Article(id=1208491440255124199, tenantId=1146029695717560320, journalId=1189982191388893191, issueId=1208491433888166474, articleNumber=null, orderNo=null, doi=10.16438/j.0513-4870.2021-0074, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=research-article, receivedDate=1610553600000, receivedDateStr=2021-01-14, revisedDate=1614700800000, revisedDateStr=2021-03-03, acceptedDate=null, acceptedDateStr=null, onlineDate=1766056412042, onlineDateStr=2025-12-18, pubDate=1631376000000, pubDateStr=2021-09-12, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1766056412042, onlineIssueDateStr=2025-12-18, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1766056412042, creator=13701087609, updateTime=1766056412042, updator=13701087609, issue=Issue{id=1208491433888166474, tenantId=1146029695717560320, journalId=1189982191388893191, year='2021', volume='56', issue='9', pageStart='2325', pageEnd='2596', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1766056410524, creator=13701087609, updateTime=1766137069648, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1208829742833332989, tenantId=1146029695717560320, journalId=1189982191388893191, issueId=1208491433888166474, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1208829742833332990, tenantId=1146029695717560320, journalId=1189982191388893191, issueId=1208491433888166474, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=2536, endPage=2543, ext={EN=ArticleExt(id=1208491440699720430, articleId=1208491440255124199, tenantId=1146029695717560320, journalId=1189982191388893191, language=EN, title=Suppression of OCT2/MRP2 decreases kidney injury and enhances the chemosensitivity of co-administration of cisplatin and astragaloside IV, columnId=1190335348761793317, journalTitle=Acta Pharmaceutica Sinica, columnName=Original Articles, runingTitle=null, highlight=null, articleAbstract=
Kidney injury and decreased chemosensitivity of tumor cells are obstacles with cisplatin (CDDP) chemotherapy. Down-regulation of the organic cation transporter 2 (OCT2) and multidrug resistance-associated protein 2 (MRP2) is a key means to alleviate CDDP-induced kidney injury and increase chemosensitivity. Astragaloside IV (AS IV) is obtained from the well-known traditional Chinese herb Astragalus membranaceus. This study explored the role of AS IV in preventing kidney injury and enhancing the antitumor effect of CDDP by suppressing OCT2 expression in kidney and MRP2 in tumors. This project was reviewed and approved by the Animal Ethics Committee of the First Hospital of Jilin University. The effects of AS IV on CDDP inhibition of tumor growth and promotion of apoptosis were assessed in Lewis lung tumor (LLC)-bearing mice by H&E and TUNEL staining. Kidney injury was assessed by serum biochemical parameters and H&E staining. We used Western blotting and immunohistochemistry assays to detect OCT2 and MRP2 expression in kidney and tumor. The concentration of CDDP in kidney and tumor was measured by HPLC-MS/MS. AS IV enhanced CDDP chemosensitivity by increasing tumor cell apoptosis and slowing tumor growth, and decreased kidney injury as evidenced by lower blood creatinine (Cr) and blood urea nitrogen (BUN). Co-administration of AS IV suppressed MRP2 overexpression induced by CDDP in tumor tissues and may be an important mechanism for enhancing CDDP chemosensitivity. Moreover, AS IV reduced CDDP-induced kidney injury in mice along with suppression of OCT2 expression in kidney. The concentration of CDDP was increased in tumor but decreased in kidney. In total, AS IV not only enhanced the antitumor effect of CDDP by suppressing MRP2 expression in tumor cells, but also decreased kidney injury induced by CDDP. The results provide new insight into the combined use of a chemotherapy drug and natural ingredients to treat cancer.
