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Article(id=1222469876501958848, tenantId=1146029695717560320, journalId=1189982191388893191, issueId=1222469875008790921, articleNumber=null, orderNo=null, doi=10.16438/j.0513-4870.2019-0599, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=research-article, receivedDate=1563984000000, receivedDateStr=2019-07-25, revisedDate=1566489600000, revisedDateStr=2019-08-23, acceptedDate=null, acceptedDateStr=null, onlineDate=1769389130950, onlineDateStr=2026-01-26, pubDate=1573488000000, pubDateStr=2019-11-12, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1769389130950, onlineIssueDateStr=2026-01-26, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1769389130950, creator=13701087609, updateTime=1769389130950, updator=13701087609, issue=Issue{id=1222469875008790921, tenantId=1146029695717560320, journalId=1189982191388893191, year='2019', volume='54', issue='11', pageStart='1881', pageEnd='2140', issueExtLink='null', onlineDate='null', pubDate='1573488000000', pubDateStr='2019-11-12', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1769389130593, creator='13701087609', updateTime=1769389577080, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1222471747778109959, tenantId=1146029695717560320, journalId=1189982191388893191, issueId=1222469875008790921, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1222471747778109960, tenantId=1146029695717560320, journalId=1189982191388893191, issueId=1222469875008790921, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=2055, endPage=2058, ext={EN=ArticleExt(id=1222469877110132933, articleId=1222469876501958848, tenantId=1146029695717560320, journalId=1189982191388893191, language=EN, title=Flavonoids from the aerial parts of Lespedeza cuneata, columnId=1218263312677130587, journalTitle=Acta Pharmaceutica Sinica, columnName=Special Reports, runingTitle=null, highlight=null, articleAbstract=

The chemical constituents of the aerial parts of Lespedeza cuneata (Dum. Cour.) G. Don were investigated using chromatographic techniques, such as silica gel, reversed phase MPLC and preparative HPLC. Five compounds were isolated and their structures were elucidated by spectroscopic data and physicochemical properties, which were identified as 7-O-glucosyllaburnetin (1), kaempferol-3-O-β-D-galactopyranoside (2), kaempferol-3-O-α-L-rhamnoside (3), vitexin (4), and isovitexin (5). Among those, compound 1 is a new compound, compounds 2-3 were isolated from this plant for the first time. Compounds 1-5 were tested for their anti-ulcerative colitis activity by dual luciferase report gene assay targeting xbp1. Compared with control group, compound 1 showed a certain activity on activating the transcription of xbp1, with its relative activating ratio being 1.80 times.

, authors=null, authorsList=Jian ZHOU, Chuang-jun LI, Fang-you CHEN, Lian-qiu WU, Jie MA, Jing-zhi YANG, Dong-ming ZHANG, authorCompany=null, correspAuthors=Dong-ming ZHANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=Copyright ©2019 Acta Pharmaceutica Sinica. All rights reserved., copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1222469877764444366, articleId=1222469876501958848, tenantId=1146029695717560320, journalId=1189982191388893191, language=CN, title=截叶铁扫帚中黄酮类成分研究, columnId=1190335348896011050, journalTitle=药学学报, columnName=研究论文, runingTitle=null, highlight=null, articleAbstract=

运用硅胶柱色谱、中压液相色谱、制备液相色谱等多种色谱技术，对截叶铁扫帚70%乙醇提取物进行了分离纯化。从中分离得到了5个黄酮类化合物，根据理化性质和波谱数据鉴定为7-O-glucosyllaburnetin（1）、山柰酚-3-O-β-D-半乳糖苷（2）、山柰酚-3-O-α-L-鼠李糖苷（3）、牡荆素（4）和异牡荆素（5）。其中化合物1为新化合物，化合物2和3均为首次从截叶铁扫帚中分离得到。采用体外靶向xbp1高通量双荧光素酶报告基因药物筛选模型，对截叶铁扫帚所含主要成分进行了xbp1转录激活作用评价，结果发现化合物1具有一定的xbp1转录激活作用，其作用强度为空载体对照组的1.80倍。

