Article(id=1208491460693963169, tenantId=1146029695717560320, journalId=1189982191388893191, issueId=1208491433888166474, articleNumber=null, orderNo=null, doi=10.16438/j.0513-4870.2021-0649, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=research-article, receivedDate=1619625600000, receivedDateStr=2021-04-29, revisedDate=1628956800000, revisedDateStr=2021-08-15, acceptedDate=null, acceptedDateStr=null, onlineDate=1766056416915, onlineDateStr=2025-12-18, pubDate=1631376000000, pubDateStr=2021-09-12, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1766056416915, onlineIssueDateStr=2025-12-18, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1766056416915, creator=13701087609, updateTime=1766056416915, updator=13701087609, issue=Issue{id=1208491433888166474, tenantId=1146029695717560320, journalId=1189982191388893191, year='2021', volume='56', issue='9', pageStart='2325', pageEnd='2596', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1766056410524, creator=13701087609, updateTime=1766137069648, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1208829742833332989, tenantId=1146029695717560320, journalId=1189982191388893191, issueId=1208491433888166474, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1208829742833332990, tenantId=1146029695717560320, journalId=1189982191388893191, issueId=1208491433888166474, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=2403, endPage=2409, ext={EN=ArticleExt(id=1208491461805453841, articleId=1208491460693963169, tenantId=1146029695717560320, journalId=1189982191388893191, language=EN, title=The mechanism of Er-xian Decoction in regulating lipid metabolism disorders on bilateral ovariectomized rats based on metabolomics study, columnId=1208491461608321532, journalTitle=Acta Pharmaceutica Sinica, columnName=Special Reports: Bioanalysis for Drug, runingTitle=null, highlight=null, articleAbstract=
Studies have shown that women's menopause caused by permanent cessation of ovarian function is closely related to lipid metabolism disorders. Er-xian Decoction has been used in the clinical treatment for gynecological diseases and has a good effect on diseases related to reduced sex hormone function. In this study, metabolomics was performed on bilateral ovariectomized model rats within 12 weeks after modeling to mimic the physiological state of menopausal women in different menopausal stages and Er-xian Decoction dosed model rats. The results of liver oil red O staining sections showed lipid metabolic disorder of bilateral ovariectomized model rats and the regulating effects of Er-xian Decoction. 46 potential biomarkers (6 steroid hormones, 3 sphingolipids, 11 phospholipids and 26 glycerides) in plasma and 32 potential biomarkers (1 steroid hormones, 20 phospholipids and 11 glycerides) in liver were obtained based on lipidomics analysis. Then, we analyzed the differential metabolic pathways and construct the lipid metabolism network significantly regulated by Er-xian Decoction. The results provided valuable information for in-depth understanding of the gradual changes on lipid metabolism disorders under menopausal conditions and the characteristics and mechanisms of compound Er-xian Decoction's regulatory effects. The study complied with the procedures established by the Animal Experiment Ethics Committee of the Institute of Materia Medica, Chinese Academy of Medical Sciences and passed the animal experiment ethics examine (No. 00000918).
, correspAuthors=Cai-sheng WU, Jin-lan ZHANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=Copyright ©2021 Acta Pharmaceutica Sinica. All rights reserved., copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, authorCompany=null, fund=null, authors=null, authorsList=Ning SHENG, Cai-hong WANG, Zhi-xin JIA, Zhe WANG, Cai-sheng WU, Jin-lan ZHANG), CN=ArticleExt(id=1208491465320280836, articleId=1208491460693963169, tenantId=1146029695717560320, journalId=1189982191388893191, language=CN, title=代谢组学探索复方二仙汤调节双侧去卵巢大鼠脂代谢紊乱特征, columnId=1208491461948060192, journalTitle=药学学报, columnName=专题报道：药物生物分析, runingTitle=null, highlight=null, articleAbstract=
卵巢功能的永久性丧失造成的妇女更年期与脂质代谢紊乱密切相关，复方二仙汤临床上用于多种妇科疾病的治疗，对与卵巢功能的永久性停止有关的疾病有良好疗效，而其作用机制尚未明确。本研究采用代谢组学技术，以双侧去卵巢模型大鼠模拟更年期妇女的生理状态，探索不同绝经阶段脂质代谢特征以及二仙汤调节更年期脂代谢紊乱可能的代谢通路和机制。结果表明，双侧去卵巢模型大鼠发生肝脂代谢异常，与对照组比较，模型组肝脏油红O染色切片发生显著性变化。与模型组比较，复方二仙汤组能显著改善肝脂代谢。动态代谢组学分析结果表明二仙汤对双侧去卵巢模型引起的脂代谢紊乱具有实时调节作用。生物统计学分析找寻得到46个(6个甾体激素、3个鞘酯、11个甘油磷脂和26个甘油酯)血浆潜在生物标志物和32个(1个甾体激素、20个甘油磷脂和11个甘油酯)肝脏潜在生物标志物。分析差异代谢通路并构建了二仙汤显著调节的脂质代谢网络，为深入了解更年期状态下脂代谢紊乱渐进变化和复方二仙汤调节作用特点和机制提供了有价值的信息。研究遵守中国医学科学院药物研究所动物实验伦理委员会制定的规程并通过动物实验伦理审查(No.00000918)。
, correspAuthors=吴彩胜, 张金兰, authorNote=null, correspAuthorsNote=
, copyrightStatement=版权所有©《药学学报》编辑部2021, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=h86Xu1Y8mv7r8KepyAdm/w==, magXml=gTzUBqr4yOJhI1O0BNy5wQ==, pdfUrl=null, pdf=aGjNMa4A+sn7b5g+xc/n5Q==, pdfFileSize=797445, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=pI9fy6RC27i8Pc2r39n6oQ==, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=yPpRcAslkEx/Ta5Z9PpDkw==, mapNumber=null, authorCompany=null, fund=null, authors=
, authorsList=生宁, 王彩虹, 贾志鑫, 王喆, 吴彩胜, 张金兰)}, authors=[Author(id=1208491465735516981, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491460693963169, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1208491465861346117, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491460693963169, authorId=1208491465735516981, language=EN, stringName=Ning SHENG, firstName=Ning, middleName=null, lastName=SHENG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1208491465978786641, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491460693963169, authorId=1208491465735516981, language=CN, stringName=生宁, firstName=宁, middleName=null, lastName=生, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
