药学学报

Herbs	Origin	Property, flavor, and channel tropism	Action and indication	Opposite effect	Corresponding indication
Notoginseng Radix et Rhizoma	Dried root and rhizome of Panax notoginseng (Burk.) F. H. Chen.	Sweet and mild bitter, warm. Liver, stomach meridians	To dissipate stasis, stanch bleeding, disperse swelling, and relieve pain. Hemoptysis, hematemesis, epistaxis, hematochezia, menstrual flooding and spotting, traumatic bleeding, stabbing pain in chest and abdomen, and swelling and pain caused by traumatic injuries	Activating blood/ stanching bleeding	Bleeding/swelling and pain caused by traumatic injuries
Panacis Quinqueflii Radix	Dried root of Panax quinquefolium L.	Sweet and mild bitter, cool. Heart, lung and kidney meridians	To tonify qi, nourish yin, clear heat and promote salivation. Deficiency of qi and yin, deficiency heat with vexation and fatigue, wheezing and cough with phlegm blood, interior heat diarrhea, dry mouth and throat	Tonify qi/clear heat	Deficiency of qi/ interior heat
Angelicae Sinensis Radix	Dried roots of Angelica sinensis (Oliv.) Diels.	Sweet and pungent, warm. Liver, heart and spleen meridians	To nourish blood, activate blood, regulate menstruation, relieve pain, moisten the intestine and relax the bowels. Blood deficiency with sallow complexion dizziness, palpitations, menstrual irregularities, amenorrhea and dysmenorrhea, abdominal pain due to deficiency-cold, arthralgia due to wind-dampness, traumatic injuries, abscesses and cellulitis, sore and ulcer, and constipation caused by intestinal dryness	Nourish blood/ activate blood	Blood deficiency/ amenorrhea
Glycyrrhizae Radix et Rhizoma	Dried root and rhizome of Glycyrrhiza uralensis Fisch., Glycyrrhiza in flate Bat. or Glycyrrhiza glabra L.	Sweet, neutral. Heart, lung, spleen and stomach meridians	To tonify spleen, tonify qi, clear heat, remove toxin, dispel phlegm, suppress cough, relax spasm, relieve pain, and harmonize the properties of different medicines. Deficiency of the spleen and stomach, fatigue, lack of strength, palpitations, shortness of breath, cough and profuse sputum, painful spasm in the stomach duct, abdomen and limbs, swelling abscess, sore, carbuncle and boil, and reducing the other drugs toxin and drastic action	Tonify qi/ clear heat	Deficiency of spleen-qi / carbuncle and boil
Astragali Radix	Dried root of Astragalus membranaceus (Fisch.) Bge. Var. mongholicus (Bge.) Hsiao or Astragalus membranaceus (Fisch.) Bge.	Sweet, mild warm. Lung, spleen meridians	To tonify qi, upraise yang, secure the exterior, stop sweating, promote urination, alleviate edema, engender fluids, nourish blood, remove stagnation, relive impediment, expel toxin and pus, promote wound healing and promote tissue regeneration. Qi deficiency and lack of strength, reduced food intake, sloppy stool, sunken middle qi, chronic diarrhea, prolapse of the rectum, bloody stool, menstrual flooding and spotting, exterior deficiency with spontaneous sweating, qi deficiency edema, interior heat wasting-thirst, blood deficiency and sallow complexion, hemiplegia, arthralgia, numbness, abscesses and cellulitis difficult to suppurate and perforate, or difficult to heal	Upraise yang/ promote urination	Descent of middle qi/ edema
Sparholobi Caulis	Dried lianoid stem of Spatholobus suberectus Dunn.	Bitter and sweet, warm. Liver and kidney meridians	To activate blood, nourish blood, regulate menstruation, relieve pain, relax sinews and activate collaterals. Menstrual irregularities, dysmenorrhea, amenorrhea, painful bi disorders caused by wind-dampness, numbness, paralysis, blood deficiency and sallow complexion	Activate blood/ nourish blood	Amenorrhea/blood deficiency
Polygoni Multiflori Radix	Dried root tuber of Polygonum multiflorum Thunb.	Bitter, sweet and astringent, mild warm. Liver, heart and kidney meridians	To remove toxin, disperse abscesses, interrupt malaria, and moisten the intestines and open the bowels. Sore and abscess, scrofula, itching caused by rubella, weak constitution caused by long-term malaria, and constipation caused by intestinal dryness	Remove toxin/ moisten the intestines	Sore and abscess/ constipation
Puerariae Lobatae Radix	Dried roots of Pueraria lobata (Willd.) Ohwi.	Sweet, pungent, cool. Spleen, and stomach, lung meridians	To release the flesh, reduce fever, engender fluid to quench thirst, promote eruption, upraise the middle qi, stop diarrhea, unblock the meridians, activate collaterals, and remove alcoholic toxin. External contraction with fever, headache, stiff and pain in a nape and neck, thirst, wasting-thirst, unerupted measles, heat dysentery, diarrhea, dizziness, headache, hemiplegia caused by wind-stroke, chest bi disorder, heart pain, and wine toxin damaging the middle	Reduce fever/ upraise the middle qi	External contraction with fever/diarrhea due to yang deficiency
Atractylodis Macrocephalae Rhizoma	Dried rhizome of Atractylodes macrocephala Koidz.	Bitter, sweet, Warm. Spleen and stomach meridians	To fortify the spleen, replenish qi, dry dampness, promote unhation, stop sweating, and prevent miscarriage. Spleen deficiency with reduced food intake abdominal distension and diarrhea, dizziness and palpitations caused by phlegm-fluid retention, edema, spontaneous sweating, and threatened miscarriage	Promote unhation/ prevent miscarriage	Edema/threatened miscarriage
Cistanches Herba	Dried fieshy stem with scales of Cistanche desertico La Y. C. Ma or Cistanche tubulosa (Schenk) Wight.	Sweet and salty, warm. Kidney and large intestine meridians	To tonify the kidney yang, replenish essence and blood, moisten the intestines and open the bowels. Deficiency of kidney yang, deficiency of essence and blood, impotence and infertility, soreness and weakness in the lower back and knees, lack of strength of sinew and bone, and constipation caused by intestinal dryness	Tonify the kidney yang/replenish essence and blood	Impotence and infertility/constipation caused by intestinal dryness
Taxilli Herba	Dried stem and branch of Taxillus chinensi (CDC.) Danser.	Bitter, sweet, neutral. Liver and kidney meridians	To dispel wind-dampness, tonify liver-kidney, strengthen sinew and bone, and prevent miscarriage. Painful bi disorder caused by wind-dampness, soreness and weakness in the low back and knees, lack of strength of sinew and bone, menstrual flooding and spotting, profuse menstruation, vaginal bleeding during pregnancy, threatened miscarriage, dizziness and vertigo	Dispel wind-dampness/tonify liver-kidney	Painful bi disorder caused by wind-dampness/threatened miscarriage
Agrimoniae Herba	Dried aerial parts of Agrimonia pilosa Ledeb.	Bitter and astringent, neutral. Heart and liver meridians	To astringe and stanch bleeding, treat malaria, relieve dysentery, remove toxin, and replenish deficiency. Hemoptysis, hematemesis, uterine bleeding, malaria, bloody dysentery, carbuncle and boil, pudendal itch, abnormal vaginal discharge, and impairment caused by overstrain	Remove toxin/ replenish deficiency	Carbuncle and boil/ impairment caused by overstrain
Siphonostegiae Herba	Dried herb of Siphonostegia chinensis Benth.	Bitter, cold. Spleen, stomach, liver and gallbladder meridians	To activate blood, and eliminate stasis, unblock the meridians, relieve pain, cool the blood, stanch bleeding, clear heat and drain dampness. Traumatic injuries, traumatic bleeding, blood-stasis amenorrhea, menstrual irregularities, postpartum stasis and pain, abdominal masses, blood dysentery, blood strangury, dampness-heat jaundice, edema, abdominal distension, and profuse white vaginal discharge	Activate blood/ stanch bleeding	Blood-stasis amenorrhea/ traumatic bleeding
Ephedra Herba	Dried grass stems of Ephedra sinica Stapf, Ephedra intermedia Schrenk et C.A. Mey. or Ephedra equisetina Bge.	Pungent, mild bitter warm. Lung and bladder meridians	To promote sweating, dissipate cold, diffuse the lung, relieve wheezing, and promote urination to alleviate edema. Common cold caused by wind-cold, manifested as oppression in the chest, wheezing and cough, and edema caused by wind. Ephedrae Herba (processed with honey) can moisten the lung to suppress cough, and can be used for wheezing and cough after relieving exterior pattern	Promote sweating/ promote urination	Exterior pattern with unsweating/ edema
Gentianae Macrophyllae Radix	Dried root of Gentiana macrophylla Pall., Gentiana straminea Maxim., Gentiana crassicaulis Duthie ex Burk. or Gentiana dahurica Fisch.	Pungent and bitter, neutral. Stomach, liver and gallbladder meridians	To dispel wind-dampness, clear dampness heat, relieve arthralgia pain, and relieve deficiency heat. Painful bi disorder caused by wind-dampness, hemiplegia caused a by wind-stroke, hypertonicity of the sinews and vessels, sore pain in joint and bone, dampness-heat jaundice, bone-steaming and tidal fever, , infantile malnutrition with retention and fever	Clear dampness heat/relieve deficiency heat	Dampness-heat jaundice/ bone-steaming and tidal fever
Catechu	Dried concentrated decoction prepared from peeled branch and stem of Aazck catechu (L.f.) Willd.	Bitter, astringent, mild cold. Lung, heart meridians	To activate blood, relieve pain, stanch bleeding, promote tissue regeneration, dispel dampness, promote wound healing, clear lung and resolve phlegm. Pain caused by traumatic injuries, traumatic bleeding, hematemesis, epistaxis, unhealed sore, ulcer, eczema and damp sore, and cough caused by lung heat.	Activate blood/ stanch bleeding	Traumatic injuries/ bleeding
Achyranthis Bidentatae Radix	Driedroots of Achyranthes bidentata Bl.	Bitter, sweet and sour, neutral. Liver and kidney meridians	To expel stasis, unblock the meridian, tonify liver kidney, strengthen sinew and bone, promote urination, relieve stranguria, and conduct blood and downward. Amenorrhea, dysmenorrhea, limp aching in the lower back and knees, lack of strength of sinew and bone, stranguria, edema, headache, dizziness, toothache, mouth sore, hematemesis, and epistaxis	Tonify liver kidney/promote urination and relieve stranguria	Lack of strength of sinew and bone/ stranguria
Plantaginis Semen	Driedripe seed of Plantago asiatica L. or Plantago depressa Willd.	Sweet, cold. Liver, kidney, lung and small intestine meridians	To clear heat, disinhibit urine, relieve stranguria, drain dampness, stop diarrhea, improve vision, and dispel phlegm. Heat strangury with chronic pain, edema distention, fullness, and diarrhea caused by summer heat-dampness, red painful swelling eyes, and phlegm-heat cough	Disinhibit urine/ stop diarrhea	Heat strangury/ dampness
Cirsii Japonici Herb (Cirsii Herba)	Driedaerial part of Cirsium japonicum Fisch.ex DC.	Sweet and bitter, cool. Heart and liver meridians	To cool the blood, stanch bleeding, dissipate stasis, remove toxin and disperse abscesses. Epistaxis, hematemesis, hematuria, blood strangury, bloody stool, menstrual flooding and spotting, traumatic bleeding, swelling abscess, sore and skin infections	Stanch bleeding/dissipate stasis	Bleeding/traumatic blood stasis
Aquilariae Lignum Resinatum	Resin containing wood of Aqui1aria sinensis (Lour.) Gilg.	Pungent and bitter, mild warm. Spleen, stomach and kidney meridians	To move qi, relieve pain, warm the middle energizer, stop vomiting, absorb qi and relieve wheezing. Distention, oppression and pain in the chest and abdomen, vomiting and hiccup caused by stomach cold, wheezing caused by qi counterflow and kidney deficiency	Move qi/absorb qi	Oppression and pain in the chest and abdomen/ wheezing caused by qi counterflow and kidney deficiency

