Article(id=1220364307351651045, tenantId=1146029695717560320, journalId=1189982191388893191, issueId=1220364301731287745, articleNumber=null, orderNo=null, doi=10.16438/j.0513-4870.2019-0683, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=research-article, receivedDate=1566403200000, receivedDateStr=2019-08-22, revisedDate=1569168000000, revisedDateStr=2019-09-23, acceptedDate=null, acceptedDateStr=null, onlineDate=1768887124145, onlineDateStr=2026-01-20, pubDate=1583942400000, pubDateStr=2020-03-12, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1768887124145, onlineIssueDateStr=2026-01-20, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1768887124145, creator=13701087609, updateTime=1768887124145, updator=13701087609, issue=Issue{id=1220364301731287745, tenantId=1146029695717560320, journalId=1189982191388893191, year='2020', volume='55', issue='3', pageStart='349', pageEnd='536', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1768887122805, creator=13701087609, updateTime=1768957149580, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1220658015389270676, tenantId=1146029695717560320, journalId=1189982191388893191, issueId=1220364301731287745, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1220658015389270677, tenantId=1146029695717560320, journalId=1189982191388893191, issueId=1220364301731287745, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=392, endPage=397, ext={EN=ArticleExt(id=1220364307959825140, articleId=1220364307351651045, tenantId=1146029695717560320, journalId=1189982191388893191, language=EN, title=Advances in pharmacological effects of higenamine on cardiovascular system, columnId=1190335348648547107, journalTitle=Acta Pharmaceutica Sinica, columnName=Reviews, runingTitle=null, highlight=null, articleAbstract=

Higenamine (HG) is an active cardiotonic component isolated from Aconite. Chinese and foreign scholars have done a lot of research on the metabolism and pharmacological effects of HG, which confirmed that it has cardiovascular pharmacological effects of cardiactonic action and vasodilation for the treatment of heart failure and bradycardia, anti-oxidative and anti-apoptotic effects which can be used to protect the heart and reduce heart ischemia and reperfusion injury. In addition, HG inhibits the expression of iNOS mRNA by inhibiting the activity of the transcription factor NF-κB, inhibits the lipopolysaccharide (LPS)-induced NO product, and inhibits platelet aggregation and thrombus formation, thereby improving the experimental septic shock in animals. This article reviews the recent progress in cardiovasular pharmacology of HG, which will contribute to the further development and clinical application of it in the future.

, correspAuthors=Jian-dong JIANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=Copyright ©2020 Acta Pharmaceutica Sinica. All rights reserved., copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, authorCompany=null, fund=null, authors=null, authorsList=Yu-hong WANG, Cong LI, Shuang JIANG, Jian-dong JIANG), CN=ArticleExt(id=1220364308635108111, articleId=1220364307351651045, tenantId=1146029695717560320, journalId=1189982191388893191, language=CN, title=去甲乌药碱对心血管药理作用的研究进展, columnId=1190335349655180086, journalTitle=药学学报, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

去甲乌药碱（higenamine，HG）是从附子中分离出的有效强心成分。国内外学者对HG的体内代谢和药理作用做了大量的研究，证实其对心血管系统具有多方面的作用。HG有正力性和正时性的强心作用，舒张血管的功能，用于治疗心力衰竭和心动过缓，近期已将其作为心脏负荷试验诊断药物。HG的抗氧化、抗凋亡作用可以用于保护心脏，减轻心脏缺血再灌损伤。另外，HG通过抑制转录因子NF-κB的活性，抑制iNOS mRNA的表达，抑制脂多糖（lipopolysaccharide，LPS）诱导的NO产物，对血小板聚集和血栓形成也有抑制作用。从而，对动物实验性感染性休克具有改善作用。本文综述了去甲乌药碱对心血管药理作用的研究进展，有助于该药物进一步研发及临床应用。

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