Article(id=1320389109026243384, tenantId=1146029695717560320, journalId=1319373289681944729, issueId=1320388874665316750, articleNumber=null, orderNo=null, doi=10.11876/mimt202503007, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1792734895235, onlineDateStr=2026-10-23, pubDate=1749484800000, pubDateStr=2025-06-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792734895235, onlineIssueDateStr=2026-10-23, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792734895235, creator=13701087609, updateTime=1792734895235, updator=13701087609, issue=Issue{id=1320388874665316750, tenantId=1146029695717560320, journalId=1319373289681944729, year='2025', volume='31', issue='3', pageStart='1', pageEnd='96', issueExtLink='null', onlineDate='null', pubDate='1749484800000', pubDateStr='2025-06-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1792734839359, creator='13701087609', updateTime=1792746430009, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1320437489425305846, tenantId=1146029695717560320, journalId=1319373289681944729, issueId=1320388874665316750, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1320437489429500151, tenantId=1146029695717560320, journalId=1319373289681944729, issueId=1320388874665316750, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=41, endPage=45, ext={EN=ArticleExt(id=1320389109357593401, articleId=1320389109026243384, tenantId=1146029695717560320, journalId=1319373289681944729, language=EN, title=The value of multislice spiral CT haemodynamic parameters in assessing the effect of chemotherapy in patients with advanced gastric cancer, columnId=null, journalTitle=Modern Instruments & Medical Treatment, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective To investigate the value of multislice spiral computed tomography (MSCT) haemodynamic parameters in evaluating the efficacy of chemotherapy in patients with advanced gastric cancer.
Methods 120 patients with advanced gastric cancer admitted to our hospital between October 2021 and October 2023 who met the criteria for natriuresis were selected as study subjects. Fluorouracil-based combined with platinum-based chemotherapy was used, once every 3 weeks, for a total of 8 cycles. After patients completed 8 cycles of chemotherapy, they were divided into effective group (54 cases) and ineffective group (66 cases) according to the solid tumour efficacy evaluation criteria. Scanning was performed using MSCT to compare the changes in haemodynamic parameters before and after chemotherapy, including blood flow (BF), blood volume (BV), permeability surface (PS), perfusion blood flow (PBV), etc.
Results When efficacy was assessed after completion of the first and eighth cycles of chemotherapy, the overall effectiveness of the 120 patients with advanced gastric cancer was 32.50% (39/120) and 45.00% (54/120), respectively. After 8 cycles of chemotherapy, 120 patients with advanced gastric cancer showed a significant decreasing trend in the haemodynamic parameters BF, BV, PS and PBV by MSCT scanning, the difference was statistically significant (P<0.001). Before chemotherapy, the BF, PS and PBV of the effective group were higher than those of the ineffective group, and the BV was lower than those of the ineffective group. Although there were numerical differences between the two groups in the parameters of BF, BV, PS and PBV, none of them was statistically significant (P>0.05). Meanwhile, the decrease of these parameters in the effective group was more significant than that in the ineffective group (P<0.001). Compared with the ineffective group, patients in the effective group showed a more significant decrease in BF, BV, PS and PBV values (P<0.001).
Conclusion MSCT haemodynamic parameters as important indicators of tumour angiogenesis and microcirculatory status, which can comprehensively assess the effect of chemotherapy in patients with advanced gastric cancer.
, authors=Yiping Wang, Guangli Meng, Xiaozhen Rao, Xiaolu Li, authorsList=Yiping Wang, Guangli Meng, Xiaozhen Rao, Xiaolu Li, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=
All copyrights in 2025 belong to the sponsor of the journal.Not content published by the journal may be reproduced or abridged without authorization., copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1320389109907047226, articleId=1320389109026243384, tenantId=1146029695717560320, journalId=1319373289681944729, language=CN, title=多层螺旋CT血流动力学参数对晚期胃癌患者化疗效果的评估价值, columnId=1320381058969883180, journalTitle=现代仪器与医疗, columnName=临床研究, runingTitle=null, highlight=null, articleAbstract=
目的 探讨多层螺旋计算机断层扫描（multislice spiral computed tomography，MSCT）血流动力学参数在评估晚期胃癌患者化疗效果方面的应用价值。
方法 选取2021年10月至2023年10月期间医院收治的120例符合纳排标准的晚期胃癌患者作为研究对象。采用氟尿嘧啶类联合铂类进行化疗，3周为1个周期，共8个周期。患者完成化疗后，根据实体瘤疗效评价标准划分为有效组（54例）和无效组（66例）。使用MSCT进行扫描，比较化疗前后血流动力学参数的变化，包含血流量（blood flow，BF）、血容量（blood volume，BV）、表面通透性（permeability surface，PS）、灌注血流量（perfusion blood volume，PBV）等指标。
结果 在完成第1个周期及第8个周期化疗后评估疗效，120例晚期胃癌患者的总有效率分别为32.50%（39/120）和45.00%（54/120）。化疗8个周期后，120例晚期胃癌患者经MSCT扫描，其血流动力学参数BF、BV、PS、PBV均呈现显著降低趋势，差异具有统计学意义（P<0.001）。化疗前，有效组的BF、PS、PBV均高于无效组，BV低于无效组，但是两组在BF、BV、PS、PBV参数上的差异均无统计学意义（P>0.05）；化疗后，有效组的BF、BV、PS、PBV均低于无效组，且差异均有统计学意义（P<0.001）。
结论 MSCT血流动力学参数作为反映肿瘤血管生成及微循环状态的重要指标，可全面评估晚期胃癌患者的化疗效果。
, authors=王义平, 孟光丽, 饶小珍, 李晓露, authorsList=王义平, 孟光丽, 饶小珍, 李晓露, authorCompany=null, correspAuthors=null, authorNote=
王义平，男，硕士研究生，主治医师，研究方向：肿瘤精准诊断及治疗
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2025年版权归本刊主办单位所有未经本刊书面许可, 不得转载、摘编本刊所有文章内容。, copyrightOwner=中国科学器材公司, extLink=null, articleAbsUrl=null, sourceXml=x5wAuxa/LoFBpOHsuY21mQ==, magXml=O0PqvD5GJ9+NVqKUZcxWwQ==, pdfUrl=null, pdf=qsmS2prFRMTByw308nn2ag==, pdfFileSize=1524395, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=ZJMAhBp0+YOMwlwOi5MzbA==, mapNumber=null, fund=null)}, authors=[Author(id=1320389110330671935, tenantId=1146029695717560320, journalId=1319373289681944729, articleId=1320389109026243384, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1320389110406169409, tenantId=1146029695717560320, journalId=1319373289681944729, articleId=1320389109026243384, authorId=1320389110330671935, language=EN, stringName=Yiping Wang, firstName=Yiping, middleName=null, lastName=Wang, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Department of Oncology, Shanghai Yangsi Hospital, Shanghai 200126, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1320389110473278274, tenantId=1146029695717560320, journalId=1319373289681944729, articleId=1320389109026243384, authorId=1320389110330671935, language=CN, stringName=王义平, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=上海杨思医院肿瘤科，上海 200126, bio={"content":"
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