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Article(id=1239231274481676827, tenantId=1146029695717560320, journalId=1205117023404326918, issueId=1239231265254207730, articleNumber=null, orderNo=null, doi=10.16155/j.0254-1793.2023-0531, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1692201600000, receivedDateStr=2023-08-17, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1773385359639, onlineDateStr=2026-03-13, pubDate=1725033600000, pubDateStr=2024-08-31, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1773385359639, onlineIssueDateStr=2026-03-13, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1773385359639, creator=13701087609, updateTime=1773385359639, updator=13701087609, issue=Issue{id=1239231265254207730, tenantId=1146029695717560320, journalId=1205117023404326918, year='2024', volume='44', issue='8', pageStart='1285', pageEnd='1462', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=0, articleOrder=1, issueType=-1, specialIssue=null, createTime=1773385357440, creator=13701087609, updateTime=1773385579800, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1239232197937393856, tenantId=1146029695717560320, journalId=1205117023404326918, issueId=1239231265254207730, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1239232197937393857, tenantId=1146029695717560320, journalId=1205117023404326918, issueId=1239231265254207730, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=1437, endPage=1442, ext={EN=ArticleExt(id=1239231274884330027, articleId=1239231274481676827, tenantId=1146029695717560320, journalId=1205117023404326918, language=EN, title=Determination of migration of 7 elements in recombinant human coagulation factor Ⅷ-Fc fusion protein for injection by ICP-MS, columnId=1206272757852074373, journalTitle=Chinese Journal of Pharmaceutical Analysis, columnName=Safety Monitoring, runingTitle=null, highlight=null, articleAbstract=
Objective:

To establish an inductively coupled plasma mass spectrometry (ICP-MS) method for the determination of migration Co，As，Br，Cd，Sb，Ba and Pb in recombinant human coagulation factor Ⅷ-Fc fusion protein for injection，and to quantitatively analyze the compatibility of long-term stored samples.

Methods:

After adding 0.75 mL of water to the sample for 4 h，the purified water was filled to 5 mL，and the contents of 7 elements in the solution were determined by standard addition method. The working parameters of ICP-MS：radio frequency (RF) power of 1 550 W，sampling depth of 10.0 mm，carrier gas flow rate of 0.50 L·min-1，atomizer pump speed of 0.30 r·s-1，atomization chamber temperature of 2 ℃，dilution gas flow rate of 0.74 L·min-1，repeated sampling times of 3 times，analysis mode of full quantitative.

Results:

The linear relationship of each element was good in the concentration range of the detected mass，and the recoveries of the element added were 92.0%-101.8%. When applied to the determination of the samples at each accelerated placement point，the increased migration amounts were 43.2，68.7 and 66.8 ng·mL-1，respectively，except the element content of Br increased slightly. The contents of the remaining 6 elements were far below the prescribed limit.

Conclusion:

The method is reliable and can be used for the determination of migration of 7 elements in recombinant human coagulation factor Ⅷ-Fc fusion protein for injection.

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目的：

建立电感耦合等离子体质谱（ICP-MS）法测定注射用重组人凝血因子Ⅷ-Fc融合蛋白中钴（Co）、砷（As）、溴（Br）、镉（Cd）、锑（Sb）、钡（Ba）、铅（Pb）的迁移量，并对相容性长期放置的样品进行定量分析。

方法：

样品加纯化水0.75 mL，倒置复溶4 h后，用纯化水定容至5 mL，采用标准加入法测定待测溶液中7个元素的含量。ICP-MS工作参数：射频功率为1 550 W，采样深度为10.0 mm，载气（氩气）流量为0.50 L·min-1，雾化器泵速为0.30 r·s-1，雾化室温度为2 ℃，稀释气流量为0.74 L·min-1，重复取样次数3次，分析模式为全定量。

结果：

各元素在各自的检测质量浓度范围内线性关系良好，元素加标回收率在92.0%~101.8%，应用于各加速放置点样品的检测时，除Br元素含量略有增长（增长迁移量分别为43.2、68.7、66.8 ng·mL-1）外，其余6个元素含量均远小于规定限度。

