Article(id=1198652629552300593, tenantId=1146029695717560320, journalId=1189982191388893191, issueId=1198652605778985059, articleNumber=null, orderNo=null, doi=10.16438/j.0513-4870.2023-0011, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1672848000000, receivedDateStr=2023-01-05, revisedDate=1683907200000, revisedDateStr=2023-05-13, acceptedDate=null, acceptedDateStr=null, onlineDate=1763710656774, onlineDateStr=2025-11-21, pubDate=1691769600000, pubDateStr=2023-08-12, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1763710656774, onlineIssueDateStr=2025-11-21, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1763710656774, creator=13701087609, updateTime=1763710656774, updator=13701087609, issue=Issue{id=1198652605778985059, tenantId=1146029695717560320, journalId=1189982191388893191, year='2023', volume='58', issue='8', pageStart='0', pageEnd='2540', issueExtLink='null', onlineDate='null', pubDate='1691769600000', pubDateStr='2023-08-12', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1763710651106, creator='13701087609', updateTime=1763710739504, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1198652976601596347, tenantId=1146029695717560320, journalId=1189982191388893191, issueId=1198652605778985059, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1198652976601596348, tenantId=1146029695717560320, journalId=1189982191388893191, issueId=1198652605778985059, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=2512, endPage=2521, ext={EN=ArticleExt(id=1198652630353412719, articleId=1198652629552300593, tenantId=1146029695717560320, journalId=1189982191388893191, language=EN, title=Preparation of mesoporous silica nanoparticles with different sizes and study on the correlation between size and toxicity, columnId=null, journalTitle=Acta Pharmaceutica Sinica, columnName=null, runingTitle=null, highlight=null, articleAbstract=

To investigate the crucial role of particle size in the biological effects of nanoparticles, a series of mesoporous silica nanoparticles (MSNs) were prepared with particle size gradients (50, 100, 150, 200 nm) with the traditional Stober method and adjusting the type and ratio of the silica source. The correlation between toxicity and size-caused biological effects were then further examined both in vitro and in vivo. The results indicated that the prepared MSNs had a uniform size, good dispersal, and ordered mesoporous structure. Hemolytic toxicity was found to be independent of particle size. At the cellular level, MSNs with smaller particle sizes were more readily internalized by cells, which initiated to more intense oxidative stress, therefor inducing higher cytotoxicity, and apoptosis rate. In vivo studies demonstrated that MSNs primarily accumulated in the liver and kidneys of mice. Pharmacokinetic analysis revealed that larger MSNs were eliminated more efficiently by the urinary system than smaller MSNs. The mice's body weight monitoring, blood tests, and pathological sections of major organs indicated good biocompatibility for MSNs of different sizes. Animal welfare and the animal experimental protocols were strictly consistent with related ethics regulations of Zhejiang Chinese Medical University. Overall, this study prepared MSNs with a particle size gradient to investigate the correlation between toxicity and particle size using macrophages and endothelial cells. The study also examined the biosafety of MSNs with different particle sizes in vivo and in vitro, which could help to improve the safety design strategy of MSNs for drug delivery systems.

, authors=null, authorsList=Xiao-wei XIE, Meng-ying CHENG, Wei-xiang FANG, Xue LIN, Wen-ting GU, Kai-ling YU, Ting-xian YE, Wei-yi CHENG, Li HE, Hang-sheng ZHENG, Ying-hui WEI, Ji-gang PIAO, Fan-zhu LI, authorCompany=null, correspAuthors=Ji-gang PIAO, Fan-zhu LI, authorNote=null, correspAuthorsNote=null, copyrightStatement=Copyright ©2023 Acta Pharmaceutica Sinica. All rights reserved., copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1198652632928715544, articleId=1198652629552300593, tenantId=1146029695717560320, journalId=1189982191388893191, language=CN, title=不同粒径介孔二氧化硅纳米颗粒的制备及其与毒性的相关性研究, columnId=1190335348896011050, journalTitle=药学学报, columnName=研究论文, runingTitle=null, highlight=null, articleAbstract=

为探究粒径对纳米粒生物学效应的关键作用, 本研究采用传统Stober法以及通过调整硅源种类以及比例制备系列粒度梯度(50、100、150、200 nm) 介孔二氧化硅纳米粒(mesoporous silica nanoparticles, MSNs), 并在体内外探究了其毒性与粒径产生的生物学效应的关联性。结果表明, 所制备的各组MSNs粒径大小均一、水分散性良好, 且具备有序的介孔结构; 溶血毒性与粒径无相关性; 细胞水平上, 小粒径的MSNs更有利于细胞内化, 引发更加强烈的氧化应激反应, 诱导更高的细胞毒性和细胞凋亡率; 体内研究结果表明MSNs主要蓄积在小鼠肝脏与肾脏; 药动学结果显示, 大粒径MSNs较小粒径MSNs更易经泌尿系统消除; 小鼠体重监测、血常规及主要脏器病理切片结果说明不同粒径MSNs均具有良好的生物相容性。所有动物实验经浙江中医药大学实验动物伦理委员会审查[批准号: SYXK (浙) 2021-0012], 符合实验动物伦理相关规范。综上所述, 本研究制备粒度梯度的MSNs对比探讨巨噬细胞和内皮细胞的毒性-粒径相关关系, 并进一步从体内外分别考察不同粒径MSNs的生物安全性, 有助于完善MSNs应用于递药系统的安全性设计策略。

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