Article(id=1222466823665209534, tenantId=1146029695717560320, journalId=1189982191388893191, issueId=1222466818573324401, articleNumber=null, orderNo=null, doi=10.16438/j.0513-4870.2019-0061, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=research-article, receivedDate=1547654400000, receivedDateStr=2019-01-17, revisedDate=1552924800000, revisedDateStr=2019-03-19, acceptedDate=null, acceptedDateStr=null, onlineDate=1769388403096, onlineDateStr=2026-01-26, pubDate=1560268800000, pubDateStr=2019-06-12, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1769388403096, onlineIssueDateStr=2026-01-26, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1769388403096, creator=13701087609, updateTime=1769388403096, updator=13701087609, issue=Issue{id=1222466818573324401, tenantId=1146029695717560320, journalId=1189982191388893191, year='2019', volume='54', issue='6', pageStart='963', pageEnd='1144', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1769388401883, creator=13701087609, updateTime=1769389420159, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1222471089591149021, tenantId=1146029695717560320, journalId=1189982191388893191, issueId=1222466818573324401, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1222471089591149022, tenantId=1146029695717560320, journalId=1189982191388893191, issueId=1222466818573324401, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=1088, endPage=1091, ext={EN=ArticleExt(id=1222466824395018458, articleId=1222466823665209534, tenantId=1146029695717560320, journalId=1189982191388893191, language=EN, title=Pharmacokinetics of two types of dipropofol crystal tablets in Beagle dogs, columnId=1190335348761793317, journalTitle=Acta Pharmaceutica Sinica, columnName=Original Articles, runingTitle=null, highlight=null, articleAbstract=
A method for determining dipropofol in the plasma of Beagle dogs was established by HPLC-MS/MS. We also studied the pharmacokinetic characteristics of two different forms of crystal tablets of dipropofol in Beagle dogs. All animal experiments were approved by the Animal Experimental Management, Welfare and Ethics Committee of Pharmacology Evaluation Research Center, Shanghai Institute of Pharmaceutical Industry. The results indicate that the maximum plasma concentration (Cmax) of dipropofol was 69.02 ±20.16 μg·L-1 after 20 mg·kg-1 crystal form Ⅰ tablet taken orally, and the AUC0-t was 160.49 ±55.26 μg·L-1·h. After 20 mg·kg-1 crystal form Ⅱ tablet taken, the Cmax of dipropofol was 92.58 ±60.26 μg·L-1, and the AUC0-t was 243.59 ±148.36 μg·L-1·h. The AUC0-t and Cmax of crystal form Ⅱ were significantly different from that of crystal form Ⅰ (P < 0.05). Crystal form Ⅱ was the dominant crystal form. The results suggest that we should control crystal form during the development of dipropofol oral tablets.
, correspAuthors=Shu-pan GUO, authorNote=null, correspAuthorsNote=null, copyrightStatement=Copyright ©2019 Acta Pharmaceutica Sinica. All rights reserved., copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, authorCompany=null, fund=null, authors=null, authorsList=Shu-pan GUO, Ru-tao WANG, Yi ZHAO, Long AN, Sa XIAO, Yan QIN), CN=ArticleExt(id=1222466825699447098, articleId=1222466823665209534, tenantId=1146029695717560320, journalId=1189982191388893191, language=CN, title=两种晶型异丙双酚片剂的比格犬药代动力学研究, columnId=1190335348896011050, journalTitle=药学学报, columnName=研究论文, runingTitle=null, highlight=null, articleAbstract=
本研究利用HPLC-MS/MS建立了比格犬血浆中异丙双酚的测定方法，并研究了异丙双酚两种晶型片剂在比格犬体内的药代动力学特性。本研究所涉及的动物实验获得了上海医药工业研究院药理评价研究中心实验动物管理和福利、伦理委员会批准。结果显示比格犬口服异丙双酚晶型Ⅰ和Ⅱ片剂各20 mg·kg-1后，血浆中异丙双酚最大血药浓度（Cmax）分别为69.02 ±20.16和92.58 ±60.26 μg·L-1。药时曲线下面积（AUC0-t）分别为160.49 ±55.26和243.59 ±148.36 μg·L-1·h。晶型Ⅱ的AUC0-t和Cmax与晶型Ⅰ相比有显著差异（P < 0.05），晶型Ⅱ为优势晶型，提示在异丙双酚口服剂型制备时要注意晶型的控制。
, correspAuthors=郭树攀, authorNote=null, correspAuthorsNote=
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| Parameter | Crystal Ⅰ | Crystal Ⅱ |
| MRT0-t/h | 2.12 ± 0.37 | 2.15 ± 0.41 |
| CLz/F /L·h-1·kg-1 | 122.58 ± 48.30 | 96.73 ± 56.35 |
| Cmax /μg·L-1 | 69.02 ± 20.16 | 92.58 ± 60.26* |
| tmax /h | 1.33 ± 0.26 | 1.33 ± 0.41 |
| t1/2 /h | 1.64 ± 0.59 | 1.75 ± 0.58 |
| AUC0-t /μg·L-1·h | 160.49 ± 55.26 | 243.59 ± 148.36* |
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Main pharmacokinetic parameters of dipropofol crystal tablets in beagle dogs after orally administration. *P < 0.05 vs Crystal Ⅰ
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| Parameter | Crystal Ⅰ | Crystal Ⅱ |
| MRT0-t/h | 2.12 ± 0.37 | 2.15 ± 0.41 |
| CLz/F /L·h-1·kg-1 | 122.58 ± 48.30 | 96.73 ± 56.35 |
| Cmax /μg·L-1 | 69.02 ± 20.16 | 92.58 ± 60.26* |
| tmax /h | 1.33 ± 0.26 | 1.33 ± 0.41 |
| t1/2 /h | 1.64 ± 0.59 | 1.75 ± 0.58 |
| AUC0-t /μg·L-1·h | 160.49 ± 55.26 | 243.59 ± 148.36* |
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