#, address=中国医学科学院、北京协和医学院药物研究所, 天然药物活性物质与功能国家重点实验室, 北京 100050, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1208491465609687845, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491460693963169, xref=null, ext=[AuthorCompanyExt(id=1208491465618076454, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491460693963169, companyId=1208491465609687845, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China), AuthorCompanyExt(id=1208491465626465063, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491460693963169, companyId=1208491465609687845, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=中国医学科学院、北京协和医学院药物研究所, 天然药物活性物质与功能国家重点实验室, 北京 100050)])]), Author(id=1208491466133975908, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491460693963169, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1208491466259805049, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491460693963169, authorId=1208491466133975908, language=EN, stringName=Cai-hong WANG, firstName=Cai-hong, middleName=null, lastName=WANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1208491466406605702, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491460693963169, authorId=1208491466133975908, language=CN, stringName=王彩虹, firstName=彩虹, middleName=null, lastName=王, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
#, address=中国医学科学院、北京协和医学院药物研究所, 天然药物活性物质与功能国家重点实验室, 北京 100050, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1208491465609687845, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491460693963169, xref=null, ext=[AuthorCompanyExt(id=1208491465618076454, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491460693963169, companyId=1208491465609687845, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China), AuthorCompanyExt(id=1208491465626465063, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491460693963169, companyId=1208491465609687845, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=中国医学科学院、北京协和医学院药物研究所, 天然药物活性物质与功能国家重点实验室, 北京 100050)])]), Author(id=1208491466586960795, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491460693963169, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1208491466696012715, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491460693963169, authorId=1208491466586960795, language=EN, stringName=Zhi-xin JIA, firstName=Zhi-xin, middleName=null, lastName=JIA, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1208491466817647547, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491460693963169, authorId=1208491466586960795, language=CN, stringName=贾志鑫, firstName=志鑫, middleName=null, lastName=贾, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=中国医学科学院、北京协和医学院药物研究所, 天然药物活性物质与功能国家重点实验室, 北京 100050, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1208491465609687845, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491460693963169, xref=null, ext=[AuthorCompanyExt(id=1208491465618076454, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491460693963169, companyId=1208491465609687845, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China), AuthorCompanyExt(id=1208491465626465063, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491460693963169, companyId=1208491465609687845, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=中国医学科学院、北京协和医学院药物研究所, 天然药物活性物质与功能国家重点实验室, 北京 100050)])]), Author(id=1208491466935088076, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491460693963169, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1208491467077694431, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491460693963169, authorId=1208491466935088076, language=EN, stringName=Zhe WANG, firstName=Zhe, middleName=null, lastName=WANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1208491467203523569, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491460693963169, authorId=1208491466935088076, language=CN, stringName=王喆, firstName=喆, middleName=null, lastName=王, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=中国医学科学院、北京协和医学院药物研究所, 天然药物活性物质与功能国家重点实验室, 北京 100050, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1208491465609687845, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491460693963169, xref=null, ext=[AuthorCompanyExt(id=1208491465618076454, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491460693963169, companyId=1208491465609687845, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China), AuthorCompanyExt(id=1208491465626465063, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491460693963169, companyId=1208491465609687845, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=中国医学科学院、北京协和医学院药物研究所, 天然药物活性物质与功能国家重点实验室, 北京 100050)])]), Author(id=1208491467341934596, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491460693963169, orderNo=4, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=wucsh@xmu.edu.cn, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1208491467471958039, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491460693963169, authorId=1208491467341934596, language=EN, stringName=Cai-sheng WU, firstName=Cai-sheng, middleName=null, lastName=WU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
