Article(id=1198628669116744251, tenantId=1146029695717560320, journalId=1189982191388893191, issueId=1198628666650493481, articleNumber=null, orderNo=null, doi=10.16438/j.0513-4870.2022-1273, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=research-article, receivedDate=1669478400000, receivedDateStr=2022-11-27, revisedDate=1676995200000, revisedDateStr=2023-02-22, acceptedDate=null, acceptedDateStr=null, onlineDate=1763704944160, onlineDateStr=2025-11-21, pubDate=1689091200000, pubDateStr=2023-07-12, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1763704944160, onlineIssueDateStr=2025-11-21, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1763704944160, creator=13701087609, updateTime=1763704944160, updator=13701087609, issue=Issue{id=1198628666650493481, tenantId=1146029695717560320, journalId=1189982191388893191, year='2023', volume='58', issue='7', pageStart='0', pageEnd='1980', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1763704943573, creator=13701087609, updateTime=1766137716668, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1208832456644490122, tenantId=1146029695717560320, journalId=1189982191388893191, issueId=1198628666650493481, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1208832456644490123, tenantId=1146029695717560320, journalId=1189982191388893191, issueId=1198628666650493481, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=1867, endPage=1879, ext={EN=ArticleExt(id=1198628669355819590, articleId=1198628669116744251, tenantId=1146029695717560320, journalId=1189982191388893191, language=EN, title=Study on the differences in chemical composition of
Scutellaria baicalensis leaves from different origins in Shanxi Province based on plant metabolomics and targeted quantitative analysis, columnId=1190335348761793317, journalTitle=Acta Pharmaceutica Sinica, columnName=Original Articles, runingTitle=null, highlight=null, articleAbstract=
By integrating plant metabonomics and target quantitative analysis methods, this study systematically analyzed the differences of chemical constituents in Scutellaria baicalensis leaves from different producing areas in Shanxi, so as to provide theoretical basis for rational and effective utilization of Scutellaria baicalensis leaves. Based on the idea of plant metabonomics, the liquid quality of 53 batches of Scutellaria baicalensis leaves from 8 different producing areas in Shanxi was analyzed by UPLC-QTOF-MS, and the collected data were imported into SIMCA 14.1 software for multivariate statistical analysis to screen the different chemical constituents among different habitats in Shanxi. Meanwhile, a method for simultaneous determination of 7 flavonoids and 3 organic acids in Scutellaria baicalensis leaves was optimized and established to quantitatively analyze the differences of chemical components in Scutellaria baicalensis leaves from different producing areas in Shanxi. The results of plant metabonomics showed that there were differences in the chemical composition of Scutellaria baicalensis leaves in northern Shanxi (Datong, Xinzhou), Jinzhong (Yangquan, Luliang) and southern Shanxi (Changzhi, Yuncheng, Jincheng, Linfen): there were 14 significant differences in chemical composition between northern Shanxi and Jinzhong; there were 18 significant differences in chemical constituents between southern Shanxi and central Shanxi. There were 15 significant differences in chemical constituents between northern Shanxi and southern Shanxi. Among them, scutellarin and isocarthamidin-7-O-glucuronide were the common differences among the three regions, and the content of scutellarin was the highest in southern Shanxi and the lowest in northern Shanxi. The content of isocarthamidin-7-O-glucuronide was the highest in Jinzhong area and the lowest in northern Shanxi area. Quantitative analysis further confirmed that the average contents of apigenin, naringenin and citric acid were the highest in northern Shanxi, scutellarin, caffeic acid, apigenin-7-O-glucuronide, malic acid and wogonoside were the highest in southern Shanxi, and wogonoside and baicalin were the highest in central Shanxi. This study is of great significance to the quality control of Scutellaria baicalensis leaf resources, and provides theoretical basis for rational and effective utilization of Scutellaria baicalensis leaf resources.
, correspAuthors=Yu-zhi ZHOU, authorNote=null, correspAuthorsNote=null, copyrightStatement=Copyright ©2023 Acta Pharmaceutica Sinica. All rights reserved., copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, authorCompany=null, fund=null, authors=null, authorsList=Peng-fei CHENG, Tao WANG, Cong-cong CHEN, Xue-mei QIN, Guan-hua DU, Yu-zhi ZHOU), CN=ArticleExt(id=1198628670765105832, articleId=1198628669116744251, tenantId=1146029695717560320, journalId=1189982191388893191, language=CN, title=基于植物代谢组学和靶标定量分析研究山西不同产地黄芩叶化学成分差异, columnId=1190335348896011050, journalTitle=药学学报, columnName=研究论文, runingTitle=null, highlight=null, articleAbstract=
