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Article(id=1320389072296727325, tenantId=1146029695717560320, journalId=1319373289681944729, issueId=1320388933154878311, articleNumber=null, orderNo=null, doi=10.11876/mimt202504011, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1792734886478, onlineDateStr=2026-10-23, pubDate=1754755200000, pubDateStr=2025-08-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792734886478, onlineIssueDateStr=2026-10-23, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792734886478, creator=13701087609, updateTime=1792734886478, updator=13701087609, issue=Issue{id=1320388933154878311, tenantId=1146029695717560320, journalId=1319373289681944729, year='2025', volume='31', issue='4', pageStart='2', pageEnd='132', issueExtLink='null', onlineDate='null', pubDate='1754755200000', pubDateStr='2025-08-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1792734853304, creator='13701087609', updateTime=1792746408152, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1320437397758791917, tenantId=1146029695717560320, journalId=1319373289681944729, issueId=1320388933154878311, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1320437397758791918, tenantId=1146029695717560320, journalId=1319373289681944729, issueId=1320388933154878311, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=101, endPage=110, ext={EN=ArticleExt(id=1320389072477082398, articleId=1320389072296727325, tenantId=1146029695717560320, journalId=1319373289681944729, language=EN, title=An overview of the application of in vivo small animal imaging technology in oncology research, columnId=null, journalTitle=Modern Instruments & Medical Treatment, columnName=null, runingTitle=null, highlight=null, articleAbstract=

In vivo small animal imaging technology serves as a powerful tool for investigating tumor biology and evaluating anti-tumor therapeutic efficacy. This non-invasive modality enables real-time, dynamic observation of tumor initiation, progression, metastasis, and treatment response in living organisms, offering distinct advantages including visualizability, high spatiotemporal resolution, and exceptional sensitivity. Widely adopted in oncology research, this technology encompasses multimodal imaging approaches such as optical, nuclear medicine, and magnetic resonance imaging, each demonstrating unique characteristics and application scenarios. This article systematically summarizes three predominant in vivo small animal imaging techniques—optical 3D imaging, near-infrared fluorescence imaging, and 3D tomographic scanning, highlighting their respective technical advantages and application domains. Through presenting cutting-edge case studies in tumor mechanism research, metastasis monitoring, and therapeutic response assessment, this review aims to provide substantive references for advancing the application of in vivo small animal imaging in oncology research and anti-tumor treatment development.

, authors=Yidan Zhou, Yuanyuan Lyu, Ximin Jin, Xingguang Liang*, authorsList=Yidan Zhou, Yuanyuan Lyu, Ximin Jin, Xingguang Liang, authorCompany=null, correspAuthors=Xingguang Liang, authorNote=null, correspAuthorsNote=null, copyrightStatement=All copyrights in 2025 belong to the sponsor of the journal.Not content published by the journal may be reproduced or abridged without authorization., copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1320389072791655199, articleId=1320389072296727325, tenantId=1146029695717560320, journalId=1319373289681944729, language=CN, title=小动物活体成像技术在肿瘤研究领域的应用综述, columnId=1320389006882357264, journalTitle=现代仪器与医疗, columnName=生物应用, runingTitle=null, highlight=null, articleAbstract=

小动物活体成像技术是研究肿瘤生物学及评估抗肿瘤治疗效果的有力工具，它允许在活体动物中无创、实时、动态地观察肿瘤的发生、发展、转移以及对治疗的反应，具有可视化、高时空分辨率、高灵敏度等优点，被广泛应用于肿瘤研究领域。该技术涵盖了光学、核医学、磁共振等多模态的成像手段，并各具特色和应用场景。本文系统总结了活体光学三维成像技术、近红外活体成像技术、活体三维断层扫描成像技术这3种主流的小动物活体成像技术的优势特点和应用方向，并介绍其在肿瘤机制研究、肿瘤转移监测、抗肿瘤疗效评估等领域的最新应用案例，以期为小动物活体成像技术在肿瘤研究及抗肿瘤治疗领域的应用提供参考。

, authors=周一丹, 吕媛媛, 金锡敏, 梁星光*, authorsList=周一丹, 吕媛媛, 金锡敏, 梁星光, authorCompany=null, correspAuthors=梁星光, authorNote=

