H, et al. Nitroreductase increases menadione-mediated oxidative stress in aspergillus nidulans[J]. Appl Environ Microbiol, 2021, 87: e0175821., articleTitle=Nitroreductase increases menadione-mediated oxidative stress in aspergillus nidulans, refAbstract=null), Reference(id=1198960117673717994, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, doi=10.1021/acs.jmedchem.1c02221, pmid=null, pmcid=null, year=2022, volume=65, issue=null, pageStart=5057, pageEnd=5071, url=null, language=null, rfNumber=[55], rfOrder=54, authorNames=null, journalName=J Med Chem, refType=null, unstructuredReference=Shi S, Du Y, Zou Y, et al. Rational design for nitroreductase (NTR)-responsive proteolysis targeting chimeras (PROTACs) selectively targeting tumor tissues[J]. J Med Chem, 2022, 65: 5057-5071., articleTitle=Rational design for nitroreductase (NTR)-responsive proteolysis targeting chimeras (PROTACs) selectively targeting tumor tissues, refAbstract=null), Reference(id=1198960117803741431, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, doi=10.1093/jtm/taab120, pmid=null, pmcid=null, year=2022, volume=29, issue=null, pageStart=taab120, pageEnd=null, url=null, language=null, rfNumber=[56], rfOrder=55, authorNames=null, journalName=J Travel Med, refType=null, unstructuredReference=Bourque DL, Neumayr A, Libman M, et al. Treatment strategies for nitroimidazole-refractory giardiasis: a systematic review[J]. J Travel Med, 2022, 29: taab120., articleTitle=Treatment strategies for nitroimidazole-refractory giardiasis: a systematic review, refAbstract=null), Reference(id=1198960117946347784, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, doi=10.1021/acschembio.2c00462, pmid=null, pmcid=null, year=2022, volume=17, issue=null, pageStart=3077, pageEnd=3085, url=null, language=null, rfNumber=[57], rfOrder=56, authorNames=null, journalName=ACS Chem Biol, refType=null, unstructuredReference=Reinhardt T, Lee KM, Niederegger L, et al. Indolin-2-one nitroimidazole antibiotics exhibit an unexpected dual mode of action[J]. ACS Chem Biol, 2022, 17: 3077-3085., articleTitle=Indolin-2-one nitroimidazole antibiotics exhibit an unexpected dual mode of action, refAbstract=null), Reference(id=1198960118088954135, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, doi=10.1039/D1CC05715D, pmid=null, pmcid=null, year=2021, volume=57, issue=null, pageStart=12852, pageEnd=12855, url=null, language=null, rfNumber=[58], rfOrder=57, authorNames=null, journalName=Chem Commun (Camb), refType=null, unstructuredReference=Cheng W, Li S, Wen X, et al. Development of hypoxia-activated PROTAC exerting a more potent effect in tumor hypoxia than in normoxia[J]. Chem Commun (Camb), 2021, 57: 12852-12855., articleTitle=Development of hypoxia-activated PROTAC exerting a more potent effect in tumor hypoxia than in normoxia, refAbstract=null), Reference(id=1198960118256726310, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, doi=10.31635/ccschem.022.202101529, pmid=null, pmcid=null, year=2022, volume=4, issue=null, pageStart=3809, pageEnd=3819, url=null, language=null, rfNumber=[59], rfOrder=58, authorNames=null, journalName=CCS Chemistry, refType=null, unstructuredReference=Liang C, Zheng Q, Luo T, et al. Enzyme-catalyzed activation of pro-PROTAC for cell-selective protein degradation[J]. CCS Chemistry, 2022, 4: 3809-3819., articleTitle=Enzyme-catalyzed activation of pro-PROTAC for cell-selective protein degradation, refAbstract=null), Reference(id=1198960118499995957, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, doi=10.1083/jcb.201804161, pmid=null, pmcid=null, year=2018, volume=217, issue=null, pageStart=2291, pageEnd=2298, url=null, language=null, rfNumber=[60], rfOrder=59, authorNames=null, journalName=J Cell Biol, refType=null, unstructuredReference=Bansal A, Simon MC. Glutathione metabolism in cancer progression and treatment resistance[J]. J Cell Biol, 2018, 217: 2291-2298., articleTitle=Glutathione metabolism in cancer progression and