本研究整合植物代谢组学和靶标定量分析方法, 系统分析山西不同产地间黄芩叶化学成分的差异, 为合理有效利用黄芩叶资源提供理论依据。基于植物代谢组学的思路, 采用UPLC-QTOF-MS对山西省8个不同产地共53批黄芩叶进行液质分析, 并通过多元统计分析方法, 筛选山西不同产地间的差异化学成分。同时, 优化并建立一种可以同时测定黄芩叶中7种黄酮类成分和3种有机酸类成分的含量测定方法, 以定量分析山西不同产地黄芩叶化学成分差异。植物代谢组学结果显示, 晋北(大同、忻州)、晋中(阳泉、吕梁) 和晋南(长治、运城、晋城、临汾) 三个区域的黄芩叶化学成分组成具有差异性: 晋北和晋中地区间存在14个显著差异化学成分; 晋南和晋中之间存在18个显著差异化学成分; 晋北和晋南之间存在15个显著差异化学成分。其中, 野黄芩苷和异红花素-7-O-葡萄糖醛酸苷是三个地区间的共有差异成分, 野黄芩苷在晋南地区含量最高, 在晋北地区含量最低; 异红花素-7-O-葡萄糖醛酸苷在晋中地区含量最高, 在晋北地区含量最低。定量分析结果进一步证实, 晋北地区芹菜素、柚皮素和柠檬酸的平均含量最高, 晋南地区野黄芩苷、咖啡酸、芹菜素-7-O-葡萄糖醛酸苷、苹果酸和汉黄芩苷的平均含量最高, 晋中地区汉黄芩素和黄芩苷的平均含量最高。该研究对于黄芩叶资源的质量控制具有重要意义, 为合理有效利用黄芩叶资源提供理论依据。
, correspAuthors=周玉枝, authorNote=null, correspAuthorsNote=
, copyrightStatement=版权所有©《药学学报》编辑部2023, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=80G/3b7g4coG9LtmHHvuyA==, magXml=oFYy/2h0w74kHXgqUPP6Bw==, pdfUrl=null, pdf=SI79GEaGFIUBfHX69L30nA==, pdfFileSize=3679228, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=YcLsjVCIvjR9/L2KYQHtlg==, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=J2HManUZ/mtpamvFJygoGw==, mapNumber=null, authorCompany=null, fund=null, authors=null, authorsList=程鹏飞, 王涛, 陈聪聪, 秦雪梅, 杜冠华, 周玉枝)}, authors=[Author(id=1198960096802861449, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198628669116744251, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1198960096962245020, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198628669116744251, authorId=1198960096802861449, language=EN, stringName=Peng-fei CHENG, firstName=Peng-fei, middleName=null, lastName=CHENG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, address=1. Shanxi Provincial Drug Inspection Center (Shanxi Provincial Vaccine Inspection Center), Taiyuan 030006, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1198960097058714023, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198628669116744251, authorId=1198960096802861449, language=CN, stringName=程鹏飞, firstName=鹏飞, middleName=null, lastName=程, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
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2, 3, 4, address=2. Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China
3. The Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University, Taiyuan 030006, China
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2, 3, 4, address=2.山西大学中医药现代研究中心, 山西 太原 030006
3.山西大学化学生物学与分子工程教育部重点实验室, 山西 太原 030006
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3. The Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University, Taiyuan 030006, China
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3.山西大学化学生物学与分子工程教育部重点实验室, 山西 太原 030006
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2, 3, 4, address=2. Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China
3. The Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University, Taiyuan 030006, China
4. The Key Laboratory of Effective Substances Research and Utilization in TCM of Shanxi Province, Taiyuan 030006, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1198960098291839538, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198628669116744251, authorId=1198960098006626838, language=CN, stringName=秦雪梅, firstName=雪梅, middleName=null, lastName=秦, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
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2021,
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Chrysanthemum morifolium Ramat flowers: a potentially rich source of bioactive compounds, refAbstract=null)], funds=[Fund(id=1198960105078223004, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198628669116744251, awardId=201703D321023-3, language=CN, fundingSource=山西省重点研发计划项目(201703D321023-3), fundOrder=null, country=null), Fund(id=1198960105262772391, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198628669116744251, awardId=1331KCIC, language=CN, fundingSource=山西省“1331工程”协同创新中心建设计划经费资助项目(1331KCIC), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1198960095758479660, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198628669116744251, xref=null, ext=[AuthorCompanyExt(id=1198960095766868269, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198628669116744251, companyId=1198960095758479660, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1. 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Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China), AuthorCompanyExt(id=1198960096190493000, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198628669116744251, companyId=1198960096165327171, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2.山西大学中医药现代研究中心, 山西 太原 030006)]), AuthorCompany(id=1198960096295350615, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198628669116744251, xref=null, ext=[AuthorCompanyExt(id=1198960096324710745, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198628669116744251, companyId=1198960096295350615, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=3. 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Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China), AuthorCompanyExt(id=1198960096651866489, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198628669116744251, companyId=1198960096639283573, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=5.中国医学科学院、北京协和医学院药物研究所, 北京 100050)])], figs=[ArticleFig(id=1198960100988777302, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198628669116744251, language=EN, label=null, caption=null, figureFileSmall=7CwXG9+suZPwcyC2c43eWQ==, figureFileBig=srUcMhJsVhP3wcI/+Lj5Zg==, tableContent=null), ArticleFig(id=1198960101135577960, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198628669116744251, language=CN, label=Figure 1, caption=
