Article(id=1320388793635558157, tenantId=1146029695717560320, journalId=1319373289681944729, issueId=1320388792901554957, articleNumber=null, orderNo=null, doi=10.11876/mimt202506003, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1792734820039, onlineDateStr=2026-10-23, pubDate=1765296000000, pubDateStr=2025-12-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792734820039, onlineIssueDateStr=2026-10-23, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792734820039, creator=13701087609, updateTime=1792734820039, updator=13701087609, issue=Issue{id=1320388792901554957, tenantId=1146029695717560320, journalId=1319373289681944729, year='2025', volume='31', issue='6', pageStart='1', pageEnd='96', issueExtLink='null', onlineDate='null', pubDate='1765296000000', pubDateStr='2025-12-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1792734819865, creator='13701087609', updateTime=1792746371372, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1320437243483902178, tenantId=1146029695717560320, journalId=1319373289681944729, issueId=1320388792901554957, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1320437243483902179, tenantId=1146029695717560320, journalId=1319373289681944729, issueId=1320388792901554957, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=13, endPage=19, ext={EN=ArticleExt(id=1320388793857856270, articleId=1320388793635558157, tenantId=1146029695717560320, journalId=1319373289681944729, language=EN, title=Clinical application of 5.0 T ultra-high field knee joint MRI and comparative study with 3.0 T MRI, columnId=null, journalTitle=Modern Instruments & Medical Treatment, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective This study aims to evaluate the application of 5.0 T ultra-high-field MRI in knee joint imaging and directly compare its performance to the widely used 3.0 T MRI to explore its primary advantages.
Methods This prospective study recruited healthy volunteers and patients with chronic knee pain between December 2023 and August 2024. All subjects underwent both 3.0 T and 5.0 T knee joint MRI scans. The imaging sequences included T1WI, 2D FS_PDWI, and 3D FS_PDWI sequences. Three musculoskeletal radiologists independently evaluated the image quality. Quantitative analysis measured the signal-to-noise ratio (SNR) of muscles, cartilage, and bone, while semi-quantitative analysis assessed overall image quality, diagnostic confidence, artifacts, homogeneity of fat suppression, and the visualization of knee structures, including cartilage, ligaments, menisci, and bone marrow edema. Statistical analysis was conducted using the Wilcoxon signed-rank test, and inter-rater agreement was evaluated using the Fleiss kappa coefficient.
Results A total of 48 healthy volunteers and 55 patients with chronic knee pain were included. Quantitative analysis showed that the SNR of muscles, cartilage, and bone in all sequences was significantly higher with 5.0 T MRI compared to 3.0 T (mean difference range -1.1 to -7.7, P<0.05). Semi-quantitative analysis indicated that the image quality of 5.0 T in 2D sequences was superior to 3.0 T (mean difference -0.24 to -0.50, P<0.05), whereas no significant advantage was observed for 3D PDWI sagittal imaging (mean difference -0.12, P=0.054). There was no significant difference between 5.0 T and 3.0 T in terms of artifacts and homogeneity of fat suppression (P>0.05). Although 5.0 T did not show significant advantages in reading outcomes, it significantly improved diagnostic confidence (mean difference -0.14 to -0.37, P<0.001) and demonstrated superior imaging of various knee structures (mean difference -0.11 to-0.35, all P<0.05). The inter-rater agreement among the three radiologists ranged from moderate to high (kappa 0.486 to 0.969).
Conclusion Compared with 3.0 T MRI, 5.0 T ultra-high-field MRI demonstrated significant advantages in knee joint imaging, particularly in the quality of muscle, cartilage, and bone imaging as well as in diagnostic confidence. Additionally, 5.0 T did not show any disadvantages in terms of artifact control and fat suppression uniformity. However, no significant advantage was noted in 3D PDWI image quality.
, authors=Suwei Liu, Ming Ni, Yali Li, Chenyu Jiang, Huishu Yuan
*, authorsList=Suwei Liu, Ming Ni, Yali Li, Chenyu Jiang, Huishu Yuan, authorCompany=null, correspAuthors=Huishu Yuan, authorNote=null, correspAuthorsNote=null, copyrightStatement=
All copyrights in 2025 belong to the sponsor of the journal.Not content published by the journal may be reproduced or abridged without authorization., copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1320388794294063888, articleId=1320388793635558157, tenantId=1146029695717560320, journalId=1319373289681944729, language=CN, title=5.0 T超高场膝关节MRI的临床应用及其与3.0 T MRI的对比研究, columnId=1320388793958519567, journalTitle=现代仪器与医疗, columnName=5.0 T超高场磁共振成像专栏, runingTitle=null, highlight=null, articleAbstract=
目的 评估5.0 T超高场MRI在膝关节病变成像中的应用效果，并与当前广泛使用的3.0 T MRI进行直接对比，以探讨其主要优势。
方法 2023年12月至2024年8月期间招募健康对照者和慢性膝关节疼痛患者，所有受试者分别接受3.0 T和5.0 T膝关节MRI扫描。扫描序列包括T1WI、2D FS_PDWI及3D FS_PDWI。3名肌肉骨骼放射科医生对图像质量进行独立评估。定量分析评估了肌肉、软骨及骨骼的信噪比（SNR），而半定量分析则对整体图像质量、诊断信心、伪影、脂肪抑制均匀性，以及软骨、韧带、半月板、骨髓水肿等关键结构的可视化效果进行了评估。统计学检验采用Wilcoxon符号秩检验，医生间一致性通过Fleiss kappa系数评估。
结果 本研究共纳入48名健康对照者和55名慢性膝关节疼痛患者。定量分析显示，5.0 T MRI在所有序列中的肌肉、软骨及骨骼SNR均优于3.0 T（平均差值-1.1～-7.7，P<0.05）。半定量分析表明，5.0 T的2D序列图像质量优于3.0 T（平均差值-0.24～-0.50，P<0.05），但在3D PDWI矢状位中无明显优势（平均差值-0.12，P=0.054）。伪影和脂肪抑制均匀性方面，两者间差异不显著（P>0.05）。尽管5.0 T在阅片结果上未表现出明显优势，但其诊断信心显著提高（平均差值-0.14～-0.37，P<0.001），并在多种组织结构显像中表现更佳（平均差值-0.11～-0.35，P均<0.05）。3名医生的评估一致性达到中度至高度（kappa=0.486～0.969）。
结论 与3.0 T MRI相比，5.0 T超高场MRI在膝关节成像中表现出显著优势，尤其在肌肉、软骨和骨骼的成像质量及诊断信心方面更为优越。5.0 T MRI在伪影和脂肪抑制均匀性方面未显示出劣势。然而，在3D PDWI图像质量上并无明显优势。5.0 T超高场MRI在小关节结构和微小病变的成像中具有较高的应用潜力，且在伪影和脂肪抑制均匀性方面表现良好。未来应进一步尝试提升3D PDWI图像质量。
, authors=刘苏卫, 倪铭, 李亚丽, 江晨雨, 袁慧书
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刘苏卫，女，在读博士研究生，研究方向：骨肌系统疾病影像诊断及人工智能
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袁慧书，女，博士研究生，主任医师，研究方向：骨肌系统疾病影像诊断及人工智能
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