结论：

经方法学验证，本方法结果可靠，可用于注射用重组人凝血因子Ⅷ-Fc融合蛋白样品中7个元素的迁移量测定。

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Tel：13641986090；E-mail：

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Tel：13641986090；E-mail：

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Tel：13641986090；E-mail：

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The results of linear relation，LOD and LOQ

, figureFileSmall=null, figureFileBig=null, tableContent=
元素
（element）		线性范围
（linear range）/（ng·mL-1）		回归方程
（regression equation）		rLOD/（ng·mL-1）LOQ/（ng·mL-1）
Co1~100Y=8.609×10-2X+1.038×10-30.999 80.0020.006
As1~100Y=1.114×10-2 X+6.113×10-41.0000.0060.021
Br10~1 000Y=2.930×10-4 X+8.868×10-40.999 92.7759.250
Cd1~100Y=4.783×10-3 X+1.860×10-40.999 90.0030.009
Sb1~100Y=3.507×10-3 X+1.037×10-40.999 90.0080.027
Ba1~100Y=1.009×10-3 X+7.463×10-50.999 60.0260.088
Pb1~100Y=8.393×10-3 X+8.207×10-40.999 70.0040.013
), ArticleFig(id=1239231279049274095, tenantId=1146029695717560320, journalId=1205117023404326918, articleId=1239231274481676827, language=CN, label=表1, caption=

线性关系、检测限及定量限结果

, figureFileSmall=null, figureFileBig=null, tableContent=
元素
（element）		线性范围
（linear range）/（ng·mL-1）		回归方程
（regression equation）		rLOD/（ng·mL-1）LOQ/（ng·mL-1）
Co1~100Y=8.609×10-2X+1.038×10-30.999 80.0020.006
As1~100Y=1.114×10-2 X+6.113×10-41.0000.0060.021
Br10~1 000Y=2.930×10-4 X+8.868×10-40.999 92.7759.250
Cd1~100Y=4.783×10-3 X+1.860×10-40.999 90.0030.009
Sb1~100Y=3.507×10-3 X+1.037×10-40.999 90.0080.027
Ba1~100Y=1.009×10-3 X+7.463×10-50.999 60.0260.088
Pb1~100Y=8.393×10-3 X+8.207×10-40.999 70.0040.013
), ArticleFig(id=1239231279149937405, tenantId=1146029695717560320, journalId=1205117023404326918, articleId=1239231274481676827, language=EN, label=Tab.2, caption=

Recoveries and RSDs

, figureFileSmall=null, figureFileBig=null, tableContent=
元素
（element）		平均回收率
（average recovery）/%		重复性
（repeatability）RSD/%
Co95.11.4
As95.22.8
Br92.24.8
Cd95.40.36
Sb101.60.62
Ba101.81.6
Pb92.00.40
), ArticleFig(id=1239231279254795010, tenantId=1146029695717560320, journalId=1205117023404326918, articleId=1239231274481676827, language=CN, label=表2, caption=

回收率与重复性（n=6）

, figureFileSmall=null, figureFileBig=null, tableContent=
元素
（element）		平均回收率
（average recovery）/%		重复性
（repeatability）RSD/%
Co95.11.4
As95.22.8
Br92.24.8
Cd95.40.36
Sb101.60.62
Ba101.81.6
Pb92.00.40
), ArticleFig(id=1239231279355458313, tenantId=1146029695717560320, journalId=1205117023404326918, articleId=1239231274481676827, language=EN, label=Tab.3, caption=

The test results of samples

, figureFileSmall=null, figureFileBig=null, tableContent=
批号
（batch No.）		不同放置条件
（different placement condition）		含量(content)/（ng·mL-1）
CoAsBrCdSbBaPb
107201704Z01B0个月（month）NDND140.1NDNDNDND
加速3个月（accelerated for 3 months）NDND164.9NDNDNDND
加速6个月（accelerated for 6 months）NDND183.3NDNDNDND
107201704Z02B0个月（month）NDND121.8NDNDNDND
加速3个月（accelerated for 3 months）NDND152.4NDNDNDND
加速6个月（accelerated for 6 months）NDND190.5NDNDNDND
107201705Z01B0个月（month）NDND131.3NDNDNDND
加速3个月（accelerated for 3 months）NDND170.8NDNDNDND
加速6个月（accelerated for 6 months）NDND198.1NDNDNDND
), ArticleFig(id=1239231279447733009, tenantId=1146029695717560320, journalId=1205117023404326918, articleId=1239231274481676827, language=CN, label=表3, caption=

