Article(id=1222467105648271959, tenantId=1146029695717560320, journalId=1189982191388893191, issueId=1222467099071603148, articleNumber=null, orderNo=null, doi=10.16438/j.0513-4870.2019-0317, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=research-article, receivedDate=1555948800000, receivedDateStr=2019-04-23, revisedDate=1557763200000, revisedDateStr=2019-05-14, acceptedDate=null, acceptedDateStr=null, onlineDate=1769388470326, onlineDateStr=2026-01-26, pubDate=1562860800000, pubDateStr=2019-07-12, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1769388470326, onlineIssueDateStr=2026-01-26, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1769388470326, creator=13701087609, updateTime=1769388470326, updator=13701087609, issue=Issue{id=1222467099071603148, tenantId=1146029695717560320, journalId=1189982191388893191, year='2019', volume='54', issue='7', pageStart='1145', pageEnd='1332', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1769388468759, creator=13701087609, updateTime=1769389451859, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1222471222554775860, tenantId=1146029695717560320, journalId=1189982191388893191, issueId=1222467099071603148, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1222471222554775861, tenantId=1146029695717560320, journalId=1189982191388893191, issueId=1222467099071603148, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=1297, endPage=1302, ext={EN=ArticleExt(id=1222467106189337196, articleId=1222467105648271959, tenantId=1146029695717560320, journalId=1189982191388893191, language=EN, title=The black phosphorus quantum dots-based photothermal effect on dendritic cells activation, columnId=1190335348761793317, journalTitle=Acta Pharmaceutica Sinica, columnName=Original Articles, runingTitle=null, highlight=null, articleAbstract=
Immunotherapy is the most active research area for cancer treatment. Tumor vaccine is one of the most developed aspects of cancer immunotherapy. Though tumor vaccine has made many breakthrough, it still faces many challenges. In this study, we coated the black phosphorus quantum dots (BPQDs) with cancer cell membrane to create a nanoparticle named BPQD-CCNVs. The BPQD-CCNVs were incubated with bone marrow-derived dendritic cells and irradiated with 808 nm infrared light. We tested the expression level of CD80, CD86 and MHC Ⅱ of dendritic cells by flow cytometry after irradiation. All animal experiments approved by the Animal Experiments Ethical Committee of Tsinghua University. The results showed that the rise of medium's temperature caused by the photothermal effect of BPQDs could upregulate the expression of CD80, CD86 and MHC-Ⅱ on dendritic cell surface. Based on these, we conclude that near infrared irradiation can stimulate the activation of dendritic cells. Our study may have provided a new strategy for tumor vaccine development.
, correspAuthors=Lin MEI, authorNote=null, correspAuthorsNote=null, copyrightStatement=Copyright ©2019 Acta Pharmaceutica Sinica. All rights reserved., copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, authorCompany=null, fund=null, authors=null, authorsList=Xin-yu YE, Lin MEI), CN=ArticleExt(id=1222467108395541236, articleId=1222467105648271959, tenantId=1146029695717560320, journalId=1189982191388893191, language=CN, title=基于黑磷量子点的光热效应在树突状细胞激活中的作用, columnId=1190335348896011050, journalTitle=药学学报, columnName=研究论文, runingTitle=null, highlight=null, articleAbstract=
癌症的免疫治疗是近年来兴起的一种治疗癌症的方法，通过人为地激活免疫系统来产生持久地杀伤肿瘤细胞的免疫反应，肿瘤疫苗是其最发达的部分之一。虽然目前肿瘤疫苗已经取得了很多突破，但仍然面临着巨大的挑战。在本研究中，采用癌细胞膜囊泡（cancer cell membrane nanovesicle，CCNVs）包裹黑磷量子点（black phosphorus quantum dots，BPQDs）制备得到负载黑磷量子点的癌细胞膜囊泡（BPQD-CCNVs），并将从小鼠骨髓中分离得到的树突状细胞与BPQD-CCNVs共同孵育，然后用808 nm近红外光对培养基照射10 min，最后用流式细胞分析仪检测树突状细胞表面分子CD80、CD86和MHC-Ⅱ的表达情况。所有动物实验均经过清华大学动物伦理委员会批准。结果表明，基于黑磷量子点的光热效应能使培养基的温度升高，刺激树突状细胞成熟，使树突状细胞表面CD80、CD86和MHC-Ⅱ的表达上调。本研究证明光热作用可以刺激树突状细胞的成熟。因此，可将光热作用引入到肿瘤疫苗中，增强肿瘤疫苗激活免疫系统的能力。
, correspAuthors=梅林, authorNote=null, correspAuthorsNote=
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(A) Transmission electron microscope image of i) single CCNV (scale bar, 100 nm), ii) single BPQD-CCNV (scale bar, 100 nm) and iii) BPQD-CCNVs. (B) Transmission electron microscope image of BPQDs (scale bar, 20 nm). CCNV: Cancer cell membrane nanovesicle; BPQD: Black phosphorus quantum dot , figureFileSmall=dnLtYFUEfG+0VxkwxyjeuA==, figureFileBig=yR+ei0Jrf6sAuYCGVoKAYA==, tableContent=null), ArticleFig(id=1222467111511908358, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222467105648271959, language=EN, label=null, caption=null, figureFileSmall=OoOVX5FbG1upLZCnzp9ECw==, figureFileBig=1qrWELloX5B+pdcDrAaE8g==, tableContent=null), ArticleFig(id=1222467111688069139, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222467105648271959, language=CN, label=Figure 2, caption=