treatment resistance, refAbstract=null), Reference(id=1198960118697128264, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, doi=10.1038/nrm3801, pmid=null, pmcid=null, year=2014, volume=15, issue=null, pageStart=411, pageEnd=421, url=null, language=null, rfNumber=[61], rfOrder=60, authorNames=null, journalName=Nat Rev Mol Cell Biol, refType=null, unstructuredReference=Holmstrom KM, Finkel T. Cellular mechanisms and physiological consequences of redox-dependent signalling[J]. Nat Rev Mol Cell Biol, 2014, 15: 411-421., articleTitle=Cellular mechanisms and physiological consequences of redox-dependent signalling, refAbstract=null), Reference(id=1198960118936203619, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, doi=10.1016/j.ejmech.2018.03.071, pmid=null, pmcid=null, year=2018, volume=151, issue=null, pageStart=304, pageEnd=314, url=null, language=null, rfNumber=[62], rfOrder=61, authorNames=null, journalName=Eur J Med Chem, refType=null, unstructuredReference=Zhang C, Han XR, Yang X, et al. Proteolysis targeting chimeras (PROTACs) of anaplastic lymphoma kinase (ALK)[J]. Eur J Med Chem, 2018, 151: 304-314., articleTitle=Proteolysis targeting chimeras (PROTACs) of anaplastic lymphoma kinase (ALK), refAbstract=null), Reference(id=1198960119095587188, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, doi=10.2217/nnm.13.198, pmid=null, pmcid=null, year=2014, volume=9, issue=null, pageStart=2339, pageEnd=2351, url=null, language=null, rfNumber=[63], rfOrder=62, authorNames=null, journalName=Nanomedicine (Lond), refType=null, unstructuredReference=Zou X, Yao M, Ma L, et al. X-ray-induced nanoparticle-based photodynamic therapy of cancer[J]. Nanomedicine (Lond), 2014, 9: 2339-2351., articleTitle=X-ray-induced nanoparticle-based photodynamic therapy of cancer, refAbstract=null), Reference(id=1198960119225610618, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, doi=10.5603/NMR.2017.0002, pmid=null, pmcid=null, year=2017, volume=20, issue=null, pageStart=45, pageEnd=48, url=null, language=null, rfNumber=[64], rfOrder=63, authorNames=null, journalName=Nucl Med Rev Cent East Eur, refType=null, unstructuredReference=Shamsi M, Islamian JP. Breast cancer: early diagnosis and effective treatment by drug delivery tracing[J]. Nucl Med Rev Cent East Eur, 2017, 20: 45-48., articleTitle=Breast cancer: early diagnosis and effective treatment by drug delivery tracing, refAbstract=null), Reference(id=1198960119343051144, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, doi=10.1021/jacs.2c10177, pmid=null, pmcid=null, year=2023, volume=145, issue=null, pageStart=385, pageEnd=391, url=null, language=null, rfNumber=[65], rfOrder=64, authorNames=null, journalName=J Am Chem Soc, refType=null, unstructuredReference=Yang C, Yang Y, Li Y, et al. Radiotherapy-triggered proteolysis targeting chimera prodrug activation in tumors[J]. J Am Chem Soc, 2023, 145: 385-391., articleTitle=Radiotherapy-triggered proteolysis targeting chimera prodrug activation in tumors, refAbstract=null)], funds=[Fund(id=1198960109553545686, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, awardId=21KJB350008, language=CN, fundingSource=江苏省高校自然科学基金(21KJB350008), fundOrder=null, country=null), Fund(id=1198960109666791899, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, awardId=TN202135, language=CN, fundingSource=泰州市社会发展项目(TN202135), fundOrder=null, country=null), Fund(id=1198960109830369775, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, awardId=YY-110, language=CN, fundingSource=江苏省“六大人才高峰”资助(YY-110), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1198960100913279817, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, xref=null, ext=[AuthorCompanyExt(id=1198960100938445647, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, companyId=1198960100913279817, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1. College of Pharmacy and Chemistry & Chemical Engineering, Taizhou University, Taizhou 225300, China), AuthorCompanyExt(id=1198960100959417172, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, companyId=1198960100913279817, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.