*, address=State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1208491467610370089, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491460693963169, authorId=1208491467341934596, language=CN, stringName=吴彩胜, firstName=彩胜, middleName=null, lastName=吴, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
*, address=中国医学科学院、北京协和医学院药物研究所, 天然药物活性物质与功能国家重点实验室, 北京 100050, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1208491465609687845, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491460693963169, xref=null, ext=[AuthorCompanyExt(id=1208491465618076454, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491460693963169, companyId=1208491465609687845, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China), AuthorCompanyExt(id=1208491465626465063, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491460693963169, companyId=1208491465609687845, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=中国医学科学院、北京协和医学院药物研究所, 天然药物活性物质与功能国家重点实验室, 北京 100050)])]), Author(id=1208491467719422004, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491460693963169, orderNo=5, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=zhjl@imm.ac.cn, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1208491467924942916, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491460693963169, authorId=1208491467719422004, language=EN, stringName=Jin-lan ZHANG, firstName=Jin-lan, middleName=null, lastName=ZHANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
*, address=State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1208491468134658129, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491460693963169, authorId=1208491467719422004, language=CN, stringName=张金兰, firstName=金兰, middleName=null, lastName=张, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
*, address=中国医学科学院、北京协和医学院药物研究所, 天然药物活性物质与功能国家重点实验室, 北京 100050, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1208491465609687845, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491460693963169, xref=null, ext=[AuthorCompanyExt(id=1208491465618076454, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491460693963169, companyId=1208491465609687845, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China), AuthorCompanyExt(id=1208491465626465063, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491460693963169, companyId=1208491465609687845, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=中国医学科学院、北京协和医学院药物研究所, 天然药物活性物质与功能国家重点实验室, 北京 100050)])])], keywords=[Keyword(id=1208491469313257576, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491460693963169, language=EN, orderNo=1, keyword=Er-xian Decoction), Keyword(id=1208491469527167094, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491460693963169, language=EN, orderNo=2, keyword=metabolomics), Keyword(id=1208491469623636096, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491460693963169, language=EN, orderNo=3, keyword=bilateral ovariectomized model rats), Keyword(id=1208491469753659542, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491460693963169, language=EN, orderNo=4, keyword=lipid metabolism disorder), Keyword(id=1208491469871100065, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491460693963169, language=CN, orderNo=1, keyword=复方二仙汤), Keyword(id=1208491470055649458, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491460693963169, language=CN, orderNo=2, keyword=代谢组学), Keyword(id=1208491470152118459, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491460693963169, language=CN, orderNo=3, keyword=双侧去卵巢模型大鼠), Keyword(id=1208491470294724814, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491460693963169, language=CN, orderNo=4, keyword=脂代谢紊乱)], refs=[Reference(id=1208491472043749795, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491460693963169, doi=null, pmid=null, pmcid=null, year=2015, volume=14, issue=null, pageStart=59, pageEnd=64, url=null, language=null, rfNumber=[1], rfOrder=0, authorNames=Stachowiak G, Pertyński T, Pertyńska-Marczewska M, journalName=Prz Menopauzalny, refType=null, unstructuredReference=
Stachowiak G ,
Pertyński T ,
Pertyńska-Marczewska M . Metabolic disorders in menopause[J].
Prz Menopauzalny,
2015,
14: 59-64., articleTitle=Metabolic disorders in menopause, refAbstract=null), Reference(id=1208491472144413100, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491460693963169, doi=10.1210/jc.2009-2509, pmid=null, pmcid=null, year=2010, volume=95, issue=null, pageStart=s1, pageEnd=s66, url=null, language=null, rfNumber=[2], rfOrder=1, authorNames=Santen RJ, Allred DC, Ardoin SP, journalName=J Clin Endocrinol Metab, refType=null, unstructuredReference=
Santen RJ ,
Allred DC ,
Ardoin SP et al . Postmenopausal hormone therapy: an Endocrine Society scientific statement[J].
J Clin Endocrinol Metab,
2010,
95: s1-s66., articleTitle=Postmenopausal hormone therapy: an Endocrine Society scientific statement, refAbstract=null), Reference(id=1208491472299602363, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491460693963169, doi=null, pmid=null, pmcid=null, year=2011, volume=17, issue=null, pageStart=48, pageEnd=53, url=http://articles.mums.ac.ir/images/article/article_90721.pdf, language=null, rfNumber=[3], rfOrder=2, authorNames=Azizi H, Feng Liu Y, Du L, journalName=Altern Ther Health Med, refType=null, unstructuredReference=
Azizi H ,
Feng Liu Y ,
Du L et al . Menopause-related symptoms: traditional Chinese medicine vs hormone therapy[J].