样品测试结果

, figureFileSmall=null, figureFileBig=null, tableContent=
批号
（batch No.）		不同放置条件
（different placement condition）		含量(content)/（ng·mL-1）
CoAsBrCdSbBaPb
107201704Z01B0个月（month）NDND140.1NDNDNDND
加速3个月（accelerated for 3 months）NDND164.9NDNDNDND
加速6个月（accelerated for 6 months）NDND183.3NDNDNDND
107201704Z02B0个月（month）NDND121.8NDNDNDND
加速3个月（accelerated for 3 months）NDND152.4NDNDNDND
加速6个月（accelerated for 6 months）NDND190.5NDNDNDND
107201705Z01B0个月（month）NDND131.3NDNDNDND
加速3个月（accelerated for 3 months）NDND170.8NDNDNDND
加速6个月（accelerated for 6 months）NDND198.1NDNDNDND
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ICP-MS测定注射用重组人凝血因子Ⅷ-Fc融合蛋白中7个元素的迁移量
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丁豪
药物分析杂志 | 安全监测 2024,44(8): 1437-1442
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药物分析杂志 | 安全监测 2024, 44(8): 1437-1442
ICP-MS测定注射用重组人凝血因子Ⅷ-Fc融合蛋白中7个元素的迁移量
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丁豪
作者信息
  • 上海市食品药品包装材料测试所，上海 201203

    • Tel：13641986090；E-mail：

Determination of migration of 7 elements in recombinant human coagulation factor Ⅷ-Fc fusion protein for injection by ICP-MS
Hao DING
Affiliations
  • Shanghai Food and Drug Packaging Material Control Center，Shanghai 201203，China
出版时间: 2024-08-31 doi: 10.16155/j.0254-1793.2023-0531
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摘要
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目的：

建立电感耦合等离子体质谱（ICP-MS）法测定注射用重组人凝血因子Ⅷ-Fc融合蛋白中钴（Co）、砷（As）、溴（Br）、镉（Cd）、锑（Sb）、钡（Ba）、铅（Pb）的迁移量，并对相容性长期放置的样品进行定量分析。

方法：

样品加纯化水0.75 mL，倒置复溶4 h后，用纯化水定容至5 mL，采用标准加入法测定待测溶液中7个元素的含量。ICP-MS工作参数：射频功率为1 550 W，采样深度为10.0 mm，载气（氩气）流量为0.50 L·min-1，雾化器泵速为0.30 r·s-1，雾化室温度为2 ℃，稀释气流量为0.74 L·min-1，重复取样次数3次，分析模式为全定量。

结果：

各元素在各自的检测质量浓度范围内线性关系良好，元素加标回收率在92.0%~101.8%，应用于各加速放置点样品的检测时，除Br元素含量略有增长（增长迁移量分别为43.2、68.7、66.8 ng·mL-1）外，其余6个元素含量均远小于规定限度。

结论：

经方法学验证，本方法结果可靠，可用于注射用重组人凝血因子Ⅷ-Fc融合蛋白样品中7个元素的迁移量测定。

电感耦合等离子体质谱  /  注射用重组人凝血因子Ⅷ-Fc融合蛋白  /  元素杂质  /  相容性  /  迁移量
Objective:

To establish an inductively coupled plasma mass spectrometry (ICP-MS) method for the determination of migration Co，As，Br，Cd，Sb，Ba and Pb in recombinant human coagulation factor Ⅷ-Fc fusion protein for injection，and to quantitatively analyze the compatibility of long-term stored samples.