Size distribution of BPQD-CCNVs (A). Zeta potentials of BPQDs and BPQD-CCNVs (B). <i>n</i> = 3, $\bar{x}\pm s$ , figureFileSmall=OoOVX5FbG1upLZCnzp9ECw==, figureFileBig=1qrWELloX5B+pdcDrAaE8g==, tableContent=null), ArticleFig(id=1222467111801315354, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222467105648271959, language=EN, label=null, caption=null, figureFileSmall=2Lp/RVfIQZFQc72xpg8uhw==, figureFileBig=diE28dIcb6x5lYF/kFYv5g==, tableContent=null), ArticleFig(id=1222467111901978655, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222467105648271959, language=CN, label=Figure 3, caption=
Cell viability of dendritic cells (DCs) after incubated with different formulations (A) and DCs 24 h after irradiated with 808 nm near infrared radiation (NIR) for 10 min when incubated with different formulations (B). <i>n</i> = 3, $\bar{x}\pm s$ , figureFileSmall=2Lp/RVfIQZFQc72xpg8uhw==, figureFileBig=diE28dIcb6x5lYF/kFYv5g==, tableContent=null), ArticleFig(id=1222467112002641956, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222467105648271959, language=EN, label=null, caption=null, figureFileSmall=3+lSS/DSiMXyOWC4+lxzPA==, figureFileBig=3GNZYFuRqOjCoc+V+057qg==, tableContent=null), ArticleFig(id=1222467112111693870, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222467105648271959, language=CN, label=Figure 4, caption=
Confocal images of cell uptake of BPQD-CCNVs (A) and BPQDs (B). Scale bar, 10 μm , figureFileSmall=3+lSS/DSiMXyOWC4+lxzPA==, figureFileBig=3GNZYFuRqOjCoc+V+057qg==, tableContent=null), ArticleFig(id=1222467112422072375, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222467105648271959, language=EN, label=null, caption=null, figureFileSmall=yQPP5n3i2eHGrxXI0A5rtw==, figureFileBig=W2Zt+ju22u40P4xADZpH6A==, tableContent=null), ArticleFig(id=1222467112526929981, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222467105648271959, language=CN, label=Figure 5, caption=
Time-dependent temperature increase of BPQDs and BPQD-CCNVs dispersed in phosphate buffer saline (PBS) and irradiated with 808 nm laser (1 W·cm<sup>-2</sup>) for 10 min , figureFileSmall=yQPP5n3i2eHGrxXI0A5rtw==, figureFileBig=W2Zt+ju22u40P4xADZpH6A==, tableContent=null), ArticleFig(id=1222467112623398981, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222467105648271959, language=EN, label=null, caption=null, figureFileSmall=KtTdczel1wPVNCIQFS8X4g==, figureFileBig=irCwVFi8/Sqv6T3P8IyyQw==, tableContent=null), ArticleFig(id=1222467112732450896, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222467105648271959, language=CN, label=Figure 6, caption=
Microscope image of DCs at 24 h after different treatments. The red arrow marked mature DCs. Scale bar, 25 μm , figureFileSmall=KtTdczel1wPVNCIQFS8X4g==, figureFileBig=irCwVFi8/Sqv6T3P8IyyQw==, tableContent=null), ArticleFig(id=1222467112803754071, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222467105648271959, language=EN, label=null, caption=null, figureFileSmall=n81lbItqOCrlloDRIcQ0GA==, figureFileBig=iukgbl8sZllCjYzSKk/n3w==, tableContent=null), ArticleFig(id=1222467112933777505, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222467105648271959, language=CN, label=Figure 7, caption=
Representative flow cytometry plots of CD80<sup>+</sup> CD86<sup>+</sup> DCs (gated on CD11C<sup>+</sup>) (A), CD11c<sup>+</sup> MMHC-Ⅱ<sup>+</sup> cells (gated on CD11c<sup>+</sup>) (B) from different treatment groups , figureFileSmall=n81lbItqOCrlloDRIcQ0GA==, figureFileBig=iukgbl8sZllCjYzSKk/n3w==, tableContent=null), ArticleFig(id=1222467113026052197, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222467105648271959, language=EN, label=null, caption=null, figureFileSmall=EaHZ8NNzmJn/lsErLUb+YA==, figureFileBig=SDMLlHZ1nX0GTS9gj1yHmQ==, tableContent=null), ArticleFig(id=1222467113139298413, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1222467105648271959, language=CN, label=Figure 8, caption=
Quantitative analysis of CD80<sup>+</sup> CD86<sup>+</sup> DCs (gated on CD11c<sup>+</sup> cells) (A) and CD11c<sup>+</sup> MMHC-Ⅱ<sup>+</sup> cells (B) from different groups. <i>n</i> = 3, $\bar{x}\pm s$. #1: Blank; #2: BPQD-CCNVs; #3: BPQD-CCNVs+NIR; #4: LPS. <sup>***</sup><i>P</i> < 0.001 <i>vs</i> blank group , figureFileSmall=EaHZ8NNzmJn/lsErLUb+YA==, figureFileBig=SDMLlHZ1nX0GTS9gj1yHmQ==, tableContent=null)], attaches=null, journal=Journal(id=1189982048455397383, delFlag=0, nameCn=药学学报, nameEn=Acta Pharmaceutica Sinica, nameHistory1=null, nameHistory2=null, issn=0513-4870, eissn=null, cn=11-2163/R, coden=null, periodic=0, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, 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