Altern Ther Health Med,
2011,
17: 48-53., articleTitle=Menopause-related symptoms: traditional Chinese medicine vs hormone therapy, refAbstract=null), Reference(id=1208491472421237196, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491460693963169, doi=10.1142/S0192415X1450027X, pmid=null, pmcid=null, year=2014, volume=42, issue=null, pageStart=409, pageEnd=426, url=null, language=null, rfNumber=[4], rfOrder=3, authorNames=Wong KC, Lee KS, Luk HK, journalName=Am J Chin Med, refType=null, unstructuredReference=
Wong KC ,
Lee KS ,
Luk HK et al . Er-xian Decoction exerts estrogen-like osteoprotective effects in vivo and in vitro[J].
Am J Chin Med,
2014,
42: 409-426., articleTitle=Er-xian Decoction exerts estrogen-like osteoprotective effects in vivo and in vitro, refAbstract=null), Reference(id=1208491472530289113, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491460693963169, doi=null, pmid=null, pmcid=null, year=2017, volume=31, issue=null, pageStart=55654, pageEnd=null, url=http://www.jove.com/pdf/55654/preparation-herbal-medicine-er-xian-decoction-er-xian-containing, language=null, rfNumber=[5], rfOrder=4, authorNames=Liu S, Sun Y, Li J, journalName=J Vis Exp, refType=null, unstructuredReference=
Liu S ,
Sun Y ,
Li J et al . Preparation of herbal medicine: Er-xian Decoction and Er-xian-containing serum for
in vivo and
in vitro experiments[J].
J Vis Exp,
2017,
31: 55654., articleTitle=Preparation of herbal medicine: Er-xian Decoction and Er-xian-containing serum for
in vivo and
in vitro experiments, refAbstract=null), Reference(id=1208491473708888553, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491460693963169, doi=10.1186/s12906-018-2311-9, pmid=null, pmcid=null, year=2018, volume=18, issue=null, pageStart=245, pageEnd=null, url=null, language=null, rfNumber=[6], rfOrder=5, authorNames=Zhang Z, Xiang L, Zhao L, journalName=BMC Complement Altern Med, refType=null, unstructuredReference=
Zhang Z ,
Xiang L ,
Zhao L et al . The protective effect of Er-xian Decoction against myocardial injury in menopausal rat model[J].
BMC Complement Altern Med,
2018,
18: 245., articleTitle=The protective effect of Er-xian Decoction against myocardial injury in menopausal rat model, refAbstract=null), Reference(id=1208491473914409471, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491460693963169, doi=10.1142/S0192415X08005746, pmid=null, pmcid=null, year=2008, volume=36, issue=null, pageStart=233, pageEnd=244, url=null, language=null, rfNumber=[7], rfOrder=6, authorNames=Chen HY, Cho WC, Sze SC, journalName=Am J Chin Med, refType=null, unstructuredReference=
Chen HY ,
Cho WC ,
Sze SC et al . Treatment of menopausal symptoms with Er-xian Decoction: a systematic review[J].
Am J Chin Med,
2008,
36: 233-244., articleTitle=Treatment of menopausal symptoms with Er-xian Decoction: a systematic review, refAbstract=null), Reference(id=1208491474048627213, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491460693963169, doi=null, pmid=null, pmcid=null, year=2020, volume=55, issue=null, pageStart=2080, pageEnd=2091, url=null, language=null, rfNumber=[8], rfOrder=7, authorNames=Wang XY, Zhang J, Li Y, journalName=Acta Pharm Sin (药学学报), refType=null, unstructuredReference=
Wang XY ,
Zhang J ,
Li Y et al . Research progress on the regulation of tumor metabolism, tumor immunotherapy and new analytical methods[J].
Acta Pharm Sin (药学学报),
2020,
55: 2080-2091., articleTitle=Research progress on the regulation of tumor metabolism, tumor immunotherapy and new analytical methods, refAbstract=null), Reference(id=1208491474220593693, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491460693963169, doi=null, pmid=null, pmcid=null, year=2020, volume=55, issue=null, pageStart=941, pageEnd=949, url=http://www.researchgate.net/publication/349492488_The_mechanism_of_the_anti-depression_effect_of_the_Radix_Bupleuri-Radix_Paeoniae_Alba_herb_pair_determined_by_liver_metabolomics, language=null, rfNumber=[9], rfOrder=8, authorNames=Chen CC, Yin QC, Tian JS, journalName=Acta Pharm Sin (药学学报), refType=null, unstructuredReference=
Chen CC ,
Yin QC ,
Tian JS et al . The mechanism of the anti-depression effect of the Radix Bupleuri-Radix Paeoniae Alba herb pair determined by liver metabolomics[J].