泰州学院医药与化学化工学院, 江苏 泰州 225300)]), AuthorCompany(id=1198960101127189351, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, xref=null, ext=[AuthorCompanyExt(id=1198960101131383655, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, companyId=1198960101127189351, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2. Jiangsu Key Laboratory of Drug Design and Optimization, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China), AuthorCompanyExt(id=1198960101143966569, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, companyId=1198960101127189351, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2.中国药科大学药学院, 江苏省药物分子设计与成药性优化重点实验室, 江苏 南京 210009)])], figs=[ArticleFig(id=1198960104742678659, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, language=EN, label=null, caption=null, figureFileSmall=wwBjki71VgH+nGy3ODR9eQ==, figureFileBig=CmevEigAtrqq+muAKk1lsA==, tableContent=null), ArticleFig(id=1198960104939810966, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, language=CN, label=Figure 1, caption= , figureFileSmall=wwBjki71VgH+nGy3ODR9eQ==, figureFileBig=CmevEigAtrqq+muAKk1lsA==, tableContent=null), ArticleFig(id=1198960105266966696, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, language=EN, label=null, caption=null, figureFileSmall=SwYBX6HxiWE8kjbpZ+TG7Q==, figureFileBig=2DBjmHvOaPiOV8jgh6Vg8A==, tableContent=null), ArticleFig(id=1198960105426350257, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, language=CN, label=Figure 2, caption= , figureFileSmall=SwYBX6HxiWE8kjbpZ+TG7Q==, figureFileBig=2DBjmHvOaPiOV8jgh6Vg8A==, tableContent=null), ArticleFig(id=1198960105564762296, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, language=EN, label=null, caption=null, figureFileSmall=SyJFAr4LJJly4txMlUroMA==, figureFileBig=SJxjY5pjPujTBqrOLxmq+g==, tableContent=null), ArticleFig(id=1198960105694785730, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, language=CN, label=Figure 3, caption= , figureFileSmall=SyJFAr4LJJly4txMlUroMA==, figureFileBig=SJxjY5pjPujTBqrOLxmq+g==, tableContent=null), ArticleFig(id=1198960105887723727, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, language=EN, label=null, caption=null, figureFileSmall=3uFHhSclSaOqYMGTOEORVA==, figureFileBig=uVfVHmtjAV9l7OLIlfWxIQ==, tableContent=null), ArticleFig(id=1198960106072273109, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, language=CN, label=Figure 4, caption= , figureFileSmall=3uFHhSclSaOqYMGTOEORVA==, figureFileBig=uVfVHmtjAV9l7OLIlfWxIQ==, tableContent=null), ArticleFig(id=1198960106240045282, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, language=EN, label=null, caption=null, figureFileSmall=FmpZOBXGTrSFMOGOf9E6qw==, figureFileBig=K7UTZi5QXb/bWj0RcHwIHA==, tableContent=null), ArticleFig(id=1198960106416206058, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, language=CN, label=Figure 5, caption= , figureFileSmall=FmpZOBXGTrSFMOGOf9E6qw==, figureFileBig=K7UTZi5QXb/bWj0RcHwIHA==, tableContent=null), ArticleFig(id=1198960106558812401, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, language=EN, label=null, caption=null, figureFileSmall=TZcLmiU4n564tLT8dfFkjg==, figureFileBig=aYlc8tfPVkcezjURPvCBDw==, tableContent=null), ArticleFig(id=1198960106672058618, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, language=CN, label=Figure 6, caption= , figureFileSmall=TZcLmiU4n564tLT8dfFkjg==, figureFileBig=aYlc8tfPVkcezjURPvCBDw==, tableContent=null), ArticleFig(id=1198960106785304835, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, language=EN, label=null, caption=null, figureFileSmall=VtbLss7e9cKvDIc2YR2ssg==, figureFileBig=UcODREpdXI9BxcfQ01e6+A==, tableContent=null), ArticleFig(id=1198960106948882701, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, language=CN, label=Figure 