Methods:

After adding 0.75 mL of water to the sample for 4 h，the purified water was filled to 5 mL，and the contents of 7 elements in the solution were determined by standard addition method. The working parameters of ICP-MS：radio frequency (RF) power of 1 550 W，sampling depth of 10.0 mm，carrier gas flow rate of 0.50 L·min-1，atomizer pump speed of 0.30 r·s-1，atomization chamber temperature of 2 ℃，dilution gas flow rate of 0.74 L·min-1，repeated sampling times of 3 times，analysis mode of full quantitative.

Results:

The linear relationship of each element was good in the concentration range of the detected mass，and the recoveries of the element added were 92.0%-101.8%. When applied to the determination of the samples at each accelerated placement point，the increased migration amounts were 43.2，68.7 and 66.8 ng·mL-1，respectively，except the element content of Br increased slightly. The contents of the remaining 6 elements were far below the prescribed limit.

Conclusion:

The method is reliable and can be used for the determination of migration of 7 elements in recombinant human coagulation factor Ⅷ-Fc fusion protein for injection.

inductively coupled plasma mass spectrometry（ICP-MS）  /  recombinant human coagulation factor Ⅷ-Fc fusion protein for injection  /  elemental impurity  /  package compatibility  /  migrating migration
丁豪. ICP-MS测定注射用重组人凝血因子Ⅷ-Fc融合蛋白中7个元素的迁移量. 药物分析杂志, 2024 , 44 (8) : 1437 -1442 . DOI: 10.16155/j.0254-1793.2023-0531
Hao DING. Determination of migration of 7 elements in recombinant human coagulation factor Ⅷ-Fc fusion protein for injection by ICP-MS[J]. Chinese Journal of Pharmaceutical Analysis, 2024 , 44 (8) : 1437 -1442 . DOI: 10.16155/j.0254-1793.2023-0531
正文
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人凝血因子Ⅷ（human coagulation factor Ⅷ，FⅧ）是人体内源性凝血系统级联反应中的一个重要因子，由肝脏中的肝窦内皮细胞和血管内皮细胞合成，是一种相对分子质量较大，由多肽前体演变而成活性杂合双体的糖蛋白，在止血过程中发挥着至关重要的作用[1-3]。由于FⅧ缺乏引起的血友病A(haemophilia A)，是临床上较为普遍的血友病类型，约占血友病患者总数的80%，其中，男性发病率约为1/5 000[4]。血友病A目前尚无法根治，FⅧ进行替代治疗是现在的主要治疗方法[5]。FⅧ是从健康人血浆中提取制备的一种血液制品，但是近年来，由于血浆来源紧张以及血源类产品有潜在传播病毒的风险，重组人凝血因子Ⅷ（recombinant coagulation factor Ⅷ，rFⅧ）注射剂产品开始被研究生产并用于临床治疗[6-8]。