周一丹，女，硕士研究生，助理实验师，研究方向：活体光学成像

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梁星光，男，博士研究生，高级实验师，研究方向：荧光探针开发及其生物学应用
, copyrightStatement=2025年版权归本刊主办单位所有未经本刊书面许可, 不得转载、摘编本刊所有文章内容。, copyrightOwner=中国科学器材公司, extLink=null, articleAbsUrl=null, sourceXml=zXq7eXC8phweDt83hRFkBg==, magXml=a5xAuTp4ujz8X9PCRH98Rg==, pdfUrl=null, pdf=UCJ9d7XUwIC1C7tQsVgv8w==, pdfFileSize=2675479, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=72jUG7Sudd3nXtTFw/rDuw==, mapNumber=null, fund=null)}, authors=[Author(id=1320389073076867876, tenantId=1146029695717560320, journalId=1319373289681944729, articleId=1320389072296727325, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1320389073139782438, tenantId=1146029695717560320, journalId=1319373289681944729, articleId=1320389072296727325, authorId=1320389073076867876, language=EN, stringName=Yidan Zhou, firstName=Yidan, middleName=null, lastName=Zhou, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Central Laboratory, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310000, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1320389073211085607, tenantId=1146029695717560320, journalId=1319373289681944729, articleId=1320389072296727325, authorId=1320389073076867876, language=CN, stringName=周一丹, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=浙江大学医学院附属第一医院中心实验室，杭州　310000, bio={"content":"

周一丹，女，硕士研究生，助理实验师，研究方向：活体光学成像

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周一丹，女，硕士研究生，助理实验师，研究方向：活体光学成像

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小动物活体成像技术在肿瘤研究领域的应用综述
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周一丹 , 吕媛媛 , 金锡敏 , 梁星光 *
现代仪器与医疗 | 生物应用 2025,31(4): 101-110
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现代仪器与医疗 |生物应用 2025 , 31 (4) : 101 -110
小动物活体成像技术在肿瘤研究领域的应用综述
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周一丹, 吕媛媛, 金锡敏, 梁星光*
作者信息
  • 浙江大学医学院附属第一医院中心实验室，杭州　310000
通讯作者:
梁星光，男，博士研究生，高级实验师，研究方向：荧光探针开发及其生物学应用
作者简介:

周一丹，女，硕士研究生，助理实验师，研究方向：活体光学成像

An overview of the application of in vivo small animal imaging technology in oncology research
Yidan Zhou, Yuanyuan Lyu, Ximin Jin, Xingguang Liang*
Affiliations
  • Central Laboratory, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310000, China
出版时间: 2025-08-10 doi: 10.11876/mimt202504011
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小动物活体成像技术是研究肿瘤生物学及评估抗肿瘤治疗效果的有力工具，它允许在活体动物中无创、实时、动态地观察肿瘤的发生、发展、转移以及对治疗的反应，具有可视化、高时空分辨率、高灵敏度等优点，被广泛应用于肿瘤研究领域。该技术涵盖了光学、核医学、磁共振等多模态的成像手段，并各具特色和应用场景。本文系统总结了活体光学三维成像技术、近红外活体成像技术、活体三维断层扫描成像技术这3种主流的小动物活体成像技术的优势特点和应用方向，并介绍其在肿瘤机制研究、肿瘤转移监测、抗肿瘤疗效评估等领域的最新应用案例，以期为小动物活体成像技术在肿瘤研究及抗肿瘤治疗领域的应用提供参考。

小动物活体成像技术  /  肿瘤研究  /  抗肿瘤治疗  /  可视化观察  /  应用总结

In vivo small animal imaging technology serves as a powerful tool for investigating tumor biology and evaluating anti-tumor therapeutic efficacy. This non-invasive modality enables real-time, dynamic observation of tumor initiation, progression, metastasis, and treatment response in living organisms, offering distinct advantages including visualizability, high spatiotemporal resolution, and exceptional sensitivity. Widely adopted in oncology research, this technology encompasses multimodal imaging approaches such as optical, nuclear medicine, and magnetic resonance imaging, each demonstrating unique characteristics and application scenarios. This article systematically summarizes three predominant in vivo small animal imaging techniques—optical 3D imaging, near-infrared fluorescence imaging, and 3D tomographic scanning, highlighting their respective technical advantages and application domains. Through presenting cutting-edge case studies in tumor mechanism research, metastasis monitoring, and therapeutic response assessment, this review aims to provide substantive references for advancing the application of in vivo small animal imaging in oncology research and anti-tumor treatment development.

Live imaging technology for small animals  /  Oncology research  /  Anti-tumor treatment  /  Visual observation  /  Application summary
周一丹, 吕媛媛, 金锡敏, 梁星光. 小动物活体成像技术在肿瘤研究领域的应用综述. 现代仪器与医疗, 2025 , 31 (4) : 101 -110 . DOI: 10.11876/mimt202504011
Yidan Zhou, Yuanyuan Lyu, Ximin Jin, Xingguang Liang. An overview of the application of in vivo small animal imaging technology in oncology research[J]. Modern Instruments & Medical Treatment, 2025 , 31 (4) : 101 -110 . DOI: 10.11876/mimt202504011
基金
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  • 浙江省自然科学基金探索类项目(LY21H090012)
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doi: 10.11876/mimt202504011
  • 首发时间：2026-10-23
  • 出版时间：2025-08-10
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基金
浙江省自然科学基金探索类项目(LY21H090012)
作者信息
    浙江大学医学院附属第一医院中心实验室，杭州　310000

通讯作者:

梁星光，男，博士研究生，高级实验师，研究方向：荧光探针开发及其生物学应用
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