Multivariate data analysis from UPLC-MS/MS. A: PCA score plots from CZ, YC, JC, LF, LL, YQ, DT, XZ, and QC samples; B: OPLS-DA model validation diagram; C: OPLS-DA score plots from JZ and JB; D: S-plot of OPLS-DA between JZ and JB; E: OPLS-DA score plots from JN and JZ; F: S-plot of OPLS-DA between JN and JZ; G: OPLS-DA score plots from JN and JB; H: S-plot of OPLS-DA between JN and JB; CZ: Changzhi City; YC: Yuncheng City; JC: Jincheng City; LF: Linfen City; LL: Lvliang City; YQ: Yangquan City; DT: Datong City; XZ: Xinzhou City; QC: Quality Control; JZ: Jinzhong; JN: Jinnan; JB: Jinbei , figureFileSmall=7CwXG9+suZPwcyC2c43eWQ==, figureFileBig=srUcMhJsVhP3wcI/+Lj5Zg==, tableContent=null), ArticleFig(id=1198960101286572920, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198628669116744251, language=EN, label=null, caption=null, figureFileSmall=kUlDMB8Cp6WGj91O65v9bA==, figureFileBig=n+BwCzIXzK272UCCXye9CA==, tableContent=null), ArticleFig(id=1198960101429179273, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198628669116744251, language=CN, label=Figure 2, caption=
Significantly different components between JZ (<i>n</i> = 11) and JB (<i>n</i> = 14). All data are expressed as the mean ± SD. <sup>*</sup><i>P</i> < 0.05, <sup>***</sup><i>P</i> < 0.001 , figureFileSmall=kUlDMB8Cp6WGj91O65v9bA==, figureFileBig=n+BwCzIXzK272UCCXye9CA==, tableContent=null), ArticleFig(id=1198960101668254628, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198628669116744251, language=EN, label=null, caption=null, figureFileSmall=4m8ePJ9GQISic8OQob+e5w==, figureFileBig=2iSRhrzydJlPflKzZ03I8g==, tableContent=null), ArticleFig(id=1198960101827638191, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198628669116744251, language=CN, label=Figure 3, caption=
Significantly different components between JN (<i>n</i> = 28) and JZ (<i>n</i> = 11). All data are expressed as the mean ± SD. <sup>*</sup><i>P</i> < 0.05, <sup>**</sup><i>P</i> < 0.01, <sup>***</sup><i>P</i> < 0.001 , figureFileSmall=4m8ePJ9GQISic8OQob+e5w==, figureFileBig=2iSRhrzydJlPflKzZ03I8g==, tableContent=null), ArticleFig(id=1198960102028964802, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198628669116744251, language=EN, label=null, caption=null, figureFileSmall=Gz4PXrfbJXC9ovqBCLLUSA==, figureFileBig=fJyPDc/7lm9FzIomVicTSA==, tableContent=null), ArticleFig(id=1198960102192542673, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198628669116744251, language=CN, label=Figure 4, caption=
Significantly different components between JN (<i>n</i> = 28) and JB (<i>n</i> = 14). All data are expressed as the mean ± SD. <sup>*</sup><i>P</i> < 0.05, <sup>***</sup><i>P</i> < 0.001 , figureFileSmall=Gz4PXrfbJXC9ovqBCLLUSA==, figureFileBig=fJyPDc/7lm9FzIomVicTSA==, tableContent=null), ArticleFig(id=1198960102481949667, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198628669116744251, language=EN, label=null, caption=null, figureFileSmall=mUwvZudCcxuPEmaeyYwgDw==, figureFileBig=2gElLhr4y2+/9XwWozH9vQ==, tableContent=null), ArticleFig(id=1198960102683276278, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198628669116744251, language=CN, label=Figure 5, caption=
The typical MRM chromatograms of the 10 analytes in <i>Scutellaria baicalensis</i> leaves samples , figureFileSmall=mUwvZudCcxuPEmaeyYwgDw==, figureFileBig=2gElLhr4y2+/9XwWozH9vQ==, tableContent=null), ArticleFig(id=1198960102792328187, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198628669116744251, language=EN, label=null, caption=null, figureFileSmall=c0RAZB9AAiRHehGh6xtycA==, figureFileBig=0u9euT/d/hFoxDU/vUqQRQ==, tableContent=null), ArticleFig(id=1198960102918156296, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198628669116744251, language=CN, label=Figure 6, caption=
Multivariate data analysis and quantitative analysis of 10 components in <i>Scutellaria baicalensis</i> leaves samples from JB (<i>n</i> = 14), JZ (<i>n</i> = 11) and JN (<i>n</i> = 28) regions. A: PCA score plots from JB, JZ, and JN; B: PLS-DA score plots from JB, JZ, and JN; C: Results of quantitative analysis of 10 components in <i>Scutellaria baicalensis</i> leaves samples from JB, JZ and JN regions. All data are expressed as the mean ± SD. <sup>*</sup><i>P</i> < 0.05, <sup>**</sup><i>P</i> < 0.01, <sup>***</sup><i>P</i> < 0.001 , figureFileSmall=c0RAZB9AAiRHehGh6xtycA==, figureFileBig=0u9euT/d/hFoxDU/vUqQRQ==, tableContent=null), ArticleFig(id=1198960103077539862, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198628669116744251, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