rFⅧ通过基因重组技术获得，可有效降低人或动物来源成分，从而降低免疫原性及病毒污染的可能，提高产品的安全性[9]。rFⅧ用于血友病A，主要是在纠正或预防出血，急诊或择期手术中，可以起到暂时代替缺失的凝血因子的作用。目前，rFⅧ注射剂通常为冻干粉针剂，主要采用硼硅管制注射剂瓶和卤化丁基橡胶塞进行包装。本文采用ICP-MS法测定注射用rFⅧ-Fc融合蛋白中可能从玻璃迁移的钴（Co）、砷（As）、镉（Cd）、锑（Sb）、钡（Ba）、铅（Pb）6个元素，以及可能从溴化丁基橡胶塞中迁移的溴（Br）元素的迁移量。该方法操作简便，准确可靠，专属性强，可对注射用重组人凝血因子Ⅷ-Fc融合蛋白中可能迁移的重金属元素进行监控，为注射用重组人凝血因子Ⅷ-Fc融合蛋白的风险监控及相容性研究提供技术参考。
1　仪器与试药
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1.1　仪器
Agilent 8900型等离子体质谱仪，安捷伦科技有限公司；Binder FD240恒温干燥箱和Binder KBF-720恒温恒湿箱，宾得公司；Milli-Q制水机，默克公司。
1.2　试药
Co、As、Cd、Sb、Ba、Pb 6个元素的混合标准溶液（100 μg·mL-1，国家钢铁材料测试中心钢铁研究总院，批号21DC302）；Br标准溶液（100 μg·mL-1，中国计量测试技术研究院，批号1904）；硝酸（65%，Merck公司，批号Z235341122）；纯化水（电阻率为18 MΩ·cm）。
1.3　样品
3批厂家提供的注射用rFⅧ-Fc融合蛋白样品，批号分别为107201704Z01B、107201704Z02B、107201705Z01B，规格为250 IU。根据药品相容性指导原则，按照加速放置条件（15 ℃±2 ℃），放置加速3、6个月。
2　方法与结果
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2.1　ICP-MS测试条件
以氩气为载气，氦气为碰撞气，取调谐溶液对仪器条件进行优化，参数为：功率1 550 W，采样深度10.0 mm，载气流量0.50 L·min-1，雾化器泵速0.30 r·s-1，雾化室温度2 ℃，稀释气流量0.74 L·min-1，重复取样3次，分析模式为全定量，测定时选取的元素质量数为59Co、75As、81Br、111Cd、121Sb、137Ba、208Pb。其中，59Co以45Sc作为内标，75As、81Br以72Ge作为内标，114Cd以115In、121Sb、137Ba作为内标，208Pb以103Rh作为内标，各元素的质谱图见图1。
2.2　溶液的配制
2.2.1　对照品溶液
取6个元素混合标准溶液（100 μg·mL-1）1.0 mL和Br元素的标准溶液（100 μg·mL-1）1.0 mL，置100 mL量瓶中，用纯化水稀释至刻度，得到质量溶液为1 μg·mL-1的混合标准溶液。取混合标准溶液0.1、0.5、1.0、2.0、2.5、5.0、10.0 mL，分别置100 mL量瓶中，用纯化水稀释至刻度，得到质量浓度分别为1、5、10、20、25、50、100 ng·mL-1的对照品溶液。
2.2.2　供试品溶液
取样品1瓶，加纯化水0.75 mL复溶，常温避光倒置4 h后，转移至5 mL量瓶中，用纯化水定容至刻度，待测，同法制备2份。
2.3　方法学验证
2.3.1　线性关系考察
取“2.2.1”项下系列浓度对照品溶液进行测定，以元素响应值Y作为纵坐标，元素质量浓度X作为横坐标，进行线性回归。结果见表1，各元素在线性范围内精密度与稳定性较好。
2.3.2　检测限与定量限
取纯化水平行测定10次。根据C=3Sb/k得到元素检测限，C=10Sb/k得到元素定量限，结果见表1。
2.3.3　精密度试验
取“2.2.1”项下20 ng·mL-1的对照品溶液，连续测定6次，计算RSD。结果显示，Co、As、Br、Cd、Sb、Ba、Pb的精密度RSD分别为0.80%、0.080%、3.4%、0.53%、0.45%、0.89%和0.79%，精密度良好。
2.3.4　回收率及重复性试验
取批号为107201704Z01B的样品6瓶，分别精密加入1 μg·mL-1的混合标准溶液1.0 mL，用纯化水稀释定容至20 mL，即得20 ng·mL-1的加标样品，进行测定，计算平均回收率，结果见表2。因样品中部分元素含量低于检测限，故本试验的重复性用6次回收率测定值的RSD表示。
2.3.5　稳定性试验
任意取回收率项下的1瓶加标样品，在测定完后放置24 h后再次测定，计算RSD，结果显示，Co、As、Br、Cd、Sb、Ba、Pb的RSD分别为2.5%、2.1%、2.1%、2.9%、2.9%、3.6%和2.4%，稳定性良好。
2.3.6　样品测定
