Article(id=1198652615283278199, tenantId=1146029695717560320, journalId=1189982191388893191, issueId=1198652605778985059, articleNumber=null, orderNo=null, doi=10.16438/j.0513-4870.2023-0453, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1681142400000, receivedDateStr=2023-04-11, revisedDate=1686672000000, revisedDateStr=2023-06-14, acceptedDate=null, acceptedDateStr=null, onlineDate=1763710653372, onlineDateStr=2025-11-21, pubDate=1691769600000, pubDateStr=2023-08-12, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1763710653372, onlineIssueDateStr=2025-11-21, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1763710653372, creator=13701087609, updateTime=1763710653372, updator=13701087609, issue=Issue{id=1198652605778985059, tenantId=1146029695717560320, journalId=1189982191388893191, year='2023', volume='58', issue='8', pageStart='0', pageEnd='2540', issueExtLink='null', onlineDate='null', pubDate='1691769600000', pubDateStr='2023-08-12', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1763710651106, creator='13701087609', updateTime=1763710739504, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1198652976601596347, tenantId=1146029695717560320, journalId=1189982191388893191, issueId=1198652605778985059, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1198652976601596348, tenantId=1146029695717560320, journalId=1189982191388893191, issueId=1198652605778985059, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=2283, endPage=2291, ext={EN=ArticleExt(id=1198652615740457366, articleId=1198652615283278199, tenantId=1146029695717560320, journalId=1189982191388893191, language=EN, title=In vivo delivery process and regulating mechanisms of lipid-based nanomedicines, columnId=null, journalTitle=Acta Pharmaceutica Sinica, columnName=null, runingTitle=null, highlight=null, articleAbstract=

Lipid-based nanocarrier is a classic drug delivery system with great biocompatibility and biodegradability. It can effectively reduce the toxicity of anti-tumor and anti-infective drugs in clinical practice. However, it has not yet met the clinical demand for enhanced therapeutic efficacy, and the clinical application is still very limited. The complex in vivo delivery process of lipid-based nanomedicine and the reciprocal interactions with body lead to unexpected changes in in vivo performance of nanomedicine and seriously hinder clinical translation. Therefore, the in-depth study of the relationships among intrinsic properties of lipid-based nanomedicine, the in vivo delivery process, and the regulatory mechanisms will not only provide guidance for the rational design of nanocarriers, but also promote the clinical translation and precision medicine of new lipid-based nanomedicine. In this review, we summarize the in vivo delivery process, regulating factors and intervention strategies for the in vivo delivery of lipid-based nanomedicine.

, authors=null, authorsList=Tian-hao DING, Er-can WU, Chang-you ZHAN, authorCompany=null, correspAuthors=Chang-you ZHAN, authorNote=null, correspAuthorsNote=null, copyrightStatement=Copyright ©2023 Acta Pharmaceutica Sinica. All rights reserved., copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1198652617095217692, articleId=1198652615283278199, tenantId=1146029695717560320, journalId=1189982191388893191, language=CN, title=脂质纳米药物体内递送过程及调控机制, columnId=1190335349655180086, journalTitle=药学学报, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

脂质纳米载体是经典的药物递送系统之一, 具有良好的生物相容性和生物可降解性, 可以有效降低抗肿瘤和抗感染药物的毒副作用, 但在增强治疗效果上远未满足临床需求, 临床应用仍然十分局限。脂质纳米药物体内过程复杂, 与机体发生相互作用后载体自身也会诱发机制不明的生物学效应, 导致药物体内性能异于设计预期, 严重阻碍临床转化。深入研究脂质纳米药物本征性质、体内递送过程及机体调控机制, 不仅为载体的理性设计提供指导, 也将助推新型脂质纳米药物的临床转化及精准用药。本文分别从脂质纳米药物体内递送过程、影响因素和调控手段三个方面进行综述, 为脂质纳米药物相关研究提供参考。

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