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 |
| No. | R | X | ADP test | | Collagen test |
Dosage
/mg·kg-1 | Result | Dosage
/mg·kg-1 | Result |
| 1 | OCH3 | 2-Cl | 3×25 | 94 ± 3 | | 3×25 | 0.14 ± 0.03 |
| reference | - | 16 ± 4 | - | 3.12 ± 0.47 |
| 1 | OCH3 | 2-Cl | 3×5 | 82 ± 11 | 3×5 | 0.19 ± 0.04 |
| reference | - | 20 ± 11 | - | 2.17 ± 0.64 |
| 1 | OCH3 | 2-Cl | 3×2.5 | 56 ± 17 | 3×2.5 | 0.60 ± 0.20 |
| reference | - | 23 ± 15 | - | 5.00 ± 1.02 |
| 5 | OCH3 | H | 3×100 | 72 ± 4 | 3×100 | 0.51 ± 0.18 |
| reference | - | 4 ± 0 | - | 5.00 ± 1.06 |
| 6 | OC2H5 | 2-CH3 | 3×100 | 89 ± 4 | 3×100 | 0.12 ± 0.02 |
| reference | | 4 ± 1 | | 4.73 ± 0.55 |
| 7 | H | H | 3×100 | 22 ± 4 | | |
| reference | - | 18 ± 1 | | |
| 8 | n-OPr | 2-Cl | | | 3×100 | 0.66 ± 0.18 |
| reference | | | | 2.00 ± 0.35 |
| 9 | n-OBu | 2-Cl | | | 3×100 | 0.86 ± 0.18 |
| reference | | | - | 2.25 ± 0.32 |
| 10 | i-OPr | 2-Cl | 3×60 | 65 ± 7 | 3×100 | 0.11 ± 0.01 |
| reference | - | 11 ± 0 | - | 3.41 ± 0.55 |
| 11 | OC2H5 | 2-Cl | 3×25 | 66 ± 2 | 3×25 | 0.16 ± 0.07 |
| reference | - | 8 ± 0 | - | 3.92 ± 0.63 |
| 11 | OC2H5 | 2-Cl | 3×12.5 | 49 ± 11 | 3×12.5 | 0.54 ± 0.12 |
| reference | - | 8 ± 1 | - | 2.00 ± 0.35 |
| 11 | OC2H5 | 2-Cl | 3×10 | 24 ± 5 | | |
| reference | - | 8 ± 1 | | |
| 12 | N(CH3)2 | 2-Cl | 3×100 | 11 ± 3 | 3×100 | 0.83 ± 0.02 |
| reference | | | 2 ± 0 | 2.25 ± 0.32 |
| 13 |  | 2-Cl | 3×100 | 27 ± 5 | | |
| reference | - | 4 ± 0 | | |
| 14 |  | 2-Cl | | | 3×100 | 1.89 ± 0.13 |
| reference | | | | 2.77 ± 0.32 |
| 15 | NHCH3 | 2-Cl | | | 3×100 | 10.82 ± 0.81 |
| reference | | | | 11.35 ± 1.01 |
| 16 | N(CH3)2 | H | 3×100 | 4 ± 1 | | |
| reference | - | 18 ± 1 | | |
| 17 | N(CH3)2 | 2-CH3 | | | 3×100 | 3.04 ± 0.22 |
| reference | | | | 11.35 ± 1.01 |
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The blood platelet aggregation inhibiting action of representative compounds. ADP: Adenosine diphosphate
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| |
| No. | R | X | ADP test | | Collagen test |
Dosage
/mg·kg-1 | Result | Dosage
/mg·kg-1 | Result |
| 1 | OCH3 | 2-Cl | 3×25 | 94 ± 3 | | 3×25 | 0.14 ± 0.03 |
| reference | - | 16 ± 4 | - | 3.12 ± 0.47 |
| 1 | OCH3 | 2-Cl | 3×5 | 82 ± 11 | 3×5 | 0.19 ± 0.04 |
| reference | - | 20 ± 11 | - | 2.17 ± 0.64 |
| 1 | OCH3 | 2-Cl | 3×2.5 | 56 ± 17 | 3×2.5 | 0.60 ± 0.20 |
| reference | - | 23 ± 15 | - | 5.00 ± 1.02 |
| 5 | OCH3 | H | 3×100 | 72 ± 4 | 3×100 | 0.51 ± 0.18 |
| reference | - | 4 ± 0 | - | 5.00 ± 1.06 |
| 6 | OC2H5 | 2-CH3 | 3×100 | 89 ± 4 | 3×100 | 0.12 ± 0.02 |
| reference | | 4 ± 1 | | 4.73 ± 0.55 |
| 7 | H | H | 3×100 | 22 ± 4 | | |
| reference | - | 18 ± 1 | | |
| 8 | n-OPr | 2-Cl | | | 3×100 | 0.66 ± 0.18 |
| reference | | | | 2.00 ± 0.35 |
| 9 | n-OBu | 2-Cl | | | 3×100 | 0.86 ± 0.18 |
| reference | | | - | 2.25 ± 0.32 |
| 10 | i-OPr | 2-Cl | 3×60 | 65 ± 7 | 3×100 | 0.11 ± 0.01 |
| reference | - | 11 ± 0 | - | 3.41 ± 0.55 |
| 11 | OC2H5 | 2-Cl | 3×25 | 66 ± 2 | 3×25 | 0.16 ± 0.07 |
| reference | - | 8 ± 0 | - | 3.92 ± 0.63 |
| 11 | OC2H5 | 2-Cl | 3×12.5 | 49 ± 11 | 3×12.5 | 0.54 ± 0.12 |
| reference | - | 8 ± 1 | - | 2.00 ± 0.35 |
| 11 | OC2H5 | 2-Cl | 3×10 | 24 ± 5 | | |