| No. | Place of origin | Harvesting period | | No. | Place of origin | Harvesting period |
| CZ-1 | Changzhi City, Shanxi Province | 2020.7 | | LF-7 | Linfen City, Shanxi Province | 2020.7 |
| CZ-2 | Changzhi City, Shanxi Province | 2020.7 | LL-1 | Luliang City, Shanxi Province | 2020.7 |
| CZ-3 | Changzhi City, Shanxi Province | 2020.7 | LL-2 | Luliang City, Shanxi Province | 2020.7 |
| CZ-4 | Changzhi City, Shanxi Province | 2020.7 | LL-3 | Luliang City, Shanxi Province | 2020.7 |
| CZ-5 | Changzhi City, Shanxi Province | 2020.7 | LL-4 | Luliang City, Shanxi Province | 2020.7 |
| CZ-6 | Changzhi City, Shanxi Province | 2020.7 | YQ-1 | Yangquan City, Shanxi Province | 2020.8 |
| CZ-7 | Changzhi City, Shanxi Province | 2020.7 | YQ-2 | Yangquan City, Shanxi Province | 2020.8 |
| YC-1 | Yuncheng City, Shanxi Province | 2020.8 | YQ-3 | Yangquan City, Shanxi Province | 2020.8 |
| YC-2 | Yuncheng City, Shanxi Province | 2020.8 | YQ-4 | Yangquan City, Shanxi Province | 2020.8 |
| YC-3 | Yuncheng City, Shanxi Province | 2020.8 | YQ-5 | Yangquan City, Shanxi Province | 2020.8 |
| YC-4 | Yuncheng City, Shanxi Province | 2020.8 | YQ-6 | Yangquan City, Shanxi Province | 2020.8 |
| YC-5 | Yuncheng City, Shanxi Province | 2020.8 | YQ-7 | Yangquan City, Shanxi Province | 2020.8 |
| YC-6 | Yuncheng City, Shanxi Province | 2020.8 | DT-1 | Datong City, Shanxi Province | 2020.7 |
| YC-7 | Yuncheng City, Shanxi Province | 2020.8 | DT-2 | Datong City, Shanxi Province | 2020.7 |
| JC-1 | Jincheng City, Shanxi Province | 2020.8 | DT-3 | Datong City, Shanxi Province | 2020.7 |
| JC-2 | Jincheng City, Shanxi Province | 2020.8 | DT-4 | Datong City, Shanxi Province | 2020.7 |
| JC-3 | Jincheng City, Shanxi Province | 2020.8 | DT-5 | Datong City, Shanxi Province | 2020.7 |
| JC-4 | Jincheng City, Shanxi Province | 2020.8 | DT-6 | Datong City, Shanxi Province | 2020.7 |
| JC-5 | Jincheng City, Shanxi Province | 2020.8 | DT-7 | Datong City, Shanxi Province | 2020.7 |
| JC-6 | Jincheng City, Shanxi Province | 2020.8 | XZ-1 | Xinzhou City, Shanxi Province | 2020.8 |
| JC-7 | Jincheng City, Shanxi Province | 2020.8 | XZ-2 | Xinzhou City, Shanxi Province | 2020.8 |
| LF-1 | Linfen City, Shanxi Province | 2020.7 | XZ-3 | Xinzhou City, Shanxi Province | 2020.8 |
| LF-2 | Linfen City, Shanxi Province | 2020.7 | XZ-4 | Xinzhou City, Shanxi Province | 2020.8 |
| LF-3 | Linfen City, Shanxi Province | 2020.7 | XZ-5 | Xinzhou City, Shanxi Province | 2020.8 |
| LF-4 | Linfen City, Shanxi Province | 2020.7 | XZ-6 | Xinzhou City, Shanxi Province | 2020.8 |
| LF-5 | Linfen City, Shanxi Province | 2020.7 | XZ-7 | Xinzhou City, Shanxi Province | 2020.8 |
| LF-6 | Linfen City, Shanxi Province | 2020.7 | | | |
), ArticleFig(id=1198960103199174687, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198628669116744251, language=CN, label=Table 1, caption=
Scutellaria baicalensis leaves origin, harvesting period, and number
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| No. | Place of origin | Harvesting period | | No. | Place of origin | Harvesting period |
| CZ-1 | Changzhi City, Shanxi Province | 2020.7 | | LF-7 | Linfen City, Shanxi Province | 2020.7 |
| CZ-2 | Changzhi City, Shanxi Province | 2020.7 | LL-1 | Luliang City, Shanxi Province | 2020.7 |
| CZ-3 | Changzhi City, Shanxi Province | 2020.7 | LL-2 | Luliang City, Shanxi Province | 2020.7 |
| CZ-4 | Changzhi City, Shanxi Province | 2020.7 | LL-3 | Luliang City, Shanxi Province | 2020.7 |
| CZ-5 | Changzhi City, Shanxi Province | 2020.7 | LL-4 | Luliang City, Shanxi Province | 2020.7 |
| CZ-6 | Changzhi City, Shanxi Province | 2020.7 | YQ-1 | Yangquan City, Shanxi Province | 2020.8 |
| CZ-7 | Changzhi City, Shanxi Province | 2020.7 | YQ-2 | Yangquan City, Shanxi Province | 2020.8 |
| YC-1 | Yuncheng City, Shanxi Province | 2020.8 | YQ-3 | Yangquan City, Shanxi Province | 2020.8 |
| YC-2 | Yuncheng City, Shanxi Province | 2020.8 | YQ-4 | Yangquan City, Shanxi Province | 2020.8 |
| YC-3 | Yuncheng City, Shanxi Province | 2020.8 | YQ-5 | Yangquan City, Shanxi Province | 2020.8 |
| YC-4 | Yuncheng City, Shanxi Province | 2020.8 | YQ-6 | Yangquan City, Shanxi Province | 2020.8 |
| YC-5 | Yuncheng City, Shanxi Province | 2020.8 | YQ-7 | Yangquan City, Shanxi Province | 2020.8 |
| YC-6 | Yuncheng City, Shanxi Province | 2020.8 | DT-1 | Datong City, Shanxi Province | 2020.7 |
| YC-7 | Yuncheng City, Shanxi Province | 2020.8 | DT-2 | Datong City, Shanxi Province | 2020.7 |
| JC-1 | Jincheng City, Shanxi Province | 2020.8 | DT-3 | Datong City, Shanxi Province | 2020.7 |
