现代仪器与医疗

小脑磁刺激对运动学习及皮质兴奋性的影响

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潘文秀 ¹^,² , 赵丹 ¹^,²

现代仪器与医疗 | 临床研究 2025,31(3): 46-50

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现代仪器与医疗 |临床研究 2025 , 31 (3) : 46 -50

小脑磁刺激对运动学习及皮质兴奋性的影响

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潘文秀¹^,², 赵丹¹^,²

作者信息

^1.上海市瑞金康复医院康复医学科，上海　200023

^2.上海交通大学医学院附属瑞金医院康复医学科，上海　200025

作者简介:

潘文秀，女，硕士研究生，主治医师，研究方向：神经调控

Effects of cerebellar magnetic stimulation on motor learning and cortical excitability

Wenxiu Pan¹^,², Dan Zhao¹^,²

Affiliations

^1.Department of Rehabilitation and Medicine, Shanghai Ruijin Rehabilitation Hospital, Shanghai 200023, China

^2.Department of Rehabilitation and Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China

出版时间: 2025-06-10 doi: 10.11876/mimt202503008

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摘要

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目的

探讨小脑θ爆发式经颅磁刺激（theta burst stimulation，TBS）对健康人运动序列学习能力及运动皮质兴奋性的短时调控作用。

方法

招募2024年3月—6月在上海市瑞金康复医院康复医学科实习的10名医学生作为受试者，采用单组前后对照设计，对受试者右侧小脑进行单次连续性θ脉冲刺激（continuous theta burst stimulation，cTBS），受试者在刺激前后通过右手完成序列反应时任务（serial reaction time task，SRTT），记录完成SRTT的反应时间及正确率。同时，通过测定左侧初级运动区（primary motor area，M1）的运动诱发电位（motor evoked potential，MEP）波幅、潜伏期、静息运动阈值（resting motor threshold，RMT）、皮质内抑制（intracortical inhibition，ICI）、皮质内易化（intracortical facilitation，ICF）、皮质静息期（cortical silent period，CSP）来评估受试者皮质脊髓兴奋性变化。

结果

cTBS后固定序列反应时延长（P<0.05），随机序列反应时缩短（P<0.05），总正确率保持稳定（P>0.05）；左侧M1区的MEP波幅下降（P<0.05），RMT升高（P<0.05），ICI抑制效应增加（P<0.05），CSP呈延长趋势（P>0.05），ICF在cTBS前后差异无统计学意义。

结论

小脑cTBS会影响健康受试者在运动序列学习中的即刻表现，导致响应延迟，表明小脑cTBS对即刻序列巩固可能产生不利影响；同时小脑cTBS降低了对侧M1区的皮质兴奋性，这与小脑对皮质运动区域产生抑制作用的概念一致。本研究为小脑TBS在运动序列学习中的特定作用提供了证据。

关键词

小脑 / θ脉冲刺激 / 运动学习 / 皮质脊髓兴奋性

Abstract

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Objective

To investigate the short-term modulatory effects of cerebellar theta burst stimulation (TBS) on motor sequence learning ability and motor cortical excitability in healthy individuals.

Methods

Ten medical interns from the Department of Rehabilitation and Medicine at Ruijin Rehabilitation Hospital (March to June 2024) were enrolled in a single-group pretest-posttest study. Participants received a single session of continuous theta burst stimulation (cTBS) over the right cerebellum. Before and after stimulation, participants performed a serial reaction time task (SRTT) with their right hand, with reaction times (RTs) and accuracy rates recorded. Changes in corticospinal excitability were assessed by measuring motor evoked potential (MEP) amplitude, latency, resting motor threshold (RMT), intracortical inhibition (ICI), intracortical facilitation (ICF), and cortical silent period (CSP).

Results

Post-cTBS, RTs for repeated sequences were prolonged (P<0.05), while RTs for random sequences shortened (P<0.05). Overall accuracy remained stable (P>0.05). In the left primary motor area (M1), MEP amplitude decreased (P<0.05), RMT increased (P<0.05), ICI inhibitory effect was enhanced (P<0.05), and CSP showed a trend toward prolongation (P>0.05). No significant changes were observed in ICF.

Conclusion

Cerebellar cTBS impairs the immediate performance of healthy participants during motor sequence learning, resulting in delayed responses, indicating that cerebellar cTBS may exert an adverse effect on immediate sequence consolidation. Concurrently, cerebellar cTBS reduces cortical excitability in the contralateral M1, consistent with the notion that the cerebellum exerts an inhibitory influence over cortical motor areas. These findings provide evidence for the specific role of cerebellar TBS in motor sequence learning.

Key words

Cerebellum / Theta burst stimulation / Motor learning / Corticospinal excitability

引用本文

潘文秀, 赵丹. 小脑磁刺激对运动学习及皮质兴奋性的影响. 现代仪器与医疗, 2025 , 31 (3) : 46 -50 . DOI: 10.11876/mimt202503008

Wenxiu Pan, Dan Zhao. Effects of cerebellar magnetic stimulation on motor learning and cortical excitability[J]. Modern Instruments & Medical Treatment, 2025 , 31 (3) : 46 -50 . DOI: 10.11876/mimt202503008

基金

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上海市卫生健康委员会青年项目(20234Y0292)

参考文献

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2025年第31卷第3期

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文章信息

doi: 10.11876/mimt202503008

首发时间：2026-10-23
出版时间：2025-06-10

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基金

上海市卫生健康委员会青年项目(20234Y0292)

作者信息

^1.上海市瑞金康复医院康复医学科，上海　200023

^2.上海交通大学医学院附属瑞金医院康复医学科，上海　200025

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2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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