, correspAuthors=Yan-qing SONG, authorNote=null, correspAuthorsNote=null, copyrightStatement=Copyright ©2021 Acta Pharmaceutica Sinica. All rights reserved., copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, authorCompany=null, fund=null, authors=null, authorsList=Xiao-yu QU, Jing-hui ZHAI, Huan GAO, Li-na TAO, Yue-ming ZHANG, Jia-wei GONG, Yan-qing SONG), CN=ArticleExt(id=1208491444004832045, articleId=1208491440255124199, tenantId=1146029695717560320, journalId=1189982191388893191, language=CN, title=OCT2/MRP2在黄芪甲苷联合顺铂的减毒增效作用中的机制研究, columnId=1190335348896011050, journalTitle=药学学报, columnName=研究论文, runingTitle=null, highlight=null, articleAbstract=
肾损伤和肿瘤细胞化疗敏感性下降已成为顺铂（CDDP）临床应用中两个亟需解决的问题。抑制肾脏中的有机阳离子转运体2（OCT2）和肿瘤中的多药耐药相关蛋白2（MRP2）分别能够达到减轻CDDP肾损伤和增强CDDP化疗敏感性的作用。本研究考察黄芪中的代表性物质黄芪甲苷（AS IV）是否能够同时抑制肾脏中的OCT2和肿瘤中的MRP2，从而达到减轻CDDP诱导的肾损伤并增加其抗肿瘤效果的作用。本研究动物实验由吉林大学第一医院动物伦理委员会审核并批准。通过构建小鼠Lewis肺癌细胞（LLC）肿瘤荷瘤小鼠考察联合给予AS IV和CDDP对肿瘤的生长情况进行观察，并通过对肿瘤组织H&E和TUNEL染色评价肿瘤的凋亡情况。通过血清生化指标和肾脏组织H&E染色评价肾损伤情况。采用Western blotting和免疫组化染色的方法考察肾脏中OCT2和肿瘤中MRP2的蛋白表达，最后通过HPLC-MS/MS测定肾脏和肿瘤组织中CDDP的含量。结果表明，联用AS IV能够减慢肿瘤组织的增殖速度，并增强CDDP诱导的肿瘤凋亡作用。血清生化指标显示，联用AS IV后能够降低肌酐和尿素氮水平，结合H&E染色结果证明AS IV能够减轻CDDP诱导的肾损伤。其减毒增效作用可能与分别抑制肿瘤组织中MRP2和肾脏中OCT2的蛋白表达有关，并最终引起CDDP在肿瘤组织中的含量上升以及在肾脏组织的含量下降。此研究为合理的联合使用化疗药物与中草药资源提供了新的尝试。
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Li J ,
Xu Z ,
Jiang L et al . Rictor/mTORC2 protects against cisplatin-induced tubular cell death and acute kidney injury[J].
Kidney Int,
2014,
86: 86-102., articleTitle=Rictor/mTORC2 protects against cisplatin-induced tubular cell death and acute kidney injury, refAbstract=null), Reference(id=1208491452628320607, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491440255124199, doi=null, pmid=null, pmcid=null, year=2020, volume=431, issue=null, pageStart=153266, pageEnd=null, url=http://www.sciencedirect.com/science/article/pii/S0300483X20300044, language=null, rfNumber=[2], rfOrder=1, authorNames=Qu X, Gao H, Sun J, journalName=Toxicology, refType=null, unstructuredReference=
Qu X ,
Gao H ,
Sun J et al . Identification of key metabolites during cisplatin-induced acute kidney injury using an HPLC-TOF/MS-based non-targeted urine and kidney metabolomics approach in rats[J].
Toxicology,
2020,
431: 153266., articleTitle=Identification of key metabolites during cisplatin-induced acute kidney injury using an HPLC-TOF/MS-based non-targeted urine and kidney metabolomics approach in rats, refAbstract=null), Reference(id=1208491452758344048, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491440255124199, doi=10.1016/j.ctrv.2006.09.006, pmid=null, pmcid=null, year=2007, volume=33, issue=null, pageStart=9, pageEnd=23, url=null, language=null, rfNumber=[3], rfOrder=2, authorNames=Rabik CA, Dolan ME, journalName=Cancer Treat Rev, refType=null, unstructuredReference=
Rabik CA ,
Dolan ME . Molecular mechanisms of resistance and toxicity associated with platinating agents[J].
Cancer Treat Rev,
2007,
33: 9-23., articleTitle=Molecular mechanisms of resistance and toxicity associated with platinating agents, refAbstract=null), Reference(id=1208491452833841530, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491440255124199, doi=null, pmid=null, pmcid=null, year=2019, volume=12, issue=null, pageStart=1756284818821560, pageEnd=null, url=http://www.onacademic.com/detail/journal_1000041653671299_2f9c.html, language=null, rfNumber=[4], rfOrder=3, authorNames=Li N, Zhu Y, journalName=Therap Adv Gastroenterol, refType=null, unstructuredReference=
Li N ,
Zhu Y . Targeting liver cancer stem cells for the treatment of hepatocellular carcinoma[J].