7, caption= , figureFileSmall=VtbLss7e9cKvDIc2YR2ssg==, figureFileBig=UcODREpdXI9BxcfQ01e6+A==, tableContent=null), ArticleFig(id=1198960107099877656, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, language=EN, label=null, caption=null, figureFileSmall=kXhy0K5sZ2+9D6/grqJtwg==, figureFileBig=xidQ1gXVhLrpOb6x57Pz0w==, tableContent=null), ArticleFig(id=1198960107255066905, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, language=CN, label=Figure 8, caption= , figureFileSmall=kXhy0K5sZ2+9D6/grqJtwg==, figureFileBig=xidQ1gXVhLrpOb6x57Pz0w==, tableContent=null), ArticleFig(id=1198960107456393512, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, language=EN, label=null, caption=null, figureFileSmall=TfBsPU08MWp2dfknI/mfiQ==, figureFileBig=cWpsx9heo8pV1k6Y5RaQww==, tableContent=null), ArticleFig(id=1198960107594805553, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, language=CN, label=Figure 9, caption= , figureFileSmall=TfBsPU08MWp2dfknI/mfiQ==, figureFileBig=cWpsx9heo8pV1k6Y5RaQww==, tableContent=null), ArticleFig(id=1198960107708051772, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, language=EN, label=null, caption=null, figureFileSmall=bItzH/DM1Mei1BUpZX/o1Q==, figureFileBig=YcAISt/0hZ/RbIadJ91aNw==, tableContent=null), ArticleFig(id=1198960107804520769, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, language=CN, label=Figure 10, caption= , figureFileSmall=bItzH/DM1Mei1BUpZX/o1Q==, figureFileBig=YcAISt/0hZ/RbIadJ91aNw==, tableContent=null), ArticleFig(id=1198960107913572682, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, language=EN, label=null, caption=null, figureFileSmall=rYz9jLEe4doYqOwJGDdU1w==, figureFileBig=oSrhFZe0xtwuW59qNTkKyg==, tableContent=null), ArticleFig(id=1198960108039401807, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, language=CN, label=Figure 11, caption= , figureFileSmall=rYz9jLEe4doYqOwJGDdU1w==, figureFileBig=oSrhFZe0xtwuW59qNTkKyg==, tableContent=null), ArticleFig(id=1198960108177813848, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, language=EN, label=null, caption=null, figureFileSmall=oWpioWuLKCGkNzPR4pnTag==, figureFileBig=W9ZAYENo+RxsSRc/0Npuyg==, tableContent=null), ArticleFig(id=1198960108379140459, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, language=CN, label=Figure 12, caption= , figureFileSmall=oWpioWuLKCGkNzPR4pnTag==, figureFileBig=W9ZAYENo+RxsSRc/0Npuyg==, tableContent=null), ArticleFig(id=1198960108559495547, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, language=EN, label=null, caption=null, figureFileSmall=jFJksRxsJMMCIcwAGmcC7g==, figureFileBig=2ftqT/gZ6KXxGhbJRfDVbw==, tableContent=null), ArticleFig(id=1198960108752433545, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, language=CN, label=Figure 13, caption= , figureFileSmall=jFJksRxsJMMCIcwAGmcC7g==, figureFileBig=2ftqT/gZ6KXxGhbJRfDVbw==, tableContent=null), ArticleFig(id=1198960108899234196, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, language=EN, label=null, caption=null, figureFileSmall=wn/AjzutyGx0pwjwekw34Q==, figureFileBig=g2GhIv+s/98d0V572A+l5Q==, tableContent=null), ArticleFig(id=1198960109016674718, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, language=CN, label=Figure 14, caption= , figureFileSmall=wn/AjzutyGx0pwjwekw34Q==, figureFileBig=g2GhIv+s/98d0V572A+l5Q==, tableContent=null), ArticleFig(id=1198960109163475374, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, language=EN, label=null, caption=null, figureFileSmall=9lU9R4Qi6fA6Ajo90mG2rw==, figureFileBig=DV4WlMa/KtuWDYUceYqOpA==, tableContent=null), ArticleFig(id=1198960109293498811, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198652615572681503, language=CN, label=Figure 15, caption= , figureFileSmall=9lU9R4Qi6fA6Ajo90mG2rw==, figureFileBig=DV4WlMa/KtuWDYUceYqOpA==, tableContent=null)], attaches=null, journal=Journal(id=1189982048455397383, delFlag=0, nameCn=药学学报, nameEn=Acta Pharmaceutica