Herbs	Origin	Property, flavor, and channel tropism	Action and indication	Opposite effect	Corresponding indication
Notoginseng Radix et Rhizoma	Dried root and rhizome of Panax notoginseng (Burk.) F. H. Chen.	Sweet and mild bitter, warm. Liver, stomach meridians	To dissipate stasis, stanch bleeding, disperse swelling, and relieve pain. Hemoptysis, hematemesis, epistaxis, hematochezia, menstrual flooding and spotting, traumatic bleeding, stabbing pain in chest and abdomen, and swelling and pain caused by traumatic injuries	Activating blood/ stanching bleeding	Bleeding/swelling and pain caused by traumatic injuries
Panacis Quinqueflii Radix	Dried root of Panax quinquefolium L.	Sweet and mild bitter, cool. Heart, lung and kidney meridians	To tonify qi, nourish yin, clear heat and promote salivation. Deficiency of qi and yin, deficiency heat with vexation and fatigue, wheezing and cough with phlegm blood, interior heat diarrhea, dry mouth and throat	Tonify qi/clear heat	Deficiency of qi/ interior heat
Angelicae Sinensis Radix	Dried roots of Angelica sinensis (Oliv.) Diels.	Sweet and pungent, warm. Liver, heart and spleen meridians	To nourish blood, activate blood, regulate menstruation, relieve pain, moisten the intestine and relax the bowels. Blood deficiency with sallow complexion dizziness, palpitations, menstrual irregularities, amenorrhea and dysmenorrhea, abdominal pain due to deficiency-cold, arthralgia due to wind-dampness, traumatic injuries, abscesses and cellulitis, sore and ulcer, and constipation caused by intestinal dryness	Nourish blood/ activate blood	Blood deficiency/ amenorrhea
Glycyrrhizae Radix et Rhizoma	Dried root and rhizome of Glycyrrhiza uralensis Fisch., Glycyrrhiza in flate Bat. or Glycyrrhiza glabra L.	Sweet, neutral. Heart, lung, spleen and stomach meridians	To tonify spleen, tonify qi, clear heat, remove toxin, dispel phlegm, suppress cough, relax spasm, relieve pain, and harmonize the properties of different medicines. Deficiency of the spleen and stomach, fatigue, lack of strength, palpitations, shortness of breath, cough and profuse sputum, painful spasm in the stomach duct, abdomen and limbs, swelling abscess, sore, carbuncle and boil, and reducing the other drugs toxin and drastic action	Tonify qi/ clear heat	Deficiency of spleen-qi / carbuncle and boil
Astragali Radix	Dried root of Astragalus membranaceus (Fisch.) Bge. Var. mongholicus (Bge.) Hsiao or Astragalus membranaceus (Fisch.) Bge.	Sweet, mild warm. Lung, spleen meridians	To tonify qi, upraise yang, secure the exterior, stop sweating, promote urination, alleviate edema, engender fluids, nourish blood, remove stagnation, relive impediment, expel toxin and pus, promote wound healing and promote tissue regeneration. Qi deficiency and lack of strength, reduced food intake, sloppy stool, sunken middle qi, chronic diarrhea, prolapse of the rectum, bloody stool, menstrual flooding and spotting, exterior deficiency with spontaneous sweating, qi deficiency edema, interior heat wasting-thirst, blood deficiency and sallow complexion, hemiplegia, arthralgia, numbness, abscesses and cellulitis difficult to suppurate and perforate, or difficult to heal	Upraise yang/ promote urination	Descent of middle qi/ edema
Sparholobi Caulis	Dried lianoid stem of Spatholobus suberectus Dunn.	Bitter and sweet, warm. Liver and kidney meridians	To activate blood, nourish blood, regulate menstruation, relieve pain, relax sinews and activate collaterals. Menstrual irregularities, dysmenorrhea, amenorrhea, painful bi disorders caused by wind-dampness, numbness, paralysis, blood deficiency and sallow complexion	Activate blood/ nourish blood	Amenorrhea/blood deficiency
Polygoni Multiflori Radix	Dried root tuber of Polygonum multiflorum Thunb.	Bitter, sweet and astringent, mild warm. Liver, heart and kidney meridians	To remove toxin, disperse abscesses, interrupt malaria, and moisten the intestines and open the bowels. Sore and abscess, scrofula, itching caused by rubella, weak constitution caused by long-term malaria, and constipation caused by intestinal dryness	Remove toxin/ moisten the intestines	Sore and abscess/ constipation
Puerariae Lobatae Radix	Dried roots of Pueraria lobata (Willd.) Ohwi.	Sweet, pungent, cool. Spleen, and stomach, lung meridians	To release the flesh, reduce fever, engender fluid to quench thirst, promote eruption, upraise the middle qi, stop diarrhea, unblock the meridians, activate collaterals, and remove alcoholic toxin. External contraction with fever, headache, stiff and pain in a nape and neck, thirst, wasting-thirst, unerupted measles, heat dysentery, diarrhea, dizziness, headache, hemiplegia caused by wind-stroke, chest bi disorder, heart pain, and wine toxin damaging the middle	Reduce fever/ upraise the middle qi	External contraction with fever/diarrhea due to yang deficiency
Atractylodis Macrocephalae Rhizoma	Dried rhizome of Atractylodes macrocephala Koidz.	Bitter, sweet, Warm. Spleen and stomach meridians	To fortify the spleen, replenish qi, dry dampness, promote unhation, stop sweating, and prevent miscarriage. Spleen deficiency with reduced food intake abdominal distension and diarrhea, dizziness and palpitations caused by phlegm-fluid retention, edema, spontaneous sweating, and threatened miscarriage	Promote unhation/ prevent miscarriage	Edema/threatened miscarriage
Cistanches Herba	Dried fieshy stem with scales of Cistanche desertico La Y. C. Ma or Cistanche tubulosa (Schenk) Wight.	Sweet and salty, warm. Kidney and large intestine meridians	To tonify the kidney yang, replenish essence and blood, moisten the intestines and open the bowels. Deficiency of kidney yang, deficiency of essence and blood, impotence and infertility, soreness and weakness in the lower back and knees, lack of strength of sinew and bone, and constipation caused by intestinal dryness	Tonify the kidney yang/replenish essence and blood	Impotence and infertility/constipation caused by intestinal dryness
Taxilli Herba	Dried stem and branch of Taxillus chinensi (CDC.) Danser.	Bitter, sweet, neutral. Liver and kidney meridians	To dispel wind-dampness, tonify liver-kidney, strengthen sinew and bone, and prevent miscarriage. Painful bi disorder caused by wind-dampness, soreness and weakness in the low back and knees, lack of strength of sinew and bone, menstrual flooding and spotting, profuse menstruation, vaginal bleeding during pregnancy, threatened miscarriage, dizziness and vertigo	Dispel wind-dampness/tonify liver-kidney	Painful bi disorder caused by wind-dampness/threatened miscarriage
Agrimoniae Herba	Dried aerial parts of Agrimonia pilosa Ledeb.	Bitter and astringent, neutral. Heart and liver meridians	To astringe and stanch bleeding, treat malaria, relieve dysentery, remove toxin, and replenish deficiency. Hemoptysis, hematemesis, uterine bleeding, malaria, bloody dysentery, carbuncle and boil, pudendal itch, abnormal vaginal discharge, and impairment caused by overstrain	Remove toxin/ replenish deficiency	Carbuncle and boil/ impairment caused by overstrain
Siphonostegiae Herba	Dried herb of Siphonostegia chinensis Benth.	Bitter, cold. Spleen, stomach, liver and gallbladder meridians	To activate blood, and eliminate stasis, unblock the meridians, relieve pain, cool the blood, stanch bleeding, clear heat and drain dampness. Traumatic injuries, traumatic bleeding, blood-stasis amenorrhea, menstrual irregularities, postpartum stasis and pain, abdominal masses, blood dysentery, blood strangury, dampness-heat jaundice, edema, abdominal distension, and profuse white vaginal discharge	Activate blood/ stanch bleeding	Blood-stasis amenorrhea/ traumatic bleeding
Ephedra Herba	Dried grass stems of Ephedra sinica Stapf, Ephedra intermedia Schrenk et C.A. Mey. or Ephedra equisetina Bge.	Pungent, mild bitter warm. Lung and bladder meridians	To promote sweating, dissipate cold, diffuse the lung, relieve wheezing, and promote urination to alleviate edema. Common cold caused by wind-cold, manifested as oppression in the chest, wheezing and cough, and edema caused by wind. Ephedrae Herba (processed with honey) can moisten the lung to suppress cough, and can be used for wheezing and cough after relieving exterior pattern	Promote sweating/ promote urination	Exterior pattern with unsweating/ edema
Gentianae Macrophyllae Radix	Dried root of Gentiana macrophylla Pall., Gentiana straminea Maxim., Gentiana crassicaulis Duthie ex Burk. or Gentiana dahurica Fisch.	Pungent and bitter, neutral. Stomach, liver and gallbladder meridians	To dispel wind-dampness, clear dampness heat, relieve arthralgia pain, and relieve deficiency heat. Painful bi disorder caused by wind-dampness, hemiplegia caused a by wind-stroke, hypertonicity of the sinews and vessels, sore pain in joint and bone, dampness-heat jaundice, bone-steaming and tidal fever, , infantile malnutrition with retention and fever	Clear dampness heat/relieve deficiency heat	Dampness-heat jaundice/ bone-steaming and tidal fever
Catechu	Dried concentrated decoction prepared from peeled branch and stem of Aazck catechu (L.f.) Willd.	Bitter, astringent, mild cold. Lung, heart meridians	To activate blood, relieve pain, stanch bleeding, promote tissue regeneration, dispel dampness, promote wound healing, clear lung and resolve phlegm. Pain caused by traumatic injuries, traumatic bleeding, hematemesis, epistaxis, unhealed sore, ulcer, eczema and damp sore, and cough caused by lung heat.	Activate blood/ stanch bleeding	Traumatic injuries/ bleeding
Achyranthis Bidentatae Radix	Driedroots of Achyranthes bidentata Bl.	Bitter, sweet and sour, neutral. Liver and kidney meridians	To expel stasis, unblock the meridian, tonify liver kidney, strengthen sinew and bone, promote urination, relieve stranguria, and conduct blood and downward. Amenorrhea, dysmenorrhea, limp aching in the lower back and knees, lack of strength of sinew and bone, stranguria, edema, headache, dizziness, toothache, mouth sore, hematemesis, and epistaxis	Tonify liver kidney/promote urination and relieve stranguria	Lack of strength of sinew and bone/ stranguria
Plantaginis Semen	Driedripe seed of Plantago asiatica L. or Plantago depressa Willd.	Sweet, cold. Liver, kidney, lung and small intestine meridians	To clear heat, disinhibit urine, relieve stranguria, drain dampness, stop diarrhea, improve vision, and dispel phlegm. Heat strangury with chronic pain, edema distention, fullness, and diarrhea caused by summer heat-dampness, red painful swelling eyes, and phlegm-heat cough	Disinhibit urine/ stop diarrhea	Heat strangury/ dampness
Cirsii Japonici Herb (Cirsii Herba)	Driedaerial part of Cirsium japonicum Fisch.ex DC.	Sweet and bitter, cool. Heart and liver meridians	To cool the blood, stanch bleeding, dissipate stasis, remove toxin and disperse abscesses. Epistaxis, hematemesis, hematuria, blood strangury, bloody stool, menstrual flooding and spotting, traumatic bleeding, swelling abscess, sore and skin infections	Stanch bleeding/dissipate stasis	Bleeding/traumatic blood stasis
Aquilariae Lignum Resinatum	Resin containing wood of Aqui1aria sinensis (Lour.) Gilg.	Pungent and bitter, mild warm. Spleen, stomach and kidney meridians	To move qi, relieve pain, warm the middle energizer, stop vomiting, absorb qi and relieve wheezing. Distention, oppression and pain in the chest and abdomen, vomiting and hiccup caused by stomach cold, wheezing caused by qi counterflow and kidney deficiency	Move qi/absorb qi	Oppression and pain in the chest and abdomen/ wheezing caused by qi counterflow and kidney deficiency