Therap Adv Gastroenterol,
2019,
12: 1756284818821560., articleTitle=Targeting liver cancer stem cells for the treatment of hepatocellular carcinoma, refAbstract=null), Reference(id=1208491452951282057, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491440255124199, doi=10.1200/JOP.2017.022996, pmid=null, pmcid=null, year=2017, volume=13, issue=null, pageStart=356, pageEnd=364, url=null, language=null, rfNumber=[5], rfOrder=4, authorNames=Rich NE, Yopp AC, Singal AG, journalName=J Oncol Pract, refType=null, unstructuredReference=
Rich NE ,
Yopp AC ,
Singal AG . Medical management of hepatocellular carcinoma[J].
J Oncol Pract,
2017,
13: 356-364., articleTitle=Medical management of hepatocellular carcinoma, refAbstract=null), Reference(id=1208491453077111196, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491440255124199, doi=null, pmid=null, pmcid=null, year=2020, volume=354, issue=null, pageStart=107, pageEnd=164, url=http://www.sciencedirect.com/science/article/pii/S1937644820300058, language=null, rfNumber=[6], rfOrder=5, authorNames=Cocetta V, Ragazzi E, Montopoli M, journalName=Int Rev Cell Mol Biol, refType=null, unstructuredReference=
Cocetta V ,
Ragazzi E ,
Montopoli M . Links between cancer metabolism and cisplatin resistance[J].
Int Rev Cell Mol Biol,
2020,
354: 107-164., articleTitle=Links between cancer metabolism and cisplatin resistance, refAbstract=null), Reference(id=1208491453249077668, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491440255124199, doi=10.3389/fcell.2020.597835, pmid=null, pmcid=null, year=2020, volume=8, issue=null, pageStart=597835, pageEnd=null, url=null, language=null, rfNumber=[7], rfOrder=6, authorNames=Shimizu T, Fujii T, Sakai H, journalName=Front Cell Dev Biol, refType=null, unstructuredReference=
Shimizu T ,
Fujii T ,
Sakai H . The relationship between actin cytoskeleton and membrane transporters in cisplatin resistance of cancer cells[J].
Front Cell Dev Biol,
2020,
8: 597835., articleTitle=The relationship between actin cytoskeleton and membrane transporters in cisplatin resistance of cancer cells, refAbstract=null), Reference(id=1208491453366518192, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491440255124199, doi=10.1007/s00204-019-02557-9, pmid=null, pmcid=null, year=2019, volume=93, issue=null, pageStart=2835, pageEnd=2848, url=null, language=null, rfNumber=[8], rfOrder=7, authorNames=Hucke A, Rinschen MM, Bauer OB, journalName=Arch Toxicol, refType=null, unstructuredReference=
Hucke A ,
Rinschen MM ,
Bauer OB et al . An integrative approach to cisplatin chronic toxicities in mice reveals importance of organic cation-transporter-dependent protein networks for renoprotection[J].
Arch Toxicol,
2019,
93: 2835-2848., articleTitle=An integrative approach to cisplatin chronic toxicities in mice reveals importance of organic cation-transporter-dependent protein networks for renoprotection, refAbstract=null), Reference(id=1208491453471375808, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491440255124199, doi=10.1016/j.ejphar.2019.172883, pmid=null, pmcid=null, year=2020, volume=868, issue=null, pageStart=172883, pageEnd=null, url=null, language=null, rfNumber=[9], rfOrder=8, authorNames=Sani FV, Palizban A, Mosaffa F, journalName=Eur J Pharmacol, refType=null, unstructuredReference=
Sani FV ,
Palizban A ,
Mosaffa F et al . Glucosamine reverses drug resistance in MRP2 overexpressing ovarian cancer cells[J].
Eur J Pharmacol,
2020,
868: 172883., articleTitle=Glucosamine reverses drug resistance in MRP2 overexpressing ovarian cancer cells, refAbstract=null), Reference(id=1208491453593010639, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491440255124199, doi=null, pmid=null, pmcid=null, year=2020, volume=55, issue=null, pageStart=2043, pageEnd=2052, url=null, language=null, rfNumber=[10], rfOrder=9, authorNames=Zhao J, Li YH, Zhang XL, journalName=Acta Pharm Sin (药学学报), refType=null, unstructuredReference=
Zhao J ,
Li YH ,
Zhang XL et al . Mechanisms of cisplatin resistance and reverse strategies with traditional Chinese medicine[J].