Acta Pharm Sin (药学学报),
2020,
55: 941-949., articleTitle=The mechanism of the anti-depression effect of the Radix Bupleuri-Radix Paeoniae Alba herb pair determined by liver metabolomics, refAbstract=null), Reference(id=1208491474350617131, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491460693963169, doi=10.1002/mas.21548, pmid=null, pmcid=null, year=2019, volume=38, issue=null, pageStart=221, pageEnd=238, url=null, language=null, rfNumber=[10], rfOrder=9, authorNames=Jacob M, Lopata AL, Dasouki M, journalName=Mass Spectrom Rev, refType=null, unstructuredReference=
Jacob M ,
Lopata AL ,
Dasouki M et al . Metabolomics toward personalized medicine[J].
Mass Spectrom Rev,
2019,
38: 221-238., articleTitle=Metabolomics toward personalized medicine, refAbstract=null), Reference(id=1208491474451280442, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491460693963169, doi=10.3390/ijms12117635, pmid=null, pmcid=null, year=2011, volume=12, issue=null, pageStart=7635, pageEnd=7651, url=null, language=null, rfNumber=[11], rfOrder=10, authorNames=Xue L, Wang Y, Liu L, journalName=Int J Mol Sci, refType=null, unstructuredReference=
Xue L ,
Wang Y ,
Liu L et al . A HNMR-based metabonomics study of postmenopausal osteoporosis and intervention effects of Er-xian Decoction in ovariectomized rats[J].
Int J Mol Sci,
2011,
12: 7635-7651., articleTitle=A HNMR-based metabonomics study of postmenopausal osteoporosis and intervention effects of Er-xian Decoction in ovariectomized rats, refAbstract=null), Reference(id=1208491474585498189, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491460693963169, doi=10.1097/GME.0b013e3182825ff2, pmid=null, pmcid=null, year=2013, volume=20, issue=null, pageStart=727, pageEnd=735, url=null, language=null, rfNumber=[12], rfOrder=11, authorNames=Paramsothy P, Harlow SD, Elliott MR, journalName=Menopause, refType=null, unstructuredReference=
Paramsothy P ,
Harlow SD ,
Elliott MR et al . Classifying menopause stage by menstrual calendars and annual interviews: need for improved questionnaires[J].
Menopause,
2013,
20: 727-735., articleTitle=Classifying menopause stage by menstrual calendars and annual interviews: need for improved questionnaires, refAbstract=null), Reference(id=1208491474740687453, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491460693963169, doi=10.1021/acs.analchem.6b02201, pmid=null, pmcid=null, year=2016, volume=88, issue=null, pageStart=7878, pageEnd=7884, url=null, language=null, rfNumber=[13], rfOrder=12, authorNames=Wang C, Wu C, Zhang L, journalName=Anal Chem, refType=null, unstructuredReference=
Wang C ,
Wu C ,
Zhang L et al . Ultraperformance liquid chromatography-tandem mass spectrometry method for profiling ketolic and phenolic sex steroids using an automated injection program combined with diverter valve switch and step analysis[J].
Anal Chem,
2016,
88: 7878-7884., articleTitle=Ultraperformance liquid chromatography-tandem mass spectrometry method for profiling ketolic and phenolic sex steroids using an automated injection program combined with diverter valve switch and step analysis, refAbstract=null), Reference(id=1208491474837156457, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491460693963169, doi=10.1371/journal.pone.0052454, pmid=null, pmcid=null, year=2012, volume=7, issue=null, pageStart=e52454, pageEnd=null, url=null, language=null, rfNumber=[14], rfOrder=13, authorNames=Qu F, Wu CS, Hou JF, journalName=PLoS One, refType=null, unstructuredReference=
Qu F ,
Wu CS ,
Hou JF et al . Sphingolipids as new biomarkers for assessment of delayed-type hypersensitivity and response to triptolide[J].
PLoS One,
2012,
7: e52454., articleTitle=Sphingolipids as new biomarkers for assessment of delayed-type hypersensitivity and response to triptolide, refAbstract=null), Reference(id=1208491474954596992, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491460693963169, doi=10.1007/s00216-013-7479-8, pmid=null, pmcid=null, year=2014, volume=406, issue=null, pageStart=555, pageEnd=564, url=null, language=null, rfNumber=[15], rfOrder=14, authorNames=Qu F, Zheng SJ, Wu CS, journalName=Anal Bioanal Chem, refType=null, unstructuredReference=
Qu F ,
Zheng SJ ,
Wu CS et al . Lipidomic profiling of plasma in patients with chronic hepatitis C infection[J].