取各批次样品的供试品溶液进行测定，结果见表3。根据ICH-Q3D的有关要求，As、Cd、Pb为1类元素，Co为2A类元素，Sb、Ba为3类元素，如通过注射给药途径进入人体，As、Cd、Pb、Co、Sb、Ba的日允许暴露量（PDE）分别为不得超过15、2、5、5、90、700 μg[10-12]。注射用rFⅧ-Fc融合蛋白每日最大用量为16瓶，按照30% PDE计算日摄入量控制阈值，每瓶用纯化水稀释定容至5 mL后测定，故限度为As不得超过56.25 ng·mL-1，Cd不得超7.5 ng·mL-1，Pb不得超过18.75 ng·mL-1，Co不得超过18.75 ng·mL-1，Sb不得超过337.5 ng·mL-1，Ba不得超过2 625 ng·mL-1。测定结果表明，不同时间加速放置的样品均符合规定。
3　讨论
收起
3.1　元素选择
本文考察的7个元素中，6个元素为ICH-Q3D所限制的金属元素，且是硼硅玻璃的的主要杂质成分，硼硅玻璃的质量及稳定性一定程度上会影响到药品的质量和稳定性[13-15]，危害人体健康，因此，我国市售的药用玻璃包装必须符合国家YBB标准的相关规定[16]。Br元素是溴化丁基橡胶塞的主要成分，考察Br元素的含量变化，可以看出胶塞对药品是否稳定安全。
3.2　测定结果的分析
加速放置的目的是为了考察样品的长期稳定性和相容性，从样品测试结果可以看出，随着放置时间的延长，除Br元素以外的其余元素均未检出，远小于30% PDE，说明玻璃中的金属元素未发生明显迁移，注射用rFⅧ-Fc融合蛋白与玻璃包装相容性良好。同时，3批样品的Br元素在加速放置6个月后含量略有增长，但相对都较小，增量分别为43.2、68.7、66.8 ng·mL-1，说明胶塞基本稳定。因此说明，一般的中硼硅玻璃瓶和溴化丁基橡胶塞足以满足注射用rFⅧ-Fc融合蛋白装药需求。
3.3　测试方法的选择
ICP-MS法可以同时测定多种元素，具有灵敏度高，干扰少，线性宽等优点，已被广泛应用于中药样品重金属的残留分析[17-19]。本文采用ICP-MS法测定注射用rFⅧ-Fc融合蛋白中7个元素，方法简便，可操作性强，且准确可靠，专属性高。从样品分析结果看，样品测试结果稳定，且回收率较好，为rFⅧ的相容性研究和产品质量控制提供了一定的经验。
3.4　同位素元素的选择
使用ICP-MS法分析时多数元素经常会受到不同程度的同量异位素干扰。本试验中的待测元素Br、Cd、Sb、Ba、Pb都有多个同位素，可按照丰度大、干扰小的原则来选定待测元素质量数[20]。以Cd为例，Cd的同位素有106Cd、108Cd、110Cd、111Cd、112Cd、113Cd、114Cd和116Cd等8种，其中106Cd、108Cd和116Cd的丰度均小于10%，在ICP-MS设置采集质量数时一般不予考虑，112Cd和114Cd的丰度均大于20%，但都存在Sn干扰，110Cd、111Cd和113Cd丰度均大于10%且小于20%，但110Cd和113Cd也都存在Sn干扰，因此综合考虑选定111Cd。Br、Sb、Ba元素也是同样的原理，分别选择81Br、121Sb、137Ba；Pb元素主要有4种同位素，分别为204Pb、206Pb、207Pb、208Pb，其中208Pb丰度最大，但因为本试验基质为纯化水体系，在试验中发现，Pb在采集时若仅选定208Pb，未开启干扰方程，样品的加标回收率会偏低，参考相关文献和标准[21]，后续试验中勾选干扰方程，即Mc(208)=M(206)×1+M(207)×1+M(208)×1，样品的加标回收率良好。
4　结论
收起
综合上述最优仪器条件，本研究使用ICP-MS方法对注射用rFⅧ-Fc融合蛋白样品中7个元素的迁移量进行检测分析，线性拟合度良好，方法操作简单，结果准确稳定，灵敏度高，满足样品测定的要求，可为注射用rFⅧ-Fc融合蛋白的风险监控及相容性研究提供技术参考。
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2024年第44卷第8期
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doi: 10.16155/j.0254-1793.2023-0531
  • 接收时间：2023-08-17
  • 首发时间：2026-03-13
  • 出版时间：2024-08-31
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  • 收稿日期：2023-08-17
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    上海市食品药品包装材料测试所，上海 201203
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2种不同金属材料的力学参数
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Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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