Acta Pharm Sin (药学学报),
2020,
55: 2043-2052., articleTitle=Mechanisms of cisplatin resistance and reverse strategies with traditional Chinese medicine, refAbstract=null), Reference(id=1208491453714645471, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491440255124199, doi=null, pmid=null, pmcid=null, year=2020, volume=55, issue=null, pageStart=2398, pageEnd=2404, url=null, language=null, rfNumber=[11], rfOrder=10, authorNames=Liu AM, Mou YL, Xu ZW, journalName=Acta Pharm Sin (药学学报), refType=null, unstructuredReference=
Liu AM ,
Mou YL ,
Xu ZW et al . Astragaloside Ⅳ ameliorates hypoxia/reoxygenation injury
via regulating mitochondrial homeostasis in rat cardiomyocytes[J].
Acta Pharm Sin (药学学报),
2020,
55: 2398-2404., articleTitle=Astragaloside Ⅳ ameliorates hypoxia/reoxygenation injury
via regulating mitochondrial homeostasis in rat cardiomyocytes, refAbstract=null), Reference(id=1208491453844668909, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491440255124199, doi=10.1016/j.bcp.2020.114299, pmid=null, pmcid=null, year=2021, volume=183, issue=null, pageStart=114299, pageEnd=null, url=null, language=null, rfNumber=[12], rfOrder=11, authorNames=Song Y, Hu T, Gao H, journalName=Biochem Pharmacol, refType=null, unstructuredReference=
Song Y ,
Hu T ,
Gao H et al . Altered metabolic profiles and biomarkers associated with astragaloside Ⅳ-mediated protection against cisplatin-induced acute kidney injury in rats: an HPLC-TOF/MS-based untargeted metabolomics study[J].
Biochem Pharmacol,
2021,
183: 114299., articleTitle=Altered metabolic profiles and biomarkers associated with astragaloside Ⅳ-mediated protection against cisplatin-induced acute kidney injury in rats: an HPLC-TOF/MS-based untargeted metabolomics study, refAbstract=null), Reference(id=1208491453953720828, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491440255124199, doi=10.2174/1389557519666190320124438, pmid=null, pmcid=null, year=2019, volume=19, issue=null, pageStart=1134, pageEnd=1143, url=null, language=null, rfNumber=[13], rfOrder=12, authorNames=Ridzuan NRA, Rashid NA, Othman F, journalName=Mini Rev Med Chem, refType=null, unstructuredReference=
Ridzuan NRA ,
Rashid NA ,
Othman F et al . Protective role of natural products in cisplatin-induced nephrotoxicity[J].
Mini Rev Med Chem,
2019,
19: 1134-1143., articleTitle=Protective role of natural products in cisplatin-induced nephrotoxicity, refAbstract=null), Reference(id=1208491454108910085, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491440255124199, doi=null, pmid=null, pmcid=null, year=2019, volume=88, issue=null, pageStart=102925, pageEnd=null, url=http://www.onacademic.com/detail/journal_1000042274934999_ae95.html, language=null, rfNumber=[14], rfOrder=13, authorNames=Ghosh S, journalName=Bioorg Chem, refType=null, unstructuredReference=
Ghosh S . Cisplatin: The first metal based anticancer drug[J].
Bioorg Chem,
2019,
88: 102925., articleTitle=Cisplatin: The first metal based anticancer drug, refAbstract=null), Reference(id=1208491454222156305, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491440255124199, doi=null, pmid=null, pmcid=null, year=2019, volume=54, issue=null, pageStart=1092, pageEnd=1100, url=http://en.cnki.com.cn/Article_en/CJFDTotal-YXXB201906019.htm, language=null, rfNumber=[15], rfOrder=14, authorNames=Zhang R, Cao Q, Li K, journalName=Acta Pharm Sin (药学学报), refType=null, unstructuredReference=
Zhang R ,
Cao Q ,
Li K et al . Examination of the correlation between grades, chemical characteristics and anti-fatigue effect of Astragali Radix[J].