, authors=null, authorsList=周健, 李创军, 陈芳有, 吴练秋, 马洁, 杨敬芝, 张东明, authorCompany=null, correspAuthors=张东明, authorNote=null, correspAuthorsNote=
*张东明, Tel: 86-10-63165702, E-mail:
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No. δH δC
2 8.43 s 154.3
3 121.1
4 180.6
5 158.8
6 111.0
7 161.7
8 6.82 s 93.1
9 155.5
10 105.9
1' 122.5
2', 6' 7.40 d (9.0) 130.2
3', 5' 6.83 d (9.0) 115.1
4' 157.5
1'' 2.88 dd (13.5, 5.0), 2.76 dd (13.0, 5.0) 28.7
2'' 4.22 m 73.6
3'' 6.77 d (8.5) 148.3
4'' 4.76 brs, 4.67 brs 109.8
5'' 1.77 s 17.3
Glc-1 4.96 d (7.0) 101.0
Glc-2 3.35 m 73.5
Glc-3 3.34 m 76.4
Glc-4 3.18 m 69.7
Glc-5 3.47 m 77.4
Glc-6 3.75 m, 4.47 m 60.7
), ArticleFig(id=1222469882239767061, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222469876501958848, language=CN, label=Table 1, caption=

1H NMR (500 MHz, DMSO-d6) and 13C NMR (125 MHz, DMSO-d6) spectral data of compound 1 (J in Hz)

, figureFileSmall=null, figureFileBig=null, tableContent=
No. δH δC
2 8.43 s 154.3
3 121.1
4 180.6
5 158.8
6 111.0
7 161.7
8 6.82 s 93.1
9 155.5
10 105.9
1' 122.5
2', 6' 7.40 d (9.0) 130.2
3', 5' 6.83 d (9.0) 115.1
4' 157.5
1'' 2.88 dd (13.5, 5.0), 2.76 dd (13.0, 5.0) 28.7
2'' 4.22 m 73.6
3'' 6.77 d (8.5) 148.3
4'' 4.76 brs, 4.67 brs 109.8
5'' 1.77 s 17.3
Glc-1 4.96 d (7.0) 101.0
Glc-2 3.35 m 73.5
Glc-3 3.34 m 76.4
Glc-4 3.18 m 69.7
Glc-5 3.47 m 77.4
Glc-6 3.75 m, 4.47 m 60.7
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截叶铁扫帚中黄酮类成分研究
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周健 1, 2 , 李创军 1 , 陈芳有 3 , 吴练秋 1 , 马洁 1 , 杨敬芝 1 , 张东明 1, *
药学学报 | 研究论文 2019,54(11): 2055-2058
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药学学报 |研究论文 2019 , 54 (11) : 2055 -2058
截叶铁扫帚中黄酮类成分研究
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周健1, 2, 李创军1, 陈芳有3, 吴练秋1, 马洁1, 杨敬芝1, 张东明1, *
作者信息
  • 1.中国医学科学院、北京协和医学院药物研究所, 天然药物活性物质与功能国家重点实验室, 北京 100050
  • 2.南昌大学第一附属医院药学部, 江西 南昌 330006
  • 3.江西中医药大学药学院, 江西 南昌 330004
通讯作者:
*张东明, Tel: 86-10-63165702, E-mail:
Flavonoids from the aerial parts of Lespedeza cuneata
Jian ZHOU1, 2, Chuang-jun LI1, Fang-you CHEN3, Lian-qiu WU1, Jie MA1, Jing-zhi YANG1, Dong-ming ZHANG1, *
Affiliations
  • 1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
  • 2. Department of Pharmacy, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China
  • 3. School of pharmacy, Jiangxi University of Traditional Chinese Medicines, Nanchang 330004, China
出版时间: 2019-11-12 doi: 10.16438/j.0513-4870.2019-0599
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摘要
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运用硅胶柱色谱、中压液相色谱、制备液相色谱等多种色谱技术，对截叶铁扫帚70%乙醇提取物进行了分离纯化。从中分离得到了5个黄酮类化合物，根据理化性质和波谱数据鉴定为7-O-glucosyllaburnetin（1）、山柰酚-3-O-β-D-半乳糖苷（2）、山柰酚-3-O-α-L-鼠李糖苷（3）、牡荆素（4）和异牡荆素（5）。其中化合物1为新化合物，化合物2和3均为首次从截叶铁扫帚中分离得到。采用体外靶向xbp1高通量双荧光素酶报告基因药物筛选模型，对截叶铁扫帚所含主要成分进行了xbp1转录激活作用评价，结果发现化合物1具有一定的xbp1转录激活作用，其作用强度为空载体对照组的1.80倍。

截叶铁扫帚  /  黄酮类成分  /  x-盒结合蛋白-1  /  转录激活

The chemical constituents of the aerial parts of Lespedeza cuneata (Dum. Cour.) G. Don were investigated using chromatographic techniques, such as silica gel, reversed phase MPLC and preparative HPLC. Five compounds were isolated and their structures were elucidated by spectroscopic data and physicochemical properties, which were identified as 7-O-glucosyllaburnetin (1), kaempferol-3-O-β-D-galactopyranoside (2), kaempferol-3-O-α-L-rhamnoside (3), vitexin (4), and isovitexin (5). Among those, compound 1 is a new compound, compounds 2-3 were isolated from this plant for the first time. Compounds 1-5 were tested for their anti-ulcerative colitis activity by dual luciferase report gene assay targeting xbp1. Compared with control group, compound 1 showed a certain activity on activating the transcription of xbp1, with its relative activating ratio being 1.80 times.