Anal Bioanal Chem,
2014,
406: 555-564., articleTitle=Lipidomic profiling of plasma in patients with chronic hepatitis C infection, refAbstract=null), Reference(id=1208491475084620427, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491460693963169, doi=10.2174/1570161116666180904094149, pmid=null, pmcid=null, year=2019, volume=17, issue=null, pageStart=595, pageEnd=603, url=null, language=null, rfNumber=[16], rfOrder=15, authorNames=Mumusoglu S, Yildiz BO, journalName=Curr Vasc Pharmacol, refType=null, unstructuredReference=
Mumusoglu S ,
Yildiz BO . Metabolic syndrome during menopause[J].
Curr Vasc Pharmacol,
2019,
17: 595-603., articleTitle=Metabolic syndrome during menopause, refAbstract=null), Reference(id=1208491475168506516, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491460693963169, doi=10.1113/EP085786, pmid=null, pmcid=null, year=2016, volume=101, issue=null, pageStart=1406, pageEnd=1417, url=null, language=null, rfNumber=[17], rfOrder=16, authorNames=Xing X, Su L, Asare PF, journalName=Exp Physiol, refType=null, unstructuredReference=
Xing X ,
Su L ,
Asare PF et al . Danzhi Qing'e (DZQE) activates AMPK pathway and regulates lipid metabolism in a rat model of perimenopausal hyperlipidaemia[J].
Exp Physiol,
2016,
101: 1406-1417., articleTitle=Danzhi Qing'e (DZQE) activates AMPK pathway and regulates lipid metabolism in a rat model of perimenopausal hyperlipidaemia, refAbstract=null), Reference(id=1208491475327890087, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491460693963169, doi=10.1016/j.lfs.2005.08.006, pmid=null, pmcid=null, year=2006, volume=78, issue=null, pageStart=1696, pageEnd=1701, url=null, language=null, rfNumber=[18], rfOrder=17, authorNames=Izumi S, Muano T, Mori A, journalName=Life Sci, refType=null, unstructuredReference=
Izumi S ,
Muano T ,
Mori A et al . Common carotid artery stiffness, cardiovascular function and lipid metabolism after menopause[J].
Life Sci,
2006,
78: 1696-1701., articleTitle=Common carotid artery stiffness, cardiovascular function and lipid metabolism after menopause, refAbstract=null)], funds=[Fund(id=1208491471926309265, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491460693963169, awardId=2016-I2M-3-010, language=CN, fundingSource=中国医学科学院医学与健康科技创新工程(2016-I2M-3-010), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1208491465609687845, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491460693963169, xref=null, ext=[AuthorCompanyExt(id=1208491465618076454, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491460693963169, companyId=1208491465609687845, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China), AuthorCompanyExt(id=1208491465626465063, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491460693963169, companyId=1208491465609687845, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=中国医学科学院、北京协和医学院药物研究所, 天然药物活性物质与功能国家重点实验室, 北京 100050)])], figs=[ArticleFig(id=1208491470458302690, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491460693963169, language=EN, label=null, caption=null, figureFileSmall=07qvukD7JkRTvOQXGXB7MQ==, figureFileBig=pI9fy6RC27i8Pc2r39n6oQ==, tableContent=null), ArticleFig(id=1208491470575743213, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491460693963169, language=CN, label=Figure 1, caption=
Oil red-O staining of liver tissues at 2 W, 4 W, and 12 W (magnification ×40). Sham: Sham operation group; OVR: Bilateral ovariectomized model group; EXD: Er-xian Decoction group; NYL: Nilestriol group , figureFileSmall=07qvukD7JkRTvOQXGXB7MQ==, figureFileBig=pI9fy6RC27i8Pc2r39n6oQ==, tableContent=null), ArticleFig(id=1208491470990979347, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491460693963169, language=EN, label=null, caption=null, figureFileSmall=ezN2Ap0x3wmhCzseg1pjxQ==, figureFileBig=BwpjCedgNx0a3dUePSjRnQ==, tableContent=null), ArticleFig(id=1208491471091642658, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491460693963169, language=CN, label=Figure 2, caption=
PCA of lipids and sex steroids at 2 week, 4 week, and 12 week in rat plasma (A) and liver (B). Each point represents a single plasma or liver sample from an individual animal, and is colored by the group , figureFileSmall=ezN2Ap0x3wmhCzseg1pjxQ==, figureFileBig=BwpjCedgNx0a3dUePSjRnQ==, tableContent=null), ArticleFig(id=1208491471192305969, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491460693963169, language=EN, label=null, caption=null, figureFileSmall=DUO+/xOmq6OAbPhNJOdAhA==, figureFileBig=3PgJUoQwzRBYk8y77a63pA==, tableContent=null), ArticleFig(id=1208491471297163587, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491460693963169, language=CN, label=Figure 3, caption=