| JC-2 | Jincheng City, Shanxi Province | 2020.8 | DT-4 | Datong City, Shanxi Province | 2020.7 |
| JC-3 | Jincheng City, Shanxi Province | 2020.8 | DT-5 | Datong City, Shanxi Province | 2020.7 |
| JC-4 | Jincheng City, Shanxi Province | 2020.8 | DT-6 | Datong City, Shanxi Province | 2020.7 |
| JC-5 | Jincheng City, Shanxi Province | 2020.8 | DT-7 | Datong City, Shanxi Province | 2020.7 |
| JC-6 | Jincheng City, Shanxi Province | 2020.8 | XZ-1 | Xinzhou City, Shanxi Province | 2020.8 |
| JC-7 | Jincheng City, Shanxi Province | 2020.8 | XZ-2 | Xinzhou City, Shanxi Province | 2020.8 |
| LF-1 | Linfen City, Shanxi Province | 2020.7 | XZ-3 | Xinzhou City, Shanxi Province | 2020.8 |
| LF-2 | Linfen City, Shanxi Province | 2020.7 | XZ-4 | Xinzhou City, Shanxi Province | 2020.8 |
| LF-3 | Linfen City, Shanxi Province | 2020.7 | XZ-5 | Xinzhou City, Shanxi Province | 2020.8 |
| LF-4 | Linfen City, Shanxi Province | 2020.7 | XZ-6 | Xinzhou City, Shanxi Province | 2020.8 |
| LF-5 | Linfen City, Shanxi Province | 2020.7 | XZ-7 | Xinzhou City, Shanxi Province | 2020.8 |
| LF-6 | Linfen City, Shanxi Province | 2020.7 | | | |
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| No. | Compound | tR/min | Q1/Q3 | DP/V | CE/eV |
| 1 | Scutellarin | 6.63 | 461.1/285.1 | -40 | -34 |
| 2 | Baicalin | 7.83 | 445.1/269.1 | -40 | -37 |
| 3 | Wogonin | 10.95 | 283.1/268.0 | -35 | -26 |
| 4 | Wogoniside | 8.66 | 459.1/268.0 | -48 | -41 |
| 5 | Apigenin | 8.97 | 269.1/117.0 | -85 | -52 |
| 6 | Apigenin-7-O-glucuronide | 7.15 | 444.9/269.1 | -40 | -30 |
| 7 | Naringenin | 8.93 | 271.1/119.0 | -57 | -48 |
| 8 | Caffeic acid | 5.17 | 179.0/135.1 | -45 | -23 |
| 9 | Malic acid | 1.29 | 133.0/115.0 | -35 | -15 |
| 10 | Citric acid | 1.57 | 191.0/111.0 | -35 | -20 |
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MRM-based mass spectrometry parameters for the detection of 10 analytes. Q1: Quadrupole 1; Q2: Quadrupole 2; DP: Declustering potential; CE: Collision energy
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| No. | Compound | tR/min | Q1/Q3 | DP/V | CE/eV |
| 1 | Scutellarin | 6.63 | 461.1/285.1 | -40 | -34 |
| 2 | Baicalin | 7.83 | 445.1/269.1 | -40 | -37 |
| 3 | Wogonin | 10.95 | 283.1/268.0 | -35 | -26 |
| 4 | Wogoniside | 8.66 | 459.1/268.0 | -48 | -41 |
| 5 | Apigenin | 8.97 | 269.1/117.0 | -85 | -52 |
| 6 | Apigenin-7-O-glucuronide | 7.15 | 444.9/269.1 | -40 | -30 |
| 7 | Naringenin | 8.93 | 271.1/119.0 | -57 | -48 |
| 8 | Caffeic acid | 5.17 | 179.0/135.1 | -45 | -23 |
| 9 | Malic acid | 1.29 | 133.0/115.0 | -35 | -15 |
| 10 | Citric acid | 1.57 | 191.0/111.0 | -35 | -20 |
), ArticleFig(id=1198960103668936762, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198628669116744251, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
| No. | tR/min | Formula | Experimental m/z [M-H]- | Error (×10-6) | Fragment ion (m/z) | Identification | Reference |
| 1 | 0.95 | C6H10O8 | 209.031 2 | 4.35 | 195.020 1 | D-Saccharic acid | [7] |
| 2 | 1.14 | C4H6O5 | 133.014 0 | -1.85 | 115.004 0, 133.013 4 | Malic acid* | [7] |
| 3 | 1.27 | C6H8O7 | 191.020 7 | 5.1 | 111.008 8, 129.018 9, 154.998 3, 173.009 2 | Citric acid* | [7] |
| 4 | 3.56 | C7H6O4 | 153.019 0 | -1.96 | 109.029 7 | Protocatechuic acid | [7] |
| 5 | 3.73 | C26H30O15 | 581.150 2 | -1.71 | 167.035 4, 383.104 9, 413.094 3, 563.134 0 | 8-Arabinosyl-6-glucosyl-2′,3,5,7-dihydroxyflavanone | [8] |
| 6 | 3.88 | C26H28O14 | 563.141 3 | 1.19 | 353.067 3, 383.078 6, 443.099 5, 473.107 1 | Schaftoside | [9] |
| 7 | 4.05 | C26H28O14 | 563.140 0 | -1.12 | 353.067 3, 383.078 6, 443.099 5 | Apigenin-6-C-glucosyl-8-C-arabonoside | [10] |
| 8 | 4.13 | C9H8O4 | 182.042 4 | -0.54 | 107.058 0, 117.030 0, 134.036 4, 135.043 6 | Caffeic acid* | [11] |
| 9 | 4.21 | C21H20O13 | 479.084 0 | 1.85 | 166.999 3, 181.014 8, 285.041 6, 303.051 4 | 5,6,7,3′,4′-Pentahydroxy flavanone-7-O-glucuronide | [10] |
| 10 | 4.35 | C26H28O14 | 563.140 7 | 0.17 | 353.067 3, 383.078 6, 443.099 5, 473.107 1 | Schaftoside isomer | [8] |
| 11 | 4.40 | C21H20O13 | 479.083 7 | 1.22 | 166.999 3, 181.014 8, 285.041 6, 303.051 4 | 5,7,8,3′,4′-Pentahydroxy flavanone-7-O-glucuronide | [10] |
| 12 | 4.58 | C26H28O13 | 547.146 0 | 0.54 | 337.073 4, 367.088 2, 427.095 4, 457.113 3 | Chrysin 6-C-β-D-glucoside-8-C-β-arabinoside | [12] |
| 13 | 4.60 | C21H20O10 | 431.096 5 | -4.34 | 269.045 9 | Baicalein-7-O-glucoside | [8] |
| 14 | 4.64 | C29H36O15 | 623.197 9 | -0.32 | 161.024 2, 179.037 2, 461.164 7 | Acteoside | [12] |
| 15 | 4.73 | C21H18O12 | 461.074 7 | 4.66 | 175.024 1, 285.040 2 | 4′,5,6,7-Tetrahydroxyflavone-7-O-glucuronide | [8] |
| 16 | 4.74 | C21H20O12 | 463.089 2 | 2.16 | 153.019 9, 181.015 1, 287.055 5 | Carthamidin-7-O-glucuronide | [10] |
| 17 | 4.77 | C15H12O6 | 287.055 6 | -1.78 | 119.050 8, 139.002 7, 153.018 7, 166.996 3, 181.012 2 | Carthamidin | [13] |
| 18 | 4.80 | C21H20O12 | 464.376 1 | 0.21 | 193.018 1, 281.043 9, 301.075 9, 461.067 1 | 2′,3,5,6′,7-Pentahydroxyflavone-2′-O-glucoside | [8] |