Lespedeza cuneata  /  flavonoid  /  x-box-binding protein 1  /  transcriptional activation
周健, 李创军, 陈芳有, 吴练秋, 马洁, 杨敬芝, 张东明. 截叶铁扫帚中黄酮类成分研究. 药学学报, 2019 , 54 (11) : 2055 -2058 . DOI: 10.16438/j.0513-4870.2019-0599
Jian ZHOU, Chuang-jun LI, Fang-you CHEN, Lian-qiu WU, Jie MA, Jing-zhi YANG, Dong-ming ZHANG. Flavonoids from the aerial parts of Lespedeza cuneata[J]. Acta Pharmaceutica Sinica, 2019 , 54 (11) : 2055 -2058 . DOI: 10.16438/j.0513-4870.2019-0599
正文
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截叶铁扫帚[Lespedeza cuneata (Dum.Cour.) G. Don]为豆科(Leguminosae)胡枝子属一年生草本植物, 又名夜关门, 全草入药, 在我国分布于东北、山东、江苏、浙江、江西、湖北、湖南、四川、云南、福建、广东、广西等地, 资源丰富。截叶铁扫帚味微苦, 性平, 具有补肝肾, 益肺阴, 散瘀消肿的功效[1]。目前, 从截叶铁扫帚中分离得到的化合物主要为黄酮类、酚酸类、木脂素类等化合物。现代药理研究表明, 截叶铁扫帚具有抗炎、抗氧化、抗菌、保肝、兴奋离体子宫等药理活性[2-6]。前期本课题组从截叶铁扫帚70%乙醇提取物的乙酸乙酯萃取部位分离到了一系列的木脂素、苯丙素类化合物, 并对其进行了药理活性筛选, 结果显示部分化合物具有良好的抗溃疡性结肠炎、保肝等活性[7-9]。为了拓展截叶铁扫帚化学物质基础范围, 补充和完善其生物活性研究内容, 进一步为截叶铁扫帚的开发利用提供科学依据。本实验采用硅胶柱色谱、中压液相色谱及制备高效液相色谱等多种方法从截叶铁扫帚70%乙醇提取物中分离得到5个黄酮类化合物, 利用MS、IR、UV、1D和2D NMR等波谱技术对其结构进行鉴定, 分别为7-O-glucosyllaburnetin (1)、山柰酚-3-O-β-D-半乳糖苷(2)、山柰酚-3-O-α-L-鼠李糖苷(3)、牡荆素(4)和异牡荆素(5)。其中化合物1为新化合物, 化合物2和3为首次从截叶铁扫帚中分离得到, 结构见图 1。采用特异的体外靶向xbp1高通量双荧光素酶报告基因药物筛选模型对化合物1~5进行了xbp1转录激活作用评价, 发现化合物1具有一定的xbp1转录激活作用, 其作用强度为空载体对照组的1.80倍。
结果与讨论
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1 结构鉴定
化合物1黄色粉末, [α]D20-172.5 (c 0.10, CH3OH), IR光谱显示有羟基(3 310 cm-1)、苯环(1 614和1 516 cm-1)的特征吸收峰, UV显示该化合物在MeOH溶液中的最大吸收为204、267 nm。HR-ESI-MS给出准分子离子峰m/z 539.153 1 [M+Na]+ (calcd. for C26H28NaO11, 539.152 4), 同时结合1H NMR和13C NMR图谱数据推测化合物1的分子式为C26H28O11, 不饱和度为13。化合物1的1D NMR (表 1)中δH 7.40 (2H, d, J = 9.0 Hz, H-2', 6')、6.83 (2H, d, J = 9.0 Hz, H-3', 5')为AA'BB'偶合系统的特征信号; δH 6.82 (1H, s, H-8)为芳环质子信号; 上述信息表明1结构中含有两个苯环:一个为1, 4-对位取代, 另一个为1, 2, 3, 4, 5-五取代。结合UV信息, δH 8.43 (1H, s, H-2)表明1可能为异黄酮类化合物。δH 4.76 (1H, brs, H-4''a)、4.67 (1H, brs, H-4''b)、4.22 (1H, m, H-2'')、2.88 (1H, dd, J = 5.0, 13.5 Hz, H-1''a)、2.76 (1H, dd, J = 4.0, 13.0 Hz, H-1''b)、1.77 (3H, s, H-5'')为2-羟基-3-甲基-3-丁烯基的信号。