Er-xian Decoction regulates plasma lipid metabolism disorders over time. A: A heatmap of all plasma metabolite markers with significant difference for OVR pathology and EXD treatment (<i>n</i> = 46). Fold change at 2 W, 4 W, and 12 W are shown (Cer: Ceramide; dhCer: Dihydroceramide; 4-MeOE<sub>2</sub>: 4-Methoxyestradiol; 4-OHE<sub>2</sub>: 4-Hydroxyestradiol; 17-OHPROG: Hydroxyprogesterone; PREG: Pregnenolone; 16-epiE<sub>3</sub>: 16-Epistriol; E<sub>1</sub>: Estrone; LPC: Lyso-phosphatidylcholine; PA: Phosphatidic acid; PC: Phosphatidylcholine; PS: Phosphatidylserine; DG: Diglycerides; TG: Triglycerides); B-D: Composition of plasma metabolites of which the pathology is exactly the same as, partial overlapped, and not recovered; E: Pathway enrichment analysis , figureFileSmall=DUO+/xOmq6OAbPhNJOdAhA==, figureFileBig=3PgJUoQwzRBYk8y77a63pA==, tableContent=null), ArticleFig(id=1208491471414604110, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491460693963169, language=EN, label=null, caption=null, figureFileSmall=T8UdiIVfsttBKRDKPHjG/w==, figureFileBig=HClaSEHFnH5s6QPqvWdfCg==, tableContent=null), ArticleFig(id=1208491471540433242, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491460693963169, language=CN, label=Figure 4, caption=
Er-xian Decoction regulates liver lipid metabolism disorders over time. A: A heatmap of all liver metabolite markers with significant difference for OVR pathology and EXD treatment (<i>n</i> = 32). Fold change at 2 W, 4 W, and 12 W are shown (SM: Sphingomyelin; PE: Phosphatidyl ethanolamine; PI: Phosphatidylinositol; LPI: Lyso-phosphatidylinositol); B, C: Composition of liver metabolites of which the pathology is exactly the same as and partial overlapped; D: Pathway enrichment analysis , figureFileSmall=T8UdiIVfsttBKRDKPHjG/w==, figureFileBig=HClaSEHFnH5s6QPqvWdfCg==, tableContent=null), ArticleFig(id=1208491471653679468, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491460693963169, language=EN, label=null, caption=null, figureFileSmall=Aj5D+EzJ/D+IVNflFkjtDA==, figureFileBig=8dvTCqB45vVrO8dhfQ6XdQ==, tableContent=null), ArticleFig(id=1208491471762731389, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491460693963169, language=CN, label=Figure 5, caption=
Main pathway network related to the biosynthesis and metabolism of sex steroids and lipids. The text indicates the sex steroids and lipids (black), and enzymes predicted by reverse molecular docking (red) , figureFileSmall=Aj5D+EzJ/D+IVNflFkjtDA==, figureFileBig=8dvTCqB45vVrO8dhfQ6XdQ==, tableContent=null)], attaches=null, journal=Journal(id=1189982048455397383, delFlag=0, nameCn=药学学报, nameEn=Acta Pharmaceutica Sinica, nameHistory1=null, nameHistory2=null, issn=0513-4870, eissn=null, cn=11-2163/R, coden=null, periodic=0, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=BTxjudbJDVO4PqdBR6On6Q==, journalPrice=null, startedYear=null, abbrevIsoEn=null, journalRemark=null, publicationField=null, createdTime=1761643429151, updatedTime=1761735768113, createdBy=18614031015, updatedBy=13701087609, firstLetterCn=A, firstLetterEn=A, subjectCode=Life Sciences, subjectName=Life Sciences, subjectCodeEn=Life Sciences, subjectNameEn=null, picCn=BTxjudbJDVO4PqdBR6On6Q==, picEn=c4l1ckL55nWbhl1KrFdWIA==, jcr=null, cjcr=null, exts=[JournalExt(id=1190369346338783397, language=CN, name=药学学报, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1761735768160, updatedTime=1761735768160, createdBy=13701087609, updatedBy=13701087609, submissionGuidelinesUrl=, submissionAuthorUrl=https://www.yxxb.com.cn/journalx_yxxb/authorLogOn.action, submissionEditorUrl=https://www.yxxb.com.cn/journalx_yxxb/editorLogOn.action, submissionReviewUrl=https://www.yxxb.com.cn/journalx_yxxb/expertLogOn.action, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""}), JournalExt(id=1190369346376532134, language=EN, name=Acta Pharmaceutica Sinica, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1761735768169, updatedTime=1761735768169, createdBy=13701087609, updatedBy=13701087609, submissionGuidelinesUrl=, submissionAuthorUrl=https://www.yxxb.com.cn/journalx_yxxb/authorLogOn.action, submissionEditorUrl=https://www.yxxb.com.cn/journalx_yxxb/editorLogOn.action, submissionReviewUrl=https://www.yxxb.com.cn/journalx_yxxb/expertLogOn.action, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""})], databaseList=null, tenantJournalId=1189982191388893191, websiteList=[Website(id=1189982271588340489, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1189982191388893191, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/yxxb/CN, language=CN, createTime=1761643482348, createBy=18614031015, updateTime=1761643498101, updateBy=18614031015, name=药学学报-中文, tplId=1146099689490845704, title=药学学报, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1189982873114448678, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271588340489, code=articleTextType, value=kx, createTime=1761643625763, updateTime=1761643625763, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982873093477155, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271588340489, code=banner, value=null, createTime=1761643625758, updateTime=1761643625758, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982873135420201, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271588340489, code=grayFlag, value=0, createTime=1761643625768, updateTime=1761643625768, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982873085088546, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271588340489, code=logo, value=https://castjournals.cast.org.cn/joweb/yxxb/CN/file/pic?fileId=w+t2v8bJnX5lh3+hRRJcDA==, createTime=1761643625756, updateTime=1761643625756, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982873152197419, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271588340489, code=minRunFlag, value=0, createTime=1761643625772, updateTime=1761643625772, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982873110254373, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271588340489, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/yxxb/CN/file/pic, createTime=1761643625762, updateTime=1761643625762, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982873143808810, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271588340489, code=silenceFlag, value=0, createTime=1761643625770, updateTime=1761643625770, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982873101865764, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271588340489, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1761643625760, updateTime=1761643625760, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982873122837287, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271588340489, code=themeColor, value=null, createTime=1761643625765, updateTime=1761643625765, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982873127031592, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271588340489, code=themeStyle, value=null, createTime=1761643625766, updateTime=1761643625766, creator=18614031015, updator=18614031015)]), Website(id=1189982271655449355, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1189982191388893191, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/yxxb/EN, language=EN, createTime=1761643482364, createBy=18614031015, updateTime=1761643514085, updateBy=18614031015, name=药学学报-英文, tplId=1146101810881728533, title=Acta Pharmaceutica Sinica, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1189982903015633534, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271655449355, code=articleTextType, value=kx, createTime=1761643632892, updateTime=1761643632892, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982902990467707, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271655449355, code=banner, value=null, createTime=1761643632886, updateTime=1761643632886, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982903036605057, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271655449355, code=grayFlag, value=0, createTime=1761643632897, updateTime=1761643632897, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982902982079098, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271655449355, code=logo, value=https://castjournals.cast.org.cn/joweb/yxxb/EN/file/pic?fileId=w+t2v8bJnX5lh3+hRRJcDA==, createTime=1761643632884, updateTime=1761643632884, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982903053382275, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271655449355, code=minRunFlag, value=0, createTime=1761643632901, updateTime=1761643632901, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982903007244925, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271655449355, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/yxxb/EN/file/pic, createTime=1761643632890, updateTime=1761643632890, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982903044993666, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271655449355, code=silenceFlag, value=0, createTime=1761643632899, updateTime=1761643632899, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982902998856316, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271655449355, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1761643632888, updateTime=1761643632888, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982903019827839, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271655449355, code=themeColor, value=null, createTime=1761643632893, updateTime=1761643632893, creator=18614031015, updator=18614031015), WebsiteProps(id=1189982903028216448, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189982271655449355, code=themeStyle, value=null, createTime=1761643632895, updateTime=1761643632895, creator=18614031015, updator=18614031015)])], journalTitle=药学学报, weixinUrl=null, journalUrl=https://www.yxxb.com.cn/aps, iacademicId=null, status=1, seqNo=null, journalTitleEn=Acta Pharmaceutica Sinica, journalPhotoCn=BTxjudbJDVO4PqdBR6On6Q==, journalPhotoEn=c4l1ckL55nWbhl1KrFdWIA==, journalFirstLetter=A, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false), detailUrlCn=https://castjournals.cast.org.cn/joweb/yxxb/CN/10.16438/j.0513-4870.2021-0649, detailUrlEn=https://castjournals.cast.org.cn/joweb/yxxb/EN/10.16438/j.0513-4870.2021-0649, pdfUrlCn=https://castjournals.cast.org.cn/joweb/yxxb/CN/PDF/10.16438/j.0513-4870.2021-0649, pdfUrlEn=https://castjournals.cast.org.cn/joweb/yxxb/EN/PDF/10.16438/j.0513-4870.2021-0649, aliStartDate=null, aliEndDate=null, collectionFlag=false, citedCount=null, citedUrl=null, reference=null)
全屏
文章导航
PDF下载
138
49
关闭全屏
北京市海淀区学院南路86号
010-62199257
qkjq@cast.org.cn