Acta Pharm Sin (药学学报),
2019,
54: 1092-1100., articleTitle=Examination of the correlation between grades, chemical characteristics and anti-fatigue effect of Astragali Radix, refAbstract=null), Reference(id=1208491454335402528, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491440255124199, doi=null, pmid=null, pmcid=null, year=2020, volume=55, issue=null, pageStart=930, pageEnd=940, url=null, language=null, rfNumber=[16], rfOrder=15, authorNames=Qi Y, Li X, Qin X, journalName=Acta Pharm Sin (药学学报), refType=null, unstructuredReference=
Qi Y ,
Li X ,
Qin X et al . Anti-cancer effect of the flavonoids of astragalus combined with cisplatin on Lewis lung carcinoma-bearing mice[J].
Acta Pharm Sin (药学学报),
2020,
55: 930-940., articleTitle=Anti-cancer effect of the flavonoids of astragalus combined with cisplatin on Lewis lung carcinoma-bearing mice, refAbstract=null), Reference(id=1208491454452843050, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491440255124199, doi=null, pmid=null, pmcid=null, year=2019, volume=26, issue=null, pageStart=25, pageEnd=null, url=http://www.onacademic.com/detail/journal_1000042309567199_26e6.html, language=null, rfNumber=[17], rfOrder=16, authorNames=Volarevic V, Djokovic B, Jankovic MG, journalName=J Biomed Sci, refType=null, unstructuredReference=
Volarevic V ,
Djokovic B ,
Jankovic MG et al . Molecular mechanisms of cisplatin-induced nephrotoxicity: a balance on the knife edge between renoprotection and tumor toxicity[J].
J Biomed Sci,
2019,
26: 25., articleTitle=Molecular mechanisms of cisplatin-induced nephrotoxicity: a balance on the knife edge between renoprotection and tumor toxicity, refAbstract=null), Reference(id=1208491454561894968, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491440255124199, doi=10.3389/fphys.2018.01898, pmid=null, pmcid=null, year=2019, volume=9, issue=null, pageStart=1898, pageEnd=null, url=null, language=null, rfNumber=[18], rfOrder=17, authorNames=Martinho N, Santos T, Florindo HF, journalName=Front Physiol, refType=null, unstructuredReference=
Martinho N ,
Santos T ,
Florindo HF et al . Cisplatin-membrane interactions and their influence on platinum complexes activity and toxicity[J].
Front Physiol,
2019,
9: 1898., articleTitle=Cisplatin-membrane interactions and their influence on platinum complexes activity and toxicity, refAbstract=null), Reference(id=1208491455849546315, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491440255124199, doi=10.3390/ijms21197416, pmid=null, pmcid=null, year=2020, volume=21, issue=null, pageStart=7416, pageEnd=null, url=null, language=null, rfNumber=[19], rfOrder=18, authorNames=Freitas-Lima LC, Budu A, Arruda AC, journalName=Int J Mol Sci, refType=null, unstructuredReference=
Freitas-Lima LC ,
Budu A ,
Arruda AC et al . PPAR-
α deletion attenuates cisplatin nephrotoxicity by modulating renal organic transporters MATE-1 and OCT-2[J].
Int J Mol Sci,
2020,
21: 7416., articleTitle=PPAR-
α deletion attenuates cisplatin nephrotoxicity by modulating renal organic transporters MATE-1 and OCT-2, refAbstract=null), Reference(id=1208491456143147610, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491440255124199, doi=10.1016/j.taap.2017.04.013, pmid=null, pmcid=null, year=2017, volume=326, issue=null, pageStart=15, pageEnd=24, url=null, language=null, rfNumber=[20], rfOrder=19, authorNames=Huang D, Wang C, Duan Y, journalName=Toxicol Appl Pharmacol, refType=null, unstructuredReference=
Huang D ,
Wang C ,
Duan Y et al . Targeting Oct2 and P53:formonoetin prevents cisplatin-induced acute kidney injury[J].
Toxicol Appl Pharmacol,
2017,
326: 15-24., articleTitle=Targeting Oct2 and P53:formonoetin prevents cisplatin-induced acute kidney injury, refAbstract=null), Reference(id=1208491456336085610, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491440255124199, doi=null, pmid=null, pmcid=null, year=2010, volume=23, issue=null, pageStart=965, pageEnd=972, url=http://www.spandidos-publications.com/or/23/4/965/download, language=null, rfNumber=[21], rfOrder=20, authorNames=Korita PV, Wakai T, Shirai Y, journalName=Oncol Rep, refType=null, unstructuredReference=
Korita PV ,
Wakai T ,
Shirai Y et al . Multidrug resistance-associated protein 2 determines the efficacy of cisplatin in patients with hepatocellular carcinoma[J].