13C NMR中δC 101.0、73.5、76.4、69.7、77.4、60.7为葡萄糖片段的碳信号; δH 4.96 (1H, d, J = 7.0 Hz)表明该糖的端基氢为β型。参照文献[10], 利用酸水解的方法获得单体葡萄糖, 结合GC分析, 确定分子中的葡萄糖为D-葡萄糖构型。基于上述信息和相关文献推断, 化合物1与已知化合物laburnetin (5, 7, 4'-trihydroxy-6-(2''-hydroxy-3''-methyl-3''-butenyl) isoflavone)结构相似[11], 区别在于化合物1的C-7位连接有一个葡萄糖片段。
化合物1结构中取代基位置通过2D NMR谱图来确定的。在HMBC谱(图 2)中, H-2 (δH 8.43, 1H, s)与C4 (δC 180.6)、C5 (δC 158.8)远程相关, 进一步证明1为异黄酮类化合物; 葡萄糖的H-1 (δH 4.96)与C-7 (δC 161.7)远程相关, 证明β-D-葡萄糖连接在异黄酮母核的C-7位; 2-羟基-3-甲基-3-丁烯基团的H-1'' (δH 2.88, 2.76)与C-5 (δC 158.8)、C-7, H-2'' (δH 4.22)与C-6 (δC 111.0)远程相关, 证明2-羟基-3-甲基-3-丁烯连接在C-6位; 因此, 该化合物的结构确定为7-O-glucosyllaburnetin。
2 活性评价
采用特异的体外靶向xbp1高通量药物筛选模型对已分离鉴定的化合物进行了体外xbp1激活作用评价。研究结果表明, 化合物1对xbp1基因启动子具有一定的转录激活效应, 其作用强度为空载体对照组的1.80倍。然而, 本实验所分离的其他化合物对xbp1的转录未显示激活效应。
实验部分
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JASCO V650型紫外分光光度计, JASCO P2000型旋光仪(日本JASCO公司); Nicolet impact 5700型傅里叶变换红外光谱仪(美国Thermo Electron Corporation公司); Mercury-400核磁共振仪(美国Varian公司); BRUKER AV500-Ⅲ核磁共振仪(德国Bruker公司); Agilent 1100系列LC/MSD Trap-SL型质谱仪, Agilent 1260型高效液相色谱仪(美国安捷伦科技有限公司); Shimadzu LC-6AD型半制备液相色谱仪(日本岛津公司); YMC ODS-A C18制备柱(250 mm×20 mm, 5 μm, 日本YMC公司); Büchi中压液相制备色谱仪(瑞士布琪有限公司); 354型酶标仪(美国Thermo公司)。柱色谱硅胶(200~300目)和薄层色谱硅胶(GF254)均为青岛海洋化工厂产品。常规试剂均为分析纯。
截叶铁扫帚于2012年9月采自江西省九江市(经度115°89'87.13" ,纬度29°58'51.73'', 海拔65.6米), 经江西省九江森林植物标本馆谭策铭研究员鉴定为豆科胡枝子属植物截叶铁扫帚[Lespedeza cuneata (Dum.Cour.) G. Don]的地上部分。标本现存于江西省九江森林植物标本馆, 标本号为12675。
1 提取分离
截叶铁扫帚地上部分20 kg, 粉碎后用70%乙醇回流提取3次, 每次2 h, 过滤, 合并提取液, 减压浓缩回收溶剂后, 得70%乙醇提取物3.7 kg。将70%乙醇提取物用硅藻土拌样, 依次用石油醚、氯仿、乙酸乙酯、丙酮、95%乙醇和70%乙醇依次洗脱, 得到各个部位。其中乙酸乙酯洗脱部位(120 g)经正相硅胶柱色谱分离, CHCl3-MeOH-H2O (4:1:0.1)系统洗脱, 经薄层色谱检识, 合并相近的组分, 得7个组分(Fr.1~Fr.7)。Fr.4 (6.8 g)通过中压柱色谱柱色谱, 梯度洗脱[甲醇-水(25:75→70:30, v/v)], 得到Fr.4-1~Fr.4-20; Fr.4-10 (0.65 g)经制备液相[乙腈-水(15:85, v/v)]分离纯化得到化合物1 (17 mg)、3 (18 mg)和5 (23 mg)。Fr.6 (14.5 g)通过中压柱色谱柱色谱, 梯度洗脱[甲醇-水(20:80→75:25, v/v)], 得到Fr.6-1~Fr.6-22。Fr.6-12 (0.70 g)经半制备液相[乙腈-水(17:83, v/v)]分离纯化得到化合物2 (26 mg)和4 (12 mg)。