Sinica, nameHistory1=null, nameHistory2=null, issn=0513-4870, eissn=null, cn=11-2163/R, coden=null, periodic=0, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=BTxjudbJDVO4PqdBR6On6Q==, journalPrice=null, startedYear=null, abbrevIsoEn=null, journalRemark=null, publicationField=null, createdTime=1761643429151, updatedTime=1788948913902, createdBy=18614031015, updatedBy=13041195026, firstLetterCn=Y, firstLetterEn=Y, subjectCode=Medical and Pharmaceutical Sciences, subjectName=Life Sciences, subjectCodeEn=Medical and Pharmaceutical Sciences, subjectNameEn=null, picCn=BTxjudbJDVO4PqdBR6On6Q==, picEn=c4l1ckL55nWbhl1KrFdWIA==, jcr=null, cjcr=null, exts=[JournalExt(id=1304509553505227679, language=CN, name=药学学报, nameHistory1=null, nameHistory2=null, managedBy=中国科学技术协会, sponsoredBy=中国药学会、中国医学科学院药物研究所, publishedBy=《药学学报》编辑委员会编辑出版, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788948914171, updatedTime=1788948914171, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://www.yxxb.com.cn/journalx_yxxb/authorLogOn.action, submissionEditorUrl=https://www.yxxb.com.cn/journalx_yxxb/editorLogOn.action, submissionReviewUrl=https://www.yxxb.com.cn/journalx_yxxb/expertLogOn.action, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""}), JournalExt(id=1304509553559753632, language=EN, name=Acta Pharmaceutica Sinica, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788948914184, updatedTime=1788948914184, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://www.yxxb.com.cn/journalx_yxxb/authorLogOn.action, submissionEditorUrl=https://www.yxxb.com.cn/journalx_yxxb/editorLogOn.action, submissionReviewUrl=https://www.yxxb.com.cn/journalx_yxxb/expertLogOn.action, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""})], databaseList=null, tenantJournalId=1189982191388893191, websiteList=[Website(id=1189982271588340489, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1189982191388893191, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/yxxb/CN, language=CN, createTime=1761643482348, createBy=18614031015, updateTime=1761643498101, updateBy=18614031015, name=药学学报-中文, tplId=1146099689490845704, title=药学学报, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1189982873114448678, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271588340489, code=articleTextType, value=kx, createTime=1761643625763, updateTime=1761643625763, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982873093477155, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271588340489, code=banner, value=null, createTime=1761643625758, updateTime=1761643625758, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982873135420201, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271588340489, code=grayFlag, value=0, createTime=1761643625768, updateTime=1761643625768, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982873085088546, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271588340489, code=logo, value=https://castjournals.cast.org.cn/joweb/yxxb/CN/file/pic?fileId=w+t2v8bJnX5lh3+hRRJcDA==, createTime=1761643625756, updateTime=1761643625756, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982873152197419, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271588340489, code=minRunFlag, value=0, createTime=1761643625772, updateTime=1761643625772, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982873110254373, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271588340489, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/yxxb/CN/file/pic, createTime=1761643625762, updateTime=1761643625762, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982873143808810, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271588340489, code=silenceFlag, value=0, createTime=1761643625770, updateTime=1761643625770, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982873101865764, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271588340489, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1761643625760, updateTime=1761643625760, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982873122837287, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271588340489, code=themeColor, value=null, createTime=1761643625765, updateTime=1761643625765, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982873127031592, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271588340489, code=themeStyle, value=null, createTime=1761643625766, updateTime=1761643625766, creator=18614031015, updator=18614031015)]), Website(id=1189982271655449355, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1189982191388893191, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/yxxb/EN, language=EN, createTime=1761643482364, createBy=18614031015, updateTime=1761643514085, updateBy=18614031015, name=药学学报-英文, tplId=1146101810881728533, title=Acta Pharmaceutica Sinica, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1189982903015633534, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271655449355, code=articleTextType, value=kx, createTime=1761643632892, updateTime=1761643632892, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982902990467707, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271655449355, code=banner, value=null, createTime=1761643632886, updateTime=1761643632886, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982903036605057, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271655449355, code=grayFlag, value=0, createTime=1761643632897, updateTime=1761643632897, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982902982079098, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271655449355, code=logo, value=https://castjournals.cast.org.cn/joweb/yxxb/EN/file/pic?fileId=w+t2v8bJnX5lh3+hRRJcDA==, createTime=1761643632884, updateTime=1761643632884, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982903053382275, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271655449355, code=minRunFlag, value=0, createTime=1761643632901, updateTime=1761643632901, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982903007244925, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271655449355, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/yxxb/EN/file/pic, createTime=1761643632890, updateTime=1761643632890, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982903044993666, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271655449355, code=silenceFlag, value=0, createTime=1761643632899, updateTime=1761643632899, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982902998856316, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271655449355, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1761643632888, updateTime=1761643632888, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982903019827839, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271655449355, code=themeColor, value=null, createTime=1761643632893, updateTime=1761643632893, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982903028216448, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271655449355, code=themeStyle, value=null, createTime=1761643632895, updateTime=1761643632895, creator=18614031015, updator=18614031015)])], journalTitle=药学学报, weixinUrl=null, journalUrl=https://www.yxxb.com.cn/aps, iacademicId=null, status=1, seqNo=null, journalTitleEn=Acta Pharmaceutica Sinica, journalPhotoCn=BTxjudbJDVO4PqdBR6On6Q==, journalPhotoEn=c4l1ckL55nWbhl1KrFdWIA==, journalFirstLetter=Y, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false, interPubPlatform=, interPubPlatformUrl=null), detailUrlCn=https://castjournals.cast.org.cn/joweb/yxxb/CN/10.16438/j.0513-4870.2023-0553, detailUrlEn=https://castjournals.cast.org.cn/joweb/yxxb/EN/10.16438/j.0513-4870.2023-0553, pdfUrlCn=https://castjournals.cast.org.cn/joweb/yxxb/CN/PDF/10.16438/j.0513-4870.2023-0553, pdfUrlEn=https://castjournals.cast.org.cn/joweb/yxxb/EN/PDF/10.16438/j.0513-4870.2023-0553, aliStartDate=null, aliEndDate=null, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=1, orderTime=1691769600000, fullTextJson=null, articleText=null, reference=null)