Oncol Rep,
2010,
23: 965-972., articleTitle=Multidrug resistance-associated protein 2 determines the efficacy of cisplatin in patients with hepatocellular carcinoma, refAbstract=null), Reference(id=1208491456575160953, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491440255124199, doi=null, pmid=null, pmcid=null, year=2016, volume=9, issue=null, pageStart=3359, pageEnd=3368, url=http://europepmc.org/articles/PMC4898431/, language=null, rfNumber=[22], rfOrder=21, authorNames=Zhang W, Zhou H, Yu Y, journalName=Onco Targets Ther, refType=null, unstructuredReference=
Zhang W ,
Zhou H ,
Yu Y et al . Combination of gambogic acid with cisplatin enhances the antitumor effects on cisplatin-resistant lung cancer cells by downregulating MRP2 and LRP expression[J].
Onco Targets Ther,
2016,
9: 3359-3368., articleTitle=Combination of gambogic acid with cisplatin enhances the antitumor effects on cisplatin-resistant lung cancer cells by downregulating MRP2 and LRP expression, refAbstract=null)], funds=[Fund(id=1208491452296970560, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491440255124199, awardId=81803608, language=CN, fundingSource=国家自然科学基金资助项目(81803608), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1208491444302627639, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491440255124199, xref=null, ext=[AuthorCompanyExt(id=1208491444311016248, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491440255124199, companyId=1208491444302627639, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Pharmacy, the First Hospital of Jilin University, Changchun 130021, China), AuthorCompanyExt(id=1208491444319404857, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491440255124199, companyId=1208491444302627639, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=吉林大学第一医院药学部, 吉林 长春 130021)])], figs=[ArticleFig(id=1208491449306431623, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491440255124199, language=EN, label=null, caption=null, figureFileSmall=mOZQGYTk0u4AhDEqjYxw2g==, figureFileBig=WsZsRwOZHNAeZ09MRywy7A==, tableContent=null), ArticleFig(id=1208491449407094932, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491440255124199, language=CN, label=Figure 1, caption=
The chemical structure of astragaloside IV (AS IV) , figureFileSmall=mOZQGYTk0u4AhDEqjYxw2g==, figureFileBig=WsZsRwOZHNAeZ09MRywy7A==, tableContent=null), ArticleFig(id=1208491449641975977, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491440255124199, language=EN, label=null, caption=null, figureFileSmall=7E2nTzUe/p5a/iFmt2vkjw==, figureFileBig=lwOIBwsMID7PtKlwv8/cZA==, tableContent=null), ArticleFig(id=1208491449717473457, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491440255124199, language=CN, label=Figure 2, caption=
The anti-tumor effects of co-treating with CDDP and AS IV. A: The growth curves of tumor volume; B: Tumor weight; C: Tumor image; D: Body weight. <i>n</i> = 5, ± <i>s.</i> <sup>*</sup><i>P</i> < 0.05, <sup>**</sup><i>P</i> < 0.01, <sup>***</sup><i>P</i> < 0.001 , figureFileSmall=7E2nTzUe/p5a/iFmt2vkjw==, figureFileBig=lwOIBwsMID7PtKlwv8/cZA==, tableContent=null), ArticleFig(id=1208491449813942458, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491440255124199, language=EN, label=null, caption=null, figureFileSmall=jkCZ9PUyDWFz7nQq11WFBQ==, figureFileBig=KYoD3iEzPbE6I4Nk+BHL+Q==, tableContent=null), ArticleFig(id=1208491449935577289, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491440255124199, language=CN, label=Figure 3, caption=