2 结果鉴定
化合物1  黄色粉末; [α]D20-172.5 (c 0.10, CH3OH); UV (MeOH) λmax (log ε): 204 (4.56)、267 (4.58) nm; IR (microscope) νmax: 3 310、2 917、1 649、1 614、1 516、1 450、1 372、1 262、1 019、953、841 cm-1; HR-ESI-MS m/z 539.153 1 [M+Na]+ (calcd. for C26H28NaO11, 539.152 4)。1H NMR (DMSO-d6, 500 MHz)和13C NMR (DMSO-d6, 125 MHz)数据见表 1。
化合物2  黄色粉末; ESI-MS m/z 471 [M+Na]+, 919 [2M+Na]+; 1H NMR (DMSO-d6, 400 MHz) δH: 8.05 (2H, d, J = 8.8 Hz, H-2', 6'), 6.85 (2H, d, J = 8.8 Hz, H-3', 5'), 6.35 (1H, brs, H-8), 6.13 (1H, brs, H-6), 5.37 (1H, d, J = 7.6 Hz, H-1'')。13C NMR (DMSO-d6, 125 MHz) δC: 156.5 (C-2), 133.1 (C-3), 177.2 (C-4), 160.0 (C-5), 99.2 (C-6), 161.1 (C-7), 93.9 (C-8), 156.0 (C-9), 103.2 (C-10), 120.9 (C-1'), 130.9 (C-2'), 115.0 (C-3'), 160.0 (C-4'), 115.0 (C-5'), 130.9 (C-6'), 101.9 (C-1''), 71.2 (C-2''), 73.1 (C-3''), 67.9 (C-4''), 75.7 (C-5''), 60.1 (C-6'')。以上数据与文献报道的山柰酚-3-O-β-D-半乳糖苷[12]的数据一致。
化合物3  黄色粉末; ESI-MS m/z 455 [M+Na]+, 471 [M+K]+; 1H NMR (DMSO-d6, 400 MHz) δH: 7.78 (2H, d, J = 8.8 Hz, H-2', 6'), 6.91 (2H, d, J = 8.8 Hz, H-3', 5'), 6.38 (1H, brs, H-8), 6.18 (1H, brs, H-6), 5.29 (1H, brs, H-1'')。13C NMR (DMSO-d6, 125 MHz) δC: 157.0 (C-2), 134.1 (C-3), 177.6 (C-4), 161.2 (C-5), 98.9 (C-6), 165.1 (C-7), 93.8 (C-8), 156.6 (C-9), 103.8 (C-10), 120.5 (C-1'), 130.6 (C-2'), 115.4 (C-3'), 160.0 (C-4'), 115.4 (C-5'), 130.6 (C-6'), 101.8 (C-1''), 70.3 (C-2''), 70.6 (C-3''), 71.1 (C-4''), 70.1 (C-5''), 17.5 (C-6'')。以上数据与文献报道的山柰酚-3-O-α-L-鼠李糖苷[13, 14]的数据一致。
化合物4  黄色粉末; ESI-MS m/z 433 [M+H]+, 455 [M+Na]+; 1H NMR (DMSO-d6, 400 MHz) δH: 8.03 (2H, d, J = 8.5 Hz, H-2', 6'), 6.89 (2H, d, J = 8.5 Hz, H-3', 5'), 6.77 (1H, s, H-3), 6.27 (1H, s, H-6), 4.69 (1H, d, J = 9.5 Hz, H-1'')。13C NMR (DMSO-d6, 125 MHz) δC: 163.9 (C-2), 102.4 (C-3), 182.1 (C-4), 161.2 (C-5), 98.2 (C-6), 162.8 (C-7), 104.6 (C-8), 156.0 (C-9), 104.0 (C-10), 121.6 (C-1'), 129.0 (C-2'), 115.8 (C-3'), 160.4 (C-4'), 115.8 (C-5'), 129.0 (C-6'), 73.4 (C-1''), 70.9 (C-2''), 78.7 (C-3''), 70.6 (C-4''), 81.8 (C-5''), 61.3 (C-6'')。以上数据与文献报道的牡荆素[15]的数据一致。