Herbs	Opposite effect	Related pharmacology research of the typical opposite effect herbs	Correlation research of opposite effect and chemical composition	Detection composition in the Chinese Pharmacopoeia 2015
Notoginseng Radix et Rhizoma	Activate blood/stanch bleeding	Yes (activate blood^[8]; stanch bleeding^[9])	Activate blood-Panax notoginseng saponins, containing more than 20 saponins^[8]; stanch bleeding-dencichine^[9]	Ginsenoside Rg_l, Rb₁ and notoginsenoside R₁
Panacis Quinqueflii Radix	Tonify qi/clear heat	Yes (tonify qi^{[10, 11]}; clear heat^[12])	Tonify qi-Ginsenoside Re^[10]; Panax polysaccharide^[11]; clear heat--neutral sugar PPQN^[12]	Ginsenoside Rg₁, Re, Rb₁
Angelicae Sinensis Radix	Nourish blood/stanch bleeding	Yes (nourish blood^[13-15]; stanch bleeding^[16])	Nourish blood-angelica polysaccharide^{[13, 14]}, ferulic acid^[15]; stanch bleeding-angelica polysaccharide and its sulfate^[16]	Ferulic acid, volatile oil
Glycyrrhizae Radix et Rhizoma	Clear heat/tonify qi	Yes (clear heat^{[17, 18]}; tonify qi^[19])	Clear heat-glycyrrhizic acid^[17]; glycyrrhetinic acid and its salts^[18]; tonify qi-glycyrrhiza polysaccharide^[19]	Liquiritin, glycyrrhizic acid
Atractylodis Macrocephalae Rhizoma	Promote unhation/prevent miscarriage	Yes (promote unhation^[20]; prevent miscarriage^[21])	N/A	N/A
Cistanches Herba	Tonify the kidney yang (yang)/replenish essence and blood (yin)	Yes (tonify the kidney yang^[22]; replenish essence and blood^[23])	Tonify the kidney yang-polysaccharide, betaine^[22]; replenish essence and blood-no.	Echinacoside, verbascoside
Taxilli Herba	Dispel wind-dampness/ tonify liver-kidney (prevent miscarriage)	Yes (tonify liver-kidney (prevent miscarriage)^[24]; prevent miscarriage^{[25, 26]})	Prevent miscarriage-no; dispel wind-dampness-total flavonoids^[25], aricularin, quercitrin^[26]	Quercetin
Siphonostegiae Herba	Activate blood/stanch bleeding	Yes (activate blood^[27]; stanch bleeding-no)	N/A	Luteolin, verbascoside
Ephedra Herba	Promote sweating/promote urination	Yes (promote sweating^{[28, 29]}; promote urination^{[30, 31]})	Promote sweating--ephedra polysaccharide^[28]; volatile oil, ephedrine^[29]; promote urination--D-pseudoephedrine^[30]; alkaloid component^[31]	Ephedrine hydrochloride, pseudoephedrine hydrochloride
Catechu	Activate blood/stanch bleeding	Yes (activate blood^[32]; stanch bleeding-no)	Activate blood-epicatechin^[32]; stanch bleeding-no	Catechin, epicatechin
Plantaginis Semen	Disinhibit urine/stop diarrhea	Yes (disinhibit urine^[33]; stop diarrhea^[34])	Disinhibit urine-no; stop diarrhea-plantago polysaccharide^[34]	Geniposidic acid, verbascoside

Herbs	Opposite effect	Related pharmacology research of the typical opposite effect herbs	Correlation research of opposite effect and chemical composition	Detection composition in the Chinese Pharmacopoeia 2015
Notoginseng Radix et Rhizoma	Activate blood/stanch bleeding	Yes (activate blood^[8]; stanch bleeding^[9])	Activate blood-Panax notoginseng saponins, containing more than 20 saponins^[8]; stanch bleeding-dencichine^[9]	Ginsenoside Rg_l, Rb₁ and notoginsenoside R₁
Panacis Quinqueflii Radix	Tonify qi/clear heat	Yes (tonify qi^{[10, 11]}; clear heat^[12])	Tonify qi-Ginsenoside Re^[10]; Panax polysaccharide^[11]; clear heat--neutral sugar PPQN^[12]	Ginsenoside Rg₁, Re, Rb₁
Angelicae Sinensis Radix	Nourish blood/stanch bleeding	Yes (nourish blood^[13-15]; stanch bleeding^[16])	Nourish blood-angelica polysaccharide^{[13, 14]}, ferulic acid^[15]; stanch bleeding-angelica polysaccharide and its sulfate^[16]	Ferulic acid, volatile oil
Glycyrrhizae Radix et Rhizoma	Clear heat/tonify qi	Yes (clear heat^{[17, 18]}; tonify qi^[19])	Clear heat-glycyrrhizic acid^[17]; glycyrrhetinic acid and its salts^[18]; tonify qi-glycyrrhiza polysaccharide^[19]	Liquiritin, glycyrrhizic acid
Atractylodis Macrocephalae Rhizoma	Promote unhation/prevent miscarriage	Yes (promote unhation^[20]; prevent miscarriage^[21])	N/A	N/A
Cistanches Herba	Tonify the kidney yang (yang)/replenish essence and blood (yin)	Yes (tonify the kidney yang^[22]; replenish essence and blood^[23])	Tonify the kidney yang-polysaccharide, betaine^[22]; replenish essence and blood-no.	Echinacoside, verbascoside
Taxilli Herba	Dispel wind-dampness/ tonify liver-kidney (prevent miscarriage)	Yes (tonify liver-kidney (prevent miscarriage)^[24]; prevent miscarriage^{[25, 26]})	Prevent miscarriage-no; dispel wind-dampness-total flavonoids^[25], aricularin, quercitrin^[26]	Quercetin
Siphonostegiae Herba	Activate blood/stanch bleeding	Yes (activate blood^[27]; stanch bleeding-no)	N/A	Luteolin, verbascoside
Ephedra Herba	Promote sweating/promote urination	Yes (promote sweating^{[28, 29]}; promote urination^{[30, 31]})	Promote sweating--ephedra polysaccharide^[28]; volatile oil, ephedrine^[29]; promote urination--D-pseudoephedrine^[30]; alkaloid component^[31]	Ephedrine hydrochloride, pseudoephedrine hydrochloride
Catechu	Activate blood/stanch bleeding	Yes (activate blood^[32]; stanch bleeding-no)	Activate blood-epicatechin^[32]; stanch bleeding-no	Catechin, epicatechin
Plantaginis Semen	Disinhibit urine/stop diarrhea	Yes (disinhibit urine^[33]; stop diarrhea^[34])	Disinhibit urine-no; stop diarrhea-plantago polysaccharide^[34]	Geniposidic acid, verbascoside