| 19 | 4.90 | C21H18O13 | 477.064 7 | -5.79 | 164.983 0, 257.045 9, 273.036 8, 301.036 6 | 6-Hydroxyluteolin-7-O-glucuronide | [10] |
| 20 | 4.93 | C21H20O12 | 463.087 2 | -2.16 | 153.019 9, 181.015 1, 287.055 5 | Isocarthamidin-7-O-glucuronide | [10] |
| 21 | 5.06 | C21H18O12 | 461.071 9 | -1.41 | 213.055 8, 239.035 1, 241.052 5, 267.029 2, 285.040 2 | Scutellarin* | [14] |
| 22 | 5.21 | C31H40O15 | 651.228 7 | -1.07 | 175.038 7, 193.052 9 | Cistanoside D | [12] |
| 23 | 5.27 | C21H20O10 | 431.098 2 | 0.46 | 135.048 4, 183.099 5, 271.067 0 | Apigenin-7-O-glucoside | [15] |
| 24 | 5.29 | C22H22O12 | 475.087 5 | -1.47 | 165.991 4, 299.054 3 | 5,7,2′-Trihydroxy-6-methoxyflavone-7-O-β-D-glucoside | [12] |
| 25 | 5.30 | C21H20O11 | 447.093 7 | 1.11 | 175.025 4, 227.071 4, 253.051 5 | Dihydrobaicalin | [7] |
| 26 | 5.31 | C21H18O11 | 445.075 9 | -3.9 | 113.024 4, 117.019 6, 151.004 2, 175.024 3, 269.045 4 | Apigenin-7-O-glucuronide* | [7] |
| 27 | 5.37 | C21H18O11 | 445.079 4 | 3.97 | 269.045 9 | Baicalein-6-O-β-D-glucuronide | [12] |
| 28 | 5.38 | C22H22O11 | 461.088 7 | 1.08 | 284.032 7, 299.055 0 | 2′,5,7-Trihydroxy-6-methoxyflavone-7-O-β-D-glucoside | [12] |
| 29 | 5.40 | C21H20O11 | 447.095 1 | 4.25 | 151.003 1, 177.019 1, 271.061 5 | Naringenin-7-O-glucuronide | [10] |
| 30 | 5.40 | C21H20O11 | 447.094 2 | 2.23 | 175.025 4, 269.049 3, 285.043 6 | Plantaginin | [12] |
| 31 | 5.81 | C21H18O12 | 461.074 2 | 3.58 | 285.040 3 | Luteolin-7-O-glucuronide | [15] |
| 32 | 5.94 | C21H18O11 | 445.076 3 | -3 | 225.063 6, 241.046 3, 269.045 5 | Norwogonin-8-O-glucuronide | [12] |
| 33 | 6.05 | C30H38O15 | 637.214 2 | 0.62 | 175.039 1, 193.054 1 | Leucosceptoside A | [12] |
| 34 | 6.23 | C22H20O12 | 475.088 7 | 1.05 | 284.032 2, 299.056 3 | 5,7,8-Trihydroxy-4′-methoxyflavanone-7-O-glucuronide | [8] |
| 35 | 6.23 | C22H20O12 | 475.088 6 | 0.84 | 284.032 2, 299.056 3 | 2′,5,7-Trihydroxy-8-methoxyflavanone-7-O-glucuronide | [8] |
| 36 | 6.23 | C22H20O12 | 475.086 0 | -4.63 | 284.033 0, 299.056 4 | 5,7,2′-Trihydroxy-6-methoxyflavone-7-O-glucuronide | [8] |
| 37 | 6.23 | C22H20O12 | 475.088 9 | 1.47 | 284.032 7, 299.055 0 | Trihydroxy-methoxyflavone-O-glucuronide | [12] |
| 38 | 6.53 | C21H18O11 | 445.077 5 | -0.3 | 113.022 5, 197.058 9, 225.057 7, 241.058 9, 269.045 9 | Baicalin* | [7] |
| 39 | 6.57 | C22H22O12 | 477.101 6 | -4.71 | 273.077 3, 301.072 5 | Trihydroxy-methoxyflavanone-7-O-glucuronide | [12] |
| 40 | 6.96 | C21H18O10 | 429.082 8 | 0.19 | 175.024 7, 181.068 2, 209.060 4, 211.037 2, 253.051 2 | Chrysin-7-O-glucoside | [10] |
| 41 | 7.01 | C15H10O4 | 253.051 6 | 3.82 | 143.049 6, 145.027 0, 209.057 9, 225.053 3 | Chrysin* | [15] |
| 42 | 7.34 | C22H20O11 | 460.388 4 | 1.73 | 113.036 9, 175.021 3, 268.037 5, 283.064 2 | Wogonoside* | [7] |
| 43 | 7.35 | C22H20O11 | 460.388 7 | 2.38 | 175.021 3, 268.037 5, 283.064 2, 459.103 7 | 5,7-Dihydroxy-6-methoxyflavanone-7-O-glucuronide | [7] |
| 44 | 7.67 | C21H20O10 | 431.097 5 | -2.02 | 151.004 9, 187.077 7, 211.076 5, 213.055 9, 255.066 6 | Pinocembrin-7-O-glucuronide | [10] |
| 45 | 8.42 | C15H12O5 | 271.061 9 | 2.59 | 107.014 7, 151.003 6, 177.019 4 | Naringenin* | [10] |
| 46 | 8.49 | C15H10O5 | 269.045 2 | -1.29 | 117.034 2, 151.004 8, 201.057 1, 225.052 9, 241.046 8 | Apigenin* | [13] |
| 47 | 8.76 | C17H14O6 | 313.072 5 | 2.23 | 283.026 3, 298.045 2 | Dihydroxy-dimethoxyflavone | [12] |
| 48 | 9.58 | C15H10O5 | 269.045 0 | 1.85 | 171.052 0, 195.043 4, 223.039 8, 241.051 9 | 5,7,2′-Trihydroxyflavone | [8] |
| 49 | 10.83 | C17H14O6 | 313.071 9 | 0.44 | 268.075 2, 283.026 3, 298.045 2 | 5,7-Dihydroxy-2′,8-dimethoxyflavone | [8] |
| 50 | 11.58 | C18H16O7 | 343.082 9 | 1.74 | 313.035 2, 328.065 6 | 2′,5-Dihydroxy-6,7,8-trimethoxyflavone | [8]
[12] |
| 51 | 11.68 | C17H14O6 | 313.072 6 | 2.55 | 211.038 9, 283.023 6, 298.045 2 | 5,8-Dihydroxy-6,7-dimethoxyflavone | [12] |
| 52 | 12.01 | C16H12O5 | 283.060 5 | -2.47 | 163.004 3, 267.030 7, 268.037 5 | Wogonin* | [12] |
| 53 | 12.19 | C15H12O4 | 255.067 0 | 2.74 | 151.003 2, 186.938 4, 213.055 2 | Pinocembrin | [10] |
), ArticleFig(id=1198960103853486156, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198628669116744251, language=CN, label=Table 3, caption=
Mass spectral information of compounds identified by UPLC-MS/MS in Scutellaria baicalensis leaves. *Validated with standard
, figureFileSmall=null, figureFileBig=null, tableContent=
| No. | tR/min | Formula | Experimental m/z [M-H]- | Error (×10-6) | Fragment ion (m/z) | Identification | Reference |
| 1 | 0.95 | C6H10O8 | 209.031 2 | 4.35 | 195.020 1 | D-Saccharic acid | [7] |
| 2 | 1.14 | C4H6O5 | 133.014 0 | -1.85 | 115.004 0, 133.013 4 | Malic acid* | [7] |
| 3 | 1.27 | C6H8O7 | 191.020 7 | 5.1 | 111.008 8, 129.018 9, 154.998 3, 173.009 2 | Citric acid* | [7] |
| 4 | 3.56 | C7H6O4 | 153.019 0 | -1.96 | 109.029 7 | Protocatechuic acid | [7] |