化合物5  黄色粉末; ESI-MS m/z 455 [M+Na]+, 431 [M-H]-; 1H NMR (DMSO-d6, 400 MHz) δH: 7.90 (2H, d, J = 8.5 Hz, H-2', 6'), 6.91 (2H, d, J = 8.5 Hz, H-3', 5'), 6.73 (1H, s, H-3), 6.45 (1H, s, H-8), 4.60 (1H, d, J = 9.5 Hz, H-1'')。13C NMR (DMSO-d6, 125 MHz) δC: 163.2 (C-2), 102.8 (C-3), 181.7 (C-4), 161.3 (C-5), 109.0 (C-6), 163.2 (C-7), 93.8 (C-8), 156.5 (C-9), 103.4 (C-10), 121.0 (C-1'), 128.4 (C-2'), 116.0 (C-3'), 160.7 (C-4'), 116.0 (C-5'), 128.4 (C-6'), 73.2 (C-1''), 70.6 (C-2''), 79.0 (C-3''), 70.2 (C-4''), 81.5 (C-5''), 61.5 (C-6'')。以上数据与文献报道的异牡荆素[15]的数据一致。
3 活性筛选
将处于对数生长期的IEC-6细胞接种于48孔板中, 每孔细胞数为5×104, 使细胞在孔内均匀分散, 放置于37 ℃、5% CO2细胞培养箱培养。待细胞生长汇和至70%~80%, 对细胞进行相应质粒的转染(每孔0.6 μg), 4 h后加入1×10-5 mol·L-1各化合物与转染细胞共孵育(n = 3)。于共培养48 h后收样, 利用双荧光素酶报告基因检测试剂盒(Promega, USA)对实验样品进行报告基因荧光素酶活性检测。
基金
收起
  • 国家自然科学基金资助项目(81560632)
  • 江西省卫生计生委科技计划项目(20175135)
  • 江西省卫计委中医药科技计划项目(2017A299)
文献
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参考文献 引证文献
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2019年第54卷第11期
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doi: 10.16438/j.0513-4870.2019-0599
  • 接收时间：2019-07-25
  • 首发时间：2026-01-26
  • 出版时间：2019-11-12
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  • 收稿日期：2019-07-25
  • 修回日期：2019-08-23
基金
国家自然科学基金资助项目(81560632)
江西省卫生计生委科技计划项目(20175135)
江西省卫计委中医药科技计划项目(2017A299)
作者信息
    1.中国医学科学院、北京协和医学院药物研究所, 天然药物活性物质与功能国家重点实验室, 北京 100050
    2.南昌大学第一附属医院药学部, 江西 南昌 330006
    3.江西中医药大学药学院, 江西 南昌 330004

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2种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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