基于反向功效差异性特点的中药质量标志物研究思路—以三七为例

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药学学报 | 专题报道：中药质量与质量标志物 2019,54(2): 211-221

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药学学报 | 专题报道：中药质量与质量标志物 2019, 54(2): 211-221

基于反向功效差异性特点的中药质量标志物研究思路—以三七为例

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侯小涛¹^,²^,³^,^#, 郝二伟²^,³^,⁴^,^#, 杜正彩²^,³^,⁴, 夏中尚¹, 邓家刚²^,³^,^*, 张铁军⁵, 刘昌孝⁵^,^*

作者信息

1.广西中医药大学药学院, 广西南宁 530200

2.广西中药药效研究重点实验室, 广西南宁 530200

3.广西农作物废弃物功能成分研究协同创新中心, 广西南宁 530200

4.广西中医药大学广西中医药科学实验中心, 广西南宁 530200

5.天津药物研究院, 天津 300193

通讯作者:

*邓家刚, Tel:86-771-3137555, E-mail:dengjg53@126.com;

刘昌孝, E-mail:liuchangxiao@163.com

A hypothesis on the Q-markers based on characteristics of opposite-effect of herbs: an example of Sanqi

Xiao-tao HOU¹^,²^,³, Er-wei HAO²^,³^,⁴, Zheng-cai DU²^,³^,⁴, Zhong-shang XIA¹, Jia-gang DENG²^,³^,^*, Tie-jun ZHANG⁵, Chang-xiao LIU⁵^,^*

Affiliations

1. School of Pharmacy, Guangxi University of Chinese Medicine, Nanning 530200, China

2. Guangxi Key Laboratory of Efficacy Study on Chinese Materia Medica, Nanning 530200, China

3. Guangxi Collaborative Innovation Center of Study on Functional Ingredients of Agricultural Residues, Nanning 530200, China

4. Guangxi Scientific Experimental Center of Traditional Chinese Medicine, Guangxi University of Chinese Medicine, Nanning 530200, China

5. Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China

出版时间: 2019-02-12 doi: 10.16438/j.0513-4870.2018-0824

文章导航

摘要

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中药质量问题是现代中药研究中的一个热点问题。中药的“一物多效”的特点已被广泛接受和研究。本文提出中药反向功效是中药“一物多效”的特殊表现，并针对反向功效中药这一特殊类型，对常用中药中典型反向功效中药进行归纳，进而基于“质量标志物（Q-marker）”的研究理论，以典型的反向功效中药—三七为例，提出反向功效中药质量标志物研究的策略与方法。从中药的反向功效的差异性特点出发，通过现代药理研究手段对其相反的传统功效进行验证，开展化学物质组及其反向功效的相关性研究，确定反向功效的物质基础，进一步进行有效化学成分的作用靶点、通路等作用机制研究和化学成分的特有性分析，确定质量标志物，为对具有相反功效的一类中药进行精准质量控制提供有益的参考。

关键词

反向功效 / 质量标志物 / 三七 / 研究策略与方法

Abstract

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The quality definition of traditional Chinese medicine (TCM) is a hot area in modern research of TCM. In recent years, the characteristics of one herb with multiple effects have been widely accepted and studied. The typical opposite-effect of herbs is considered as a special part of one herb with multiple effects, and was summarized in this paper. Sanqi was used as an example of opposite-effect herbs for developing the strategies and approaches on the Q-markers. The traditional opposite-effect should be studied by modern pharmacological research methods. The correlation of the chemical components with the opposite effects should be established in order to verify the material basis and evaluate the mechanism including targets and pathways. The unique characteristics of chemical components should be analyzed and defined. Finally, the Q-markers of the opposite effect herb will be confirmed. This paper provides a useful reference for the precise quality control of herbal opposite-effects.

Key words

opposite-effect / Q-marker / Sanqi / strategies and approaches

引用本文

侯小涛, 郝二伟, 杜正彩, 夏中尚, 邓家刚, 张铁军, 刘昌孝. 基于反向功效差异性特点的中药质量标志物研究思路—以三七为例. 药学学报, 2019 , 54 (2) : 211 -221 . DOI: 10.16438/j.0513-4870.2018-0824

Xiao-tao HOU, Er-wei HAO, Zheng-cai DU, Zhong-shang XIA, Jia-gang DENG, Tie-jun ZHANG, Chang-xiao LIU. A hypothesis on the Q-markers based on characteristics of opposite-effect of herbs: an example of Sanqi[J]. Acta Pharmaceutica Sinica, 2019 , 54 (2) : 211 -221 . DOI: 10.16438/j.0513-4870.2018-0824

正文

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中药质量问题, 一直是现代中药研究中的一个热点问题。目前, 中药质量标准体系是以《中华人民共和国药典》为核心, 包括部颁标准和地方标准的一个多级标准体系。各级标准对中药(药材、饮片和制剂)的质量控制, 主要是通过控制中药中一种或者几种有效成分或特征成分的含量, 以确保这些成分在样品检验时的质量可控性和稳定性^[1]。中药是通过多靶点多通路的作用机制发挥其药效的, 这种复杂机制的化学物质基础正是中药化学成分类型的复杂性以及化学成分生物合成途径的多样性。很显然, 现有的质量标准体系需要进一步的健全和完善。刘昌孝^[2]提出“中药质量标志物(Q-marker)”这一中药产品质量控制的新概念, 指出中药效应是确定中药质量标志物(Q-marker)的基础。因此, 深入理解中药的基本属性, 进而阐明其药效及作用机制, 辨析药效物质基础, 最终明确中药质量标志物, 是中药质量控制的关键。

1 中药反向功效是中药“一物多效”的特殊表现

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一种中药具有多种功效, 不同的中药具有相同的功效, 这是中药功效认知上的普遍现象, 如人参, 既可大补元气, 复脉固脱, 用于体虚欲脱, 肢冷脉微; 又可安神益智, 用于惊悸失眠, 还可补脾益肺, 用于脾虚食少, 肺虚喘咳。又如麻黄, 既可发汗散寒, 用于风寒感冒; 又可宣肺平喘, 治疗胸闷喘咳; 还可利水消肿, 用于治疗风水浮肿。而人参、西洋参、党参、黄芪等虽不同一物, 却均具有“补气”相同功效。麻黄、五加皮、防已、赤小豆等不同功效分类的中药, 均具“利水消肿”的相同功效。对中药这种“一物多效”的共性表现及其物质基础等问题, 已有学者进行了深入的讨论^[2]。本文所讨论的是中药“一物多效”中的特殊表现——反向功效。

所谓中药的反向功效, 是指一种中药中具有的两种特性相反的药效作用。这种现象主要有两种类型, 一种类型是同一药物的不同部位表现出相反药性药效, 如, 西瓜瓤湿热, 西瓜皮清凉; 芒果肉湿热, 芒果皮清凉; 中华鲎箭湿热, 中华鲎壳清热; 桑椹补血养血, 桑叶清热凉血, 等等。另一种类型是同一植株部位(药用部位)表现出反向功效, 如西洋参的补气和清热, 一“补”一“泻”; 白术的利水与安胎, 一“利”一“固”; 秦艽的清湿热和清虚热, 一“实”一“虚”; 三七活血、补血与止血, 一“散”一“补”和“一涩”; 再如麻黄的发汗与利水、黄芪的升阳与利水, 一升一降; 何首乌的解毒与润肠, 一为驱邪一为扶正, 凡此种种, 不胜枚举。进一步分析中药反向功效所产生的机制, 一部分可能与该中药的归经属性与核心功效相关, 如白术的核心功效为健脾益气, 通过健脾这一核心功效, 既有助于运脾化湿而利水, 又可助脾固摄以安胎。但更多的时候, 这种特殊的相反功效表现, 与其核心功效并不相关, 如西洋参, 其核心功效是补气, 但其清热与补气之间并无关联。同样, 秦艽的清湿热与清虚热之间也并非通过核心功效来实现。因此, 可以认为, 中药相反功效是中药“一物多效”的一种特殊表现。由于这种特殊的表现在学术界鲜有关注, 对其进行深入研究, 将对临床应用和质量的精准控制提供有益的参考。经对2015版《中华人民共和国药典》(后简称《中国药典》)中收录的具有反向功效的中药品种进行了分析, 具有反向功效的常用中药约占20%~30%左右, 仅选取典型的20种, 如表 1所示。

2 现行质量控制体系无法实现对反向功效质量标志物的精准控制

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目前, 我国中药的最高质量标准是《中国药典》。许多方法包括化学方法、显微方法、生物模式等都用于中药材的检测。但对中药及其饮片质量控制, 仍然是通过对其中的单一成分或某几类成分提取后检测其含量来衡量药材质量的方法应用最为普遍^[3]。由于中药有效成分复杂性, 仅利用单一指标成分的定性、定量分析方法, 未能切实、全面地反映其临床功效。因此, 随着色谱技术和波谱技术的飞速进步, 一测多评^[4]、指纹图谱^[5]、血清药物化学、代谢组学、药代动力学、系统生物学^[6]等方法被越来越多的应用于中药质量标准研究。2015年版《中国药典》(一部)在部分中成药、中药材和中药提取物质量标准中采用指纹图谱或特征图谱技术来控制药品质量, 在沉香、心脑健胶囊等29个标准中新增加指纹图谱或特征图谱控制要求, 使2015年版《中国药典》在整体性控制中药质量方面有了大幅度的提高^[7]。

中药药效物质基础是什么？化学成分与药效之间如何关联？如何根据中药的性-效-物三元体系来确定质量标志物, 进而进行整体全面的质量控制？这些问题都是在中药质量标准研究中必须要回答的。而对于具有反向功效中药这一类特殊的中药, 则还应该更精准的探究其反向功效与化学成分的关系, 从而明晰同一中药所表现出反向功效的物质基础, 制定更为全面和精准的质量标准。目前, 存在两个层面的问题, 一个是基础研究层面, 未能明确反向功效中药的药效物质基础, 进而阐明功效与物质基础之间的关联性; 另一层面, 现行质量标准即使选择了有效成分作为检测指标, 也未能体现反向功效与物质基础的关联性(表 2^[8-34])。以上两个问题, 严重影响了这类药材及其制剂的质量评价和临床应用的安全有效。