| 5 | 3.73 | C26H30O15 | 581.150 2 | -1.71 | 167.035 4, 383.104 9, 413.094 3, 563.134 0 | 8-Arabinosyl-6-glucosyl-2′,3,5,7-dihydroxyflavanone | [8] |
| 6 | 3.88 | C26H28O14 | 563.141 3 | 1.19 | 353.067 3, 383.078 6, 443.099 5, 473.107 1 | Schaftoside | [9] |
| 7 | 4.05 | C26H28O14 | 563.140 0 | -1.12 | 353.067 3, 383.078 6, 443.099 5 | Apigenin-6-C-glucosyl-8-C-arabonoside | [10] |
| 8 | 4.13 | C9H8O4 | 182.042 4 | -0.54 | 107.058 0, 117.030 0, 134.036 4, 135.043 6 | Caffeic acid* | [11] |
| 9 | 4.21 | C21H20O13 | 479.084 0 | 1.85 | 166.999 3, 181.014 8, 285.041 6, 303.051 4 | 5,6,7,3′,4′-Pentahydroxy flavanone-7-O-glucuronide | [10] |
| 10 | 4.35 | C26H28O14 | 563.140 7 | 0.17 | 353.067 3, 383.078 6, 443.099 5, 473.107 1 | Schaftoside isomer | [8] |
| 11 | 4.40 | C21H20O13 | 479.083 7 | 1.22 | 166.999 3, 181.014 8, 285.041 6, 303.051 4 | 5,7,8,3′,4′-Pentahydroxy flavanone-7-O-glucuronide | [10] |
| 12 | 4.58 | C26H28O13 | 547.146 0 | 0.54 | 337.073 4, 367.088 2, 427.095 4, 457.113 3 | Chrysin 6-C-β-D-glucoside-8-C-β-arabinoside | [12] |
| 13 | 4.60 | C21H20O10 | 431.096 5 | -4.34 | 269.045 9 | Baicalein-7-O-glucoside | [8] |
| 14 | 4.64 | C29H36O15 | 623.197 9 | -0.32 | 161.024 2, 179.037 2, 461.164 7 | Acteoside | [12] |
| 15 | 4.73 | C21H18O12 | 461.074 7 | 4.66 | 175.024 1, 285.040 2 | 4′,5,6,7-Tetrahydroxyflavone-7-O-glucuronide | [8] |
| 16 | 4.74 | C21H20O12 | 463.089 2 | 2.16 | 153.019 9, 181.015 1, 287.055 5 | Carthamidin-7-O-glucuronide | [10] |
| 17 | 4.77 | C15H12O6 | 287.055 6 | -1.78 | 119.050 8, 139.002 7, 153.018 7, 166.996 3, 181.012 2 | Carthamidin | [13] |
| 18 | 4.80 | C21H20O12 | 464.376 1 | 0.21 | 193.018 1, 281.043 9, 301.075 9, 461.067 1 | 2′,3,5,6′,7-Pentahydroxyflavone-2′-O-glucoside | [8] |
| 19 | 4.90 | C21H18O13 | 477.064 7 | -5.79 | 164.983 0, 257.045 9, 273.036 8, 301.036 6 | 6-Hydroxyluteolin-7-O-glucuronide | [10] |
| 20 | 4.93 | C21H20O12 | 463.087 2 | -2.16 | 153.019 9, 181.015 1, 287.055 5 | Isocarthamidin-7-O-glucuronide | [10] |
| 21 | 5.06 | C21H18O12 | 461.071 9 | -1.41 | 213.055 8, 239.035 1, 241.052 5, 267.029 2, 285.040 2 | Scutellarin* | [14] |
| 22 | 5.21 | C31H40O15 | 651.228 7 | -1.07 | 175.038 7, 193.052 9 | Cistanoside D | [12] |
| 23 | 5.27 | C21H20O10 | 431.098 2 | 0.46 | 135.048 4, 183.099 5, 271.067 0 | Apigenin-7-O-glucoside | [15] |
| 24 | 5.29 | C22H22O12 | 475.087 5 | -1.47 | 165.991 4, 299.054 3 | 5,7,2′-Trihydroxy-6-methoxyflavone-7-O-β-D-glucoside | [12] |
| 25 | 5.30 | C21H20O11 | 447.093 7 | 1.11 | 175.025 4, 227.071 4, 253.051 5 | Dihydrobaicalin | [7] |
| 26 | 5.31 | C21H18O11 | 445.075 9 | -3.9 | 113.024 4, 117.019 6, 151.004 2, 175.024 3, 269.045 4 | Apigenin-7-O-glucuronide* | [7] |
| 27 | 5.37 | C21H18O11 | 445.079 4 | 3.97 | 269.045 9 | Baicalein-6-O-β-D-glucuronide | [12] |
| 28 | 5.38 | C22H22O11 | 461.088 7 | 1.08 | 284.032 7, 299.055 0 | 2′,5,7-Trihydroxy-6-methoxyflavone-7-O-β-D-glucoside | [12] |
| 29 | 5.40 | C21H20O11 | 447.095 1 | 4.25 | 151.003 1, 177.019 1, 271.061 5 | Naringenin-7-O-glucuronide | [10] |
| 30 | 5.40 | C21H20O11 | 447.094 2 | 2.23 | 175.025 4, 269.049 3, 285.043 6 | Plantaginin | [12] |
| 31 | 5.81 | C21H18O12 | 461.074 2 | 3.58 | 285.040 3 | Luteolin-7-O-glucuronide | [15] |
| 32 | 5.94 | C21H18O11 | 445.076 3 | -3 | 225.063 6, 241.046 3, 269.045 5 | Norwogonin-8-O-glucuronide | [12] |
| 33 | 6.05 | C30H38O15 | 637.214 2 | 0.62 | 175.039 1, 193.054 1 | Leucosceptoside A | [12] |
| 34 | 6.23 | C22H20O12 | 475.088 7 | 1.05 | 284.032 2, 299.056 3 | 5,7,8-Trihydroxy-4′-methoxyflavanone-7-O-glucuronide | [8] |
| 35 | 6.23 | C22H20O12 | 475.088 6 | 0.84 | 284.032 2, 299.056 3 | 2′,5,7-Trihydroxy-8-methoxyflavanone-7-O-glucuronide | [8] |
| 36 | 6.23 | C22H20O12 | 475.086 0 | -4.63 | 284.033 0, 299.056 4 | 5,7,2′-Trihydroxy-6-methoxyflavone-7-O-glucuronide | [8] |
| 37 | 6.23 | C22H20O12 | 475.088 9 | 1.47 | 284.032 7, 299.055 0 | Trihydroxy-methoxyflavone-O-glucuronide | [12] |
| 38 | 6.53 | C21H18O11 | 445.077 5 | -0.3 | 113.022 5, 197.058 9, 225.057 7, 241.058 9, 269.045 9 | Baicalin* | [7] |
| 39 | 6.57 | C22H22O12 | 477.101 6 | -4.71 | 273.077 3, 301.072 5 | Trihydroxy-methoxyflavanone-7-O-glucuronide | [12] |
| 40 | 6.96 | C21H18O10 | 429.082 8 | 0.19 | 175.024 7, 181.068 2, 209.060 4, 211.037 2, 253.051 2 | Chrysin-7-O-glucoside | [10] |
| 41 | 7.01 | C15H10O4 | 253.051 6 | 3.82 | 143.049 6, 145.027 0, 209.057 9, 225.053 3 | Chrysin* | [15] |
| 42 | 7.34 | C22H20O11 | 460.388 4 | 1.73 | 113.036 9, 175.021 3, 268.037 5, 283.064 2 | Wogonoside* | [7] |
| 43 | 7.35 | C22H20O11 | 460.388 7 | 2.38 | 175.021 3, 268.037 5, 283.064 2, 459.103 7 | 5,7-Dihydroxy-6-methoxyflavanone-7-O-glucuronide | [7] |
| 44 | 7.67 | C21H20O10 | 431.097 5 | -2.02 | 151.004 9, 187.077 7, 211.076 5, 213.055 9, 255.066 6 | Pinocembrin-7-O-glucuronide | [10] |
| 45 | 8.42 | C15H12O5 | 271.061 9 | 2.59 | 107.014 7, 151.003 6, 177.019 4 | Naringenin* | [10] |
| 46 | 8.49 | C15H10O5 | 269.045 2 | -1.29 | 117.034 2, 151.004 8, 201.057 1, 225.052 9, 241.046 8 | Apigenin* | [13] |