| reference | - | 8 ± 1 | | |
| 12 | N(CH3)2 | 2-Cl | 3×100 | 11 ± 3 | 3×100 | 0.83 ± 0.02 |
| reference | | | 2 ± 0 | 2.25 ± 0.32 |
| 13 | | 2-Cl | 3×100 | 27 ± 5 | | |
| reference | - | 4 ± 0 | | |
| 14 | | 2-Cl | | | 3×100 | 1.89 ± 0.13 |
| reference | | | | 2.77 ± 0.32 |
| 15 | NHCH3 | 2-Cl | | | 3×100 | 10.82 ± 0.81 |
| reference | | | | 11.35 ± 1.01 |
| 16 | N(CH3)2 | H | 3×100 | 4 ± 1 | | |
| reference | - | 18 ± 1 | | |
| 17 | N(CH3)2 | 2-CH3 | | | 3×100 | 3.04 ± 0.22 |
| reference | | | | 11.35 ± 1.01 |
), ArticleFig(id=1210147817109189094, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1210147811975360653, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
 |
| Compd. | R | X | Antithrombotic activity | | | | Bleeding time |
| Dosage/mg·kg-1 | Wt thrombosis/mg | Variation/% | Dosage/mg·kg-1 | Result/s |
| 1 | OCH3 | 2-Cl | 3×25 | 6.65 ± 0.51 | | -85 | | 3×25 | 1 200 |
| reference | - | 36.24 ± 2.05 | - | - | 420 |
| 1 | OCH3 | 2-Cl | 3×12.5 | 15.89 ± 1.81 | -56 | 3×12.5 | 1 200 |
| reference | - | 36.24 ± 2.05 | - | - | 420- |
| 1 | OCH3 | 2-Cl | 3×5 | 27.7 ± 2.82 | 32 | 3×5 | 1 080 |
| reference | - | 36.24 ± 2.05 | - | - | 435 |
| 5 | OCH3 | H | 3×200 | 8.42 ± 3.28 | -79 | 3×200 | 1 200 |
| reference | - | 40.68 ± 1.74 | - | - | 420 |
| 6 | OC2H5 | 2-Cl | 3×200 | 5.89 ± 0.99 | -86 | 3×200 | 1 200 |
| reference | - | 40.68 ± 1.74 | - | - | 420 |
| 9 | n-OBu | 2-Cl | 3×200 | 29.99 ± 3.05 | -22 | - | - |
| reference | | 38.56 ± 2.42 | - | - | - |
| 12 | N(CH3)2 | 2-Cl | 3×200 | 21.39 ± 2.92 | -40 | - | - |
| reference | - | 35.76 ± 1.76 | - | - | - |
| 13 |  | 2-Cl | - | - | - | 3×200 | 1 200 |
| reference | - | - | - | - | 600 |
| 15 | NHCH3 | 2-Cl | - | - | - | 3×200 | 1 200 |
| reference | - | - | - | - | 600 |
), ArticleFig(id=1210147818333925884, tenantId=1146029695717560320, journalId=1189982191388893191, articleId=1210147811975360653, language=CN, label=Table 2, caption=
The anti-thrombotic activity and bleeding time of representative compounds
, figureFileSmall=null, figureFileBig=null, tableContent=
| |
| Compd. | R | X | Antithrombotic activity | | | | Bleeding time |
| Dosage/mg·kg-1 | Wt thrombosis/mg | Variation/% | Dosage/mg·kg-1 | Result/s |
| 1 | OCH3 | 2-Cl | 3×25 | 6.65 ± 0.51 | | -85 | | 3×25 | 1 200 |
| reference | - | 36.24 ± 2.05 | - | - | 420 |
| 1 | OCH3 | 2-Cl | 3×12.5 | 15.89 ± 1.81 | -56 | 3×12.5 | 1 200 |
| reference | - | 36.24 ± 2.05 | - | - | 420- |
| 1 | OCH3 | 2-Cl | 3×5 | 27.7 ± 2.82 | 32 | 3×5 | 1 080 |
| reference | - | 36.24 ± 2.05 | - | - | 435 |
| 5 | OCH3 | H | 3×200 | 8.42 ± 3.28 | -79 | 3×200 | 1 200 |
| reference | - | 40.68 ± 1.74 | - | - | 420 |
| 6 | OC2H5 | 2-Cl | 3×200 | 5.89 ± 0.99 | -86 | 3×200 | 1 200 |
| reference | - | 40.68 ± 1.74 | - | - | 420 |
| 9 | n-OBu | 2-Cl | 3×200 | 29.99 ± 3.05 | -22 | - | - |
| reference | | 38.56 ± 2.42 | - | - | - |
| 12 | N(CH3)2 | 2-Cl | 3×200 | 21.39 ± 2.92 | -40 | - | - |
| reference | - | 35.76 ± 1.76 | - | - | - |
| 13 | | 2-Cl | - | - | - | 3×200 | 1 200 |
| reference | - | - | - | - | 600 |
| 15 | NHCH3 | 2-Cl | - | - | - | 3×200 | 1 200 |
| reference | - | - | - | - | 600 |
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