3 传统功效差异性研究给反向功效的科学内涵分析提供了借鉴

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据统计, 现有中药12 807种, 常用者400~600种, 组成方剂约十万首, 用于治疗不同疾病^[35]。中药“一物多效、一物多性、一物多用”等特性所体现的传统药物学内涵已被广泛接受^[2]。

传统功效差异性的生物学基础包括: ①次生代谢产物生物合成途径的多样性; ②化学成分在植物器官和组织分布的特异性; ③生物合成与植物个体发育阶段的相关性。由于以上三个因素的影响, 使得不同植物的化学成分存在结构类型和数量以及在植物中分布的差异, 从而带来功效的差异性^{[1, 36]}。

在对中药功效差异性的研究中, 可以从以下几方面来概括功效差异的化学生物学实质: ①单一成分可以作用于多靶点产生不同作用; ②同一药材的多个成分具有不同作用; ③不同组织部位的成分差异使得不同部位可以产生不同功效; ④中药材炮制前后的化学成分变化, 使得饮片与原药材产生功效上的差异^{[1, 36]}。

反向功效作为中药“一物多效”的特殊表现形式, 虽未得到足够重视, 但仍可从现有的对传统功效差异性的研究和阐述中获得有益信息。以中医的宏观、整体思维模式与现代医学微观、精细的逻辑理论有机结合, 将是探索和研究反向功效中药科学内涵的可行方法和思路。

4 反向功效中药质量标志物研究的策略与方法

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中药复杂的生物效应表达形式是以其复杂的化学物质体系为基础的^[36]。因此, 从中药的反向功效出发, 通过现代药理研究手段对其相反的传统功效进行验证, 开展化学物质组及其反向功效的相关性研究, 确定反向功效的物质基础, 进一步进行有效化学成分的作用靶点、通路等作用机制研究和化学成分的特有性分析, 确定质量标志物, 是建立系统、科学的中药质量评价体系的关键。本文尝试以三七为例对此进行探讨。

三七活血化瘀、止血生肌、补血养血、消肿定痛的疗效已在长期的临床应用中得到证实, 在心脑血管系统、消化系统、呼吸系统的相关疾病治疗中都表现出良好的疗效^[37], 是具有反向功效中药的典型代表。《中国药典》2015年版对三七的质量控制主要是测定其中三七皂苷R₁、人参皂苷R_g1及R_b1的含量, 各地方标准如《四川省中药饮片炮制规范》也沿用此规定。很显然, 目前的质量标准未考虑其反向功效的物质基础差异和特点, 并不能全面反映三七药材的质量。本文以三七为例, 根据质量标志物研究的基本原则^{[1, 36]}, 通过对三七化学成分、药理作用和物质基础研究现状进行归纳总结, 分析其反向功效的物质基础, 并在此基础上, 提出三七质量标志物研究的策略和方法, 为反向功效中药的质量标志物研究提供借鉴。

4.1 化学物质组的系统研究是质量标志物确定的基本前提

自20世纪70年代以来, 研究人员对三七进行了系统的化学成分研究^[38]。已从三七中分离得到百余种单体皂苷成分, 其中原人参二醇型皂苷占大多数, 主要包括人参皂苷R_b1、R_d、R_b3、R_c、R_g3和三七皂苷F_c、F_a以及七叶胆苷(绞股蓝皂苷) Ⅸ、ⅩⅦ等; 原人参三醇型皂苷包括三七皂苷R₁、R₂和人参皂苷R_g1、R_e、R_g2等; 还有一类C17侧链变化的四环三萜皂苷, 约占三七皂苷数量的一半。尤以人参皂苷R_g1和R_b1含量最高。三七所含的氨基酸成分中有特殊氨基酸三七素。此外, 三七中还含黄酮类、挥发油、甾醇、炔醇类、糖类、微量元素^[39]等多种化学成分。三七中皂苷成分中至今未发现齐墩果酸型皂苷, 这是其与同属植物人参和西洋参的显著区别^[38]; 还发现三七挥发油与人参挥发油有8种成分不同^[40]。

三七化学物质组研究, 为三七药效物质研究以及化学成分特有性分析提供了基础。

4.2 基于传统功效的药理作用及机制研究是质量标志物确定的重要基础

三七“善化血瘀”, 故凡产后、跌打所致瘀血、瘀肿皆可破, 具有活血化瘀之功效。目前对活血功效的研究主要集中表现在三七总皂苷对脑血管系统疾病^{[41, 42]}和心血管系统疾病^[43], 如高血脂、动脉粥样硬化^{[44, 45]}等, 可表现出明显的抗血栓、抑制血小板聚集等活性作用^[46]。

三七入肝经血分, 功善止血。关于其止血作用的药理研究也验证了这一功效。三七表现出明显止血效果^[9]。且有研究发现三七素可能通过促进组织胺使血管收缩从而发挥止血作用^[47]。

4.3 反向功效与化学成分关联性分析及药效物质基础的表征是质量标志物确定的必要保障

三七止血活血作用与其化学成分密切关联。大量数据表明, 三七的活血有效成分是含有多种皂苷成分的三七总皂苷(PNS), 其中人参皂苷R_g1、R_b1、R₁等都是三七活血的主要有效成分^{[46, 47]}。人参三醇皂苷(PTS)活血作用显著^[41]。而其止血有效成分主要为特殊氨基酸三七素^[48], 还有槲皮苷和钙离子^[49]。

根据以上研究, 三七中的人参皂苷类成分应是其活血作用的主要物质基础, 三七素、槲皮苷等是其止血作用的主要物质基础, 这些成分应是三七质量标志物的主要选择。

应用各种色谱波谱联用技术^[50]对三七的活血止血有效部位进行化学成分分析, 并考察体内过程对药物作用的影响^[51]等方面的研究, 则为进一步开展三七指纹图谱、阐明三七有效部位中药效物质基础及其代谢研究奠定了基础。

4.4 在现有技术条件下, 化学成分可测性是质量标志物确定的必要条件

化学成分的可测性是质量标志物的基本条件之一。目前, 对三七化学成分分析的研究主要针对其中皂苷类成分, 如, 采用HPLC法测定三七皂苷R₂(S)^[52]、R₁^[53]、人参皂苷F₂^[52]、Rc、Re、Rd^[54]、Rg₁、Rb₁^[53]、七叶胆苷XVII^[52]; 采用UPLC法测定三七皂苷K^[55]以及5种稀有人参皂苷20(S)-Rg₂、20(S)-Rh₁、Rk₃、20(S)-Rg₃及Rk₁^[56]; 一测多评法也被应用于测定三七中人参皂苷的含量^[57]。三七药材及其提取液、三七二醇皂苷(PDS) ^[58]、三七制剂^[59]等的HPLC指纹图谱方法已经建立。还有研究采用核磁共振方法建立不同产地三七的¹H NMR指纹图谱^[60]。比色法^[61]、近红外光谱法^[62]被应用于三七药材中皂苷的快速检测。

除了关注皂苷类成分的分析, 也兼顾了其他成分的分析, 如多糖^[63]、黄酮^[64]、三七素^[65]等成分的含量测定, 为三七质量标志物的确定提供了一定的基础。

4.5 三七反向功效质量标志物的研究路径和技术方案

以三七化学物质组以及反向功效的实验研究成果为基础, 进行成分与药效的关联性分析, 确定三七的反向功效物质基础, 进一步进行特有性分析和可测性研究, 确定三七的反向功效质量标志物, 为建立三七的质量评价方法, 完善质量标准提供科学支撑和有力保障(图 1)。

5 结语

收起

中药质量是对中药有效性和安全性的反映和表征, 是中医临床用药的重要依据。刘昌孝院士提出进行质量标志物研究, 提升了中药质量研究理论的科学性和系统性, 其中特别强调中药的传统功效是质量标志物发现和确定的重要基础。具有反向功效的中药是我国传统中药的一个重要组成部分, 因此, 基于该类中药的反向功效, 阐明反向功效的物质基础, 进而明确物质基础与反向功效的相关性, 并在此基础上确定质量标志物, 是这类中药质量标准制定的基本前提。本文对具有反向功效中药的存在情况、质量标准现状等进行了阐述, 并以三七为例, 根据质量标志物研究原则, 提出了反向功效中药质量标志物研究的策略与方法, 从一个新的研究角度为中药质量标志物研究提供了新思路。

尽管已有研究者关注到三七等中药具有反向功效的特殊性, 在化学物质基础、相反功效与现代药理作用的关系等方面进行了一些研究, 但总的来说, 研究的广度和深度都不够, 更遑论对具有反向功效的中药质量标志物研究的关注。因此, 本文围绕质量标志物这一中药质量评价的核心概念, 首次提出开展反向功效中药质量标志物研究, 以实现对此类中药质量的精确控制的新观点, 无疑对中药质量控制体系的丰富和发展具有积极的意义。

基金

收起

2017广西科技计划项目(桂科AD17195025)
广西中药药效研究重点实验室(16-380-29)
广西中药药效研究重点实验室(17-259-20)

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2019年第54卷第2期

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doi: 10.16438/j.0513-4870.2018-0824

接收时间：2018-09-08
首发时间：2026-01-26
出版时间：2019-02-12

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出版历史

收稿日期：2018-09-08
修回日期：2018-12-03

基金

2017广西科技计划项目(桂科AD17195025)

广西中药药效研究重点实验室(16-380-29)

广西中药药效研究重点实验室(17-259-20)

作者信息

1.广西中医药大学药学院, 广西南宁 530200

2.广西中药药效研究重点实验室, 广西南宁 530200

3.广西农作物废弃物功能成分研究协同创新中心, 广西南宁 530200

4.广西中医药大学广西中医药科学实验中心, 广西南宁 530200

5.天津药物研究院, 天津 300193

通讯作者:

*邓家刚, Tel:86-771-3137555, E-mail:dengjg53@126.com;