| 47 | 8.76 | C17H14O6 | 313.072 5 | 2.23 | 283.026 3, 298.045 2 | Dihydroxy-dimethoxyflavone | [12] |
| 48 | 9.58 | C15H10O5 | 269.045 0 | 1.85 | 171.052 0, 195.043 4, 223.039 8, 241.051 9 | 5,7,2′-Trihydroxyflavone | [8] |
| 49 | 10.83 | C17H14O6 | 313.071 9 | 0.44 | 268.075 2, 283.026 3, 298.045 2 | 5,7-Dihydroxy-2′,8-dimethoxyflavone | [8] |
| 50 | 11.58 | C18H16O7 | 343.082 9 | 1.74 | 313.035 2, 328.065 6 | 2′,5-Dihydroxy-6,7,8-trimethoxyflavone | [8]
[12] |
| 51 | 11.68 | C17H14O6 | 313.072 6 | 2.55 | 211.038 9, 283.023 6, 298.045 2 | 5,8-Dihydroxy-6,7-dimethoxyflavone | [12] |
| 52 | 12.01 | C16H12O5 | 283.060 5 | -2.47 | 163.004 3, 267.030 7, 268.037 5 | Wogonin* | [12] |
| 53 | 12.19 | C15H12O4 | 255.067 0 | 2.74 | 151.003 2, 186.938 4, 213.055 2 | Pinocembrin | [10] |
), ArticleFig(id=1198960104079978589, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198628669116744251, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
| Compound | Regression equation | Correlation coefficient (r2) | Liner range/μg·mL-1 | LOQ/ng·mL-1 |
| Scutellarin | Y = 0.389 6X - 0.034 7 | 0.999 1 | 0.000 7-3.650 0 | 0.76 |
| Baicalin | Y = 0.232 4X - 0.012 5 | 0.998 5 | 0.000 4-1.866 2 | 0.45 |
| Wogonin | Y = 0.083 2X - 0.001 6 | 0.998 7 | 0.000 5-2.625 3 | 0.58 |
| Wogoniside | Y = 0.074 3X + 0.002 7 | 0.999 5 | 0.001 2-6.126 1 | 1.31 |
| Apigenin | Y = 0.077 1X - 0.008 3 | 0.999 1 | 0.001 0-5.144 3 | 1.09 |
| Apigenin-7-O-glucuronide | Y = 0.209 2X - 0.006 2 | 0.998 6 | 0.000 8-3.024 6 | 0.94 |
| Naringenin | Y = 0.126 4X - 0.005 7 | 0.998 8 | 0.000 7-1.050 2 | 0.78 |
| Caffeic acid | Y = 0.112 8X + 0.003 9 | 0.999 3 | 0.001 1-2.220 4 | 1.23 |
| Malic acid | Y = 0.713 3X + 0.009 2 | 0.999 0 | 0.000 9-2.357 8 | 0.98 |
| Citric acid | Y = 0.553 8X - 0.017 9 | 0.998 9 | 0.000 6-1.685 6 | 0.64 |
), ArticleFig(id=1198960104243556453, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198628669116744251, language=CN, label=Table 4, caption=
Liner range, regression equation, correlation coefficient of 10 analytes
, figureFileSmall=null, figureFileBig=null, tableContent=
| Compound | Regression equation | Correlation coefficient (r2) | Liner range/μg·mL-1 | LOQ/ng·mL-1 |
| Scutellarin | Y = 0.389 6X - 0.034 7 | 0.999 1 | 0.000 7-3.650 0 | 0.76 |
| Baicalin | Y = 0.232 4X - 0.012 5 | 0.998 5 | 0.000 4-1.866 2 | 0.45 |
| Wogonin | Y = 0.083 2X - 0.001 6 | 0.998 7 | 0.000 5-2.625 3 | 0.58 |
| Wogoniside | Y = 0.074 3X + 0.002 7 | 0.999 5 | 0.001 2-6.126 1 | 1.31 |
| Apigenin | Y = 0.077 1X - 0.008 3 | 0.999 1 | 0.001 0-5.144 3 | 1.09 |
| Apigenin-7-O-glucuronide | Y = 0.209 2X - 0.006 2 | 0.998 6 | 0.000 8-3.024 6 | 0.94 |
| Naringenin | Y = 0.126 4X - 0.005 7 | 0.998 8 | 0.000 7-1.050 2 | 0.78 |
| Caffeic acid | Y = 0.112 8X + 0.003 9 | 0.999 3 | 0.001 1-2.220 4 | 1.23 |
| Malic acid | Y = 0.713 3X + 0.009 2 | 0.999 0 | 0.000 9-2.357 8 | 0.98 |
| Citric acid | Y = 0.553 8X - 0.017 9 | 0.998 9 | 0.000 6-1.685 6 | 0.64 |
), ArticleFig(id=1198960104470048885, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198628669116744251, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
| Compound | Precision RSD/% | Stability RSD/% | Repeatability RSD/% | Recovery |
| Intra-day | Inter-day | Mean/% | RSD/% |
| Scutellarin | 1.65 | 1.33 | 1.42 | 1.38 | 100.02 | 2.11 |
| Baicalin | 1.39 | 1.45 | 1.85 | 1.05 | 99.84 | 2.78 |
| Wogonin | 1.07 | 1.32 | 1.74 | 1.12 | 101.09 | 1.63 |
| Wogoniside | 3.11 | 3.20 | 5.14 | 5.35 | 107.24 | 2.94 |
| Apigenin | 1.77 | 1.86 | 2.31 | 2.90 | 104.26 | 2.63 |
| Apigenin-7-O-glucuronide | 1.31 | 1.56 | 1.47 | 1.87 | 102.56 | 2.87 |
| Naringenin | 1.86 | 1.56 | 3.38 | 3.53 | 99.42 | 1.98 |
| Caffeic acid | 3.19 | 2.98 | 2.94 | 3.91 | 102.81 | 2.50 |
| Malic acid | 1.62 | 1.48 | 1.08 | 1.43 | 103.45 | 1.79 |
| Citric acid | 1.44 | 1.53 | 1.77 | 1.95 | 106.53 | 2.92 |
), ArticleFig(id=1198960104713318528, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1198628669116744251, language=CN, label=Table 5, caption=
The precision, stability, repeatability and recovery of 10 analytes (n = 6).
, figureFileSmall=null, figureFileBig=null, tableContent=
| Compound | Precision RSD/% | Stability RSD/% | Repeatability RSD/% | Recovery |
| Intra-day | Inter-day | Mean/% | RSD/% |
| Scutellarin | 1.65 | 1.33 | 1.42 | 1.38 | 100.02 | 2.11 |
| Baicalin | 1.39 | 1.45 | 1.85 | 1.05 | 99.84 | 2.78 |
| Wogonin | 1.07 | 1.32 | 1.74 | 1.12 | 101.09 | 1.63 |
| Wogoniside | 3.11 | 3.20 | 5.14 | 5.35 | 107.24 | 2.94 |
| Apigenin | 1.77 | 1.86 | 2.31 | 2.90 | 104.26 | 2.63 |
| Apigenin-7-O-glucuronide | 1.31 | 1.56 | 1.47 | 1.87 | 102.56 | 2.87 |
| Naringenin | 1.86 | 1.56 | 3.38 | 3.53 | 99.42 | 1.98 |
| Caffeic acid | 3.19 | 2.98 | 2.94 | 3.91 | 102.81 | 2.50 |
| Malic acid | 1.62 | 1.48 | 1.08 | 1.43 | 103.45 | 1.79 |
| Citric acid | 1.44 | 1.53 | 1.77 | 1.95 | 106.53 | 2.92 |
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