The staining images for tumor tissue of Lewis lung tumor-bearing mice. －－－: The area of necrosis cells; ▲: Apoptosis tumor cell. Scale bar = 50 μm (200×) and 100 μm (400×) , figureFileSmall=jkCZ9PUyDWFz7nQq11WFBQ==, figureFileBig=KYoD3iEzPbE6I4Nk+BHL+Q==, tableContent=null), ArticleFig(id=1208491450065600725, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491440255124199, language=EN, label=null, caption=null, figureFileSmall=09BjPxk2hpgbXS7jcIO7LA==, figureFileBig=NuohmJeOhdSsTZdHFo13bQ==, tableContent=null), ArticleFig(id=1208491451298726117, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491440255124199, language=CN, label=Figure 4, caption=
Assessment of kidney injury in response to CDDP and AS IV. A: Serum levels of creatinine (Cr); B: Serum levels of blood urea nitrogen (BUN); C: H & E staining images of kidney. <i>n</i> = 5, ± <i>s.</i> <sup>*</sup><i>P</i> < 0.05. △: Inflammatory infiltration; ▲: Protein cast. Scale bar = 50 μm (200×) and 100 μm (400×) , figureFileSmall=09BjPxk2hpgbXS7jcIO7LA==, figureFileBig=NuohmJeOhdSsTZdHFo13bQ==, tableContent=null), ArticleFig(id=1208491451428749553, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491440255124199, language=EN, label=null, caption=null, figureFileSmall=NlbHagpEjQZIAUZj+IZPWQ==, figureFileBig=2+Jy031gHphjq5tH/fA1ZQ==, tableContent=null), ArticleFig(id=1208491451634270468, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491440255124199, language=CN, label=Figure 5, caption=
Expression levels of organic cation transporter 2 (OCT2) in response to CDDP and AS IV. A: Images of mouse kidney immunohistochemistry sections stained for OCT2 expression; B: Relative expression levels of OCT2 in mouse kidneys, as measured by Western blotting. The relative expression of OCT2 was calculated as the band intensity of OCT2 normalized to GAPDH. <i>n</i> = 3, ± <i>s.</i> <sup>**</sup><i>P</i> < 0.01, <sup>***</sup><i>P</i> < 0.001. Scale bar = 50 μm (200×) and 100 μm (400×) , figureFileSmall=NlbHagpEjQZIAUZj+IZPWQ==, figureFileBig=2+Jy031gHphjq5tH/fA1ZQ==, tableContent=null), ArticleFig(id=1208491451768488204, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491440255124199, language=EN, label=null, caption=null, figureFileSmall=MwryYtgtNts3dLUWIvNtTg==, figureFileBig=GyARJr0p2ny6LHvJsvyg7g==, tableContent=null), ArticleFig(id=1208491451869151512, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491440255124199, language=CN, label=Figure 6, caption=
Expression levels of multidrug resistance-associated protein 2 (MRP2) in response to CDDP and AS IV. A: Images of mouse tumor immunohistochemistry sections stained for MRP2 expression; B: Relative expression levels of MRP2 in mouse tumors, as measured by Western blotting. The relative expression of MRP2 was calculated as the band intensity of MRP2 normalized to GAPDH. <i>n</i> = 3, ± <i>s.</i> <sup>***</sup><i>P</i> < 0.001. Scale bar = 50 μm (200×) and 100 μm (400×) , figureFileSmall=MwryYtgtNts3dLUWIvNtTg==, figureFileBig=GyARJr0p2ny6LHvJsvyg7g==, tableContent=null), ArticleFig(id=1208491451965620514, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491440255124199, language=EN, label=null, caption=null, figureFileSmall=s+uDuC21xoi75GbvFRGK2g==, figureFileBig=1OabBQxgmyHRLEOucCPNJw==, tableContent=null), ArticleFig(id=1208491452083061039, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1208491440255124199, language=CN, label=Figure 7, caption=
The concentrations of CDDP in mouse tumors and kidneys in response to CDDP and AS IV. <i>n</i> = 5, ± <i>s.</i> <sup>*</sup><i>P</i> < 0.05 , figureFileSmall=s+uDuC21xoi75GbvFRGK2g==, figureFileBig=1OabBQxgmyHRLEOucCPNJw==, tableContent=null)], attaches=null, journal=Journal(id=1189982048455397383, delFlag=0, nameCn=药学学报, nameEn=Acta Pharmaceutica Sinica, nameHistory1=null, nameHistory2=null, issn=0513-4870, eissn=null, cn=11-2163/R, coden=null, periodic=0, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=BTxjudbJDVO4PqdBR6On6Q==, journalPrice=null, startedYear=null, abbrevIsoEn=null, journalRemark=null, publicationField=null, createdTime=1761643429151, 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