刘昌孝, E-mail:liuchangxiao@163.com

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2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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Herbs	Origin	Property, flavor, and channel tropism	Action and indication	Opposite effect	Corresponding indication
Notoginseng Radix et Rhizoma	Dried root and rhizome of Panax notoginseng (Burk.) F. H. Chen.	Sweet and mild bitter, warm. Liver, stomach meridians	To dissipate stasis, stanch bleeding, disperse swelling, and relieve pain. Hemoptysis, hematemesis, epistaxis, hematochezia, menstrual flooding and spotting, traumatic bleeding, stabbing pain in chest and abdomen, and swelling and pain caused by traumatic injuries	Activating blood/ stanching bleeding	Bleeding/swelling and pain caused by traumatic injuries
Panacis Quinqueflii Radix	Dried root of Panax quinquefolium L.	Sweet and mild bitter, cool. Heart, lung and kidney meridians	To tonify qi, nourish yin, clear heat and promote salivation. Deficiency of qi and yin, deficiency heat with vexation and fatigue, wheezing and cough with phlegm blood, interior heat diarrhea, dry mouth and throat	Tonify qi/clear heat	Deficiency of qi/ interior heat
Angelicae Sinensis Radix	Dried roots of Angelica sinensis (Oliv.) Diels.	Sweet and pungent, warm. Liver, heart and spleen meridians	To nourish blood, activate blood, regulate menstruation, relieve pain, moisten the intestine and relax the bowels. Blood deficiency with sallow complexion dizziness, palpitations, menstrual irregularities, amenorrhea and dysmenorrhea, abdominal pain due to deficiency-cold, arthralgia due to wind-dampness, traumatic injuries, abscesses and cellulitis, sore and ulcer, and constipation caused by intestinal dryness	Nourish blood/ activate blood	Blood deficiency/ amenorrhea
Glycyrrhizae Radix et Rhizoma	Dried root and rhizome of Glycyrrhiza uralensis Fisch., Glycyrrhiza in flate Bat. or Glycyrrhiza glabra L.	Sweet, neutral. Heart, lung, spleen and stomach meridians	To tonify spleen, tonify qi, clear heat, remove toxin, dispel phlegm, suppress cough, relax spasm, relieve pain, and harmonize the properties of different medicines. Deficiency of the spleen and stomach, fatigue, lack of strength, palpitations, shortness of breath, cough and profuse sputum, painful spasm in the stomach duct, abdomen and limbs, swelling abscess, sore, carbuncle and boil, and reducing the other drugs toxin and drastic action	Tonify qi/ clear heat	Deficiency of spleen-qi / carbuncle and boil
Astragali Radix	Dried root of Astragalus membranaceus (Fisch.) Bge. Var. mongholicus (Bge.) Hsiao or Astragalus membranaceus (Fisch.) Bge.	Sweet, mild warm. Lung, spleen meridians	To tonify qi, upraise yang, secure the exterior, stop sweating, promote urination, alleviate edema, engender fluids, nourish blood, remove stagnation, relive impediment, expel toxin and pus, promote wound healing and promote tissue regeneration. Qi deficiency and lack of strength, reduced food intake, sloppy stool, sunken middle qi, chronic diarrhea, prolapse of the rectum, bloody stool, menstrual flooding and spotting, exterior deficiency with spontaneous sweating, qi deficiency edema, interior heat wasting-thirst, blood deficiency and sallow complexion, hemiplegia, arthralgia, numbness, abscesses and cellulitis difficult to suppurate and perforate, or difficult to heal	Upraise yang/ promote urination	Descent of middle qi/ edema
Sparholobi Caulis	Dried lianoid stem of Spatholobus suberectus Dunn.	Bitter and sweet, warm. Liver and kidney meridians	To activate blood, nourish blood, regulate menstruation, relieve pain, relax sinews and activate collaterals. Menstrual irregularities, dysmenorrhea, amenorrhea, painful bi disorders caused by wind-dampness, numbness, paralysis, blood deficiency and sallow complexion	Activate blood/ nourish blood	Amenorrhea/blood deficiency
Polygoni Multiflori Radix	Dried root tuber of Polygonum multiflorum Thunb.	Bitter, sweet and astringent, mild warm. Liver, heart and kidney meridians	To remove toxin, disperse abscesses, interrupt malaria, and moisten the intestines and open the bowels. Sore and abscess, scrofula, itching caused by rubella, weak constitution caused by long-term malaria, and constipation caused by intestinal dryness	Remove toxin/ moisten the intestines	Sore and abscess/ constipation
Puerariae Lobatae Radix	Dried roots of Pueraria lobata (Willd.) Ohwi.	Sweet, pungent, cool. Spleen, and stomach, lung meridians	To release the flesh, reduce fever, engender fluid to quench thirst, promote eruption, upraise the middle qi, stop diarrhea, unblock the meridians, activate collaterals, and remove alcoholic toxin. External contraction with fever, headache, stiff and pain in a nape and neck, thirst, wasting-thirst, unerupted measles, heat dysentery, diarrhea, dizziness, headache, hemiplegia caused by wind-stroke, chest bi disorder, heart pain, and wine toxin damaging the middle	Reduce fever/ upraise the middle qi	External contraction with fever/diarrhea due to yang deficiency
Atractylodis Macrocephalae Rhizoma	Dried rhizome of Atractylodes macrocephala Koidz.	Bitter, sweet, Warm. Spleen and stomach meridians	To fortify the spleen, replenish qi, dry dampness, promote unhation, stop sweating, and prevent miscarriage. Spleen deficiency with reduced food intake abdominal distension and diarrhea, dizziness and palpitations caused by phlegm-fluid retention, edema, spontaneous sweating, and threatened miscarriage	Promote unhation/ prevent miscarriage	Edema/threatened miscarriage
Cistanches Herba	Dried fieshy stem with scales of Cistanche desertico La Y. C. Ma or Cistanche tubulosa (Schenk) Wight.	Sweet and salty, warm. Kidney and large intestine meridians	To tonify the kidney yang, replenish essence and blood, moisten the intestines and open the bowels. Deficiency of kidney yang, deficiency of essence and blood, impotence and infertility, soreness and weakness in the lower back and knees, lack of strength of sinew and bone, and constipation caused by intestinal dryness	Tonify the kidney yang/replenish essence and blood	Impotence and infertility/constipation caused by intestinal dryness
Taxilli Herba	Dried stem and branch of Taxillus chinensi (CDC.) Danser.	Bitter, sweet, neutral. Liver and kidney meridians	To dispel wind-dampness, tonify liver-kidney, strengthen sinew and bone, and prevent miscarriage. Painful bi disorder caused by wind-dampness, soreness and weakness in the low back and knees, lack of strength of sinew and bone, menstrual flooding and spotting, profuse menstruation, vaginal bleeding during pregnancy, threatened miscarriage, dizziness and vertigo	Dispel wind-dampness/tonify liver-kidney	Painful bi disorder caused by wind-dampness/threatened miscarriage
Agrimoniae Herba	Dried aerial parts of Agrimonia pilosa Ledeb.	Bitter and astringent, neutral. Heart and liver meridians	To astringe and stanch bleeding, treat malaria, relieve dysentery, remove toxin, and replenish deficiency. Hemoptysis, hematemesis, uterine bleeding, malaria, bloody dysentery, carbuncle and boil, pudendal itch, abnormal vaginal discharge, and impairment caused by overstrain	Remove toxin/ replenish deficiency	Carbuncle and boil/ impairment caused by overstrain
Siphonostegiae Herba	Dried herb of Siphonostegia chinensis Benth.	Bitter, cold. Spleen, stomach, liver and gallbladder meridians	To activate blood, and eliminate stasis, unblock the meridians, relieve pain, cool the blood, stanch bleeding, clear heat and drain dampness. Traumatic injuries, traumatic bleeding, blood-stasis amenorrhea, menstrual irregularities, postpartum stasis and pain, abdominal masses, blood dysentery, blood strangury, dampness-heat jaundice, edema, abdominal distension, and profuse white vaginal discharge	Activate blood/ stanch bleeding	Blood-stasis amenorrhea/ traumatic bleeding
Ephedra Herba	Dried grass stems of Ephedra sinica Stapf, Ephedra intermedia Schrenk et C.A. Mey. or Ephedra equisetina Bge.	Pungent, mild bitter warm. Lung and bladder meridians	To promote sweating, dissipate cold, diffuse the lung, relieve wheezing, and promote urination to alleviate edema. Common cold caused by wind-cold, manifested as oppression in the chest, wheezing and cough, and edema caused by wind. Ephedrae Herba (processed with honey) can moisten the lung to suppress cough, and can be used for wheezing and cough after relieving exterior pattern	Promote sweating/ promote urination	Exterior pattern with unsweating/ edema
Gentianae Macrophyllae Radix	Dried root of Gentiana macrophylla Pall., Gentiana straminea Maxim., Gentiana crassicaulis Duthie ex Burk. or Gentiana dahurica Fisch.	Pungent and bitter, neutral. Stomach, liver and gallbladder meridians	To dispel wind-dampness, clear dampness heat, relieve arthralgia pain, and relieve deficiency heat. Painful bi disorder caused by wind-dampness, hemiplegia caused a by wind-stroke, hypertonicity of the sinews and vessels, sore pain in joint and bone, dampness-heat jaundice, bone-steaming and tidal fever, , infantile malnutrition with retention and fever	Clear dampness heat/relieve deficiency heat	Dampness-heat jaundice/ bone-steaming and tidal fever
Catechu	Dried concentrated decoction prepared from peeled branch and stem of Aazck catechu (L.f.) Willd.	Bitter, astringent, mild cold. Lung, heart meridians	To activate blood, relieve pain, stanch bleeding, promote tissue regeneration, dispel dampness, promote wound healing, clear lung and resolve phlegm. Pain caused by traumatic injuries, traumatic bleeding, hematemesis, epistaxis, unhealed sore, ulcer, eczema and damp sore, and cough caused by lung heat.	Activate blood/ stanch bleeding	Traumatic injuries/ bleeding
Achyranthis Bidentatae Radix	Driedroots of Achyranthes bidentata Bl.	Bitter, sweet and sour, neutral. Liver and kidney meridians	To expel stasis, unblock the meridian, tonify liver kidney, strengthen sinew and bone, promote urination, relieve stranguria, and conduct blood and downward. Amenorrhea, dysmenorrhea, limp aching in the lower back and knees, lack of strength of sinew and bone, stranguria, edema, headache, dizziness, toothache, mouth sore, hematemesis, and epistaxis	Tonify liver kidney/promote urination and relieve stranguria	Lack of strength of sinew and bone/ stranguria
Plantaginis Semen	Driedripe seed of Plantago asiatica L. or Plantago depressa Willd.	Sweet, cold. Liver, kidney, lung and small intestine meridians	To clear heat, disinhibit urine, relieve stranguria, drain dampness, stop diarrhea, improve vision, and dispel phlegm. Heat strangury with chronic pain, edema distention, fullness, and diarrhea caused by summer heat-dampness, red painful swelling eyes, and phlegm-heat cough	Disinhibit urine/ stop diarrhea	Heat strangury/ dampness
Cirsii Japonici Herb (Cirsii Herba)	Driedaerial part of Cirsium japonicum Fisch.ex DC.	Sweet and bitter, cool. Heart and liver meridians	To cool the blood, stanch bleeding, dissipate stasis, remove toxin and disperse abscesses. Epistaxis, hematemesis, hematuria, blood strangury, bloody stool, menstrual flooding and spotting, traumatic bleeding, swelling abscess, sore and skin infections	Stanch bleeding/dissipate stasis	Bleeding/traumatic blood stasis
Aquilariae Lignum Resinatum	Resin containing wood of Aqui1aria sinensis (Lour.) Gilg.	Pungent and bitter, mild warm. Spleen, stomach and kidney meridians	To move qi, relieve pain, warm the middle energizer, stop vomiting, absorb qi and relieve wheezing. Distention, oppression and pain in the chest and abdomen, vomiting and hiccup caused by stomach cold, wheezing caused by qi counterflow and kidney deficiency	Move qi/absorb qi	Oppression and pain in the chest and abdomen/ wheezing caused by qi counterflow and kidney deficiency

Herbs

Origin

Property, flavor, and channel tropism

Action and indication

Opposite effect

Corresponding indication

Notoginseng Radix et Rhizoma

Dried root and rhizome of Panax notoginseng (Burk.) F. H. Chen.

Sweet and mild bitter, warm. Liver, stomach meridians

To dissipate stasis, stanch bleeding, disperse swelling, and relieve pain. Hemoptysis, hematemesis, epistaxis, hematochezia, menstrual flooding and spotting, traumatic bleeding, stabbing pain in chest and abdomen, and swelling and pain caused by traumatic injuries

Activating blood/ stanching bleeding

Bleeding/swelling and pain caused by traumatic injuries

Panacis Quinqueflii Radix

Dried root of Panax quinquefolium L.

Sweet and mild bitter, cool. Heart, lung and kidney meridians

To tonify qi, nourish yin, clear heat and promote salivation. Deficiency of qi and yin, deficiency heat with vexation and fatigue, wheezing and cough with phlegm blood, interior heat diarrhea, dry mouth and throat

Tonify qi/clear heat

Deficiency of qi/ interior heat

Angelicae Sinensis Radix

Dried roots of Angelica sinensis (Oliv.) Diels.

Sweet and pungent, warm. Liver, heart and spleen meridians

To nourish blood, activate blood, regulate menstruation, relieve pain, moisten the intestine and relax the bowels. Blood deficiency with sallow complexion dizziness, palpitations, menstrual irregularities, amenorrhea and dysmenorrhea, abdominal pain due to deficiency-cold, arthralgia due to wind-dampness, traumatic injuries, abscesses and cellulitis, sore and ulcer, and constipation caused by intestinal dryness

Nourish blood/ activate blood

Blood deficiency/ amenorrhea

Glycyrrhizae Radix et Rhizoma

Dried root and rhizome of Glycyrrhiza uralensis Fisch., Glycyrrhiza in flate Bat. or Glycyrrhiza glabra L.

Sweet, neutral. Heart, lung, spleen and stomach meridians

To tonify spleen, tonify qi, clear heat, remove toxin, dispel phlegm, suppress cough, relax spasm, relieve pain, and harmonize the properties of different medicines. Deficiency of the spleen and stomach, fatigue, lack of strength, palpitations, shortness of breath, cough and profuse sputum, painful spasm in the stomach duct, abdomen and limbs, swelling abscess, sore, carbuncle and boil, and reducing the other drugs toxin and drastic action

Tonify qi/ clear heat

Deficiency of spleen-qi / carbuncle and boil

Astragali Radix

Dried root of Astragalus membranaceus (Fisch.) Bge. Var. mongholicus (Bge.) Hsiao or Astragalus membranaceus (Fisch.) Bge.

Sweet, mild warm. Lung, spleen meridians

To tonify qi, upraise yang, secure the exterior, stop sweating, promote urination, alleviate edema, engender fluids, nourish blood, remove stagnation, relive impediment, expel toxin and pus, promote wound healing and promote tissue regeneration. Qi deficiency and lack of strength, reduced food intake, sloppy stool, sunken middle qi, chronic diarrhea, prolapse of the rectum, bloody stool, menstrual flooding and spotting, exterior deficiency with spontaneous sweating, qi deficiency edema, interior heat wasting-thirst, blood deficiency and sallow complexion, hemiplegia, arthralgia, numbness, abscesses and cellulitis difficult to suppurate and perforate, or difficult to heal

Upraise yang/ promote urination

Descent of middle qi/ edema

Sparholobi Caulis

Dried lianoid stem of Spatholobus suberectus Dunn.

Bitter and sweet, warm. Liver and kidney meridians

To activate blood, nourish blood, regulate menstruation, relieve pain, relax sinews and activate collaterals. Menstrual irregularities, dysmenorrhea, amenorrhea, painful bi disorders caused by wind-dampness, numbness, paralysis, blood deficiency and sallow complexion

Activate blood/ nourish blood

Amenorrhea/blood deficiency

Polygoni Multiflori Radix

Dried root tuber of Polygonum multiflorum Thunb.

Bitter, sweet and astringent, mild warm. Liver, heart and kidney meridians

To remove toxin, disperse abscesses, interrupt malaria, and moisten the intestines and open the bowels. Sore and abscess, scrofula, itching caused by rubella, weak constitution caused by long-term malaria, and constipation caused by intestinal dryness

Remove toxin/ moisten the intestines

Sore and abscess/ constipation

Puerariae Lobatae Radix

Dried roots of Pueraria lobata (Willd.) Ohwi.

Sweet, pungent, cool. Spleen, and stomach, lung meridians

To release the flesh, reduce fever, engender fluid to quench thirst, promote eruption, upraise the middle qi, stop diarrhea, unblock the meridians, activate collaterals, and remove alcoholic toxin. External contraction with fever, headache, stiff and pain in a nape and neck, thirst, wasting-thirst, unerupted measles, heat dysentery, diarrhea, dizziness, headache, hemiplegia caused by wind-stroke, chest bi disorder, heart pain, and wine toxin damaging the middle

Reduce fever/ upraise the middle qi

External contraction with fever/diarrhea due to yang deficiency

Atractylodis Macrocephalae Rhizoma

Dried rhizome of Atractylodes macrocephala Koidz.

Bitter, sweet, Warm. Spleen and stomach meridians

To fortify the spleen, replenish qi, dry dampness, promote unhation, stop sweating, and prevent miscarriage. Spleen deficiency with reduced food intake abdominal distension and diarrhea, dizziness and palpitations caused by phlegm-fluid retention, edema, spontaneous sweating, and threatened miscarriage

Promote unhation/ prevent miscarriage

Edema/threatened miscarriage

Cistanches Herba

Dried fieshy stem with scales of Cistanche desertico La Y. C. Ma or Cistanche tubulosa (Schenk) Wight.

Sweet and salty, warm. Kidney and large intestine meridians

To tonify the kidney yang, replenish essence and blood, moisten the intestines and open the bowels. Deficiency of kidney yang, deficiency of essence and blood, impotence and infertility, soreness and weakness in the lower back and knees, lack of strength of sinew and bone, and constipation caused by intestinal dryness

Tonify the kidney yang/replenish essence and blood

Impotence and infertility/constipation caused by intestinal dryness

Taxilli Herba

Dried stem and branch of Taxillus chinensi (CDC.) Danser.

Bitter, sweet, neutral. Liver and kidney meridians

To dispel wind-dampness, tonify liver-kidney, strengthen sinew and bone, and prevent miscarriage. Painful bi disorder caused by wind-dampness, soreness and weakness in the low back and knees, lack of strength of sinew and bone, menstrual flooding and spotting, profuse menstruation, vaginal bleeding during pregnancy, threatened miscarriage, dizziness and vertigo

Dispel wind-dampness/tonify liver-kidney

Painful bi disorder caused by wind-dampness/threatened miscarriage

Agrimoniae Herba

Dried aerial parts of Agrimonia pilosa Ledeb.

Bitter and astringent, neutral. Heart and liver meridians

To astringe and stanch bleeding, treat malaria, relieve dysentery, remove toxin, and replenish deficiency. Hemoptysis, hematemesis, uterine bleeding, malaria, bloody dysentery, carbuncle and boil, pudendal itch, abnormal vaginal discharge, and impairment caused by overstrain

Remove toxin/ replenish deficiency

Carbuncle and boil/ impairment caused by overstrain

Siphonostegiae Herba

Dried herb of Siphonostegia chinensis Benth.

Bitter, cold. Spleen, stomach, liver and gallbladder meridians

To activate blood, and eliminate stasis, unblock the meridians, relieve pain, cool the blood, stanch bleeding, clear heat and drain dampness. Traumatic injuries, traumatic bleeding, blood-stasis amenorrhea, menstrual irregularities, postpartum stasis and pain, abdominal masses, blood dysentery, blood strangury, dampness-heat jaundice, edema, abdominal distension, and profuse white vaginal discharge

Activate blood/ stanch bleeding

Blood-stasis amenorrhea/ traumatic bleeding

Ephedra Herba

Dried grass stems of Ephedra sinica Stapf, Ephedra intermedia Schrenk et C.A. Mey. or Ephedra equisetina Bge.

Pungent, mild bitter warm. Lung and bladder meridians

To promote sweating, dissipate cold, diffuse the lung, relieve wheezing, and promote urination to alleviate edema. Common cold caused by wind-cold, manifested as oppression in the chest, wheezing and cough, and edema caused by wind. Ephedrae Herba (processed with honey) can moisten the lung to suppress cough, and can be used for wheezing and cough after relieving exterior pattern

Promote sweating/ promote urination

Exterior pattern with unsweating/ edema

Gentianae Macrophyllae Radix

Dried root of Gentiana macrophylla Pall., Gentiana straminea Maxim., Gentiana crassicaulis Duthie ex Burk. or Gentiana dahurica Fisch.

Pungent and bitter, neutral. Stomach, liver and gallbladder meridians

To dispel wind-dampness, clear dampness heat, relieve arthralgia pain, and relieve deficiency heat. Painful bi disorder caused by wind-dampness, hemiplegia caused a by wind-stroke, hypertonicity of the sinews and vessels, sore pain in joint and bone, dampness-heat jaundice, bone-steaming and tidal fever, , infantile malnutrition with retention and fever

Clear dampness heat/relieve deficiency heat

Dampness-heat jaundice/ bone-steaming and tidal fever

Catechu

Dried concentrated decoction prepared from peeled branch and stem of Aazck catechu (L.f.) Willd.

Bitter, astringent, mild cold. Lung, heart meridians

To activate blood, relieve pain, stanch bleeding, promote tissue regeneration, dispel dampness, promote wound healing, clear lung and resolve phlegm. Pain caused by traumatic injuries, traumatic bleeding, hematemesis, epistaxis, unhealed sore, ulcer, eczema and damp sore, and cough caused by lung heat.

Activate blood/ stanch bleeding

Traumatic injuries/ bleeding

Achyranthis Bidentatae Radix

Driedroots of Achyranthes bidentata Bl.

Bitter, sweet and sour, neutral. Liver and kidney meridians

To expel stasis, unblock the meridian, tonify liver kidney, strengthen sinew and bone, promote urination, relieve stranguria, and conduct blood and downward. Amenorrhea, dysmenorrhea, limp aching in the lower back and knees, lack of strength of sinew and bone, stranguria, edema, headache, dizziness, toothache, mouth sore, hematemesis, and epistaxis

Tonify liver kidney/promote urination and relieve stranguria

Lack of strength of sinew and bone/ stranguria

Plantaginis Semen

Driedripe seed of Plantago asiatica L. or Plantago depressa Willd.

Sweet, cold. Liver, kidney, lung and small intestine meridians

To clear heat, disinhibit urine, relieve stranguria, drain dampness, stop diarrhea, improve vision, and dispel phlegm. Heat strangury with chronic pain, edema distention, fullness, and diarrhea caused by summer heat-dampness, red painful swelling eyes, and phlegm-heat cough

Disinhibit urine/ stop diarrhea

Heat strangury/ dampness

Cirsii Japonici Herb (Cirsii Herba)

Driedaerial part of Cirsium japonicum Fisch.ex DC.

Sweet and bitter, cool. Heart and liver meridians

To cool the blood, stanch bleeding, dissipate stasis, remove toxin and disperse abscesses. Epistaxis, hematemesis, hematuria, blood strangury, bloody stool, menstrual flooding and spotting, traumatic bleeding, swelling abscess, sore and skin infections

Stanch bleeding/dissipate stasis

Bleeding/traumatic blood stasis

Aquilariae Lignum Resinatum

Resin containing wood of Aqui1aria sinensis (Lour.) Gilg.

Pungent and bitter, mild warm. Spleen, stomach and kidney meridians

To move qi, relieve pain, warm the middle energizer, stop vomiting, absorb qi and relieve wheezing. Distention, oppression and pain in the chest and abdomen, vomiting and hiccup caused by stomach cold, wheezing caused by qi counterflow and kidney deficiency

Move qi/absorb qi

Oppression and pain in the chest and abdomen/ wheezing caused by qi counterflow and kidney deficiency

Herbs	Opposite effect	Related pharmacology research of the typical opposite effect herbs	Correlation research of opposite effect and chemical composition	Detection composition in the Chinese Pharmacopoeia 2015
Notoginseng Radix et Rhizoma	Activate blood/stanch bleeding	Yes (activate blood^[8]; stanch bleeding^[9])	Activate blood-Panax notoginseng saponins, containing more than 20 saponins^[8]; stanch bleeding-dencichine^[9]	Ginsenoside Rg_l, Rb₁ and notoginsenoside R₁
Panacis Quinqueflii Radix	Tonify qi/clear heat	Yes (tonify qi^{[10, 11]}; clear heat^[12])	Tonify qi-Ginsenoside Re^[10]; Panax polysaccharide^[11]; clear heat--neutral sugar PPQN^[12]	Ginsenoside Rg₁, Re, Rb₁
Angelicae Sinensis Radix	Nourish blood/stanch bleeding	Yes (nourish blood^[13-15]; stanch bleeding^[16])	Nourish blood-angelica polysaccharide^{[13, 14]}, ferulic acid^[15]; stanch bleeding-angelica polysaccharide and its sulfate^[16]	Ferulic acid, volatile oil
Glycyrrhizae Radix et Rhizoma	Clear heat/tonify qi	Yes (clear heat^{[17, 18]}; tonify qi^[19])	Clear heat-glycyrrhizic acid^[17]; glycyrrhetinic acid and its salts^[18]; tonify qi-glycyrrhiza polysaccharide^[19]	Liquiritin, glycyrrhizic acid
Atractylodis Macrocephalae Rhizoma	Promote unhation/prevent miscarriage	Yes (promote unhation^[20]; prevent miscarriage^[21])	N/A	N/A
Cistanches Herba	Tonify the kidney yang (yang)/replenish essence and blood (yin)	Yes (tonify the kidney yang^[22]; replenish essence and blood^[23])	Tonify the kidney yang-polysaccharide, betaine^[22]; replenish essence and blood-no.	Echinacoside, verbascoside
Taxilli Herba	Dispel wind-dampness/ tonify liver-kidney (prevent miscarriage)	Yes (tonify liver-kidney (prevent miscarriage)^[24]; prevent miscarriage^{[25, 26]})	Prevent miscarriage-no; dispel wind-dampness-total flavonoids^[25], aricularin, quercitrin^[26]	Quercetin
Siphonostegiae Herba	Activate blood/stanch bleeding	Yes (activate blood^[27]; stanch bleeding-no)	N/A	Luteolin, verbascoside
Ephedra Herba	Promote sweating/promote urination	Yes (promote sweating^{[28, 29]}; promote urination^{[30, 31]})	Promote sweating--ephedra polysaccharide^[28]; volatile oil, ephedrine^[29]; promote urination--D-pseudoephedrine^[30]; alkaloid component^[31]	Ephedrine hydrochloride, pseudoephedrine hydrochloride
Catechu	Activate blood/stanch bleeding	Yes (activate blood^[32]; stanch bleeding-no)	Activate blood-epicatechin^[32]; stanch bleeding-no	Catechin, epicatechin
Plantaginis Semen	Disinhibit urine/stop diarrhea	Yes (disinhibit urine^[33]; stop diarrhea^[34])	Disinhibit urine-no; stop diarrhea-plantago polysaccharide^[34]	Geniposidic acid, verbascoside

Herbs

Opposite effect

Related pharmacology research of the typical opposite effect herbs

Correlation research of opposite effect and chemical composition

Detection composition in the Chinese Pharmacopoeia 2015

Notoginseng Radix et Rhizoma

Activate blood/stanch bleeding

Yes (activate blood^[8]; stanch bleeding^[9])

Activate blood-Panax notoginseng saponins, containing more than 20 saponins^[8]; stanch bleeding-dencichine^[9]

Ginsenoside Rg_l, Rb₁ and notoginsenoside R₁

Panacis Quinqueflii Radix

Tonify qi/clear heat

Yes (tonify qi^{[10, 11]}; clear heat^[12])

Tonify qi-Ginsenoside Re^[10]; Panax polysaccharide^[11]; clear heat--neutral sugar PPQN^[12]

Ginsenoside Rg₁, Re, Rb₁

Angelicae Sinensis Radix

Nourish blood/stanch bleeding

Yes (nourish blood^[13-15]; stanch bleeding^[16])

Nourish blood-angelica polysaccharide^{[13, 14]}, ferulic acid^[15]; stanch bleeding-angelica polysaccharide and its sulfate^[16]

Ferulic acid, volatile oil

Glycyrrhizae Radix et Rhizoma

Clear heat/tonify qi

Yes (clear heat^{[17, 18]}; tonify qi^[19])

Clear heat-glycyrrhizic acid^[17]; glycyrrhetinic acid and its salts^[18]; tonify qi-glycyrrhiza polysaccharide^[19]

Liquiritin, glycyrrhizic acid

Atractylodis Macrocephalae Rhizoma

Promote unhation/prevent miscarriage

Yes (promote unhation^[20]; prevent miscarriage^[21])

N/A

Cistanches Herba

Tonify the kidney yang (yang)/replenish essence and blood (yin)

Yes (tonify the kidney yang^[22]; replenish essence and blood^[23])

Tonify the kidney yang-polysaccharide, betaine^[22]; replenish essence and blood-no.

Echinacoside, verbascoside

Taxilli Herba

Dispel wind-dampness/ tonify liver-kidney (prevent miscarriage)

Yes (tonify liver-kidney (prevent miscarriage)^[24]; prevent miscarriage^{[25, 26]})

Prevent miscarriage-no; dispel wind-dampness-total flavonoids^[25], aricularin, quercitrin^[26]

Quercetin

Siphonostegiae Herba

Activate blood/stanch bleeding

Yes (activate blood^[27]; stanch bleeding-no)

N/A

Luteolin, verbascoside

Ephedra Herba

Promote sweating/promote urination

Yes (promote sweating^{[28, 29]}; promote urination^{[30, 31]})

Promote sweating--ephedra polysaccharide^[28]; volatile oil, ephedrine^[29]; promote urination--D-pseudoephedrine^[30]; alkaloid component^[31]

Ephedrine hydrochloride, pseudoephedrine hydrochloride

Catechu

Activate blood/stanch bleeding

Yes (activate blood^[32]; stanch bleeding-no)

Activate blood-epicatechin^[32]; stanch bleeding-no

Catechin, epicatechin

Plantaginis Semen

Disinhibit urine/stop diarrhea

Yes (disinhibit urine^[33]; stop diarrhea^[34])

Disinhibit urine-no; stop diarrhea-plantago polysaccharide^[34]

Geniposidic acid, verbascoside